Review
Biochemistry & Molecular Biology
Kate S. Hutson, Ian C. Davidson, Jerusha Bennett, Robert Poulin, Patrick L. Cahill
Summary: Identifying the cause of disease in aquatic organisms is challenging but crucial, especially with the increasing prevalence of diseases in a changing climate and global pathogen spread. Emerging diseases have significant implications for various aspects, including evolutionary ecology, wildlife conservation, seafood industry, recreation, cultural practices, and human health. Timely diagnosis and understanding of aetiology are essential for response and sustainability of aquatic ecosystems. Integrating traditional and modern microbiology advancements across ecological, veterinary, and medical fields will facilitate risk assessment and biosecurity management, promoting healthier aquatic ecosystems.
TRENDS IN MICROBIOLOGY
(2023)
Article
Computer Science, Information Systems
Mamoun T. Mardini, Zbigniew W. Ras
Summary: In recent years, the rise in healthcare spending has become a burden on governments, particularly in the United States. The selection of the primary medical procedure by physicians is crucial in the patient treatment process, as an incorrect choice can lead to hospital readmissions. This study proposes a system that can accurately identify the primary medical procedure for newly admitted patients, using three approaches and a procedure graph. The system also extracts possible associations between the primary procedure and other procedures during the hospital visit.
INFORMATION SYSTEMS FRONTIERS
(2022)
Article
Endocrinology & Metabolism
Ted D. Adams, Huong Meeks, Alison Fraser, Lance E. Davidson, John Holmen, Michael Newman, Anna R. Ibele, Nathan Richards, Steven C. Hunt, Jaewhan Kim
Summary: This retrospective study examined the long-term mortality outcomes of different bariatric surgery procedures and age groups. The study found that all-cause mortality was lower in the surgery group compared to the non-surgery group, with significant reductions in mortality from cardiovascular disease, cancer, and diabetes. However, the rate of death from suicide was higher in the surgery group, particularly in the youngest age group.
Article
Medicine, General & Internal
Giulia Ottaviani, Simone G. Ramos
Summary: Sudden unexpected death (SUD) is a fatal event that occurs suddenly in apparently healthy individuals without any prediction. SUD can occur as the first manifestation of an unknown underlying disease or within a few hours of the presentation of a disease. The study examined 75 SUD victims and found frequent congenital alterations of the cardiac conduction system in fetuses and infants.
Article
Gastroenterology & Hepatology
Chun-Han Lo, Peiyun Ni, Yan Yan, Wenjie Ma, Amit D. Joshi, Long H. Nguyen, Raaj S. Mehta, Paul Lochhead, Mingyang Song, Gary C. Curhan, Yin Cao, Andrew T. Chan
Summary: This study suggests that the use of PPIs is not associated with an increased risk of all-cause mortality and mortality due to major causes after accounting for protopathic bias.
Article
Gastroenterology & Hepatology
Bo Hyun Kim, Dahhay Lee, Kyu-Won Jung, Young-Joo Won, Hyunsoon Cho
Summary: This study found that patients with liver cancer are most likely to die from liver cancer and related liver disease, even 10 years after the diagnosis. Specialized long-term follow-up care is needed.
CLINICAL AND MOLECULAR HEPATOLOGY
(2022)
Article
Medicine, General & Internal
Elias Waezsada, Julie Hutter, Patrick Kahle, Joerg Yogarajah, Johannes Sperzel, Malte Kuniss, Thomas Neumann, Horst Esser, Christian Hamm, Andreas Hain
Summary: Heart failure is a global disease that can be effectively treated by following guideline-directed medical therapy, which reduces mortality and rehospitalization rates. The use of a defibrillator vest can protect patients from the risk of sudden cardiac death. This study evaluated the effects of GDMT on LV recovery and ICD implantation, finding that there was no significant difference in LV improvement between the groups with and without medication uptitration.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Hava Izci, Tim Tambuyzer, Jessica Vandeven, Jerome Xicluna, Hans Wildiers, Kevin Punie, Nynke Willers, Eva Oldenburger, Els Van Nieuwenhuysen, Patrick Berteloot, Ann Smeets, Ines Nevelsteen, Anne Deblander, Harlinde De Schutter, Patrick Neven, Geert Silversmit, Freija Verdoodt
Summary: This study found a fair agreement of cause of death between death certificates and medical files for breast cancer patients, with 84.7% concordance, 10.7% false positive, and 4.5% false negative rates. However, the five-year cause-specific survival and relative survival probability estimates were comparable for both sources.
ARCHIVES OF PUBLIC HEALTH
(2021)
Article
Pediatrics
Eyad Altamimi, Yousef Odeh, Tuka Al-Quraan, Elmi Mohamed, Naif Rawabdeh
Summary: This study aimed to evaluate the indications, diagnostic yields, concordance between histopathological and endoscopic findings, and suitability of pediatric upper endoscopies at a tertiary university hospital in Jordan. The results showed that abdominal pain was the most common indication for endoscopy, and factors such as age, symptoms, and appropriateness were predictive of abnormal results. It is suggested that normal endoscopic findings should not be overlooked, and obtaining more tissue biopsies may improve pathological detection rates.
Article
Medicine, General & Internal
Mohammed Madadin
Summary: This study investigated the understanding and ability of final-year medical students in completing the medical certificate of cause-of-death. Results showed that while students were able to correctly identify the immediate cause of death, many misunderstood the underlying cause and the chain of events leading to death. Most students made errors in completing the cause-of-death statement, indicating a need for continuous training in this area.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Food Science & Technology
Hyein Jung, Sangah Shin
Summary: This study finds that higher intake of tomatoes and lycopene is inversely associated with the risk of cardiovascular disease (CVD) mortality, and lycopene consumption is associated with a lower risk of all-cause mortality.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Peter Konyn, Omar Alshuwaykh, Brittany B. Dennis, George Cholankeril, Aijaz Ahmed, Donghee Kim
Summary: Gallstone disease is an independent risk factor for NAFLD but is not associated with all-cause mortality in individuals with NAFLD. Screening for gallstone disease may help stratify the risk of all-cause mortality related to gallstone disease.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Juyeong Kim, Eun-Cheol Park
Summary: This study aimed to assess the specific associations between stroke and all-cause and cause-specific mortality among Korean adults. The results showed that stroke was associated with a higher risk of all-cause, natural cause, and suicide mortality.
JOURNAL OF PUBLIC HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Uwe Guth, Christoph Junker, Marion Schafroth, Shaun Mcmillan, Andres R. Schneeberger, Constanze Elfgen, Edouard Battegay, Rolf Weitkunat
Summary: The study evaluates the recent developments in medical aid in dying (MAID) in Switzerland and highlights the need for more accurate recording of the diseases and conditions underlying the wish to die.
INTERNATIONAL JOURNAL OF PUBLIC HEALTH
(2023)
Article
Multidisciplinary Sciences
Iain M. Carey, Derek G. Cook, Tess Harris, Stephen DeWilde, Umar A. R. Chaudhry, David P. Strachan
Summary: The study identified factors such as age, non-white ethnicity, obesity, cognitive impairment, learning disabilities, severe mental illness, and place of residence that were closely associated with excess mortality during the COVID-19 pandemic in England. In contrast, gender did not show a significant association. While some comorbidities led to a decrease in excess mortality rates, they still remained higher than usual levels.
Letter
Obstetrics & Gynecology
Nnabuike Chibuoke Ngene, Jagidesa Moodley, Lameck Chinula, Mushi Matjila
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2021)
Article
Obstetrics & Gynecology
Samantha Budhram, Valerie Vannevel, Tanita Botha, Lawrence Chauke, Shastra Bhoora, Gaynor M. Balie, Natalie Odell, Hennie Lombaard, Amy Wise, Chrysanthi Georgiou, Nondumiso Ngxola, Emma Wynne, Unati Mbewu, Mfundo Mabenge, Sibusiso Phinzi, Nontsikelelo Gubu-Ntaba, Gareth Goldman, Kay Tunkyi, Sudhir Prithipal, Keshree Naidoo, Santhi Venkatachalam, Terence Moodley, Sean Mould, Mzuvele Hlabisa, Logie Govender, Charlene Maistry, John P. Habineza, Priya Israel, Serantha Foolchand, Nomandla Tsibiyane, Mala Panday, Priya Soma-Pillay, Sumaiya Adam, Felicia Molokoane, Matthew S. Mojela, Elizabeth J. van Rensburg, Tshililo Mashamba, Mushi Matjila, Sue Fawcus, Ayesha Osman, Mareli Venter, Gregory Petro, Ahminah Fakier, Eduard Langenegger, Catherine A. Cluver, Adrie Bekker, Liesl de Waard, Chantal Stewart, Nnabuike C. Ngene, Ongombe Lunda, Sylvia N. Cebekhulu, Siva Moodley, Mama-Asu Koranteng-Peprah, Emmanuel M. C. Ati, Salome Maswime, Laura M. Yates
Summary: The maternal mortality rate was high among pregnant women admitted with SARS-CoV-2 infection in South African healthcare facilities, with higher rates in those admitted primarily for COVID-19 illness and tuberculosis being the only co-morbidity associated with admission. Rates of cesarean delivery did not significantly differ and neonatal outcomes were similar among infected women admitted for COVID-19 and other indications.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2021)
Article
Obstetrics & Gynecology
Nnabuike Chibuoke Ngene, Jagidesa Moodley
Summary: In normotensive women, there were positive correlations between sFlt-1 and postpartum PSS, and between sFlt-1/PIGF ratio and postpartum PSS. In both normotensive and severe pre-eclampsia groups, there were non-significant correlations between PIGF and postpartum PSS, and non-significant correlations between pre-delivery PSS and pre-delivery VNRS. Other correlations were inconclusive.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2022)
Article
Medicine, General & Internal
Sergius C. Onwukwe, Nnabuike C. Ngene
Summary: This study assessed the extent of uncontrolled blood pressure and its predictors among hypertensive patients in a rural community in South Africa. The results showed that poor treatment adherence, obesity, and diabetes were significant predictors of uncontrolled blood pressure. To improve the management of hypertension, behavior change interventions and the use of a Community-Based Physical and Electronic Reminding and Tracking System (CB-PERTS) are recommended.
SOUTH AFRICAN FAMILY PRACTICE
(2022)
Article
Medicine, General & Internal
Nnabuike C. Ngene
Summary: In this case, a patient developed severe vaginal bleeding during MVA procedure, leading to the discovery of multiple uterine perforations during surgery. The surgical procedure was complicated, emphasizing the importance of maintaining awareness and avoiding loss of perception during surgery.
AFRICAN HEALTH SCIENCES
(2022)
Article
Infectious Diseases
Nnabuike C. Ngene, Jagidesa Moodley
Summary: Determining the primary cause of death for deceased patients with multiple diagnoses is challenging. The authors propose a modified version of the NJ model II to improve the objectivity and reproducibility of assigning the primary cause of death in deceased patients with multiple diagnoses.
SOUTHERN AFRICAN JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Medicine, General & Internal
Nnabuike Chibuoke Ngene
Summary: The proximity of the uterus and cervix to the urinary tract predisposes the latter to injury during obstetrical and gynaecological surgical procedures. Preliminary imaging reports should be limited to emergencies when determining the indication for invasive procedures.
AFRICAN HEALTH SCIENCES
(2022)
Article
Medicine, General & Internal
N. F. Moran, O. P. Khaliq, N. C. Ngene, J. Moodley
Summary: Isolated maternal tachycardia at rest is a clinical alert and should be investigated and managed promptly to avoid serious adverse events. This report reflects on a case of persistent maternal tachycardia resulting in fatal collapse due to mitral stenosis, highlighting the importance of timely investigation and management.
SAMJ SOUTH AFRICAN MEDICAL JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Nnabuike Chibuoke Ngene, Jagidesa Moodley
Summary: Pre-eclampsia complicated by pulmonary edema, severe hypertension, and other complications is a devastating condition, and understanding the underlying mechanisms during such emergencies is challenging without functional and responsive point-of-care imaging, laboratory, and critical-care services. This case highlights the experience of an unbooked 26-year-old patient presenting with symptoms of pre-eclampsia, severe hypertension, and pulmonary edema, who developed complications during transfer and eventually died in the intensive care unit. The article emphasizes several lessons, including the need for central venous pressure monitoring before cesarean delivery to facilitate timely surgery in case of deterioration.
CARDIOVASCULAR JOURNAL OF AFRICA
(2022)
Editorial Material
Obstetrics & Gynecology
Lawrence Chauke, Shastra Bhoora, Nnabuike Chibuoke Ngene
CASE REPORTS IN WOMENS HEALTH
(2023)
Article
Obstetrics & Gynecology
Nnabuike Chibuoke Ngene
Summary: This article describes a three-layer repair of an obstetric rectal buttonhole tear (ORBT) and provides clinical lessons. The three-layer repair may improve the tensile strength at the injury site. However, a two-layer repair can also be chosen in rare cases where the vagino-rectal fascia is not identifiable.
CASE REPORTS IN WOMENS HEALTH
(2023)
Article
Medicine, General & Internal
Raymond Bvumbi, Nnabuike Chibuoke Ngene
Summary: This study discusses a case of a 14-year-old girl who experienced pelvic pain and vaginal hematocolpometra due to an imperforate hymen during the COVID-19 pandemic. Treatment with partial and wide hymenectomy can prevent closure of the hymenal orifice after surgery. It is recommended to strengthen community awareness and counseling to mitigate the negative effects of imperforate hymen on girls.
AFRICAN HEALTH SCIENCES
(2023)
Review
Education, Scientific Disciplines
Nnabuike Chibuoke Ngene
Summary: This article discusses the principles of educational domains that academics need to know in order to write their teaching philosophy statements. The study found a lack of comprehensive literature on the required domain knowledge. It emphasizes the importance of using various teaching practices and models to achieve high-quality learning and valuable transformations in the Scholarship of Teaching and Learning.
ADVANCES IN MEDICAL EDUCATION AND PRACTICE
(2023)
Article
Obstetrics & Gynecology
Ugonna Aja-Okorie, Nnabuike Chibuoke Ngene
Summary: This case report highlights the importance of increased vigilance by healthcare professionals in diagnosing and treating atypical preeclampsia to prevent adverse outcomes. The report suggests that robust screening using history, physical examination, ultrasonography, and biomarkers in the first trimester can help identify women at high risk for prophylactic therapy with aspirin.
CASE REPORTS IN WOMENS HEALTH
(2022)
Article
Obstetrics & Gynecology
Ogbonnaya Orji, Nnabuike Chibuoke Ngene
Summary: We report a rare case of childbirth trauma resulting in stretching and prolapsing of the anterior lip of the cervix, and describe the management approach.
CASE REPORTS IN WOMENS HEALTH
(2022)
Article
Medicine, Research & Experimental
Tong Cheng, Zhusheng Chen, Yibin Qin, Xiang Zhu, Hongsheng Chen, Zhongling Xu, Xiaqing Ma
Summary: Morphine is commonly used and effective for pain relief, but its side effect of itching limits its clinical use. This paper discusses the potential of using esketamine to treat morphine-induced itching.
MEDICAL HYPOTHESES
(2024)
Article
Medicine, Research & Experimental
Sung Eun Lee, Eunjung Park, Ji-yun Kim, HyukHoon Kim
Summary: Hyperbaric oxygen therapy (HBOT) is a potential therapeutic modality that has been recognized for its favorable mechanisms in various diseases, including sepsis-associated encephalopathy (SAE). HBOT has neuroprotective effects through its anti-inflammatory and antiapoptotic effects as well as increased tissue oxygenation capacity. However, there are caveats and limitations in applying HBOT in sepsis.
MEDICAL HYPOTHESES
(2024)