4.7 Article

Tetrakis(1-3-diazinane-2-thione)platinum(II) chloride monohydrate complex: Synthesis, spectroscopic characterization, crystal structure and in vitro cytotoxic activity against A549, MCF7, HCT15 and HeLa human cancer lines

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INORGANIC CHEMISTRY COMMUNICATIONS
卷 44, 期 -, 页码 159-163

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ELSEVIER SCIENCE BV
DOI: 10.1016/j.inoche.2014.03.020

关键词

Dichloridotetrakis(1,3-diazinane-2-thione); platinum(II) complex; Single crystal X-ray structure; Pt-195 NMR; In vitro cytotoxicity studies

资金

  1. King Fahd University of Petroleum & Minerals (KFUPM) [IN131018]

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This communication reports on the synthesis, crystal structure and anticancer activities of a new Pt(II) complex [Pt(Diaz)(4)]Cl-2 center dot H2O of a heterocyclic thione, where Diaz = 1,3-diazinane-2-thione. Solid state Pt-195, N-15 and C-13 NMR are also reported along with other spectroscopic data. The cytotoxic evaluation of the complex against A549, MCF7, HCT15 and HeLa human cancer lines is reported. The title compound was found to be a better cytotoxic agent against MCF7 than cisplatin. (C) 2014 Elsevier B.V. All rights reserved.

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