期刊
INORGANIC CHEMISTRY COMMUNICATIONS
卷 13, 期 9, 页码 1050-1053出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.inoche.2010.06.008
关键词
Ruthenium complexes; G-quadruplex; Stabilization; ITC; FRET
资金
- 973 Program of China [2007CB815306]
- NSFC [20771105, 20871122, 00730420]
- NCET [NCET-06-0718]
- Ministry of Education [108103]
- GDNSFC [9351027501000003]
- Sun Yat-Sen University
Two new trinuclear ruthenium(II) complexes [(bpy)(6)Ru-3(tpbip)](6+) (1) and [(bPY)(6)Ru-3(tptaip)](6+) (2) (bpy=2,2'-bipyridine, tpbip=1,3,5-tris(1,10-phenanthroline-[5,6-d]imidazol-2-yl)-benzene, tptaip=2,4,6-tri(1,10-phenanthroline-[5,6-d]imidazol-2-yl)-1,3,5-triazine) have been synthesized and characterized. The interaction of human telomeric DNA with Ru(II) complexes was explored by means of CD spectroscopy, fluorescence titration, ITC and FRET melting. Results indicated that two complexes not only induce a remarkable conformational change of human telomeric DNA, but also have the ability to stabilize the C-quadruplex. (C) 2010 Elsevier B.V. All rights reserved.
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