Article
Chemistry, Inorganic & Nuclear
Maynak Pal, Vanitha Ramu, Dulal Musib, Amit Kunwar, Arunima Biswas, Mithun Roy
Summary: Iron(III)-phenolate/carboxylate complexes have potential for photo-activated chemotherapy. A new red light-absorbing iron(III)-phenolate/carboxylate complex-functionalized gold nanocomposite showed remarkable photocytotoxicity in adenocarcinomic human immortalized keratinocytes and alveolar basal epithelial cells.
INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Dulal Musib, Vanitha Ramu, Md Kausar Raza, Aarti Upadhyay, Maynak Pal, Amit Kunwar, Mithun Roy
Summary: Red light-activatable transition metal complexes have shown remarkable photodynamic activity in this study, with the La(iii)-curcumin-functionalized gold nanocomposite demonstrating high photosensitivity and inducing apoptosis in adenocarcinomic cells through red light-induced generation of singlet oxygen.
INORGANIC CHEMISTRY FRONTIERS
(2022)
Review
Biochemistry & Molecular Biology
Felix Funk, Beat Fluehmann, Amy E. Barton
Summary: Un-complexed polynuclear ferric oxyhydroxide is not safe or effective for patient administration. Stable complexes formed with carbohydrates provide usable iron while avoiding adverse effects. The surface characteristics of iron-carbohydrate complexes determine their clearance rate, tissue distribution, pharmacokinetic, and pharmacodynamic profiles.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Organic
Shen-Zhen Zhang, Shan-Shan Zhang, Jun-Li Li, Shigang Shen, Xiu-Long Yang, Xiaoying Niu
Summary: A photocatalyst- and additive-free visible-light-induced 6 pi-photocyclization of ortho-biaryl-appended beta-ketoesters has been developed, which allows the efficient and selective formation of trans-fused products. Preliminary mechanistic studies indicate the feasibility of both 1,5-H shift and intersystem crossing of the diradical intermediate.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Bholey Singh, Balaram Pani, Deepak Gupta
Summary: These facial-Re(CO)(3)-based acyclic complexes exhibit unique structural features and strong DNA binding ability, confirmed by X-ray diffraction analysis which shows a variety of intermolecular supramolecular interactions.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Inorganic & Nuclear
Aarti Upadhyay, Paramita Kundu, Vanitha Ramu, Paturu Kondaiah, Akhil R. Chakravarty
Summary: Three compounds were synthesized and characterized, and their anticancer activities were studied. They generated singlet oxygen under red light and showed photocytotoxicity.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Roy Cineus, Samira M. Abozeid, Gregory E. Sokolow, Joseph A. Spernyak, Janet R. Morrow
Summary: This study characterizes and studies Fe(III) complexes containing a triamine framework and phenolate or hydroxypyridine donors as T-1 MRI probes. The ligands reported here are pentadentate, giving six-coordinate complexes with a coordination site for innersphere water. These complexes show potential for enhanced contrast in T-1-weighted imaging analyses in BALB/c mice.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Didar Asik, Samira M. Abozeid, Steven G. Turowski, Joseph A. Spernyak, Janet R. Morrow
Summary: Four high-spin Fe(III) macrocyclic complexes were synthesized for potential applications as iron-based MRI contrast agents, with dinuclear complexes showing significantly increased relaxivity compared to mononuclear counterparts at appropriate field strengths.
INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Atrayee Banaspati, Md Kausar Raza, Tridib K. Goswami
Summary: The Cu(II) complexes synthesized in this study exhibit strong DNA binding propensity and high affinity for human serum albumin. These complexes demonstrate efficient cytotoxicity against various cancer cells under visible light, with low toxicity.
Article
Chemistry, Inorganic & Nuclear
Cyril Rajnak, Romana Micova, Jan Moncol, Lubor Dlhan, Christoph Krueger, Franz Renz, Roman Boca
Summary: The iron(iii) mononuclear complex [Fe(Cl-3,Cl-5-L)(NCSe)] exhibits a thermally induced spin crossover with a broad hysteresis width, showing different spin states at different temperatures. Analogous complexes of the [Fe(X-3,X-5-L)(Y)] type are high-spin over the whole temperature interval.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Multidisciplinary
Yuta Ishikawa, Tatsuya Kameyama, Tsukasa Torimoto, Hajime Maeda, Masahito Segi, Taniyuki Furuyama
Summary: Phthalocyanine ruthenium complexes have been identified as red-light activatable catalysts for trifluoromethylation reactions, enabling the chlorotrifluoromethylation of alkenes without sacrificial reducing reagents. This reaction shows good compatibility with a blue-light-absorbing substrate, unlike traditional photoreaction conditions where the substrate decomposes completely under blue light irradiation.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Inorganic & Nuclear
Somarupa Sahoo, Abinaya Raghavan, Arun Kumar, Dipankar Nandi, Akhil R. Chakravarty
Summary: Iron(III) complexes of curcumin with tridentate NNN-donor dipicolylamine-based ligands were prepared and studied for their photo-induced cytotoxicity in cancer cell lines. The biotinylated analogue of the complex showed enhanced cellular uptake and cytotoxicity, making it a potential targeted photodynamic therapy drug.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Joseph A. Zurakowski, Brady J. H. Austen, Maeve C. Dufour, Moulika Bhattacharyya, Denis M. Spasyuk, Marcus W. Drover
Summary: This study reported the preparation of a novel cobalt (III) hydride and the influence of ligand design on reactivity, combining synchrotron-radiation crystallography and electrochemical studies for detailed investigation.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Inorganic & Nuclear
Zhilin Guo, Maolin You, Yi-Fei Deng, Qiang Liu, Yin-Shan Meng, Zoe Pikramenou, Yuan-Zhu Zhang
Summary: The study successfully obtained two Fe(ii) grid-like complexes using a coordination-driven supramolecular assembly strategy, demonstrating spin-crossover behavior in azido-bridged complexes. By substitution of the ligand, the complex showed a synergistic effect between spin-crossover behavior and luminescence.
DALTON TRANSACTIONS
(2021)
Article
Biochemistry & Molecular Biology
Wenyu Wu Klingler, Nadine Giger, Lukas Schneider, Vipin Babu, Christiane Konig, Patrick Spielmann, Roland H. Wenger, Stefano Ferrari, Bernhard Spingler
Summary: This study reports the design of short PEG chain functionalized Pc photosensitizers to decrease aggregation and increase aqueous solubility. The best-performing photosensitizer, MLC31, showed high photocytotoxicity and mitochondrial targeting under near-infrared light, making it a potential candidate for cisplatin-resistant cancer cell therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Wolfgang Walther, Dhiyaa Althagafi, Danielle Curran, Cillian O'Beirne, Cian Mc Carthy, Ingo Ott, Uttara Basu, Britta Buttner, Anja Sterner-Kock, Helge Mueller-Bunz, Goar Sanchez-Sanz, Xiangming Zhu, Matthias Tacke
Article
Chemistry, Medicinal
Anna Notaro, Angelo Frei, Riccardo Rubbiani, Marta Jakubaszek, Uttara Basu, Severin Koch, Cristina Mari, Mazzarine Dotou, Olivier Blacque, Jeremie Gouyon, Fethi Bedioui, Nils Rotthowe, Rainer F. Winter, Bruno Goud, Stefano Ferrari, Mickael Tharaud, Martina Rezacova, Jana Humajova, Pavel Tomsik, Gilles Gasser
JOURNAL OF MEDICINAL CHEMISTRY
(2020)
Review
Chemistry, Inorganic & Nuclear
Uttara Basu, Mithun Roy, Akhil R. Chakravarty
COORDINATION CHEMISTRY REVIEWS
(2020)
Article
Chemistry, Multidisciplinary
Maria Gil-Moles, Uttara Basu, Rolf Bussing, Henrik Hoffmeister, Sebastian Turck, Agnieszka Varchmin, Ingo Ott
CHEMISTRY-A EUROPEAN JOURNAL
(2020)
Article
Chemistry, Multidisciplinary
Saurav Bhattacharya, Uttara Basu, Mohamed Haouas, Pei Su, Michael Forrester Espenship, Fei Wang, Albert Sole-Daura, Dereje H. Taffa, Michael Wark, Josep M. Poblet, Julia Laskin, Emmanuel Cadot, Ulrich Kortz
Summary: This paper reports the synthesis, structure, and characterization of neutral palladium-oxo clusters (POCs), specifically the Pd-16, Pd-16Cl, and Pd-24 compounds. These compounds exhibit novel chemical properties based on their different structural units. Comprehensive characterization of these compounds was conducted in the solid, solution, and gas phases.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Inorganic & Nuclear
Tukki Sarkar, Arun Kumar, Somarupa Sahoo, Akhtar Hussain
Summary: The bioessential nature of cobalt and the rich photochemistry of its coordination complexes have been utilized to develop six novel mixed-ligand cobalt(III) complexes for studying their light-triggered cytotoxicity in cancer cells, with one of the complexes showing remarkable visible-light-triggered cytotoxicity against cancer cells.
INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Silva Khodjoyan, Edwyn Remadna, Heloise Dossmann, Denis Lesage, Geoffrey Gontard, Jeremy Forte, Henrik Hoffmeister, Uttara Basu, Ingo Ott, Philip Spence, Zoe A. E. Waller, Michele Salmain, Benoit Bertrand
Summary: A library of eleven cationic gold(III) complexes with novel structures were synthesized and tested for their antiproliferative activity on cancer cells, showing contrasting effects on viability and two complexes with high activity or selectivity. Reactivity studies with biological molecules revealed unique behavior compared to known gold complexes, indicating a new mode of action.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Maria Gil-Moles, Sebastian Tuerck, Uttara Basu, Andrea Pettenuzzo, Saurav Bhattacharya, Ananthu Rajan, Xiang Ma, Rolf Buessing, Jessica Woelker, Hilke Burmeister, Henrik Hoffmeister, Pia Schneeberg, Andre Prause, Petra Lippmann, Josephine Kusi-Nimarko, Storm Hassell-Hart, Andrew McGown, Daniel Guest, Yan Lin, Anna Notaro, Robin Vinck, Johannes Karges, Kevin Cariou, Kun Peng, Xue Qin, Xing Wang, Joanna Skiba, Lukasz Szczupak, Konrad Kowalski, Ulrich Schatzschneider, Catherine Hemmert, Heinz Gornitzka, Elena R. Milaeva, Alexey A. Nazarov, Gilles Gasser, John Spencer, Luca Ronconi, Ulrich Kortz, Jindrich Cinatl, Denisa Bojkova, Ingo Ott
Summary: The global spread of SARS-CoV-2 has highlighted the need for antiviral therapeutics, with studies showing potential activity of metal complexes, including gold, silver, and POMs, in inhibiting the replication mechanisms of the virus.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Bappaditya Gole, Brice Kauffmann, Arnaud Tron, Victor Maurizot, Nathan McClenaghan, Ivan Huc, Yann Ferrand
Summary: Aromatic helix-sheet-helix foldamers composed of photosensitive diaza-anthracene units were designed and synthesized. Their conformations can be manipulated by solvent, temperature, and helix handedness control. The photoreactivity of diazaanthracene units was found to be dependent on their position. Cooperative effects were observed in the photoreactions, which could be programmed to occur in a specific order.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Oncology
Imran Khan, Brunilde Gril, Ayuko Hoshino, Howard H. Yang, Maxwell P. Lee, Simone Difilippantonio, David C. Lyden, Patricia S. Steeg
Summary: This study demonstrates that tumor-derived exosomes can suppress metastasis by delivering the NME1 metastasis suppressor to recipient tumor cells, resulting in altered endocytic patterns and reduced cell motility and migration. Proteomic analysis of the exosomes identified differentially expressed proteins that may contribute to these effects. Liposomes containing rNME1 also exhibited similar suppressive effects. These findings expand our understanding of the functions of exosomes and liposomes and provide a novel approach to prevent metastasis.
CLINICAL & EXPERIMENTAL METASTASIS
(2022)
Article
Chemistry, Multidisciplinary
Tomer Babu, Hiba Ghareeb, Uttara Basu, Hemma Schueffl, Sarah Theiner, Petra Heffeter, Gunda Koellensperger, Norman Metanis, Valentina Gandin, Ingo Ott, Claudia Schmidt, Dan Gibson
Summary: Au-I-carbene and Pt-IV-Au-I-carbene prodrugs exhibit low to sub-mu M activity against various cancer cell lines and overcome cisplatin resistance. The most potent prodrug is achieved by linking a cisplatin-derived Pt-IV(phenylbutyrate) complex to an Au-I-phenylimidazolylidene complex 2. In vivo tests on Lewis Lung Carcinoma demonstrate that the prodrug Pt-IV(phenylbutyrate)-Au-I-carbene (7) and the co-administration of cisplatin:phenylbutyrate:2 efficiently inhibit tumor growth (approximately 95%), surpassing the effectiveness of 2 (75%) or cisplatin (84%), while only causing 5% body weight loss compared to 14% for 2, 20% for cisplatin, and >30% for the co-administration.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Computer Science, Information Systems
Akhtar Hussain, Van-Hai Bui, Hak-Man Kim
Summary: A dynamic pricing model is proposed to manage EV loads locally and mitigate equipment overloading in distribution systems. The model considers the sensitivity of EV owners to battery state of charge and urgency of recharge, and the welfare of the EV fleet operator in terms of net load and electricity price. The proposed method achieves privacy preservation and has shown effectiveness in mitigating transformer overloading during peak load hours.
Review
Computer Science, Information Systems
Masooma Nazari, Akhtar Hussain, Petr Musilek
Summary: The growing penetration of electric vehicles presents challenges for power systems, especially distribution systems, due to uncertain load. Clustering methods can address this problem, and previous studies have applied clustering methods to various aspects of electric vehicles. This contribution reviews existing clustering methods, discusses their application in different aspects of electric vehicles, and identifies gaps and future research directions.
Article
Energy & Fuels
Akhtar Hussain, Petr Musilek
Summary: A marginal capacity value-based sizing approach is proposed to determine the trade-off between BESS size and corresponding benefits in managing load of distribution systems under high EV penetration. An iterative method and search algorithm are used to determine BESS size, showing significant reduction in BESS size while maintaining peak shaving ability.
JOURNAL OF ENERGY STORAGE
(2022)
Article
Chemistry, Multidisciplinary
Xue-Quan Zhou, Imma Carbo-Bague, Maxime A. Siegler, Jonathan Hilgendorf, Uttara Basu, Ingo Ott, Rongfang Liu, Liyan Zhang, Vadde Ramu, Adriaan P. IJzerman, Sylvestre Bonnet
Summary: Two gold(III) complexes with similar molecular shapes and monocationic charges were prepared in this work, allowing comparison of their chemistry, protein interaction, and anticancer properties. Despite their similarities, the complexes exhibited differences in reactivity towards biological thiols and cytotoxicity towards cancer cells, highlighting the potential of bis-cyclometalation for developing novel gold-based cytotoxic compounds.