Article
Chemistry, Inorganic & Nuclear
Dmitry I. Pavlov, Denis G. Samsonenko, Laura Bonfili, Massimiliano Cuccioloni, Enrico Benassi, Riccardo Pettinari, Andrei S. Potapov, Vladislava V. Matveevskaya
Summary: Six new arene-ruthenium(II) complexes with different arene and oxime ligands were synthesized and characterized. The complexes exhibited a half-sandwich piano-stool geometry and showed promising anti-proliferative activity.
INORGANICA CHIMICA ACTA
(2022)
Article
Chemistry, Inorganic & Nuclear
Lorenzo Pietracci, Riccardo Pettinari, Alessia Tombesi, Fabio Marchetti, Claudio Pettinari, Agustiïn Galindo, Farzaneh Fadaei-Tirani, Mouna Hadiji, Paul J. Dyson
Summary: This study investigates the coordination mechanisms of pyrazolone ligands containing a pyridine ring with the (Ru(II)) fragment through experimental and theoretical calculations. The ligands were found to coordinate in an unusual N,O-chelating fashion with Ru(II), and various complexes were synthesized. The study provides important insights into the properties of the ligands and complexes.
Article
Chemistry, Applied
Ramya Prabaharan, Ramesh Rengan, Devan Umapathy, Antony Joseph Velanganni Arockiam, Jan Grzegorz Malecki
Summary: The study synthesized six new arene ruthenium (II) complexes and evaluated their anticancer activity through MTT assay and staining techniques, demonstrating good cytotoxicity against cancer cell lines, particularly with complex 6 showing potential anticancer activity.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Alba Hernandez-Garcia, Lenka Markova, Maria Dolores Santana, Jitka Pracharova, Delia Bautista, Hana Kostrhunova, Vojtech Novohradsky, Viktor Brabec, Jose Ruiz, Jana Kasparkova
Summary: This study presents the synthesis and characterization of six new heteroleptic osmium(II) complexes with varying substituents in the R3 position of the phenyl ring of the cyclometalating C^N ligand. These complexes are highly kinetically inert and absorb a full-wavelength range of visible light. The antiproliferative activity of these complexes has been investigated using human cancer and noncancerous cell cultures, showing that they are more potent than conventional cisplatin. The mechanism of action involves the activation of the endoplasmic reticulum stress pathway and disruption of calcium homeostasis.
INORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Dalila Iacopini, Jan Vanco, Sebastiano Di Pietro, Vittorio Bordoni, Stefano Zacchini, Fabio Marchetti, Zdenek Dvorak, Tomas Malina, Lorenzo Biancalana, Zdenek Travnicek, Valeria Di Bussolo
Summary: Glycoconjugation is a powerful strategy to enhance the anticancer activity of metal complexes. In this study, glycoconjugated ruthenium(II) p-cymene complexes were synthesized by modifying commercial arylphosphanes with carbohydrate-derived fragments. These complexes exhibited significant cytotoxicity against various cancer cell lines and showed potential as novel anticancer agents.
BIOORGANIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Stephen Mensah, Joseph D. Rosenthal, Mamta Dagar, Tyson Brown, Jonathan J. Mills, Christopher G. Hamaker, Gregory M. Ferrence, Michael I. Webb
Summary: The evolution of high virulence bacterial strains has led to the development of novel therapeutic agents. Metal-based therapeutics, with their structural variability and unique modes of action, show great promise. This study focused on the preparation and evaluation of ruthenium(ii)-arene complexes containing Schiff base ligands with an attached ferrocene, and identified a complex with prominent activity against clinically relevant bacterial strains.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Applied
Saranya Sundar, Ramesh Rengan, Anandaraj Pennamuthiriyan, David Semeril
Summary: A facile catalytic one-pot synthesis of N-acylhydrazones has been described using arene ruthenium (II) complexes. The method provides a wide range of N-acylhydrazones in good yields with high selectivity and functional group tolerance, without any alkylated products.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Sofia Friaes, Sara Realista, Clara S. B. Gomes, Paulo N. Martinho, Luis F. Veiros, Martin Albrecht, Beatriz Royo
Summary: New manganese complexes with di-triazolylidene ligands display different ligand coordination modes, bridging and chelating, depending on the substituents and synthetic procedure. The structures of monometallic and bimetallic complexes were determined by X-ray diffraction studies. Cyclic voltammetry studies indicate reversible redox processes for monometallic Mn(i) complexes and a quasi-reversible EC mechanism for the oxidation of bimetallic complexes.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Inorganic & Nuclear
Piotr Pander, Larissa Gomes Franca, Fernando B. Dias, Valery N. Kozhevnikov
Summary: Alkylation of a phenolic hydroxyl group in a salen-type ligand changes its coordination mode and allows the synthesis of a new luminescent Pt(II) complex 2. While the complex is not luminescent in solution, it exhibits emission in the solid state, making it suitable for organic light-emitting diodes. Complex 2 shows high external quantum efficiency and luminance in a vacuum-deposited device. Comparative analysis shows that the luminescent properties of O<^>N<^>N<^>O and C<^>N<^>N<^>O complexes are coincidental, and the two complexes display different electrochemical behavior.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Pragti, Sreshtha Nayek, Satyam Singh, Avinash Sonawane, Ivo Grabchev, Rakesh Ganguly, Suman Mukhopadhyay
Summary: In this study, three Ru(II) arene complexes with a bidentate benzimidazole-based ligand were synthesized and their antitumor activity was studied by varying the co-ligand X. The synthesized compounds showed good interactions with serum albumin proteins, had good drug stability and lipophilic character. They were found to bind with DNA and could induce apoptosis in cancer cells, as well as upregulate cleaved caspase-3 expression and downregulate BCLXL expression. These findings provide a new direction for the investigation of antitumor ruthenium-based metallodrugs using benzimidazole-based ligands.
DALTON TRANSACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Franco Bisceglie, Giorgio Pelosi, Nicolo Orsoni, Marianna Pioli, Mauro Carcelli, Paolo Pelagatti, Silvana Pinelli, Peter J. Sadler
Summary: We synthesized and characterized three half-sandwich Ru(II) arene complexes with different ligands, where one of the complexes exhibited good phototoxicity towards lung cancer cells upon blue light irradiation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Inorganic & Nuclear
Riccardo Pettinari, Fabio Marchetti, Alessia Tombesi, Corrado Di Nicola, Claudio Pettinari, Chuanpan Guo, Zhihong Zhang, Agustin Galindo, Farzaneh Fadaei-Tirani, Mouna Hadiji, Paul J. Dyson
Summary: Two new pyrazole ligands with a pyridine moiety were synthesized and fully characterized, and their coordination modes in metal complexes were analyzed. Cytotoxicity studies showed similar activity of these ligands and complexes in cisplatin-sensitive and cisplatin-resistant ovarian carcinoma cells.
INORGANICA CHIMICA ACTA
(2021)
Article
Chemistry, Multidisciplinary
Bruno Therrien
Summary: This article discusses the author's contributions to the development and popularity of arene ruthenium assemblies, which have been mainly driven by applications in the biological field. The author has focused on using arene ruthenium building blocks as tools to construct added-value objects for nearly 15 years.
Article
Chemistry, Multidisciplinary
Sankar Monika, Rengan Ramesh
Summary: This study reports the synthesis of a new series of organometallic dinuclear ruthenium(ii) arene complexes and investigates their in vitro antiproliferative activity and cancer cell death mechanism. The formation of complexes was confirmed by various spectroscopic techniques. The synthesized complexes showed higher inhibition of cancer cells compared to the standard cisplatin drug, and apoptosis was confirmed through morphological changes and phosphatidylserine externalization.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
David Gomez de Segura, Elena Lalinde, M. Teresa Moreno
Summary: New cyclometalated PtII complexes with different picolinate ligands were synthesized, and the solid-state packing and photophysical properties were modulated through donor-acceptor H-bonding interactions and stacking interactions. Theoretical calculations and experimental studies revealed the influence of metal-metal contacts and chelate stacking on the charge transfer character.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Physical
Gabriela Gastelu, David Savary, Martin Hulla, Daniel Ortiz, Jorge G. Uranga, Paul J. Dyson
Summary: The article introduces an alternative reaction pathway for the O-formylation of alcohols and bio-alcohols, which produces industrially relevant formate esters. The reaction is catalyzed by formic acid, which can be produced from CO2 captured in the reaction. The in situ produced formic acid improves the reaction rate, and each catalyst can be recycled for reuse.
Article
Chemistry, Medicinal
Daphne Romani, Fabio Marchetti, Corrado Di Nicola, Massimiliano Cuccioloni, Chunmei Gong, Anna Maria Eleuteri, Agustin Galindo, Farzaneh Fadaei-Tirani, Massimo Nabissi, Riccardo Pettinari
Summary: A series of Ga(Q(n))(3) coordination compounds were synthesized and characterized through various techniques. Cytotoxicity studies showed interesting results in terms of selectivity and toxicity values compared with cisplatin. Mechanistic investigations revealed that the gallium(III) complexes induced cancer cell death through ferroptosis, triggering various cell death signals and altering cell redox homeostasis.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Editorial Material
Chemistry, Organic
Xiao-Feng Wu, Paul J. Dyson, Bruce A. Arndtsen
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Lorenzo Pietracci, Riccardo Pettinari, Alessia Tombesi, Fabio Marchetti, Claudio Pettinari, Agustiïn Galindo, Farzaneh Fadaei-Tirani, Mouna Hadiji, Paul J. Dyson
Summary: This study investigates the coordination mechanisms of pyrazolone ligands containing a pyridine ring with the (Ru(II)) fragment through experimental and theoretical calculations. The ligands were found to coordinate in an unusual N,O-chelating fashion with Ru(II), and various complexes were synthesized. The study provides important insights into the properties of the ligands and complexes.
Article
Multidisciplinary Sciences
Mingyang Liu, Paul J. Dyson
Summary: Efficient valorization of lignin, a sustainable and renewable source, is essential for reducing dependence on fossil-derived feedstocks. This study presents a highly efficient strategy for extracting aromatic monomers and generating functionalized diaryl ethers from lignin using oxidative cross-coupling reactions.
NATURE COMMUNICATIONS
(2023)
Article
Polymer Science
Yury A. Belousov, Mikhail T. Metlin, Darya A. Metlina, Mikhail A. Kiskin, Ilya A. Yakushev, Trofim A. Polikovskiy, Ilya V. Taydakov, Andrei A. Drozdov, Fabio Marchetti, Claudio Pettinari
Summary: A new strategy for the easy polymerization of anionic [Ln(Q(cy))(4)](-) into two-dimensional layers of [AgLn(Q(cy))(4)](n) is proposed by binding the single molecular anions [Ln(Q(cy))(4)](-) to silver cations through coordination. The luminescent properties of [AgLn(Q(cy))(4)](n) have been studied, and it was found that LMCT quenching is effectively suppressed in the heterometallic [AgEu(Q(cy))(4)](n) polymer, explaining the low PLQY in [Eu(Q(cy))(4)](-). Sensibilization coefficients for H3O[Eu(Q(cy))(4)], [AgEu(Q(cy))(4)](n), and H3O[Sm(Q(cy))(4)] complexes were estimated via theoretical analysis and PLQY measurements.
Article
Chemistry, Physical
Gabriela Gastelu, Pritha Saha, Paul J. Dyson, Martin Hulla, Jorge G. Uranga
Summary: Autocatalytic reactions play a key role in the beginning of life and carbon capture and utilization, providing inspiration for the development of advanced systems for the synthesis of value-added chemicals.
Article
Biochemistry & Molecular Biology
Sonila Xhafa, Laura Olivieri, Corrado Di Nicola, Riccardo Pettinari, Claudio Pettinari, Alessia Tombesi, Fabio Marchetti
Summary: In this study, a new synthetic protocol based on microwave-assisted synthesis was used to prepare higher yields of zinc and copper in MOFs with different ligands. The antibacterial activity of these MOFs was tested against Gram-negative and Gram-positive bacteria, and the results showed that they exhibited broad-spectrum activity and strong efficiency in inhibiting bacterial growth. The mechanism of action was found to be based on the surface contact of MOF particles with bacterial cells and the generation of reactive oxygen species.
Article
Chemistry, Multidisciplinary
Yue Hu, Xinmin Li, Mingyang Liu, Stephan Bartling, Henrik Lund, Paul J. Dyson, Matthias Beller, Rajenahally V. Jagadeesh
Summary: Catalytic hydrodeoxygenation is a crucial technology for converting biomass-based feedstocks into essential chemicals and fuels. This study reports the preparation and application of Ni nanoparticles supported on ZSM-5 as an efficient hydrodeoxygenation catalyst. The Ni-based nanoparticles exhibit selective hydrodeoxygenation of various functional substrates, showcasing their versatility.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Patrick Doerflinger, Yong Ding, Valentin Schmid, Melina Armer, Roland C. Turnell-Ritson, Bin Ding, Paul J. Dyson, Mohammad Khaja Nazeeruddin, Vladimir Dyakonov
Summary: This study investigates the effect of a stabilizing additive on the charge carrier mobility and lifetime in triple cation perovskite thin films under thermal stress. The results reveal different conductivity behaviors in two temperature regions and identify two dominant scattering mechanisms. The stabilizing additive limits temperature-activated mobile ions and retards degradation of the perovskite film, leading to improved performance and stability.
Review
Chemistry, Physical
Patrizio Campitelli, Alessia Tombesi, Corrado Di Nicola, Claudio Pettinari, Anna Mauri, Simona Galli, Tongan Yan, Dahuan Liu, Jiaxin Dawn Duan, Subhadip Goswami, Giulia Tuci, Giuliano Giambastiani, Joseph T. Hupp, Andrea Rossin
Summary: The reaction of 3,5-diamino-4,4'-bis(1H-pyrazole) with copper(II) and nickel(II) acetates under solvothermal conditions produced four mixed-metal metal-organic frameworks. These frameworks have macroporous structures and high CO2 adsorption capacity. They were also tested as heterogeneous catalysts for CO2 electrochemical reduction, with Cu0.05Ni0.95 showing the best performance and producing CO and CH4 as the main reduction products.
ACS APPLIED ENERGY MATERIALS
(2023)
Article
Chemistry, Inorganic & Nuclear
Sarah A. P. Pereira, Jan Romano-deGea, Ana Isabel Barbosa, Sofia A. Costa A. Lima, Paul J. J. Dyson, M. Lucia M. F. S. Saraiva
Summary: The study demonstrates that ruthenium-based compounds, especially [Ru(& eta;(6)-toluene)(PPh3)(2)Cl]Cl, show high selectivity and cytotoxicity against breast cancer cells. This compound has potential as a promising candidate for breast cancer treatment.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Multidisciplinary
Corrado Di Nicola, Fabio Marchetti, Alessia Tombesi, Sonila Xhafa, Patrizio Campitelli, Marco Moroni, Simona Galli, Riccardo Pettinari, Claudio Pettinari
Summary: Novel copper(ii) coordination polymers were synthesized and their thermal behavior and structural features were investigated. The nanoparticles showed potential antibacterial activity through a contact kill mechanism involving ROS production.
NEW JOURNAL OF CHEMISTRY
(2023)
