Article
Chemistry, Multidisciplinary
Sankar Monika, Rengan Ramesh
Summary: This study reports the synthesis of a new series of organometallic dinuclear ruthenium(ii) arene complexes and investigates their in vitro antiproliferative activity and cancer cell death mechanism. The formation of complexes was confirmed by various spectroscopic techniques. The synthesized complexes showed higher inhibition of cancer cells compared to the standard cisplatin drug, and apoptosis was confirmed through morphological changes and phosphatidylserine externalization.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Stephen Mensah, Joseph D. Rosenthal, Mamta Dagar, Tyson Brown, Jonathan J. Mills, Christopher G. Hamaker, Gregory M. Ferrence, Michael I. Webb
Summary: The evolution of high virulence bacterial strains has led to the development of novel therapeutic agents. Metal-based therapeutics, with their structural variability and unique modes of action, show great promise. This study focused on the preparation and evaluation of ruthenium(ii)-arene complexes containing Schiff base ligands with an attached ferrocene, and identified a complex with prominent activity against clinically relevant bacterial strains.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Inorganic & Nuclear
Pragti, Sreshtha Nayek, Satyam Singh, Avinash Sonawane, Ivo Grabchev, Rakesh Ganguly, Suman Mukhopadhyay
Summary: In this study, three Ru(II) arene complexes with a bidentate benzimidazole-based ligand were synthesized and their antitumor activity was studied by varying the co-ligand X. The synthesized compounds showed good interactions with serum albumin proteins, had good drug stability and lipophilic character. They were found to bind with DNA and could induce apoptosis in cancer cells, as well as upregulate cleaved caspase-3 expression and downregulate BCLXL expression. These findings provide a new direction for the investigation of antitumor ruthenium-based metallodrugs using benzimidazole-based ligands.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Dmitry I. Pavlov, Denis G. Samsonenko, Laura Bonfili, Massimiliano Cuccioloni, Enrico Benassi, Riccardo Pettinari, Andrei S. Potapov, Vladislava V. Matveevskaya
Summary: Six new arene-ruthenium(II) complexes with different arene and oxime ligands were synthesized and characterized. The complexes exhibited a half-sandwich piano-stool geometry and showed promising anti-proliferative activity.
INORGANICA CHIMICA ACTA
(2022)
Article
Chemistry, Inorganic & Nuclear
Stefan Nikolic, Jemma Arakelyan, Vladimir Kushnarev, Samah Mutasim Alfadul, Dalibor Stankovic, Yaroslav I. Kraynik, Sanja Grguric-Sipka, Maria V. Babak
Summary: The astable half-sandwich Ru-dipyridophenazine complex can significantly decrease tumor burden in mouse xenografts without causing kidney and liver toxicity, and its mechanism of action is linked to DNA degradation and ROS induction.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Arunachalam Abirami, Umapathy Devan, Rengan Ramesh, Arockiam Antony Joseph Velanganni, Jan Grzegorz Malecki
Summary: This study synthesized six arene ruthenium(ii) complexes and evaluated their inhibitory effects on breast cancer cells. The complexes exhibited good antiproliferative activities by inducing apoptotic cell death through an intrinsic mitochondrial pathway.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Srividya Swaminathan, Jebiti Haribabu, Mahendiran Dharmasivam, Nikhil Maroli, Jayachandra Prakasan Jayadharini, Nithya Balakrishnan, Nattamai Bhuvanesh, Cesar Echeverria, Ramasamy Karvembu
Summary: We designed and synthesized bipodal ligands with varying substitution on the phenyl group spacer. Ligands and complexes with different arene units were successfully synthesized and characterized. The coordination behavior of the ligands was minimally influenced by substitution change, but differences were observed in the anticancer activity of the complexes. DFT and X-ray diffraction studies revealed structural variations between the different substitutions, and UV-visible spectroscopy determined the correlation between anticancer activity, hydrolysis rate, and lipophilicity index of the complexes. Staining assays, flow cytometry, and Western blot analysis confirmed the apoptotic cell death mechanism of the active complexes.
INORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Christoph A. Riedl, Alexander Rosner, Sophia Harringer, Philipp Salomon, Michaela Hejl, Michael A. Jakupec, Wolfgang Kandioller, Bernhard K. Keppler
Summary: The use of bisphosphonate-functionalized ligands in the synthesis of trithiolato-bridged dinuclear ruthenium(II) and osmium(II) arene complexes improved aqueous solubility but decreased antiproliferative activity in vitro.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Emanuele Zanda, Natalia Busto, Lorenzo Biancalana, Stefano Zacchini, Tarita Biver, Begona Garcia, Fabio Marchetti
Summary: The study found that certain ruthenium complexes exhibited remarkable stability in water and cell culture medium, showing strong cytotoxicity against cancer cell lines, with RUCYN being the most promising one with significant selectivity compared to non-cancerous cells. The variability of affinity of the complexes for BSA and DNA binding was determined, with certain complexes showing enhanced cell internalization and cytotoxicity at the expense of selectivity.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Chemistry, Inorganic & Nuclear
Xian-Tao Jiang, Xiao-Hui Wang, Pei-Yuan Li, Wei Su
Summary: Three ruthenium-arene complexes with curcuminoids were synthesized and found to exhibit significant inhibitory effects on human liver cancer cells under light conditions, with their anticancer activity greatly improved by light exposure.
CHINESE JOURNAL OF INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Sonia Infante-Tadeo, Vanessa Rodriguez-Fanjul, Cintia C. Vequi-Suplicy, Ana M. Pizarro
Summary: The passage describes the rapid hydrolysis and high basicity of complexes [Os(eta 6-arene)(C,N-phenylpyridine)Z] with chlorido or tethered oxygen as the ligand. It also reveals the structure-activity relationship between Os-CN and Os-NN complexes.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Betty Y. T. Lee, Matthew P. Sullivan, Ena Yano, Kelvin K. H. Tong, Muhammad Hanif, Tomoyo Kawakubo-Yasukochi, Stephen M. F. Jamieson, Tilo Soehnel, David C. Goldstone, Christian G. Hartinger
Summary: N-Heterocyclic carbene (NHC) ligands have been widely studied in medicinal inorganic chemistry. In this study, a series of half-sandwich [M(L)(NHC)Cl-2] complexes with N-flanking anthracenyl moiety were prepared and their anticancer activities were investigated, showing cytotoxicity in low micromolar range. The Ru derivative 1a exhibited stability and specific interactions with biomolecules.
INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Anna Rovira, Enrique Ortega-Forte, Cormac Hally, Mireia Jorda-Redondo, Diego Abad-Montero, Gloria Vigueras, Jesus I. Martinez, Manel Bosch, Santi Nonell, Jose Ruiz, Vicente Marchan
Summary: Photodynamic therapy shows potential as a non-invasive anticancer tool, but the development of highly effective and non-toxic photosensitizers that can work under hypoxic conditions is still needed. In this study, Ir(III)-COUPY conjugates were developed based on the advantageous properties of COUPY fluorophores and cyclometalated Ir(III) complexes, aiming to explore structure-activity relationships. The structural modifications within the coumarin scaffold had a significant impact on the photophysical properties and cellular uptake of the conjugates. All Ir(III)-COUPY conjugates exhibited high phototoxicity under green light irradiation, attributed to the photogeneration of reactive oxygen species (ROS), while remaining non-toxic in the dark. Two hit conjugates showed excellent phototherapeutic indexes in cisplatin-resistant A2780cis cancer cells, indicating the potential of photoactive therapy approaches based on the conjugation of far-red/NIR-emitting COUPY dyes and transition metal complexes to overcome acquired resistance to cisplatin.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Qi-Yuan Yang, Rui Ma, Yun-Qiong Gu, Xiao-Fang Xu, Zhen-Feng Chen, Hong Liang
Summary: Targeting metabolic reprogramming to treat cancer, by using arene-ruthenium(II)/osmium(II) complexes to potentiate the anticancer effect of metformin (Met.) via glucose metabolism reprogramming, could increase overall survival and reduce side effects.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Applied
Ramya Prabaharan, Ramesh Rengan, Devan Umapathy, Antony Joseph Velanganni Arockiam, Jan Grzegorz Malecki
Summary: The study synthesized six new arene ruthenium (II) complexes and evaluated their anticancer activity through MTT assay and staining techniques, demonstrating good cytotoxicity against cancer cell lines, particularly with complex 6 showing potential anticancer activity.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
M. R. Rodriguez, G. A. Espino, O. E. Piro, G. A. Echeverria, B. S. Parajon-Costa, A. C. Gonzalez-Baro
Summary: The co-product (o-VA)(2)TPNH2 was isolated and characterized during the synthesis of the Schiff base o-HVATPNH2. Its crystal structure was determined by X-ray diffraction methods, revealing a specific chiral structure. The proposed formation reaction mechanism and revised structural properties of (o-VA)(2)TPNH2 were presented, along with evidence of the presence of the zwitterionic form of a Schiff base in the solid state.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Igor Echevarria, Monica Vaquero, Blanca R. Manzano, Felix A. Jalon, Roberto Quesada, Gustavo Espino
Summary: Photoredox catalysis is a powerful tool in inorganic synthesis, and this paper presents an efficient and selective photocatalytic procedure for the oxidative dehydrogenation of partially saturated N-heterocycles to produce N-heteroarenes. The researchers established structure-activity relationships and proposed a dual mechanism for the reactions based on in-depth experimental and theoretical studies.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Applied
Jorge Leal, Gema Dura, Felix A. Jalon, Elisenda Zafon, Anna Massaguer, Jose Vicente Cuevas, Lucia Santos, Ana M. Rodriguez, Blanca R. Manzano
Summary: Luminescent platinum cyclometalated complexes have applications in optoelectronic and biological fields, especially in anticancer activity. A series of these complexes with different ligands were synthesized, and their emission wavelengths could be tuned. Density-functional theory provided descriptions of their molecular orbital characteristics, and time-dependent DFT calculations showed different excited states for different complexes. Biological studies demonstrated that some complexes exhibited cytotoxic activity against human cervical and lung carcinoma cells, and microscopy assays showed their accumulation in cytoplasmic organelles. The disruption of mitochondrial metabolism was observed, leading to a decrease in cellular ATP content. These complexes may have potential as alternative anticancer drugs.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Marta Martinez-Alonso, Albert Gandioso, Chloe Thibaudeau, Xue Qin, Philippe Arnoux, Nurikamal Demeubayeva, Vincent Guerineau, Celine Frochot, Alain C. Jung, Christian Gaiddon, Gilles Gasser
Summary: A novel Ru(II) cyclometalated photosensitizer, Ru-NH2, and its bioconjugates, Ru-Mal-CTX and Ru-BAA-CTX, were synthesized and characterized. Ru-NH2 showed absorption maxima around 580 nm and generated singlet oxygen upon light irradiation. In vitro experiments demonstrated the excellent phototoxicity of Ru-NH2 towards CT-26 and SQ20B cells under specific light conditions.
Article
Biochemistry & Molecular Biology
Carlos Tardio, Javier Alvarez Conde, Ana Maria Rodriguez, Pilar Prieto, Antonio de la Hoz, Juan Cabanillas-Gonzalez, Ivan Torres-Moya
Summary: A new series of donor-acceptor-donor (D-A-D) structures derived from arylethynyl 1H-benzo[d]imidazole were synthesized and processed into single crystals to test their ability to act as optical waveguides. Some crystals exhibited luminescence in the 550-600 nm range and showed optical waveguiding behavior with low optical loss coefficients, indicating efficient light transport. The 1H-benzo[d]imidazole derivatives with 1D assembly, single crystal structure, and notable light emission properties are promising compounds for optical waveguide applications.
Review
Nutrition & Dietetics
Diego Fernandez-Lazaro, Carlos Dominguez-Ortega, Natalia Busto, Mirian Santamaria-Pelaez, Enrique Roche, Eduardo Gutierez-Abejon, Juan Mielgo-Ayuso
Summary: N-acetylcysteine (NAC) is a sports supplement that can improve physical performance by modulating exercise-induced oxidative damage and maintaining glutathione homeostasis. A systematic review of studies on NAC supplementation in adult men found that it has beneficial effects on exercise performance, antioxidant capacity, and glutathione homeostasis. However, the evidence for its effects on haematological markers, inflammatory response, and muscle behavior is not clear. Overall, NAC supplementation appears to be safe and effective, but more research is needed to fully understand its relevance.
Article
Food Science & Technology
Mari Mar Cavia, Nerea Arlanzon, Natalia Busto, Celia Carrillo, Sara R. Alonso-Torre
Summary: Various factors, including apple variety, maturity, farming and storage conditions, and fermentation method, can influence the polyphenol content and antioxidant capacity of ciders, leading to differences in values among ciders from different origins. This study aimed to characterize Spanish ciders in terms of their polyphenol content and antioxidant capacity, and determine whether these properties change after digestion. The Basque Country ciders showed higher levels of polyphenols and antioxidant capacity compared to ciders from other regions, and the in vitro digestion process resulted in a loss of phenolic compounds.
Article
Biochemistry & Molecular Biology
Borja Diaz de Grenu, Diego M. Fernandez-Aroca, Juan A. Organero, Gema Dura, Felix Angel Jalon, Ricardo Sanchez-Prieto, M. Jose Ruiz-Hidalgo, Ana Maria Rodriguez, Lucia Santos, Jose L. Albasanz, Blanca R. Manzano
Summary: Compound 6, a new derivative of aromatase inhibitors, exhibits higher inhibitory activity and potent cytostatic behavior compared to established inhibitors, making it a promising candidate for hormone-dependent cancer treatment.
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Alicia Marco, Gloria Vigueras, Natalia Busto, Natalia Cutillas, Delia Bautista, Jose Ruiz
Summary: New valproate Ir(iii) and Rh(iii) half-sandwich conjugates with a C,N-phenylbenzimidazole chelated ligand have been synthesized and characterized. The conjugation of valproic acid to organometallic fragments appears to enhance the antibacterial activity of the complexes against Enterococcus faecium and Staphylococcus aureus Gram-positive bacteria.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Marc Martinez de Sarasa Buchaca, Felipe de la Cruz-Martinez, Luis F. F. Sanchez-Barba, Juan Tejeda, Ana M. M. Rodriguez, Jose A. Castro-Osma, Agustin Lara-Sanchez
Summary: Ring-opening copolymerization reactions of epoxides, carbon dioxide and cyclic esters using bimetallic chloride indium complexes as catalysts were conducted under mild reaction conditions. The catalysts exhibited high catalytic activity and selectivity in the absence of a co-catalyst, leading to the formation of poly(cyclohexene carbonate) (PCHC). Furthermore, polyester-polycarbonate copolymers poly(lactide-co-cyclohexene carbonate) (PLA-co-PCHC) were synthesized via a one-pot one-step route without the use of a co-catalyst. The copolymers showed different thermal properties by adjusting the CO2 pressure and monomer feed.
DALTON TRANSACTIONS
(2023)
Article
Oncology
M. Isabel Acuna, Ana R. Rubio, Marta Martinez-Alonso, Natalia Busto, Ana Maria Rodriguez, Nerea Davila-Ferreira, Carl Smythe, Gustavo Espino, Begona Garcia, Fernando Dominguez
Summary: Iridium complexes have potential as cancer drug candidates due to their structural versatility and ability to target mitochondria. The most promising complex, 1[C,NH], induces cell death by disrupting mitochondria membrane permeability. In vivo studies in mice showed reduced tumor burden. These findings could guide the development of next-generation anticancer drugs.