Article
Spectroscopy
Mingcong Gao, Jiawei Li, Lei Qiu, Xinyi Xia, Xia Cheng, Feifei Xu, Guanhong Xu, Fangdi Wei, Jing Yang, Qin Hu, Yao Cen
Summary: In this study, silicon-coated CsPbBr3 quantum dots (CsPbBr3@SiO2) were synthesized to improve their stability in ambient air. The SiO2 coating effectively protected the PQDs from water and oxygen, maintaining their structural stability. CsPbBr3@SiO2 showed excellent dispersibility in aqueous solution and remained stable for more than 2 months. It exhibited high sensitivity to pH and was successfully applied to the detection of glucose in human serum with satisfactory performance.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Biotechnology & Applied Microbiology
Felix J. Hartmann, Dunja Mrdjen, Erin McCaffrey, David R. Glass, Noah F. Greenwald, Anusha Bharadwaj, Zumana Khair, Sanne G. S. Verberk, Alex Baranski, Reema Baskar, William Graf, David Van Valen, Jan Van den Bossche, Michael Angelo, Sean C. Bendall
Summary: This antibody-based method allows profiling of metabolic protein expression and regulation in single cells using mass spectrometry while characterizing cellular phenotype. The approach was validated using mass cytometry and applied to clinical samples, revealing tissue-restricted, metabolically repressed immune cells in human colorectal carcinoma. The combination with multiplexed ion beam imaging unveiled the spatial organization of metabolic programs in human tissues.
NATURE BIOTECHNOLOGY
(2021)
Article
Chemistry, Physical
Yirong Fang, Pei Cheng, Hang Yuan, Hao Zhao, Lishu Zhang
Summary: A new composite system of nitrogen-doped reduced graphene oxide and black phosphorus quantum dots has been developed for tumor therapy, showing improved electrochemical properties and stability. The system generates hydrogen peroxide and hydroxyl radical to effectively kill tumor cells.
JOURNAL OF ALLOYS AND COMPOUNDS
(2024)
Article
Chemistry, Analytical
Jianwen Qiu, Chunli Zhong, Meng Liu, Xinyi Xiong, Yong Gao, Hu Zhu
Summary: The pH of mitochondria is crucial for their function. We have developed a fluorescence pH probe and successfully used it to measure mitochondrial pH changes. Our research found that cancer cells have lower adaptability to oxidative stress than normal cells under high glucose concentration.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Biochemistry & Molecular Biology
Nerilson M. Lima, Gagan Preet, Sara R. Marqui, Thais de O. R. S. Falcoski, Geovana Navegante, Christiane P. Soares, Teresinha de Jesus A. S. Andrade, Felipe A. La Porta, Harinantenaina Liva R. Rakotondraie, Marcel Jaspars, Dulce H. S. Silva
Summary: This study evaluated the metabolic profiling and antigenotoxicity of Inga species with potential antitumor effects. It also used a proteomic approach to investigate the response of HepG2 cells to polyphenols isolated from I. laurina. The results showed cytotoxic activity against cancer cell lines and identified potential bioactive compounds. The proteomic analysis revealed proteins related to ROS elimination, DNA repair, tumor protein expression, and apoptosis.
Article
Chemistry, Physical
Tingting Cai, Wenjing Zheng, Qing Chang, Ning Li, Jinlong Yang, Shengliang Hu
Summary: This study presents a novel method of tuning visible light conversion to facilitate the release and activation of H2O2 through the integration of CaO2 with biocompatible carbon dots. The incorporation of carbon dots significantly enhances the catalytic performance of H2O2 released from CaO2.
JOURNAL OF MATERIALS CHEMISTRY A
(2022)
Article
Dentistry, Oral Surgery & Medicine
Toshimitsu Ohashi, Kosuke Terazawa, Hirofumi Shibata, Norimitsu Inoue, Takenori Ogawa
Summary: This study compared and assessed the metabolic profiles of head and neck squamous cell carcinoma (HNSCC) and normal tissues, finding that HNSCC exhibits enhanced metabolic activity, providing more energy and structural components, which promote rapid tumor growth and progression.
Article
Chemistry, Physical
Zinan Chen, Zhiyuan Qin, Sikai Su, Shuming Chen
Summary: The study reveals that the presence of H2O and O-2 affects the performance of Mg-doped zinc oxide (ZnMgO) and ZnMgO-based inverted quantum-dot light-emitting diodes (QLEDs). Exposure to ultraviolet (UV) irradiation can reduce the impact of O-2 on ZnMgO and increase the driving current.
Article
Nanoscience & Nanotechnology
Kaimin Xu, Liang Ke, Hongbin Dou, Rui Xu, Wenjia Zhou, Qi Wei, Xinzuo Sun, Hao Wang, Haobo Wu, Lin Li, Jiamin Xue, Baile Chen, Tsu-Chien Weng, Li Zheng, Yuehui Yu, Zhijun Ning
Summary: PbS colloidal quantum dots (CQDs) show promise as low-cost and high-performance infrared photodetectors. By creating a self-trapped ZnO layer on the surface, significant photomultiplication can be achieved at extremely low bias.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Ying Huang, Si Wu, Lu Zhang, Qingqing Deng, Jinsong Ren, Xiaogang Qu
Summary: In this study, a multistage chemodynamic therapy (CDT) specific to tumor cells is proposed, which can efficiently deplete the high glutathione (GSH) content in tumor cells. By consuming reserved GSH and inhibiting GSH synthesis in cancer cells, the CDT achieves potent GSH exhaustion. The glycolysis inhibitor used in this study not only increases the sensitivity of tumor cells to CDT, but also stimulates a protective mode in normal cells. This tumor-specific CDT utilizes the responsiveness of the glycolysis inhibitor and nanocarrier to the tumor microenvironment.
Article
Nanoscience & Nanotechnology
Livy Laysandra, Darwin Kurniawan, Chen-Lin Wang, Wei-Hung Chiang, Yu-Cheng Chiu
Summary: By incorporating NGQDs into a polymer matrix, the nanocomposite material shows improved mechanical strength, Young's modulus, toughness, and sensitivity to pH levels. Additionally, the material has a high self-healing efficiency and stable sensing performance, making it ideal for wearable pH sensors.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Nanoscience & Nanotechnology
Shuaijie Ding, Zeming Liu, Chunyu Huang, Ning Zeng, Wei Jiang, Qing Li
Summary: In this study, a novel engineered bacterial system was developed to target hypoxic tumor tissues and efficiently mediate photodynamic therapy through the release of oxygen. The system successfully killed tumor cells in vivo, demonstrating good therapeutic efficacy and highlighting new avenues for cancer treatment using black phosphorus quantum dots.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Environmental Sciences
Tanya L. Maurer, Joshua N. Plant, Kenneth S. Johnson
Summary: The SOCCOM project has deployed 194 profiling floats equipped with biogeochemical sensors, and post-deployment quality control for float-based oxygen, nitrate, and pH data is essential. In situ calibration of chemical sensors using atmospheric reanalysis and empirical algorithms can improve accuracy. A methodology and software have been developed to visualize float data, assess QC adjustments, and support a growing number of BGC floats globally, demonstrating successful post-deployment calibration and QC of over 250 floats.
FRONTIERS IN MARINE SCIENCE
(2021)
Article
Spectroscopy
Li Ruiyi, Zhang Huahua, Li Zaijun
Summary: Graphene quantum dots are a promising material used in various fields such as biosensing, fluorescence imaging, biomedicine, and environmental monitoring. This study presents a synthesis method for producing polychromatic graphene quantum dots with high luminous efficiency. The synthesized graphene quantum dots exhibit switchable two-color luminescence and sensitivity to environmental pH value.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Biochemistry & Molecular Biology
An-Nan Zhang, Chengdi Huang, Lili Yan, Xiaoyi Liu, Fengyu Wang, Zhichao Zhang, Luqi Li, Cunli Zhang, Qiang Zhang
Summary: Diabetes is a significant disease, and food intervention with 1,2,3,4,6-penta-O-galloyl-beta-d-glucose (PGG) can effectively prevent its development. PGG has antihypoglycemic, antibacterial, and antitumor activities. In this study, we investigated the effects of PGG on zebrafish exposed to high glucose and found that it restored the expression of four key genes and six metabolites, related to glucose metabolism pathways. Our findings provide a mechanistic basis for the hypoglycemic function of PGG and suggest its potential use in regulating metabolic disorders.
Article
Physics, Applied
Mathew L. Kelley, Grigory Simin, Kamal Hussain, Asif Khan, Andrew B. Greytak, M. V. S. Chandrashekhar
Summary: The study demonstrates a technique to quickly build and spatially map the frequency response of optoelectronic devices, using Fourier transform impedance spectroscopy for experimental validation. The results show the utility of this technique in advanced thin film and flexible electronics.
APPLIED PHYSICS LETTERS
(2021)
Article
Chemistry, Physical
Fiaz Ahmed, Mathew L. Kelley, M. V. S. Chandrashekhar, Andrew B. Greytak
Summary: The electronic properties of lead sulfide quantum dot films varied significantly depending on the purification method used, with the GPC-purified films showing lower resistivity and decreased contact resistance with gold contacts compared to films purified by conventional precipitation/redispersion. By tuning the workfunction of metal contacts, a transition from ohmic to rectifying behavior characteristic of p-type conductivity was observed in the GPC-purified films. The results suggest that film properties are sensitive to preparation conditions and that GPC is a highly effective route to quantum dots suited for optoelectronic applications.
JOURNAL OF PHYSICAL CHEMISTRY C
(2021)
Article
Chemistry, Inorganic & Nuclear
Christopher M. Lemon, Deirdre Hanley, Allison E. Batka, Michael A. Marletta
Summary: Ratiometric sensors are a type of self-referencing constructs that can function in cells and tissues, and their read-out is not affected by sensor concentration. This study developed protein-based ratiometric oxygen sensors using heme nitric oxide/oxygen-binding protein (H-NOX) and oxygen-responsive fluorescent probes. By modifying the amino acid residues on the protein surface, the oxygen sensitivity of the sensor can be adjusted.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Nuwanthaka P. Jayaweera, John H. Dunlap, Fiaz Ahmed, Taylor Larison, Leman Buzoglu Kurnaz, Morgan Stefik, Perry J. Pellechia, Augustus W. Fountain, Andrew B. Greytak
Summary: In this study, a quantitative ligand exchange was performed on oleate-capped CdSe/ZnS quantum dots using imidazole ligands, and different reaction mechanisms were identified and quantified using various analytical methods.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Physical
John H. Dunlap, Nuwanthaka P. Jayaweera, Perry J. Pellechia, Andrew B. Greytak
Summary: This study examines the relative binding strength of thiolate ligands to the surfaces of zincblende CdSe/ZnS core/shell quantum dots passivated by phosphonate ligands. The results provide insights into the effects of chain length and denticity on binding strength, which are important for developing stable and versatile water-soluble QD colloids.
JOURNAL OF PHYSICAL CHEMISTRY C
(2022)
Article
Chemistry, Multidisciplinary
Grace C. Thaggard, Gabrielle A. Leith, Daniil Sosnin, Corey R. Martin, Kyoung Chul Park, Margaret K. McBride, Jaewoong Lim, Brandon J. Yarbrough, Buddhima K. P. Maldeni Kankanamalage, Gina R. Wilson, Austin R. Hill, Mark D. Smith, Sophya Garashchuk, Andrew B. Greytak, Ivan Aprahamian, Natalia B. Shustova
Summary: Confinement-imposed photophysics was investigated for hydrazone-based compounds with novel stimuli-responsiveness, showing a conceptual difference in behavior between 2D and 3D porous matrices. The challenges of photoswitch isomerization in 2D scaffolds could be overcome in 3D materials by immobilizing the sterically demanding hydrazone derivatives. This approach enables the synthesis of hydrazone-based materials with fast photoisomerization kinetics in the solid state.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Inorganic & Nuclear
Christopher M. Lemon, David C. Powers, Michael Huynh, Andrew G. Maher, Austin A. Phillips, Brian P. Tripet, Daniel G. Nocera
Summary: Metallophilic interactions between metal centers are well-known for d10 ions, such as Au(I) aurophilic interactions. In contrast, silver corroles with Ag(III) ions show rare argentophilic interactions. This study identifies argentophilic interactions in silver corroles and confirms their presence through crystal structure analysis and theoretical calculations.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Christopher M. Lemon, Andrew G. Maher, Bryce L. Anderson, Eric D. Bloch, Michael Huynh, Abie L. McCollar, Daniel G. Nocera
Summary: This study demonstrates the mechanism of solvent-induced spin state change in copper corroles and the related paramagnetic and color changes.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Physical
Nattakarn Phromsiri, Sakiru L. Abiodun, Chonnavee Manipuntee, Pannee Leeladee, Andrew B. Greytak, Numpon Insin
Summary: In this study, a new ratiometric mixed-QDs probe for the quantification of Cu2+ in an aqueous solution was reported. This probe combines the concepts of ratiometric and fluorescence resonance energy transfer. The detection method is simple, fast, sensitive, selective, and accurate, with a low detection limit for Cu2+ and high selectivity towards other biological and environmental relevant ions. Additionally, the mixed-QDs probe shows potential for naked-eye detection of Cu2+ in water samples and biological specimens.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Polymer Science
Md Faizul Islam, Emely Adame-Ramirez, Eric R. Williams, Preecha Kittikhunnatham, Andrew Wijesekera, Siteng Zhang, Ting Ge, Morgan Stefik, Mark D. Smith, Perry J. Pellechia, Andrew B. Greytak, Linda S. Shimizu
Summary: In this study, pyrrole and ethylenedioxythiophene monomers are loaded into a self-assembled bis-urea host and polymerized within its nanochannels, dramatically altering the properties of the crystalline complexes. The findings suggest that supramolecular polymerization strategies have the potential to easily modulate the properties of nanostructured materials.
Article
Biochemistry & Molecular Biology
Christopher M. Lemon
Summary: Heme proteins are versatile platforms for developing new functional proteins. This review explores the replacement of heme with non-porphyrin cofactors and the unique properties and reactivity of these hybrids. These substitutions can lead to the development of superior catalysts and provide opportunities for innovative antibiotic strategies.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Andrew B. Greytak, Sakiru L. Abiodun, Jennii M. Burrell, Emily N. Cook, Nuwanthaka P. Jayaweera, Md Moinul Islam, Abdulla E. Shaker
Summary: Manipulations of nanocrystal surfaces play a vital role in various applications. This article focuses on the surface chemistry of colloidal nanocrystals and the binding motifs for ligands that coordinate nanocrystal surfaces, particularly for semiconductor quantum dots. The use of isothermal titration calorimetry (ITC) and other techniques to study the thermodynamics of nanocrystal-ligand interactions is discussed, along with different thermodynamic models for interpretation. Understanding the complexity of nanocrystal surface-ligand interactions provides opportunities to tune their properties for desired applications.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Physical
Muhammad Saddam Hossain, Fiaz Ahmed, Stavros G. Karakalos, Mark D. Smith, Namrata Pant, Sophya Garashchuk, Andrew B. Greytak, Pablo Docampo, Linda S. Shimizu
Summary: This study reports on the structural, computational, and conductivity studies of urea-directed self-assembled iodinated triphenylamine derivatives. It compares the assembled structures of different derivatives and their charge transport properties, showcasing one derivative with higher conductivity due to urea hydrogen bonding and specific interactions, making it a potential dopant-free p-type hole transporter.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2022)
Article
Biochemistry & Molecular Biology
Christopher M. Lemon, Amos J. Nissley, Naomi R. Latorraca, Elizabeth C. Wittenborn, Michael A. Marletta
Summary: Replacing the native porphyrin cofactor in haem proteins with non-natural cofactors has led to the development of novel designer proteins. However, the interactions between the non-natural cofactors and the proteins are different from those with native haem, highlighting the need for further investigation.
RSC CHEMICAL BIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Fiaz Ahmed, John H. Dunlap, Perry J. Pellechia, Andrew B. Greytak
Summary: A highly stable p-type PbS-QDs ink was prepared using a single-step biphasic ligand exchange route, leading to improved film resistivity and surface roughness compared to previous reports, with proof of concept photovoltaic devices showing efficiency > 5.5%.
CHEMICAL COMMUNICATIONS
(2021)
