期刊
INORGANIC CHEMISTRY
卷 50, 期 4, 页码 1213-1219出版社
AMER CHEMICAL SOC
DOI: 10.1021/ic1015252
关键词
-
资金
- Department of Science and Technology (DST), New Delhi, India
A new 2,6-bis(5,6-dihydrobenzo[4,5]imidazo[1,2-c]quinazolin-6-yl)-4-methylphenol (1) serves as a highly selective and sensitive fluorescent probe for Zn2+ in a HEPES buffer (50 mM, DMSO:water = 1:9 (v/v), pH = 7.2) at 25 degrees C. The increase in fluorescence in the presence of Zn2+ is accounted for by the formation of dinuclear Zn2+ complex [Zn-2(C35H25N6O)(OH)(NO3)(2)(H2O)] (2), characterized by X-ray crystallography. The fluorescence quantum yield of the chemosensor 1 is only 0.019, and it increases more than 12-fold (0.237) in the presence of 2 equiv of the zinc ion. Interestingly, the introduction of other metal ions causes the fluorescence intensity to be either unchanged or weakened. By incubation of cultured living cells (A375 and HT-29) with the chemosensor 1, intracellular Zn2+ concentrations could be monitored through selective fluorescence chemosensing.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据