Article
Chemistry, Multidisciplinary
Lukas Englert, Uwe Schmidt, Michael Domling, Max Passargus, Tom E. Stennett, Alexander Hermann, Merle Arrowsmith, Marcel Harterich, Jonas Mussig, Alexandra Phillipps, Dominic Prieschl, Anna Rempel, Felix Rohm, Krzysztof Radacki, Fabian Schorr, Torsten Thiess, J. Oscar C. Jimenez-Halla, Holger Braunschweig
Summary: Reactions of terminal acetylenes with doubly Lewis base-stabilised diborenes exhibit distinct outcomes based on temperature and ligand properties, involving either cycloaddition or hydroalkynylation. Phosphine-stabilised diborenes undergo exclusively cycloaddition, leading to significant molecular rearrangement.
Article
Chemistry, Organic
Fatema Jagot, Songeziwe Ntsimango, Kennedy J. Ngwira, Manuel A. Fernandes, Charles B. de Koning
Summary: This article describes the key steps in the synthesis of derivatives of angucycline, tetrangulol, including the catalyzed SuzukiMiyaura cross-coupling reaction, iron-catalyzed ring-closing carbonyl-olefin metathesis reaction, and late-stage oxidation reaction. The chlorinated compounds were obtained as final products.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Polymer Science
Mohammad Yasir, Andreas F. M. Kilbinger
Summary: Norbornene and cyclohexene show different polymerization behaviors using Grubbs' catalysts due to their varying ring strain energy levels; a sequence-selective cascade polymerization of a monomer containing both rings resulted in polymers with moderate molecular weight dispersities and good control over molecular weight.
Article
Chemistry, Multidisciplinary
Nils Ansmann, Thaddaus Thorwart, Lutz Greb
Summary: The Lewis superacid bis(perchlorocatecholato)silane catalyzes C-O bond metathesis of alkyl ethers with high efficiency, enabling chemoselective ring contractions of macrocyclic crown ethers and unprecedented ring-closing metathesis of polyethylene glycols for polymer-selective degradation.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Yecai Lai, Wei-Min Dai
Summary: A pentamodule assembly approach has been developed for the total synthesis of (-)-palmyrolide A and (+)-5,7-epi-palmyrolide A. The flexibility of the multimodule assembly strategy for diverted total synthesis is demonstrated by the ability to obtain two diastereoisomeric macrolides from the same sequence of reactions.
CHINESE JOURNAL OF CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Anna Brodzka, Dominik Koszelewski, Ryszard Ostaszewski
Summary: The goal of diversity-oriented synthesis is to achieve structural diversity of compounds, but issues with low efficiency and multiple purification steps in kinetic resolution exist. A new concept has been proposed to simultaneously form two skeletally and enantiomerically diverse platform molecules in a one-pot protocol to overcome these limitations.
Review
Chemistry, Organic
Waqar Ahmed, Vikrant Jayant, Shakeel Alvi, Nadeem Ahmed, Azeem Ahmed, Rashid Ali
Summary: The synthesis of natural products has always been a top priority for synthetic chemists worldwide. Various synthetic methodologies have been used to extract, elucidate, synthesize, and document a wide range of natural products. The synthesis of complex natural products often presents challenges that can be overcome through modification or development of new synthetic methods. Metathesis tactics, discovered unexpectedly in the 1950s and awarded the Nobel Prize in 2005, have greatly influenced and changed the landscape of total and formal synthesis. This review article provides a comprehensive detail of metathetic tools used in the synthesis of natural products from 2017 to 2019.
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Andrea Ojeda-Porras, Remi Aouzal, Claire Wilson, Joelle Prunet
Summary: Two synthetic routes for the ABC tricycle of Taxol are presented, both involving a relay ring-closing metathesis reaction to form the central B ring. In the first approach, the extender arm is positioned on the A ring, while the C ring bears the relay tether in the second route. Despite the efficient synthesis of metathesis precursors with diverse extender arms, the crucial metathesis reactions failed to yield the target compounds in all cases.
Article
Biochemistry & Molecular Biology
Ervin Kovacs, Bence Balterer, Nguyen Anh Duc, Gyorgyi Szarka, Michael C. Owen, Attila Domjan, Bela Ivan
Summary: A large number of organic solvents contaminate the environment on a daily basis worldwide. This study demonstrates that benzotrifluoride can be used as a suitable solvent for olefin metathesis reactions, providing high yields and similar or even higher reaction rates compared to dichloromethane.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Dmitry S. Belov, Gabriela Tejeda, Charlene Tsay, Konstantin V. Bukhryakov
Summary: Vanadium-based catalysts have been demonstrated to catalyze ring-closing olefin metathesis reactions by well-defined V chloride alkylidene phosphine complexes, exhibiting good functional group tolerance. The properties of the imido group and phosphine were found to play a crucial role in the stability of active intermediates.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Polymer Science
Junkun Fan, Ning Ren, Chongyin Zhang, Mao Li, Xinyuan Zhu, Gangsheng Tong
Summary: This study reports the synthesis of hyperbranched polyolefins using a one-pot process and a bi-functional acyclic olefin as a chain-transfer agent. The method provides a new route for the synthesis of functional hyperbranched polyolefin materials.
Article
Chemistry, Physical
Lantao Liu, Fangyuan Cheng, Chenxiang Meng, An-An Zhang, Mingliang Zhang, Kai Xu, Naoki Ishida, Masahiro Murakami
Summary: A Pd-catalyzed chemo-, regio-, and enantioselective ring-closing/ring-opening cross coupling reaction has been developed with diverse aryl halide-tethered alkenes and benzocyclobutenols as substrates. This method provides a convenient approach to chiral 2,3-dihydrobenzofurans with excellent enantioselectivities, and has been applied in the concise synthesis of analogues of cannabinoid receptor 2 agonists.
Article
Chemistry, Multidisciplinary
Myron Triantafyllakis, Sam Alexander, Sophie Woolford, Claire Wilson, J. Stephen Clark
Summary: The fully functionalized A-F fragment of the Pacific ciguatoxin CTX3C has been synthesized using specific reaction sequences and synthesis routes, achieving the construction of a multi-ring system and the introduction of functional groups.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Review
Chemistry, Multidisciplinary
Shrikant G. Pharande
Summary: Isocyanide-based multicomponent reactions (IMCR) and ruthenium-catalyzed ring-closing olefin metathesis (RCM) are powerful tools in organic synthesis, and their combination offers an efficient approach for the synthesis of complex cyclic olefins.
Review
Chemistry, Applied
Fei Zhou, Meng Li, Huanfeng Jiang, Wanqing Wu
Summary: This review highlights the recent advances in reaction development of electron-rich alkenes since 2000, including various types of reactions and methods for transforming them into valuable compounds.
ADVANCED SYNTHESIS & CATALYSIS
(2021)
Article
Chemistry, Multidisciplinary
Young Ho Song, Nem Singh, Jaehoon Jung, Hyunuk Kim, Eun-Hee Kim, Hae-Kap Cheong, Yousoo Kim, Ki-Whan Chi
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2016)
Article
Chemistry, Multidisciplinary
Nem Singh, Sunphil Jang, Jae-Ho Jo, Dong Hwan Kim, Dae Won Park, Inhye Kim, Hyunuk Kim, Se Chan Kang, Ki-Whan Chi
CHEMISTRY-A EUROPEAN JOURNAL
(2016)
Article
Chemistry, Inorganic & Nuclear
Jae-Ho Jo, Nem Singh, Donghyuk Kim, Se Min Cho, Anurag Mishra, Hyunuk Kim, Se Chan Kang, Ki-Whan Chi
INORGANIC CHEMISTRY
(2017)
Article
Chemistry, Multidisciplinary
Dong Hwan Kim, Nem Singh, Jihun Oh, Eun-Hee Kim, Jaehoon Jung, Hyunuk Kim, Ki-Whan Chi
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2018)
Article
Chemistry, Inorganic & Nuclear
Nem Singh, Jatinder Singh, Dongwook Kim, Dong Hwan Kim, Eun-Hee Kim, Myoung Soo Lah, Ki-Whan Chi
INORGANIC CHEMISTRY
(2018)
Article
Chemistry, Multidisciplinary
Jatinder Singh, Dae Won Park, Dong Hwan Kim, Nem Singh, Se Chan Kang, Ki-Whan Chi
Article
Nanoscience & Nanotechnology
Nem Singh, Dolly Yadav, Sandip Mulay, Jae Young Kim, No-Joong Park, Jin-Ook Baeg
Summary: This study presents a new strategy of band gap engineering in covalent organic framework (COF) photocatalysts by varying the push-pull electronic effect. Four different COFs with fine-tuned band gaps and band edge positions were synthesized, demonstrating high-efficiency photobiocatalytic systems for NADH photoregeneration and formic acid production under visible light. Morphology-guided enhanced surface area and dual keto-enol tautomerism-induced push-pull effect were identified as key features in fine-tuning the photocatalysts.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Chemistry, Inorganic & Nuclear
Li Huang, Shaojing Zhao, Jiasheng Wu, Le Yu, Nem Singh, Ke Yang, Minhuan Lan, Pengfei Wang, Jong Seung Kim
Summary: Photodynamic therapy (PDT) is a preferred clinical technology for treating tumors, but the hypoxic tumor microenvironment weakens its efficiency. Strategies for improving PDT efficacy in hypoxic tumors include increasing oxygen concentration, disregarding hypoxia, and exploiting hypoxia. Combining PDT with other therapeutics can also enhance treatment outcomes.
COORDINATION CHEMISTRY REVIEWS
(2021)
Review
Chemistry, Multidisciplinary
Ji Hyeon Kim, Dong Won Kang, Hongyeol Yun, Minjung Kang, Nem Singh, Jong Seung Kim, Chang Seop Hong
Summary: Porous organic polymers (POPs) are prepared through crosslinked polymerization of multidimensional rigid aromatic building blocks, and can be classified into crystalline COFs and other porous polymers. Due to their outstanding properties, such as high porosity and stability, POPs are being developed for applications in various scientific fields. The recently developed post-synthetic modification (PSM) strategies have allowed for advanced applications of POPs, particularly in biomedical applications, leading to a resurgence in their diverse functions.
CHEMICAL SOCIETY REVIEWS
(2022)
Review
Materials Science, Biomaterials
Le Tu, Qian Li, Sheng Qiu, Meiqin Li, Jinwoo Shin, Pan Wu, Nem Singh, Junrong Li, Qihang Ding, Cong Hu, Xiaoxing Xiong, Yao Sun, Jong Seung Kim
Summary: This review article provides an overview of the recent development of carbon dots (CDs) in biomedical research. It highlights the crucial applications of CDs in biosensing, bioimaging, cancer therapy, and antibacterial applications. The challenges and future potential of CD-based biomedicine are also emphasized, enriching biomedical researchers' knowledge about the potential of CDs and the need for overcoming technical obstacles.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Multidisciplinary
Minhyeok Choi, Nem Singh, Subin Son, Ji Hyeon Kim, Minjung Kang, Su Hong Park, Dong Hoon Choi, Chang Seop Hong, Jong Seung Kim
Summary: The discharge of chemicals and textile waste into industrial effluents significantly pollutes water, making it unbearable for humans and other organisms. Conventional water treatment processes are efficient in degrading stable organic dye molecules. However, there is a continuous demand for sustainable technology to degrade toxic organic pollutants. In this study, a porphyrin-based porous organic polymer (PNP) modified with platinum clusters (Pt@PNP) was developed to enhance the photocatalytic degradation of toxic organic dyes in water. This modified catalyst effectively decomposed carcinogenic organic dyes by generating reactive oxygen species (ROS) under mild light irradiation, and it showed high efficiency and recyclability.
MATERIALS CHEMISTRY FRONTIERS
(2023)
Review
Chemistry, Multidisciplinary
Nem Singh, Subin Son, Jusung An, Ilwha Kim, Minhyeok Choi, Na Kong, Wei Tao, Jong Seung Kim
Summary: Finding a personalized nano theranostics solution for cancer diagnosis and therapy is a top challenge in current medicinal science. Porous organic polymers (POPs) show remarkable advantages for cancer theranostics due to their specific physicochemical characteristics. Both crystalline and non-crystalline POPs, such as covalent organic frameworks (COFs), have shown potential applications across various research areas. Early research on nanoscale POPs for theranostics has demonstrated promising applications in drug loading, targeted delivery, stimuli-responsive release, cancer imaging, and combination therapy.
CHEMICAL SOCIETY REVIEWS
(2021)
Article
Chemistry, Multidisciplinary
Jatinder Singh, Dong Hwan Kim, Eun-Hee Kim, Nem Singh, Hyunuk Kim, Rizky Hadiputra, Jaehoon Jung, Ki-Whan Chi
CHEMICAL COMMUNICATIONS
(2019)
Article
Chemistry, Multidisciplinary
Dolly Yadav, Nem Singh, Tae Wu Kim, Jae Young Kim, No-Joong Park, Jin-Ook Baeg
Article
Chemistry, Inorganic & Nuclear
Nem Singh, Dongwook Kim, Dong Hwan Kim, Eun-Hee Kim, Hyunuk Kim, Myoung Soo Lah, Ki-Whan Chi
DALTON TRANSACTIONS
(2017)