Article
Chemistry, Analytical
Dong Peng, Yuhong Yang, Mingming Que, Ying Ding, Mingzhu Wu, Xiulong Deng, Qifang He, Xiaoming Ma, Xun Li, Hongdeng Qiu
Summary: Surface oxidation engineering is effective in enhancing biocatalytic activity of nanomaterials. This study developed a facile one-pot oxidation strategy to synthesize partially oxidized molybdenum disulfide nanosheets (ox-MoS2 NSs) with good water solubility, serving as an excellent peroxidase substitute. The ox-MoS2 NSs demonstrated enhanced peroxidase-mimic activity and were utilized for colorimetric sensing of glutathione (GSH) with good sensitivity and stability.
ANALYTICA CHIMICA ACTA
(2023)
Article
Chemistry, Physical
Elena Yu. Tupikina, Valerii V. Karpov, Peter M. Tolstoy
Summary: The preferential direction of nucleophilic attack on the R-Se(-) fragment by a peroxide molecule is determined by the electron-depleted region of the selenium atom, and the attack can be facilitated by the solvation of R-Se(-) by water molecules. Additionally, solvation does not block the direction of potential nucleophilic attack and leads to an increase in the maximal value of the molecular electrostatic potential on the selenium atom.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2021)
Article
Biochemistry & Molecular Biology
Sun-Chol Yu, In-Chol Kim, Kum-Ju Ri, Jin Ri, Hartmut Kuehn
Summary: Molecular docking studies revealed that the distance between selenenylsulfides and the active site plays a crucial role in inhibiting the glutathione peroxidase (GPx)-like activity by preventing reduction by glutathione reductase (GR). Additionally, strong binding of selenenylsulfides to the active site results in inhibition of GPx-like activity.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Ting Liu, Ling Wang, Yang Yu, Zhuo Zhang, Zelong Duan, Yawen Li, Chencan Li
Summary: Zeolitic imidazole framework-67 (ZIF-67) exhibits intrinsic peroxidase-like activity, but its catalytic activity is severely affected by the inherent defects in chemical and thermal stability. The addition of ATP enhances the catalytic activity and stability of ZIF-67, enabling colorimetric detection of glutathione.
INORGANIC CHEMISTRY COMMUNICATIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Kaustav Banerjee, Debojit Bhattacherjee, Sulendar K. Mahato, Abu Sufian, Krishna Pada Bhabak
Summary: The synthesis and antioxidant activities of three new classes of ionic organoselenium compounds with cationic benzimidazolium and imidazolium ring systems containing selenocyanates as counterions were described. Mechanistic studies showed the feasibility of cyclization processes in the presence of potassium selenocyanate (KSeCN). The cyclic selenazolium and selenazinium compounds exhibited significantly higher antioxidant activities than the corresponding acyclic selenocyanates, possibly due to their cationic nature which may target and scavenge mitochondrial ROS in the cellular medium.
INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Chun-Yan Zhang, Wei-Yi Zhang, Guo-Ying Chen, Tong-Qing Chai, Hao Zhang, Yi Xu, Feng-Qing Yang
Summary: This study demonstrates the peroxidase mimicking activity of nicotinic acid (VB3) and explores its catalytic mechanism. A convenient and sensitive colorimetric method for detecting H2O2 and glutathione based on the VB3-H2O2-TMB chromogenic system is developed.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Organic
Manish Kumar, Babli Chhillar, Divya Verma, Sumit Nain, Vijay P. Singh
Summary: Copper-catalyzed direct selenation of substituted 2-bromo-N-phenylbenzamide substrates with elemental selenium powder provides methoxysubstituted isoselenazolones through C-Se and Se-N bond formations. O-demethylation of the methoxy-substituted analogues using boron tribromide yields phenolic substituted isoselenazolones. Isoselenazolones exhibit good glutathione peroxidase-like antioxidant activity.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Analytical
Jie Wang, Chenglong Zhao, Feijin Zhou, Hui Lu, Zhenhong Huang, Cheng Yao, Chan Song
Summary: The development of novel nanozymes is crucial for the analysis of biomolecules in disease diagnosis. In this study, Fe@CNs-based nanozymes were constructed to detect GSH, H2O2, and glucose, demonstrating excellent reusability and potential application in biosensing.
Article
Chemistry, Analytical
Serena Fiorito, Francesco Epifano, Lucia Palumbo, Chiara Collevecchio, Salvatore Genovese
Summary: Assessing the GPx-like activity of compounds is important for screening potential anti-inflammatory, neuroprotective, and anti-cancer agents. We propose a method using GC-MS and HPLC-DAD, which compares favorably to the NMR-based test.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Article
Chemistry, Organic
Manisha Yadav, Manish Kumar, Alka Chahal, Nikhil Sodhi, Babli Chhillar, Hema Kumari Alajangi, Ravi Pratap Barnwal, Vijay P. Singh
Summary: Bis(3-amino-1-hydroxybenzyl)diselenide was synthesized using 7-nitro-3H-2,1-benzoxasele-nole and sodium benzene tellurolate. 1,3-benzoselenazoles were then synthesized from bis(3-amino-1-hydroxybenzyl)diselenide and aryl aldehydes using acetic acid as a catalyst. The compounds exhibited good antioxidant activity and antibacterial properties against biofilm formation.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Nutrition & Dietetics
Yung-Fang Hsiao, Shao-Bin Cheng, Chia-Yu Lai, Hsiao-Tien Liu, Shih-Chien Huang, Yi-Chia Huang
Summary: This study compared the changes in oxidative stress and GSH-related antioxidant capacities before and after tumor resection in HCC patients, showing a decrease in plasma malondialdehyde level and varying increases in GSH and related enzyme activities. The findings suggest a potential therapeutic use of GPx or GR as targets for reducing HCC recurrence.
Article
Spectroscopy
Cheng Cheng, Juan Qiao, Hongyi Zhang, Zhenwen Zhao, Li Qi
Summary: Recently, the loading of polymer-ligand onto the surface of gold nanoparticles as nanozymes has attracted attention. A study reported a method to modulate the peroxidase-mimic catalytic capability of PNIPAM@AuNPs by changing temperature. The presence of glutathione inhibits the generation of oxidized TMB, and the method could be used for the analysis of serum glutathione.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Pharmacology & Pharmacy
Snehal Nirgude, Bibha Choudhary
Summary: GPx3, a well-known antioxidant enzyme, plays a vital role as a tumor suppressor in various cancers and can serve as a potential target for clinical intervention.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Maria Schwarz, Alina Loeser, Qing Cheng, Mareike Wichmann-Costaganna, Patrick Schaedel, Oliver Werz, Elias S. J. Arner, Anna P. Kipp
Summary: In humans, there are eight glutathione peroxidases (GPXs), and five of them are selenoproteins that play a crucial role in cellular redox homeostasis. Among the three main cytosolic GPXs, GPX1 and GPX2 reduce soluble hydroperoxides, while GPX4 reduces complex lipid hydroperoxides. The experiments show that GPX1 has the highest activity in reducing soluble and fatty-acid derived hydroperoxides among these isoforms.
Article
Chemistry, Multidisciplinary
Xinghua Chen, Lufang Zhao, Kaiqing Wu, Hong Yang, Qing Zhou, Yuan Xu, Yongjun Zheng, Yanfei Shen, Songqin Liu, Yuanjian Zhang
Summary: Advances in nanoscience have led to the exploration of nanozymes as enzyme alternatives. This study found that the substrate selectivity of the peroxidase-mimic M-N-C can be significantly altered by forming bound intermediates with different metals, leading to superior selectivity compared to commonly used horseradish peroxidase.
Article
Biochemistry & Molecular Biology
Dhruva K. Chakravorty, Pengfei Li, Trang T. Tran, Craig A. Bayse, Kenneth M. Merz
Article
Chemistry, Multidisciplinary
S. D. Tsotsoros, P. B. Lutz, A. G. Daniel, E. J. Peterson, R. E. F. de Paiva, E. Rivera, Y. Qu, C. A. Bayse, N. P. Farrell
Article
Chemistry, Multidisciplinary
Ashley L. Shoaf, Craig A. Bayse
JOURNAL OF COMPUTATIONAL CHEMISTRY
(2018)
Article
Chemistry, Multidisciplinary
Craig A. Bayse
NEW JOURNAL OF CHEMISTRY
(2018)
Article
Biochemistry & Molecular Biology
Craig A. Bayse, Deanna B. Pollard
JOURNAL OF PEPTIDE SCIENCE
(2019)
Article
Chemistry, Multidisciplinary
Eric S. Marsan, Craig A. Bayse
CHEMISTRY-A EUROPEAN JOURNAL
(2020)
Review
Biochemistry & Molecular Biology
Eric S. Marsan, Craig A. Bayse
Article
Chemistry, Physical
Craig A. Bayse, Mohammad Jaffar
THEORETICAL CHEMISTRY ACCOUNTS
(2020)
Article
Chemistry, Medicinal
Ana Dreab, Craig A. Bayse
Summary: This study investigated the effect of Cys oxidation on the ZF456 fragment of transcription factor III A and its complex with RNA through molecular dynamics simulations, revealing that oxidation resulted in unfolding of ZF domains and disruption of key hydrogen bonding interactions.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2022)
Article
Chemistry, Organic
Elizabeth R. Zengel, Jenna R. Garcia, Daja A. Goodrich, Craig A. Bayse
Summary: This study investigated the trends in bond strength for a series of aromatic azo compounds using density functional theory and Wiberg bond index analysis. The interaction between ortho ring hydrogens and an azo nitrogen lone pair was found to strengthen the azo bond, while steric groups substituted ortho to the azo linkage weakened the C-N-azo bond due to molecular twisting. The discrepancies between calculated bond strengths and experimental impact sensitivities could be attributed to packing forces affecting molecular planarity in the solid state.
JOURNAL OF PHYSICAL ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Craig A. A. Bayse
Summary: Halogen bonding (XB) has the potential to inhibit the thyroid-activating/deactivating iodothyronine deiodinase family of selenoproteins through interactions with halogenated endocrine disrupting compounds (EDCs). The strengths of these interactions depend on the halogen, the level of substitution, and the position of the acceptor. The meta position interactions have the highest energy and may be linked to TH topology.
Article
Chemistry, Physical
Craig A. Bayse
Summary: The efficiency of organic semiconductors is enhanced by parallel displacement of & pi;-stacked component molecules, promoting maximum interpenetration of the & pi;-densities. Density functional theory is used to examine dimers of symmetric polyaromatic hydrocarbons, and the stack bonding perspective considers the contributions of monomer & pi;-orbital overlap to the character of dimer orbitals. Energetically favored parallel displaced and/or twisted dimer conformations are consistent with the mixing patterns of monomer molecular orbitals that maximize interpenetration of the & pi; densities. The identified minima along the parallel displacement coordinates coincide with the formation of dimer molecular orbitals from formally antibonding between monomers at the sandwich conformation to bonding at the parallel displacement minima. The favorable stack bonding minima are consistent with polymorphs found in large polyaromatic hydrocarbons.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Biochemistry & Molecular Biology
Ana Dreab, Craig A. Bayse
Summary: Metalation of the N-terminal ATCUN motif enhances the antimicrobial properties of piscidins. Molecular dynamics simulations show that nickelation decreases conformation dynamics of the ATCUN motif and lowers N-terminus charge, allowing it to embed deeper in the bilayer. Nickelated P1 exhibits cation-pi and CH-pi interactions that partially protect the metal, while P3 with a substitution of Phe2 for Ile2 offers less protection. This difference may suggest a mechanism by which peptide sequence influences antimicrobial properties. Moreover, the presence of metalated piscidins may enhance loss of bilayer integrity due to chain reversal of oxidized phospholipid chains.
RSC CHEMICAL BIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Ashley L. Shoaf, Craig A. Bayse
NEW JOURNAL OF CHEMISTRY
(2019)
Article
Chemistry, Multidisciplinary
Eric S. Marsan, Craig A. Bayse
CHEMISTRY-A EUROPEAN JOURNAL
(2017)