Article
Chemistry, Multidisciplinary
Sean J. Steinke, Eric J. Piechota, Lauren M. Loftus, Claudia Turro
Summary: This study investigates the excited states of a series of complexes [Ru(tpy)(L)(CH3CN)]n+ (1-11), and finds that the photoinduced CH3CN dissociation in these complexes occurs from the metal-to-ligand charge transfer (3MLCT) excited state instead of a dissociative triplet ligand field (3LF) state as previously believed. This discovery suggests alternative pathways for ligand photodissociation and has broad implications for the design principles of applications that require ligand photodissociation.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Inorganic & Nuclear
Animesh Paul, Anik Sahoo, Sohini Bhattacharya, Sujoy Baitalik
Summary: This study explores the alteration of photoredox behaviors of trimetallic complexes through anion- and temperature-induced changes, resulting in potential molecular switches. The triads in focus exhibit notable variations in photophysical and electrochemical properties upon interaction with anions. The addition of basic anions leads to red-shifts in absorption and emission and a decrease in the M3+/M2+ potential. These triads act as sensors for various anions in acetonitrile and as selective probes for CN- and SCN- in water. Temperature also affects the luminescence properties of the triads, influencing their emission intensity and lifetime in a reversible manner. Overall, this work demonstrates the potential of the triads as switches based on their reversible spectral and redox behaviors under the influence of anions, acids, and temperature.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Austin P. Lanquist, Eric J. Piechota, Lanka D. Wickramasinghe, Alexia Marques Silva, Randolph P. Thummel, Claudia Turro
Summary: Two new complexes, [Ru(tpy)(qdppz)](PF6)(2) and [Ru(qdppz)(2)](PF6)(2), were investigated for their potential use as phototherapeutic agents. They exhibit different photophysical properties compared to [Ru(tpy)(2)](2+), with distinct absorption and emission spectra.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Sean J. Steinke, Sayak Gupta, Eric J. Piechota, Curtis E. Moore, Jeremy J. Kodanko, Claudia Turro
Summary: This paper reports two new tris-heteroleptic Ru(II) complexes with triphenylphosphine coordination, which show suitable photochemical properties for photochemotherapeutic applications. The study reveals that under visible light irradiation, the complexes exhibit increased activity due to the photoinduced substitution reaction of PPh3 ligand in the excited state. These complexes represent a new design motif for the selective release of PPh3 and CH3CN for use in photochemotherapy.
Article
Chemistry, Inorganic & Nuclear
Ivana Ramirez-Wierzbicki, German E. Pieslinger, Bruno M. Aramburu-Troselj, Pedro O. Abate, Alejandro Cadranel
Summary: The photophysical properties of monodentate-imine ruthenium complexes do not usually meet the requirements for supramolecular solar energy conversion schemes. Two strategies are explored to extend the excited-state lifetime, which involve chemical modification of the distal N atom of pyrazine. The strategies achieve a 2 orders of magnitude extension of the excited-state lifetime, reaching compatibility with bimolecular or long-range photoinduced reactivity.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
J. A. Eremina, E. Lider, N. Kuratieva, D. G. Samsonenko, L. S. Klyushova, D. G. Sheven, R. E. Trifonov, V. A. Ostrovskii
Summary: A series of mixed-ligand copper(II) complexes have been synthesized and characterized by various methods. The structures, cytotoxic effects on cell lines, and stability of the complexes were investigated. Additionally, the interaction of the complexes with DNA was also studied.
INORGANICA CHIMICA ACTA
(2021)
Article
Chemistry, Inorganic & Nuclear
Chao Zhang, Xusheng Guo, Xuwen Da, Zhanhua Wang, Xuesong Wang, Qianxiong Zhou
Summary: The Ru1 compound designed in this study exhibits multiple anticancer mechanisms and significantly enhanced photocytotoxicity under 600 nm light irradiation, making it a promising candidate for photodynamic therapy and photoactivated chemotherapy.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Physical
Agustina Cotic, Koen Veys, Daniel Escudero, Alejandro Cadranel
Summary: This study demonstrates the presence of high kinetic barriers for internal conversion in anti-Kasha chromophores and provides guidelines for their design. The results highlight the importance of wavefunction symmetry in inhibiting dissipative IC and offer insights into the dissipation process at the atomistic level.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2022)
Article
Chemistry, Multidisciplinary
Nicholas Toupin, Sean J. Steinke, Sandeep Nadella, Ao Li, Thomas N. Rohrabaugh, Eric R. Samuels, Claudia Turro, Irina F. Sevrioukova, Jeremy J. Kodanko
Summary: Metal-based inhibitors of CYP3A4 show potent and selective inhibition of the drug metabolizing enzyme, suggesting potential clinical applications in enhancing the therapeutic efficacy of anticancer drugs.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Pharmacology & Pharmacy
Ilya A. Shutkov, Yulia N. Okulova, Dmitrii M. Mazur, Nikolai A. Melnichuk, Denis A. Babkov, Elena V. Sokolova, Alexander A. Spasov, Elena R. Milaeva, Alexey A. Nazarov
Summary: The combination of organic and metal-based fragments with antitumor activity is a modern approach to discover new drugs. This study introduces biologically active ligands based on lonidamine into antitumor organometallic ruthenium scaffold. The stability in ligand exchange reactions does not affect cytotoxicity, while the introduction of a second lonidamine fragment doubles the cytotoxicity. The ability to induce apoptosis and caspase activation in tumor cells was also studied.
Article
Chemistry, Inorganic & Nuclear
Xiao-Lin Liu, Yi Li, Qing-Dou Xu, Yu-Ying Yang, Jin-Hui Fu, Xin-Tao Wu, Tian-Lu Sheng
Summary: Investigations on mixed-valent complexes in the Class II/ Class III frontier have been conducted, and a pair of Ru-Ru-Ru compounds were synthesized and characterized. The experimental and computational results show that these compounds belong to the Class II-III systems.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Johannes Karges, Ryjul W. Stokes, Seth M. Cohen
Summary: The research presents a conjugate consisting of a metalloenzyme inhibitor and a Ru(ii) polypyridine complex, which can release the inhibitor upon light exposure. This prodrug design helps achieve spatial and temporal control over treatment, offering a new approach for designing prodrugs of metalloenzyme inhibitors.
DALTON TRANSACTIONS
(2021)
Review
Biochemistry & Molecular Biology
Yongjie Chen, Lijuan Bai, Pu Zhang, Hua Zhao, Qianxiong Zhou
Summary: Photoactivated chemotherapy (PACT) is a novel cancer treatment method that has garnered attention due to its high selectivity and minimal side effects. Oxygen-independent PACT is more suitable for treating hypoxic tumors, and Ru(II) complexes have shown potential as PACT agents by undergoing photoinduced ligand dissociation. Researchers in this field face challenges in refining ligand structures and coordination configurations.
Article
Chemistry, Multidisciplinary
Jingqi Han, Shun-Cheung Cheng, Shek-Man Yiu, Man-Kit Tse, Chi-Chiu Ko
Summary: These new luminescent complexes with environmentally-sensitive dimerization equilibrium can be used as gas sensors for detecting humidity, ammonia, and amine vapors, thanks to their strong interaction with H-bonding donor/acceptor molecules involving diaminocarbene ligand orbitals in the emissive excited state. By responding to amines and humidity and changing the luminescence properties accordingly, a proof-of-principle for binary optical data storage with reversible concealment process has been demonstrated.
Article
Chemistry, Physical
Benedicto A. V. Lima, Jaldyr de J. G. Varela Jr, Javier Ellena, Alzir A. Batista, Alberico B. F. da Silva, Rodrigo S. Correa
Summary: Reactions of cis-[RuCl2(P-P)(bipy)] precursors with the SpymMe2 ligand yielded complexes of the [Ru(SpymMe2)(P-P)(bipy)]PF6 type. The structures of the complexes were characterized and analyzed using various techniques, including spectroscopy, electrochemical analysis, elemental analysis, and single-crystal X-ray diffraction. Theoretical studies were also conducted using the DFT/B3LYP method, which helped to explain the stability and properties of the complexes compared to the precursors. The results showed the importance of coordination and ligand positioning in determining the stability and properties of the complexes.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Review
Chemistry, Multidisciplinary
Shaoyang Lin, Claudia Turro
Summary: Dinuclear rhodium complexes exhibit attractive photophysical and redox properties for electro- and photocatalysis. They have shown promising catalytic activity towards generating clean fuel and selectively reducing CO2. Optimization of these catalysts is crucial for their future application in fuel production from sunlight.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Jie Huang, Jiaonan Sun, Yiying Wu, Claudia Turro
Summary: A new Rh-2(II,II) dimer has been synthesized and anchored onto a NiO photocathode, acting as both sensitizer and catalyst for hydrogen production. This single-molecule design simplifies the hydrogen production pathway and allows for greater absorption of solar irradiance compared to traditional dyes, offering a promising new system for solar fuel production.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Multidisciplinary
Nicholas Toupin, Sean J. Steinke, Sandeep Nadella, Ao Li, Thomas N. Rohrabaugh, Eric R. Samuels, Claudia Turro, Irina F. Sevrioukova, Jeremy J. Kodanko
Summary: Metal-based inhibitors of CYP3A4 show potent and selective inhibition of the drug metabolizing enzyme, suggesting potential clinical applications in enhancing the therapeutic efficacy of anticancer drugs.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Multidisciplinary
Sean J. Steinke, Sayak Gupta, Eric J. Piechota, Curtis E. Moore, Jeremy J. Kodanko, Claudia Turro
Summary: This paper reports two new tris-heteroleptic Ru(II) complexes with triphenylphosphine coordination, which show suitable photochemical properties for photochemotherapeutic applications. The study reveals that under visible light irradiation, the complexes exhibit increased activity due to the photoinduced substitution reaction of PPh3 ligand in the excited state. These complexes represent a new design motif for the selective release of PPh3 and CH3CN for use in photochemotherapy.
Editorial Material
Chemistry, Multidisciplinary
Claudia Turro
Summary: The mechanism of degradation of a ruthenium-platinum-based hydrogen-evolving photocatalyst has been identified, leading to the development of a repair strategy using singlet oxygen to regenerate an inactivated bridging ligand.
Article
Chemistry, Inorganic & Nuclear
Madeline Denison, Sean J. Steinke, Aliza Majeed, Claudia Turro, Thomas A. Kocarek, Irina F. Sevrioukova, Jeremy J. Kodanko
Summary: CYPs are a superfamily of enzymes responsible for biosynthesis and drug metabolism. A more dynamic approach for monitoring the activity of CYP3A4 was developed using Ir(III) and Ru(II) complexes, allowing real-time monitoring of the occupancy of the CYP3A4 active site.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Sean J. Steinke, Eric J. Piechota, Lauren M. Loftus, Claudia Turro
Summary: This study investigates the excited states of a series of complexes [Ru(tpy)(L)(CH3CN)]n+ (1-11), and finds that the photoinduced CH3CN dissociation in these complexes occurs from the metal-to-ligand charge transfer (3MLCT) excited state instead of a dissociative triplet ligand field (3LF) state as previously believed. This discovery suggests alternative pathways for ligand photodissociation and has broad implications for the design principles of applications that require ligand photodissociation.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Shaoyang Lin, Samragni Banerjee, Matthew T. Fortunato, Congcong Xue, Jie Huang, Claudia Turro, Alexander Yu. Sokolov
Summary: A new method of enhancing reactivity near an active catalytic site by installing a proton relay has been reported. This method involves the electrochemical reduction and protonation of one of the ligands in a hydrogen evolution complex. The study provides insights into the reaction mechanism and suggests a new design strategy for incorporating proton relays in molecular bimetallic hydrogen evolution electrocatalysts.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Physical
James V. Coe, Walter J. Dressick, Claudia Turro
Summary: A new method is developed to determine the wavelength-dependent complex index of refraction of a solution in the mid-infrared range using an etalon cavity. This method is employed to investigate the cavity-vibration polaritons of PF6- in acetonitrile. The results are used to simulate the etalon transmission and study the interaction of vibrations with cavity modes and other vibrations.
JOURNAL OF PHYSICAL CHEMISTRY B
(2023)
Article
Chemistry, Inorganic & Nuclear
Madeline Denison, Justin J. Ahrens, Marilyn N. Dunbar, Habon Warmahaye, Aliza Majeed, Claudia Turro, Thomas A. Kocarek, Irina F. Sevrioukova, Jeremy J. Kodanko
Summary: A library of Ir(III) probes that detect occupancy of the CYP3A4 active site were synthesized and characterized. These probes show high selectivity for CYP3A4 inhibition, low cellular toxicity, and high emission intensity with long lifetimes in cell growth media. The lead probes demonstrated effective inhibition of CYP3A4 activity in CYP3A4-overexpressing HepG2 cells at low concentrations, making them promising tools for studying drug metabolism and drug-drug interactions.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Austin P. Lanquist, Eric J. Piechota, Lanka D. Wickramasinghe, Alexia Marques Silva, Randolph P. Thummel, Claudia Turro
Summary: Two new complexes, [Ru(tpy)(qdppz)](PF6)(2) and [Ru(qdppz)(2)](PF6)(2), were investigated for their potential use as phototherapeutic agents. They exhibit different photophysical properties compared to [Ru(tpy)(2)](2+), with distinct absorption and emission spectra.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Physical
James V. Coe, Walter J. Dressick, Claudia Turro
Summary: A new method using etalon cavity is established to determine the wavelength-dependent complex index of refraction of a solution in the mid-infrared range. The method is applied to study the cavity-vibration polaritons of PF6- in acetonitrile. The results are used to simulate the measured etalon transmission and provide input data for testing quantum mechanical models.
JOURNAL OF PHYSICAL CHEMISTRY B
(2023)
Correction
Engineering, Electrical & Electronic
Claudia Turro, Walter J. Dressick
ACS APPLIED ELECTRONIC MATERIALS
(2023)
Review
Engineering, Electrical & Electronic
Claudia Turro, Walter J. Dressick
Summary: The electroless plating technology is critically important for various industries such as automotive, aerospace, machine tools, and especially electronics. Since the mid-20th century, this technology has evolved from plating a few industrially important metals to a wide range of elements, enabling progress and new applications. This review provides a collection and survey of available electroless processes organized by the periodic table, offering examples to showcase the field's advancements. It concludes with an outlook for future developments and a challenge to scientists and engineers to explore new applications.
ACS APPLIED ELECTRONIC MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Austin P. Lanquist, Sayak Gupta, Kathlyn F. Al-Afyouni, Malik Al-Afyouni, Jeremy J. Kodanko, Claudia Turro
Summary: A series of five ruthenium complexes containing triphenyl phosphine groups were synthesized and characterized, with one complex showing enhanced cytotoxicity upon irradiation with blue light due to apoptosis mechanism. These findings highlight the enhancement of photochemotherapy by -CF3 groups and provide insight for future design of photocages for photochemotherapeutic drug delivery.