Article
Biochemistry & Molecular Biology
Philipp M. Rutz, Joerg Grunenberg, Christian Kleeberg
Summary: This article investigates the versatile use of an unsymmetrical diborane(4) derivative as a precursor for PBP boryl pincer ligand for the synthesis of Co(I), Rh(I) and Ir(I/III) complexes. The coordination chemistry of a homologous series of PBP pincer complexes, particularly the interconversion of five- and four-coordinate complexes, is studied in detail.
Article
Chemistry, Inorganic & Nuclear
Yufang Xie, Qiyi Miao, Wenhao Deng, Yilei Lu, Yinuo Yang, Xiaohui Chen, Rong-Zhen Liao, Shengfa Ye, Chen-Ho Tung, Wenguang Wang
Summary: A diamido-bridged dicobalt complex supported by a diamidonaphthalene ligand, Cp*Co2(2)(mu-1,8-C10H8(NH)(2)) (1), was synthesized and its reactivity towards redox transformations of the Co2N2 core was investigated. It was found that the Co(II)-Co(II) bond can be protonated, resulting in the formation of a bridging hydride [1H](+). The diamidonaphthalene ligand stabilizes the Co(II)Co(III) mixed-valent state (1(+)), which can bind CO to form [1-CO](+). Surprisingly, the mixed-valent complex also activates H2O to give a Co(III)Co(III) hydroxy complex [1-OH](+), accompanied by the release of H2.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Philipp Dabringhaus, Ingo Krossing
Summary: This study reports the synthesis of AlCp*-complexes with low-valent main-group metals, including the first covalent Al-In and Al-Tl bonds. The Ga complex exhibits a solvent and temperature dependent equilibrium between monomeric and dimeric forms, while the In and Tl complexes are monomeric and can be reduced by AlCp*. Addition of Me(3)TACN leads to the isomerization to a novel low-valent Al-4(+) cation. This research provides valuable insights into the reactivity of metal-main-group element complexes.
Article
Physics, Applied
Mandira Das, Subhradip Ghosh
Summary: This study systematically investigates the capacitances of MXene materials, including pristine and functionalized MXenes Mn+1CnO2, using first-principles electronic structure methods.
JOURNAL OF PHYSICS D-APPLIED PHYSICS
(2022)
Article
Chemistry, Organic
Zhi-Kai Liu, Jia-Hao Zeng, Zhuang-Ping Zhan
Summary: A concise and useful method for synthesizing 3-substituted indole derivatives via a palladium-catalyzed reaction has been reported. The method showed moderate to good yields and demonstrated great potential for application through gram-scale experiments and diverse product transformations.
ORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Chemistry, Physical
Luyan Meng, Siying Liu, Qifeng Qin, Bin Zeng, Zhen Luo, Chaoxian Chi
Summary: Heteronuclear group 15 metal-iron carbonyl cluster complexes were studied in the gas phase using infrared photodissociation spectroscopy, revealing their structures and bonding configurations. The cluster anions all showed Fe(CO)(n)(-) fragments with CO ligands terminally bonded to the iron center, forming A-Fe single bonds and A-A double or single bonds in the A(m)Fe(CO)(n)(-) clusters.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2021)
Article
Chemistry, Applied
Uttam Kumar Das, Sayan Kar, Yehoshoa Ben-David, Yael Diskin-Posner, David Milstein
Summary: The first example of homogeneously catalyzed hydrogenation of the N=N bond of azo compounds has been reported using a complex of an earth-abundant-metal. The hydrogenation reaction is catalyzed by a manganese pincer complex, proceeds under mild conditions, and yields amines, which makes this methodology a sustainable alternative route for the conversion of azo compounds. A plausible mechanism involving metal-ligand cooperation and hydrazine intermediacy is proposed based on mechanistic studies.
ADVANCED SYNTHESIS & CATALYSIS
(2021)
Article
Chemistry, Inorganic & Nuclear
Ruth Weller, Igor Mueller, Carine Duhayon, Sylviane Sabo-Etienne, Sebastien Bontemps, C. Gunnar Werncke
Summary: This study reports the synthesis and characterization of neutral quasilinear 3d-metal(i) complexes of chromium to cobalt. The different forms of these metal(i) complexes in solid state and solution, the results of using sodium or lithium metal for the reduction of iron(i) precursor, and the impact of cation on the metal(i) complexes are discussed.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Inorganic & Nuclear
Florian Ritter, Karl N. McCabe, Laurent Maron, Thomas P. Spaniol, Jun Okuda
Summary: Selective protonolysis of polymeric zinc dihydride using the conjugate acid of TMPDA yielded stable molecular zinc hydride cations, with further reactions forming dimeric zinc hydride or dizinc trihydride cations.
Article
Chemistry, Multidisciplinary
Samaneh Hokmi, Sadegh Salehzadeh, Yasin Gholiee
Summary: This paper presents a computational study on various metal complexes, investigating their bonding energies, bond properties, and the possible existence of cooperativity/anticooperativity between different types of bonds. The results provide valuable insights into the behavior of these complexes.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Luong Phong Ho, Matthias Tamm
Summary: A new bismuth complex was synthesized in this study, and a bismuth-bismuth double bond was identified in the resulting compound.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Inorganic & Nuclear
Krzesimir Korona, Arkadiusz Kornowicz, Iwona Justyniak, Michal Terlecki, Artur Blachowski, Janusz Lewinski
Summary: This study reports on the reactivity between CO2 and V(ii) and Fe(ii) complexes, leading to the preparation of three novel complexes through multiple insertions of CO2. The study provides the first well-documented studies of CO2 reactivity towards the V-N bond and expands the research in this field. Additionally, the study shows that the efficiency of the CO2 insertion processes depends on solvent characteristics (for the Fe(ii) system) and the metal center's coordination sphere geometry (for the V(ii) system).
DALTON TRANSACTIONS
(2022)
Article
Materials Science, Multidisciplinary
Daichi Nakato, Masahiko Hatakeyama, Norio Nunomura, Satoshi Sunada
Summary: The corrosion behaviors of Co-Cr-Mo alloys with fcc and hcp structures were studied in a 2.5 M H2SO4 + 0.2 M NaCl solution using polarization tests and weight-loss method. The results showed that the fcc Co-Cr-Mo alloy exhibited better corrosion resistance compared to the hcp Co-Cr-Mo alloy. Additionally, a mixed-phase Co-Cr-Mo alloy with a dominant fcc phase and a small amount of hcp phase displayed similar corrosion resistance to the single-phase fcc alloy.
Article
Biochemistry & Molecular Biology
Cristiana Cesari, Beatrice Berti, Francesco Calcagno, Cristina Femoni, Marco Garavelli, Maria Carmela Iapalucci, Ivan Rivalta, Stefano Zacchini
Summary: The study revealed a case of polymerization isomerism in cluster chemistry when [Co(CO)(4)](-) reacts with M(I) compounds (M = Cu, Ag, Au), resulting in the formation of trinuclear clusters with unique molecular structures. This phenomenon was further explored both experimentally and theoretically, demonstrating that dimerization occurs in the solid state only with Ag species, while Cu and Au species exist as monomers.
Review
Chemistry, Inorganic & Nuclear
Sabyasachi Sarkar, Firoz Shah Tuglak Khan, Tapas Guchhait, Sankar Prasad Rath
Summary: Metal complexes with a binuclear structural motif of M-X-M have attracted significant attention due to their presence in the active site of metalloprotein/metalloenzymes. The replacement of bridging hydroxo groups with isoelectronic fluoride substituents has become a common practice for investigating various bioorganic and bioinorganic problems. This review article focuses on the progress of single fluoro-bridged binuclear metal complexes and examines the impact of fluoride substitution for hydroxide.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Jeremie Rossier, Joachim Delasoie, Laetitia Haeni, Daniel Hauser, Barbara Rothen-Rutishauser, Fabio Zobi
JOURNAL OF INORGANIC BIOCHEMISTRY
(2020)
Article
Biochemistry & Molecular Biology
Sara Nasiri Sovari, Isabelle Kolly, Kevin Schindler, Youri Cortat, Shing-Chi Liu, Aurelien Crochet, Aleksandar Pavic, Fabio Zobi
Summary: The reaction between rhenium alpha-diimine tricarbonyl complexes and nitrosonium tetrafluoroborate yields dicarbonyl-nitrosyl [Re(CO)(2)(NO)(N-N)X](+) species, showing potential antimicrobial applications. The metal ion in the complexes behaves as a hard Re acid with strong affinity for pi-basic ligands, making it difficult to replace with other ligands. The complexes can be photo-activated towards CO release, representing a new class of photoCORMs.
Review
Chemistry, Analytical
Lucyano J. A. Macedo, Fernando P. Rodrigues, Ayaz Hassan, Leandro N. C. Maximo, Fabio Zobi, Roberto S. da Silva, Frank N. Crespilho
Summary: Recent emergence of FTIR spectromicroscopy (micro-FTIR) as a dynamic spectroscopy for imaging to study biological chemistry has opened new possibilities for investigating in situ drug release, redox chemistry effects on biological molecules, DNA and drug interactions, membrane dynamics, and redox reactions with proteins at the single cell level. Micro-FTIR applied to metallodrugs has been playing an important role since the last decade because of its great potential to achieve more robust and controlled pharmacological effects against several diseases, including cancer. An important aspect in the development of these drugs is to understand their cellular properties, such as uptake, accumulation, activity, and toxicity. The review highlights both the potential application of micro-FTIR and its importance for studying metal-based drugs, emphasizing the perspectives of chemistry of living cells and the significance of bioimaging for localization of cellular processes to understand the mechanism of action.
ANALYTICAL METHODS
(2022)
Article
Chemistry, Multidisciplinary
Kevin Schindler, Fabio Zobi
Summary: Luminescent rhenium complexes are of growing scientific interest for catalytic, diagnostic, and therapeutic applications, with a focus on their photophysical and photochemical properties. The choice of ligands and strategies to exploit the potential of these molecules in medicinal applications are crucial. Their applications include being used as luminescent cellular probes and developing photoactive carbon monoxide-releasing molecules for anticancer and antimicrobial purposes.
Article
Chemistry, Medicinal
Sara Nasiri Sovari, Natasa Radakovic, Paul Roch, Aurelien Crochet, Aleksandar Pavic, Fabio Zobi
Summary: Antimicrobial resistance poses a major threat to public health, with lack of financial incentive leading pharmaceutical companies to halt antibiotic discovery programs. Metal complexes have untapped antibiotic potential with unique action mechanisms, offering effective and non-toxic solutions for various infections.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Kevin Schindler, Fabio Zobi
Summary: Organometallic compounds of rhenium, particularly its tri- and dicarbonyl complexes, have shown promising potential as anticancer and antibiotic drugs due to their ease of preparation, stability, and unique photophysical and luminescent properties. This review focuses on discussing the structural variations and in vitro efficacy of these complexes in the past seven years, with an initial emphasis on tricarbonyl complexes and a later discussion on the future prospects of dicarbonyl species in this field.
Article
Multidisciplinary Sciences
Hagir B. Suliman, Zachary Healy, Fabio Zobi, Bryan D. Kraft, Karen Welty-Wolf, Joshua Smith, Christina Barkauskas, Claude A. Piantadosi
Summary: The preclinical model of bleomycin-induced lung fibrosis is useful to study mechanisms related to human pulmonary fibrosis. The study found that HO-1/NRF-1 signaling protects lung AT2 cells against injury and fibrosis by maintaining mitochondrial health and suppressing the TGF beta 1 pathway.
Article
Biochemistry & Molecular Biology
Sara Nasiri Sovari, Taryn M. Golding, Mziyanda Mbaba, Roxanne Mohunlal, Timothy J. Egan, Gregory S. Smith, Fabio Zobi
Summary: A small library of aminoquinoline and imidazolopiperidine (IMP)-based ligands showed potent inhibitory activities against chloroquine-sensitive (CQS) and multidrug-resistant (MDR) strains of P. falciparum. The compounds may act through hemozoin inhibition and the quinoline-based compounds exhibited higher binding affinities than the reference drug chloroquine.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Chemistry, Medicinal
Kevin Schindler, Youri Cortat, Miroslava Nedyalkova, Aurelien Crochet, Marco Lattuada, Aleksandar Pavic, Fabio Zobi
Summary: Antimicrobial resistance poses a significant threat to human health and has a major impact on the global economy. Metal complexes, including rhenium complexes, have untapped potential as antimicrobial agents. This study investigates the antimicrobial potential of rhenium di- and tricarbonyl diimine complexes and identifies two potential targets for these compounds. The findings have implications for the future design of rhenium tricarbonyl diimine-based antibiotics.
Article
Chemistry, Organic
Fatlinda Rahmani, Aurelien Crochet, Fabio Zobi
Summary: In this study, (E)-3-(2-(4-methylthiazol-2-yl)hydrazineylidene)chromane-2,4-dione was synthesized for the first time and characterized using various spectroscopic techniques. The chemical structure and isomeric configuration of the molecule were confirmed by single-crystal X-ray diffraction.
Article
Infectious Diseases
Youri Cortat, Miroslava Nedyalkova, Kevin Schindler, Parth Kadakia, Gozde Demirci, Sara Nasiri Sovari, Aurelien Crochet, Stefan Salentinig, Marco Lattuada, Olimpia Mamula Steiner, Fabio Zobi
Summary: In the context of the global health issue caused by antimicrobial resistance (AMR), the need for novel antimicrobial agents is urgent. Inorganic and organometallic complexes show potential as untapped sources of antibiotics. This study used a computer-aided drug design approach to synthesize and evaluate fac-Re(I) tricarbonyl complexes as antibacterial agents, with promising results.
Article
Chemistry, Inorganic & Nuclear
Kevin Schindler, Justine Horner, Gozde Demirci, Youri Cortat, Aurelien Crochet, Olimpia Mamula Steiner, Fabio Zobi
Summary: Cancer is still a leading cause of death worldwide, and the interest in organometallic complexes as anticancer drug candidates is crucial. Rhenium dicarbonyl complexes have been given less attention compared to tricarbonyl complexes. This study tested various rhenium dicarbonyl complexes in vitro against different cancer cell lines and found that some compounds showed good activity against specific cancer lines but were also toxic to healthy cells.
Review
Pharmacology & Pharmacy
Youri Cortat, Fabio Zobi
Summary: This review discusses the research work on coordination derivatives of antifungal azoles (AAs) synthesized for medical purposes, highlighting the most promising compounds and emphasizing the efficiency of AAs and their metallic species.
Article
Chemistry, Inorganic & Nuclear
Sara Nasiri Sovari, Isabelle Kolly, Kevin Schindler, Ana Djuric, Tatjana Srdic-Rajic, Aurelien Crochet, Aleksandar Pavic, Fabio Zobi
Summary: This study reports the synthesis, characterization, and in vivo evaluation of a series of rhenium tricarbonyl complexes containing 5- and 6-(halomethyl)-2,2'-bipyridine ligands. The aim was to investigate the role of a reactive halomethyl substituent on the diimine ligand system in the design of effective and non-toxic anticancer agents. Compounds capable of undergoing ligand-based alkylating reactions exhibited significant antiproliferative activity against colorectal and pancreatic cell lines. One specific compound (5-(chloromethyl)-2,2'-bipyridine derivative) displayed significant inhibition of pancreatic tumor growth in vivo in zebrafish-Panc-1 xenografts at a concentration of 8 μM, lower than its in vitro IC50 values, and also inhibited in vivo cancer cell dissemination.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Multidisciplinary
Kevin Schindler, Aurelien Crochet, Fabio Zobi
Summary: The article introduces new synthetic routes to produce aerobically stable and substitutionally labile alpha-diimine rhenium(i) dicarbonyl complexes. These complexes can be prepared in high yield and exhibit different reactions in various solvents, providing a convenient entry into the chemistry of the core.