Article
Cell Biology
Shan He, Hanxiang Zhang, Yang Lu, Zhaosi Zhang, Xiang Zhang, Nian Zhou, Zhenming Hu
Summary: The Nicotinamide phosphoribosyltransferase (Nampt)-NAD-Sirt1 pathway plays a role in modulating inflammation and osteogenic differentiation in MC3T3-E1 cells.
Article
Biochemistry & Molecular Biology
Hui Gong, Honghan Chen, Peng Xiao, Ning Huang, Xiaojuan Han, Jian Zhang, Yu Yang, Tiepeng Li, Tingting Zhao, Haoran Tai, Weitong Xu, Gongchang Zhang, Chuhui Gong, Ming Yang, Xiaoqiang Tang, Hengyi Xiao
Summary: In this study, researchers found that miR-146a negatively regulates the AMPK and NAD(+)/SIRT pathway by inhibiting the expression of NAMPT. Additionally, AMPK activators suppress the expression of miR-146a, further enhancing NAMPT expression. This mutual inhibitory relationship provides new insights into the molecular connections between AMPK and SIRT and offers a potential intervention point for the prevention of aging and age-related diseases.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)
Article
Pharmacology & Pharmacy
Dahu Qi, Hui Liu, Xuying Sun, Danni Luo, Meipeng Zhu, Tenghui Tao, Chenghao Gao, Chuankun Zhou, Wei Zhou, Jun Xiao
Summary: Pristimerin exerts potential therapeutic effects on osteoporosis by inhibiting NF-kappa B and MAPK signaling pathways, reducing ROS production, activating Nrf2/HO-1 signaling pathway, and affecting osteoclast differentiation and function.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Ximiao Chen, Zhengli Li, Haofeng Hong, Ning Wang, Junyi Chen, Sisi Lu, Hongyuan Zhang, Xiaolei Zhang, Chaoyong Bei
Summary: The research found that Xanthohumol (XN) can inhibit the expression of nitric oxide synthase (INOS), IL-1 beta-promoted inducible nitric oxide (NO), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and cyclooxygenase-2 (COX-2) in vitro. Additionally, it down-regulates matrix metalloproteinase-13 and prothrombin, while up-regulating type II collagen and Aggrecan expression. XN also activates nuclear factor (Nrf2) and inhibits nuclear factor B (NF-kappaB) signal transduction to slow down the progression of osteoarthritis.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Cell Biology
Yongxian Li, Sipeng Lin, Panjie Liu, Jianbin Huang, Junxiong Qiu, Zhenkang Wen, Jinbo Yuan, Heng Qiu, Yuhao Liu, Qian Liu, Tengpeng Zhou, Peijie Luo, Huizhi Guo, Yanhuai Ma, Danqing Guo, Guoye Mo, Yongchao Tang, Liangliang Xu, De Liang, Jiake Xu, Yue Ding, Shuncong Zhang
Summary: The study found that Carnosol has a strong inhibitory effect on osteoclast differentiation induced by RANKL, potentially serving as a therapeutic supplementary in the prevention or treatment of osteolysis by suppressing the formation and function of RANKL-induced osteoclasts.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Immunology
Zhiyan Zhou, Ranhui Xi, Jiaxin Liu, Xian Peng, Lei Zhao, Xuedong Zhou, Jiyao Li, Xin Zheng, Xin Xu
Summary: The study identified multiple subtypes of taste receptors in human gingival fibroblasts and highlighted TAS2R16's role in inhibiting pro-inflammatory responses by regulating NF-kappa B signaling. This provides a new target and paradigm for the treatment of periodontitis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Endocrinology & Metabolism
Mengbo Zhu, Wenbin Xu, Jiuzhou Jiang, Yining Wang, Yanjing Guo, Ruijia Yang, Yaqiong Chang, Bin Zhao, Zhenyu Wang, Jianfeng Zhang, Te Wang, Liqin Shangguan, Shaowei Wang
Summary: The study found that peiminine can inhibit the differentiation and function of OCs by regulating the levels of specific genes and proteins, with potential targets including NF-kappa B and ERK1/2 signaling pathways. In an animal model, peiminine can alleviate bone loss in ovariectomized mice.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yang Yang, Wei Zhou, Xiuqi Xu, Xianxiu Ge, Fei Wang, Guang-Qin Zhang, Lin Miao, Xueting Deng
Summary: This study suggests that Aprepitant alleviates inflammatory pain in mice by inhibiting the phosphorylation of JNK and p38, as well as the NF-kappa B signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Xin Liu, Shenglin Zhang, Yi Dong, Yunpeng Xie, Qingshan Li
Summary: Gliomas, the most common primary brain tumors in adults, present clinical challenges due to their infiltrative growth patterns and high relapse tendencies. This study identified SENP1 as an upregulated SUMOylation regulator in gliomas and demonstrated its association with poor prognoses. Mechanistically, SENP1 inhibited SIRT1 expression through de-SUMOylation, leading to the activation of NF-kappa B and promotion of glioma cell malignant phenotype. This suggests that SENP1-mediated de-SUMOylation of SIRT1 could have therapeutic implications for gliomas.
EXPERIMENTAL CELL RESEARCH
(2023)
Article
Immunology
Jianxia Chen, Fen Tang, Haohao Li, Xiangyang Wu, Yong Yang, Zhonghua Liu, Xiaochen Huang, Jie Wang, Ruijuan Zheng, Lin Wang, Haipeng Liu, Junfang Xu, Peng Wang, Feng Liu
Summary: This study reveals a significant decrease in Aplp2 levels in TB patients, M.tb-infected macrophages, and mice. Knockdown or mutation of Aplp2 leads to reduced macrophage-mediated killing of M.tb, accompanied by decreased expression of iNOS and reduced cytokine production. Aplp2 mutant mice show increased susceptibility to mycobacterial infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Shu Yang, Jianhong Wang, Duozi Wang, Lei Guo, Dalin Yu
Summary: Ramelteon ameliorates LPS-induced inflammatory responses in astrocytes by reducing expressions of inflammatory cytokines and inhibiting the TLR4/I kappa B alpha/NF-kappa B p65 axis, suggesting its potential as a protective agent against LPS-induced damage in astrocytes.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Cell Biology
Ruiqin Hu, Yanna Xu, Bingshe Han, Yi Chen, Wenhao Li, Guijun Guan, Peng Hu, Yan Zhou, Qianghua Xu, Liangbiao Chen
Summary: Developmental growth is a complex process that involves the coordinated regulation of gene expression. This study identifies miR-202-3p as a key factor in determining embryonic fate during the mid-blastula transition (MBT) in zebrafish. miR-202-3p regulates the expression of a trio of genes involved in cell proliferation and survival, and is crucial for embryonic viability and development during MBT.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Donghui Bai, Tianxiao Sun, Fang Lu, Yancheng Shen, Yan Zhang, Bo Zhang, Guangli Yu, Haihua Li, Jiejie Hao
Summary: The study showed that Eupatilin can attenuate the inflammatory response in OVA-induced asthma by regulating NF-kappa B, MAPK, and Nrf2 signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Yong Zhang, Jiaqi Fu, Shuxin Liu, Lidong Wang, Jiazhang Qiu, Erin J. van Schaik, James E. Samuel, Lei Song, Zhao-Qing Luo
Summary: In this study, we identified an effector of C. burnetii, CinF, which functions as an inhibitor of NF-kappa B signaling by dephosphorylating and stabilizing I kappa B alpha. Our findings provide insights into how C. burnetii utilizes a protein adapted from sugar metabolism to evade host immunity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Plant Sciences
Yifeng Shi, Jiaoxiang Chen, Sunlong Li, Yuhao Wu, Caiyu Yu, LiBin Ni, Jian Xiao, Zhenxuan Shao, Huanqing Zhu, Jianshun Wang, Xiangyang Wang, Xiaolei Zhang
Summary: Tangeretin, a natural flavonoid with anti-inflammatory properties, has been found to inhibit inflammation and extracellular matrix (ECM) degradation, effectively preventing the progression of osteoarthritis (OA). These effects are mediated through the Nrf2/NF-kappa B and MAPK/NF-kappa B pathways.