Free DNA in Cystic Fibrosis Airway Fluids Correlates with Airflow Obstruction

Lack of Neutrophil Elastase Reduces Inflammation, Mucus Hypersecretion, and Emphysema, but Not Mucus Obstruction, in Mice with Cystic Fibrosis–like Lung Disease

(2014) Stefanie Gehrig et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

CFTR: cystic fibrosis and beyond

(2014) M. A. Mall et al.   EUROPEAN RESPIRATORY JOURNAL

NET formation induced by Pseudomonas aeruginosa cystic fibrosis isolates measured as release of myeloperoxidase–DNA and neutrophil elastase–DNA complexes

(2014) Dae-goon Yoo et al.   IMMUNOLOGY LETTERS

Distinct Susceptibilities of Corneal Pseudomonas aeruginosa Clinical Isolates to Neutrophil Extracellular Trap-Mediated Immunity

(2014) Qiang Shan et al.   INFECTION AND IMMUNITY

Early cystic fibrosis lung disease: Role of airway surface dehydration and lessons from preventive rehydration therapies in mice

(2014) Marcus A. Mall et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Papillon-Lefèvre syndrome patient reveals species-dependent requirements for neutrophil defenses

(2014) Ole E. Sørensen et al.   JOURNAL OF CLINICAL INVESTIGATION

Release of Cystic Fibrosis Airway Inflammatory Markers from Pseudomonas aeruginosa-Stimulated Human Neutrophils Involves NADPH Oxidase-Dependent Extracellular DNA Trap Formation

(2014) D.-g. Yoo et al.   JOURNAL OF IMMUNOLOGY

NADPH Oxidase-Independent Formation of Extracellular DNA Traps by Basophils

(2014) M. Morshed et al.   JOURNAL OF IMMUNOLOGY

Cystic Fibrosis Sputum DNA Has NETosis Characteristics and Neutrophil Extracellular Trap Release Is Regulated by Macrophage Migration-Inhibitory Factor

(2014) Markryan Dwyer et al.   Journal of Innate Immunity

Neutrophils sense microbe size and selectively release neutrophil extracellular traps in response to large pathogens

(2014) Nora Branzk et al.   NATURE IMMUNOLOGY

Airway, but not serum or urinary, levels of YKL-40 reflect inflammation in early cystic fibrosis lung disease

(2014) Emmanuelle Fantino et al.   BMC Pulmonary Medicine

A Myeloperoxidase-Containing Complex Regulates Neutrophil Elastase Release and Actin Dynamics during NETosis

(2014) Kathleen D. Metzler et al.   Cell Reports

Does NETosis Contribute to the Bacterial Pathoadaptation in Cystic Fibrosis?

(2014) Samir Rahman et al.   Frontiers in Immunology

Extracellular DNA traps in allergic, infectious, and autoimmune diseases

(2013) D. Simon et al.   ALLERGY

NETosis: how vital is it?

(2013) B. G. Yipp et al.   BLOOD

Risk Factors for Bronchiectasis in Children with Cystic Fibrosis

(2013) Peter D. Sly et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pyocyanin-Enhanced Neutrophil Extracellular Trap Formation Requires the NADPH Oxidase

(2013) Balázs Rada et al.   PLoS One

Molecular mechanisms regulating NETosis in infection and disease

(2013) Nora Branzk et al.   Seminars in Immunopathology

NET balancing: a problem in inflammatory lung diseases

(2013) Olivia Z. Cheng et al.   Frontiers in Immunology

Influence of DNA on the Activities and Inhibition of Neutrophil Serine Proteases in Cystic Fibrosis Sputum

(2012) Alice V. Dubois et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Neutrophil Extracellular Trap (NET) Impact on Deep Vein Thrombosis

(2012) Tobias A. Fuchs et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

State of progress in treating cystic fibrosis respiratory disease

(2012) Patrick A Flume et al.   BMC Medicine

Fighting against the dark side of neutrophil extracellular traps in disease

(2012) Mona Saffarzadeh et al.   CURRENT OPINION IN HEMATOLOGY

Eosinophil extracellular DNA traps: molecular mechanisms and potential roles in disease

(2012) Shida Yousefi et al.   CURRENT OPINION IN IMMUNOLOGY

Treatment of lung infection in patients with cystic fibrosis: Current and future strategies

(2012) Gerd Döring et al.   Journal of Cystic Fibrosis

Innate immunity in cystic fibrosis lung disease

(2012) D. Hartl et al.   Journal of Cystic Fibrosis

Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo

(2012) Marie-Luise von Brühl et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Anuclear neutrophils keep hunting

(2012) Andreas Peschel et al.   NATURE MEDICINE

Neutrophil Extracellular Traps Directly Induce Epithelial and Endothelial Cell Death: A Predominant Role of Histones

(2012) Mona Saffarzadeh et al.   PLoS One

MMP-9 Cleaves SP-D and Abrogates Its Innate Immune Functions In Vitro

(2012) Preston E. Bratcher et al.   PLoS One

Eosinophil and neutrophil extracellular DNA traps in human allergic asthmatic airways

(2011) Ryszard Dworski et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The ENaC-overexpressing mouse as a model of cystic fibrosis lung disease

(2011) Zhe Zhou et al.   Journal of Cystic Fibrosis

Ultrastructural characterization of cystic fibrosis sputum using atomic force and scanning electron microscopy

(2011) Reinhard Manzenreiter et al.   Journal of Cystic Fibrosis

Innate Immune Collectin Surfactant Protein D Simultaneously Binds Both Neutrophil Extracellular Traps and Carbohydrate Ligands and Promotes Bacterial Trapping

(2011) D. N. Douda et al.   JOURNAL OF IMMUNOLOGY

Neutrophil Extracellular Trap (NET)-Mediated Killing of Pseudomonas aeruginosa: Evidence of Acquired Resistance within the CF Airway, Independent of CFTR

(2011) Robert L. Young et al.   PLoS One

The Chitinase-Like Protein YKL-40 Modulates Cystic Fibrosis Lung Disease

(2011) Andreas Hector et al.   PLoS One

Neutrophil Elastase Enhances Sputum Solubilization in Cystic Fibrosis Patients Receiving DNase Therapy

(2011) Venizelos Papayannopoulos et al.   PLoS One

Airway Surface Liquid Volume Regulation Determines Different Airway Phenotypes in Liddle Compared with βENaC-overexpressing Mice

(2010) Marcus A. Mall et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps

(2010) Venizelos Papayannopoulos et al.   JOURNAL OF CELL BIOLOGY

Serum-surfactant SP-D correlates inversely to lung function in cystic fibrosis

(2010) Hanne Vebert Olesen et al.   Journal of Cystic Fibrosis

A Novel Mechanism of Rapid Nuclear Neutrophil Extracellular Trap Formation in Response to Staphylococcus aureus

(2010) F. H. Pilsczek et al.   JOURNAL OF IMMUNOLOGY

Noninvasive and Invasive Pulmonary Function in Mouse Models of Obstructive and Restrictive Respiratory Diseases

(2009) Jeroen A. J. Vanoirbeek et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Viable neutrophils release mitochondrial DNA to form neutrophil extracellular traps

(2009) S Yousefi et al.   CELL DEATH AND DIFFERENTIATION

A review of STRIDE-2 and STRIDE-2X: the case for selective endothelin receptor blockade

(2009) D. Langleben et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

NETs: a new strategy for using old weapons

(2009) Venizelos Papayannopoulos et al.   TRENDS IN IMMUNOLOGY

Inhibition of airway proteases in cystic fibrosis lung disease

(2008) M. Griese et al.   EUROPEAN RESPIRATORY JOURNAL

Patterns of neutrophil serine protease-dependent cleavage of surfactant protein D in inflammatory lung disease

(2008) J. Cooley et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense

(2008) Shida Yousefi et al.   NATURE MEDICINE

Development of Chronic Bronchitis and Emphysema in β-Epithelial Na+Channel–Overexpressing Mice

(2007) Marcus A. Mall et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE