Article
Biotechnology & Applied Microbiology
Limei Wang, Haijing Yan, Xiaomeng Chen, Lin Han, Guibo Liu, Hua Yang, Danli Lu, Wenting Liu, Chengye Che
Summary: Thymol was found to have an anti-inflammatory effect in Aspergillus fumigatus keratitis. Wound healing and fluorescein staining were used to confirm the safety of thymol. The study showed that treatment with 50 μg/ml thymol reduced the infiltration of inflammatory cells and increased corneal transparency. Thymol also downregulated the TLR4/MyD88/NF-kB/IL-1 beta signaling and reduced necroptosis and pyroptosis.
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Article
Food Science & Technology
Liang Wang, Hui Shi, Chun-chun Zhao, Jing-ya Li, Jian-fei Peng, An-lu Shen, Peng Zhou, Hui-min Bian
Summary: This study found that astragaloside IV can inhibit inflammatory response, reduce cardiac pathology, and have anti-apoptotic effects.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Cell Biology
Milton Pereira, Danielle F. Durso, Clare E. Bryant, Evelyn A. Kurt-Jones, Neal Silverman, Douglas T. Golenbock, Ricardo T. Gazzinelli
Summary: This study examines the importance of IRAK proteins in TLR4 activation and confirms the essential role of IRAK4 kinase activity in MYD88 signaling. It also reveals the crucial role of the IRAK4 scaffold in integrating MYD88 and TRIF in TLR4 signaling.
Article
Immunology
Kang Huo, Jing Xu, Meng Wei, Kaige Ma, Jianyi Wang, Jianfeng Han
Summary: Solasonine exhibits neuroprotective effects on cerebral ischemia/reperfusion injury by reducing inflammatory responses, oxidative stress, and neuronal apoptosis, and improving neurological function and neuronal damage.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Anatomy & Morphology
Qinhan Hou, Hongmou Chen, Quan Liu, Xianlei Yan
Summary: The overexpression of FGF10 can alleviate neurological deficits, neuronal apoptosis, and neuroinflammation in experimental TBI mice by inhibiting the TLR4/MyD88/NF-kappa B pathway, providing a potential therapeutic strategy for brain injury.
CELLS TISSUES ORGANS
(2021)
Article
Biochemistry & Molecular Biology
Yage Liu, Yimiao Tian, Xuan Dai, Tianyuan Liu, Yueyi Zhang, Shan Wang, Hanfen Shi, Jiyuan Yin, Tianshu Xu, Ruyuan Zhu, Yanfei Zhang, Dandan Zhao, Sihua Gao, Xiang-Dong Wang, Lili Wang, Dongwei Zhang
Summary: This study demonstrates that dietary lycopene consumption can suppress inflammation and apoptosis of pancreatic islets, improve islet function, and reduce hyperglycemia and dyslipidemia in diabetes by regulating the TLR4/MyD88/NF-kappa B signaling pathway. These findings highlight lycopene as a novel strategy for managing patients with diabetes.
Article
Immunology
Zhen-Ni Liu, Xue Wu, Qian Fang, Zi-Xuan Li, Guo-Qing Xia, Jun-Nan Cai, Xiong-Wen Lv
Summary: This study found that overexpression of CD73 can reduce alcohol-induced liver injury and inflammation, suggesting CD73 as a potential therapeutic target for ALD.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Food Science & Technology
Lijun Zhu, Wei Li, Ziying Fan, Xianying Ye, Ruyi Lin, Mengmeng Ban, Lingzhi Ren, Xiaoqing Chen, Danyan Zhang
Summary: The study revealed that AGPp polysaccharide extracted from Arca granosa can enhance immune responses by increasing the quantity of macrophages, enhancing phagocytosis, and improving nitric oxide and cytokine secretion. The mechanism involves binding to the TLR4 receptor and promoting TLR4 pathway-related protein expression, with significant changes observed when TLR4 inhibitor was added. The immune-modulation effect of AGPp is mainly related to the mediation of TLR4/MyD88/NF kappa B and TLR4/TRIF signaling pathways.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Gastroenterology & Hepatology
Chaoqin Duan, Xi Xu, Xiaoyi Lu, Ling Wang, Zhongkai Lu
Summary: This study explored the role of RIP3 in ulcerative colitis (UC) and found that its expression is positively associated with disease severity. Targeting RIP3 can inhibit necroptosis and alleviate inflammation. The RIP3 inhibitor Nec-1 may be an effective drug to reduce intestinal inflammation and cell death in UC patients.
BMC GASTROENTEROLOGY
(2022)
Article
Medicine, Research & Experimental
Wenxun Liu, Yan Li, Zhaozhao Wu, Kerong Hai, Yun Wang, Xiaohong Zhou, Qingshan Ye
Summary: In this study, heparin was found to suppress LPS-induced endothelial injury by regulating the TLR4/MyD88/NF-κB (p65) signaling pathway in vitro. Heparin treatment led to decreased levels of pro-inflammatory cytokines, increased cell proliferation, and decreased apoptosis. These results suggest a potential protective role of heparin in preventing endothelial injury.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Sheng Li, Jingyi Zhang, Mingxiao Ma, Mengyao Zhang, Linzhi Li, Weixin Chen, Shugang Li
Summary: The exact molecular mechanism of arsenic-induced liver injury is not fully understood. This study aimed to investigate the potential mechanism of NaAsO2-induced cytotoxicity in BRL-3A cells and found that it may be related to the inhibition of SOCS1 through regulation of DNMT1 and activation of the TLR4/MyD88/NF-kappa B signaling pathway.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Plant Sciences
Yanhui Zhu, Qianqian Han, Lei Wang, Baiyan Wang, Jianshuang Chen, Bangrong Cai, Can Wu, Xiali Zhu, Fugang Liu, Deen Han, Haoran Dong, Yongyan Jia, Yalin Liu
Summary: Jinhua Qinggan granules (JHQG) has potential therapeutic value in the treatment of acute lung injury (ALI) by promoting neutrophil apoptosis and inhibiting the TLR4/MyD88/NF-Kappa B pathway, thus reducing pulmonary inflammation.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Anesthesiology
Zeyu Li, Tao Wang, Yonghao Yu
Summary: Sevoflurane can induce apoptosis and inflammatory response, while miR-424 can regulate this process.
BMC ANESTHESIOLOGY
(2022)
Article
Plant Sciences
Yuxin Dai, Qiulu Lu, Peiyi Li, Junyu Zhu, Jiaxin Jiang, Tong Zhao, Yue Hu, Kang Ding, Min Zhao
Summary: This study aimed to investigate the mechanism of Xianglian Pill (XLP) in treating ulcerative colitis (UC) induced by dextran sulfate sodium (DSS). The results showed that XLP treated UC by regulating the TLR4/MyD88/NF-kappa B signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
Hong Fan, Zhe Chen, Hai-Bin Tang, Le-Qun Shan, Zi-Yi Chen, Shi-Chang Liu, Yong-Yuan Zhang, Xin-Yu Guo, Hao Yang, Ding-Jun Hao
Summary: This study reveals the involvement of the MyD88 signaling pathway in the necroptosis of NP cells in IVDD, providing new insights into the pathogenesis of IVDD and a potential therapeutic target.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Immunology
Erin Harberts, Hua Zhou, Rita Fishelevich, Juan Liu, Anthony A. Gaspari
JOURNAL OF IMMUNOLOGY
(2015)
Article
Dermatology
Hua Zhou, Erin Harberts, Rita Fishelevich, Anthony A. Gaspari
EXPERIMENTAL DERMATOLOGY
(2016)
Article
Microbiology
Kelsey A. Gregg, Erin Harberts, Francesca M. Gardner, Mark R. Pelletier, Corinne Cayatte, Li Yu, Michael P. McCarthy, Jason D. Marshall, Robert K. Ernst
Article
Immunology
Courtney E. Chandler, Erin M. Harberts, Tim Laemmermann, Qin Zeng, Belita N. Opene, Ronald N. Germain, Christopher M. Jewell, Alison J. Scott, Robert K. Ernst
INFECTION AND IMMUNITY
(2018)
Article
Biochemical Research Methods
Benjamin L. Oyler, Mohd M. Khan, Donald F. Smith, Erin M. Harberts, David P. A. Kilgour, Robert K. Ernst, Alan S. Cross, David R. Goodlett
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
(2018)
Correction
Biochemical Research Methods
Benjamin L. Oyler, Mohd M. Khan, Donald F. Smith, Erin M. Harberts, David P. A. Kilgour, Robert K. Ernst, Alan S. Cross, David R. Goodlett
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
(2018)
Letter
Dermatology
Papapit Tuchinda, Yaqian Liu, Antonella Tammaro, Erin Harberts, Ronald Goldner, Anthony A. Gaspari
Article
Dermatology
Laurie Shallcross, Simon Ritchie, Erin Harberts, Antonella Tammaro, Joanna Gaitens, Anthony A. Gaspari
Article
Dermatology
Hannah Liu, Papapit Tuchinda, Rita Fishelevich, Erin Harberts, Anthony A. Gaspari
JOURNAL OF DERMATOLOGICAL SCIENCE
(2014)
Article
Dermatology
Juan Liu, Erin Harberts, Antonella Tammaro, Nicholas Girardi, Renata B. Filler, Rita Fishelevich, Angela Temann, Paula Licona-Limon, Michael Girardi, Richard A. Flavell, Anthony A. Gaspari
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2014)
Article
Biochemical Research Methods
Erin Harberts, Tao Liang, Sung Hwan Yoon, Belita N. Opene, Melinda A. McFarland, David R. Goodlett, Robert K. Ernst
JOURNAL OF PROTEOME RESEARCH
(2020)
Article
Immunology
Katharina Richard, Darren J. Perkins, Erin M. Harberts, Yang Song, Archana Gopalakrishnan, Kari Ann Shirey, Wendy Lai, Alexandra Vlk, Anup Mahurkar, Shreeram Nallar, Lynn D. Hawkins, Robert K. Ernst, Stefanie N. Vogel
Article
Multidisciplinary Sciences
Courtney E. Chandler, Erin M. Harberts, Mark R. Pelletier, Iyarit Thaipisuttikul, Jace W. Jones, Adeline M. Hajjar, Jason W. Sahl, David R. Goodlett, Aaron C. Pride, David A. Rasko, M. Stephen Trent, Russell E. Bishop, Robert K. Ernst
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Immunology
Athina Zacharia, Erin Harberts, Sarah M. Valencia, Breana Myers, Chelsea Sanders, Akshay Jain, Nicholas R. Larson, C. Russell Middaugh, William D. Picking, Simone Difilippantonio, Reinhard Kirnbauer, Richard B. Roden, Ligia A. Pinto, Robert H. Shoemaker, Robert K. Ernst, Jason D. Marshall
Summary: The study demonstrated that utilizing novel BECC/Alhydrogel adjuvants can enhance the immunogenicity of HPV vaccines against multiple HPV types, promote the generation of cross-neutralizing antibodies, reduce the number of vaccinations needed, spare vaccine doses, accelerate immune responses, and establish longer-lasting humoral immunity.
Article
Immunology
Robert E. Haupt, Erin M. Harberts, Robert J. Kitz, Shirin Strohmeier, Florian Krammer, Robert K. Ernst, Matthew B. Frieman
Summary: The study shows that TLR4 immunostimulatory molecules BECC438 and BECC470 are superior IAV vaccine adjuvants, allowing for antigen sparing, eliciting a more balanced immune response, and providing protection against heterologous IAV strains.
Article
Biochemistry & Molecular Biology
Binbin Chang, Zhang Wang, Hui Cheng, Tingyuan Xu, Jieyu Chen, Wan Wu, Yizhi Li, Yong Zhang
Summary: Acacetin can attenuate sepsis-induced ALI by inhibiting the inflammatory response and promoting macrophage polarization. This study is of great significance for the development of new treatments for sepsis-induced ALI.
Review
Biochemistry & Molecular Biology
Nikoleta Bizymi, Andreas M. Matthaiou, Irene Mavroudi, Aristea Batsali, Helen A. Papadaki
Summary: Myeloid-derived suppressor cells (MDSCs) are innate immune cells that have immunomodulatory properties. They interact extensively with other innate or adaptive immune cells and can either enhance or attenuate immune responses depending on the triggering conditions. However, their positive role in host defense mechanisms is rarely discussed in the literature.