Article
Veterinary Sciences
Yunxiao Zhou, Xiaofen Hu, Shengwei Zhong, Wanting Yu, Jue Wang, Wenlu Zhu, Tingyu Yang, Guotong Zhao, Yijie Jiang, Yong Li
Summary: Continuous low-dose lipopolysaccharide (LPS) induction in weaned piglets causes oxidative damage and liver injury at the early stage, but the damage weakens over time, indicating the development of endotoxin tolerance. Weaned piglets are susceptible to external environment and diseases, especially bacterial infections, which affect their growth and lead to tissue damage or death. This study examines the effects of continuous low-dose LPS induction on liver injury mechanisms in weaned piglets using an Escherichia coli LPS-induced model.
VETERINARY SCIENCES
(2023)
Article
Agriculture, Dairy & Animal Science
Fujun Miao, Chunlan Shan, Shuxiang Geng, Delu Ning
Summary: This study aimed to investigate the ameliorative effect of oleocanthal (OC) on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in chickens and its possible mechanisms. The results showed that OC treatment improved the pathological morphology and suppressed apoptosis in LPS-induced ALI chickens. OC supplementation also enhanced antioxidant capacity and inhibited the activation of the toll-like receptor 4/nuclear factor-kappa B (TLR4/NF-κB) pathway in LPS group. Overall, OC supplementation can alleviate LPS-induced ALI in chickens by suppressing apoptosis, enhancing lung antioxidant capacities, and inhibiting TLR4/NF-κB pathway activation.
Article
Gastroenterology & Hepatology
Jie Li, Xiao-Ming Chen, Chun-Ze Zhou, Wei-Wei Fang, Wei-Fu Lv, De-Lei Cheng
Summary: The study found that LPS levels were significantly elevated in BCS model groups, leading to increased expression of TLR4, NF-kappa B, and inflammatory cytokines in liver tissues. Importantly, chronic BCS patients had significantly higher levels of LPS, TLR4, NF-kappa B, and inflammatory cytokines compared to healthy controls and acute BCS patients.
WORLD JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Biochemistry & Molecular Biology
Eman T. Mehanna, Al-Shimaa A. Ali, Fatma El-Shaarawy, Noha M. Mesbah, Dina M. Abo-Elmatty, Nora M. Aborehab
Summary: This study demonstrates the protective effects of lipopolysaccharide from Rhodobacter sphaeroides (LPS-RS) against ethanol-induced hepatotoxicity and nephrotoxicity in experimental rats. LPS-RS alleviated oxidative stress, inflammation, and preserved iron homeostasis in the liver and kidney of the rats.
Article
Chemistry, Applied
F. F. Huang, Y. Yang, L. M. Wang, H. Wang, P. Li, K. Xiao, X. Xu, J. S. Liu, Y. L. Liu, H. L. Zhu
Summary: The study found that dietary supplementation of holly polyphenols can alleviate liver injury induced by lipopolysaccharide in weaned pigs and inhibit inflammatory response and oxidative stress.
FOOD AND AGRICULTURAL IMMUNOLOGY
(2022)
Article
Neurosciences
Pushpa Gandi Sangaran, Zaridatul Aini Ibrahim, Zamri Chik, Zahurin Mohamed, Abolhassan Ahmadiani
Summary: LPS pre-conditioning exerts protective effects on cells by modulating gene and protein expression; LPS-treated cells secrete more inflammatory cytokines and reactive oxygen species, while LPS-preconditioned cells contain higher levels of anti-inflammatory cytokines and suppress expression of certain apoptotic molecules.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Review
Medicine, Research & Experimental
Ankush Kumar Jha, Shobhit Gairola, Sourav Kundu, Pakpi Doye, Abu Mohammad Syed, Chetan Ram, Upadhyayula Suryanarayana Murty, V. G. M. Naidu, Bidya Dhar Sahu
Summary: This review emphasizes the role of TLR4 signaling pathway in AKI and highlights potential compounds of natural and synthetic origin that can avert renal TLR4 signaling and offer protection against AKI in preclinical models. Targeting TLR4 and its downstream effectors could serve as an effective therapeutic intervention to prevent renal inflammation and subsequent kidney damage.
Article
Biochemistry & Molecular Biology
Shujun Zhang, Zhuan Li, Steven Weinman
Summary: This study demonstrated the role of forkhead box o3 in regulating the inflammatory response of monocytes in the presence of lipopolysaccharide. It was found that there might be a positive feedback loop between lipopolysaccharide and forkhead box o3 in promoting the inflammatory response.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Agriculture, Dairy & Animal Science
Bingxin Li, Longsheng Hong, Yindan Luo, Bingqi Zhang, Ziyu Yu, Wanyan Li, Nan Cao, Yunmao Huang, Danning Xu, Yugu Li, Yunbo Tian
Summary: LPS is a virulence factor of Gram-negative bacteria and its excessive concentration in geese can induce liver damage and reduce production performance. In this study, transcriptome sequencing analysis identified 727 differentially expressed genes related to LPS-induced liver injury and enrichment analysis showed the involvement of Toll-like receptor, MAPK, NOD-like receptor, FoxO, and PPAR signaling pathways. The TLR7-mediated MAPK signaling pathway played a major role in LPS-induced liver injury in geese.
Article
Agriculture, Dairy & Animal Science
Nicole C. Burdick Sanchez, Jeffery W. Dailey, Paul R. Broadway, Emily M. Davis, Brooke M. Bowen, Amy L. Petry, Michael A. Ballou, Kristin E. Hales, Jeffery A. Carroll
Summary: The objective of this study was to compare the temperature of weaned pigs under a lipopolysaccharide challenge through different subcutaneous and intraperitoneal locations. In experiment 1, temperature loggers were placed in four different anatomical locations of the pigs, while in experiment 2, the loggers were placed subcutaneously in the Flank and surgically within the intraperitoneal cavity. The results showed that the Flank subcutaneous temperature was strongly correlated with the intraperitoneal temperature, suggesting it as a less invasive alternative to measure pig's temperature.
Article
Chemistry, Medicinal
Seokwon Shin, Jayeon Park, Ye Eun Lee, Hanbin Ko, Hyung-Sun Youn
Summary: Toll-like receptors (TLRs) play a crucial role in immune responses by activating signaling pathways that induce inflammation. Research has shown that isobavachalcone (IBC) can inhibit the activation of TLR signaling pathways, opening up new therapeutic options for inflammatory diseases involving TLRs.
ARCHIV DER PHARMAZIE
(2022)
Article
Pharmacology & Pharmacy
Huizong Su, Qian Wang, Yue Li, Jingyi Jin, Bo Tan, Dongming Yan, Bin Zou, Guochao Song, Fengyi Weng, Furong Qiu
Summary: The study found that YGD with a high proportion of Gancao has a protective effect on ANIT-induced IC mice by inhibiting the inflammatory response. On the other hand, YGD with a high proportion of Yinchen may exacerbate the condition of IC mice, leading to liver cell damage and inflammation.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Ruonan Zhang, Xiaofeng Li, Jie Zhang, Yanjun Li, Yuan Wang, Yuhang Song, Feifei Ren, Huiyu Yi, Xiaojuan Deng, Yangjin Zhong, Yang Cao, Michael R. Strand, Xiao-Qiang Yu, Wanying Yang
Summary: Toll/Toll-like receptors play different roles in mammals and insects, with insects primarily activating the Toll pathway through binding Spatzle cytokines rather than directly recognizing pathogen-associated molecular patterns.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Agriculture, Dairy & Animal Science
Yue Li, Hao Zhang, Feng Tu, Jing Cao, Xiang Hou, Yanan Chen, Junshu Yan
Summary: The study suggests that pterostilbene (PT) may alleviate LPS-induced liver injury and immunological stress in weaned piglets via the PP2A/NF-kappa B/NLRP3 signaling pathway, proving to be more effective than resveratrol (RSV).
JOURNAL OF ANIMAL SCIENCE
(2022)
Article
Engineering, Environmental
Je-Oh Lim, Woong-Il Kim, So-Won Pak, Se-Jin Lee, Sung-Hyeuk Park, In-Sik Shin, Jong-Choon Kim
Summary: This study investigates the exacerbation of asthma induced by aluminum oxide nanoparticles (Al2O3 NPs) and explores the correlation between toll-like receptor 4 (TLR4) signaling and Al2O3 NP-induced asthma exacerbation. The results show that Al2O3 NP exposure leads to increased inflammatory cell counts, airway hyperresponsiveness, and inflammatory cytokine levels in asthmatic mice. The expression levels of TLR4 and related signaling proteins are also affected by Al2O3 NP exposure.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Binbin Chang, Zhang Wang, Hui Cheng, Tingyuan Xu, Jieyu Chen, Wan Wu, Yizhi Li, Yong Zhang
Summary: Acacetin can attenuate sepsis-induced ALI by inhibiting the inflammatory response and promoting macrophage polarization. This study is of great significance for the development of new treatments for sepsis-induced ALI.
Review
Biochemistry & Molecular Biology
Nikoleta Bizymi, Andreas M. Matthaiou, Irene Mavroudi, Aristea Batsali, Helen A. Papadaki
Summary: Myeloid-derived suppressor cells (MDSCs) are innate immune cells that have immunomodulatory properties. They interact extensively with other innate or adaptive immune cells and can either enhance or attenuate immune responses depending on the triggering conditions. However, their positive role in host defense mechanisms is rarely discussed in the literature.