Review
Neurosciences
Teng Wan, Xiaoyu Li, Mingyuan Fu, Xiaoyu Gao, Peiling Li, Weiming Guo
Summary: This article provides a timely review of recent findings on the activation and regulation of pyroptosis in relation to depression, highlighting the important role of neuroinflammation in the pathogenesis of depression. It also discusses the therapeutic effects of chemical agents and natural products by modulating pyroptosis.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Yu Zheng, Xinda Xu, Fanglu Chi, Ning Cong
Summary: Ischemia-reperfusion (I/R) injury can cause cell death and organ dysfunction, and different types of cell death occur during this process. Pyroptosis, closely related to I/R injury, may be targeted for the treatment of I/R injury by focusing on its signaling pathways and key regulators.
Review
Food Science & Technology
Faezeh Malakoti, Erfan Mohammadi, Mahsa Akbari Oryani, Darioush Shanebandi, Bahman Yousefi, Azadeh Salehi, Zatollah Asemi
Summary: MiRNAs play a role in the occurrence and development of diabetic complications by interacting with mRNA to prevent translation, and polyphenols are considered safe drugs for treating diabetic complications.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Cell Biology
Jiaqiang Deng, Lijun Zhong, Zihan Zhou, Congwei Gu, Xiaoya Huang, Liuhong Shen, Suizhong Cao, Zhihua Ren, Zhicai Zuo, Junliang Deng, Shumin Yu
Summary: MSCs are promising therapeutic materials with self-renewal, multilineage differentiation, and immunomodulation capabilities. However, external factors like donor age, disease, and environmental pressure may affect their functions. Autophagy, as a critical process in maintaining cellular homeostasis, shows potential in improving MSC functions, making it a promising therapeutic target.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Review
Immunology
Ruixuan You, Xinglan He, Zhuotong Zeng, Yi Zhan, Yangfan Xiao, Rong Xiao
Summary: Autoimmune diseases are a group of heterogeneous diseases caused by the destruction of immune tolerance and the production of autoantibodies. Excessive exacerbation of pyroptosis, a form of programmed cell death, plays a crucial role in the development of autoimmune diseases. Inflammasomes act as switches for pyroptosis, and various pyroptosis pathways disrupt immune system homeostasis and promote autoimmunity.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Geriatrics & Gerontology
Yuehua Huang, Xiaoyu Li, Guifei Luo, Junli Wang, Ranhui Li, Chuyi Zhou, Teng Wan, Fenglian Yang
Summary: This paper reviews the recent research progress on pyroptosis and focuses on the pathogenic roles of pyroptosis in Alzheimer's disease (AD) and the potential of targeted inhibition of inflammasome-dependent pyroptosis for AD treatment.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Review
Pharmacology & Pharmacy
Zhengyao Cai, Suxin Yuan, Xingzhao Luan, Jian Feng, Li Deng, Yumei Zuo, Jiafu Li
Summary: This review summarizes the role of pyroptosis and the inflammasome in the development of diabetic cardiomyopathy (DCM) and discusses potential anti-DCM strategies targeting this pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Hongfeng Ruan, Huihao Zhang, Jing Feng, Huan Luo, Fangda Fu, Sai Yao, Chengcong Zhou, Zhiguo Zhang, Yishan Bian, Hongting Jin, Yuliang Zhang, Chengliang Wu, Peijian Tong
Summary: This study found that the levels of pyroptosis-related proteins were significantly increased in patients with osteoporosis and a mouse model, while osteogenic capacity was compromised. Bioinformatics analysis confirmed shared gene expression patterns between pyroptosis and osteoporosis pathology. In vitro experiments revealed that inhibition of Caspase-1-mediated pyroptosis promotes osteogenic differentiation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Cell Biology
Tong Li, Guangjuan Zheng, Ben Li, Lipeng Tang
Summary: Pyroptosis is a form of programmed cell death characterized by the formation of inflammatory pores, cellular lysis, and release of pro-inflammatory cytokines, associated with intracellular pathogens-induced infection. However, it is now understood that pyroptosis also plays a role in sterile inflammation. Targeting the pyroptotic signaling pathway with specific inhibitors may offer a promising approach for the treatment of noninfective inflammatory disorders.
CELL PROLIFERATION
(2021)
Review
Neurosciences
Lingui Gu, Mingjiang Sun, Ruihao Li, Yihao Tao, Xu Luo, Xingyu Zhang, Ye Yuan, Zongyi Xie
Summary: This review outlines the role of microglial pyroptosis in the pathological process of intracerebral hemorrhage (ICH) and highlights the potential of targeted strategies to inhibit microglial pyroptosis as a therapeutic approach.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Cell Biology
Conghui Zhou, Jinfeng Zheng, Yunpeng Fan, Junsong Wu
Summary: This review summarizes the role and underlying mechanism of NLRP3 inflammasome in CNS trauma and discusses the therapeutic applications of NLRP3 inflammasome activation inhibitors.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Neurosciences
Lixia Wang, Wei Ren, Qingjuan Wu, Tianzhu Liu, Ying Wei, Jiru Ding, Chen Zhou, Houping Xu, Sijin Yang
Summary: Ischemic stroke is a serious condition, and understanding the molecular mechanisms behind cerebral ischemia-reperfusion (I/R) injury is crucial in developing effective treatments. This review focuses on the role of the NLRP3 inflammasome in regulating the inflammatory response in brain cells after I/R injury. The assembly and activation of the NLRP3 inflammasome leads to the release of pro-inflammatory cytokines and the induction of pyroptosis, a form of pro-inflammatory cell death. Inhibitors targeting the NLRP3 inflammasome may hold promise for treating cerebral I/R injury.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Review
Immunology
Subhashini Brahadeeswaran, Tiasha Dasgupta, Venkatraman Manickam, Viswanathan Saraswathi, Ramasamy Tamizhselvi
Summary: The liver is responsible for important physiological processes and its role in activating the innate immune system and causing inflammation is crucial. Chronic ethanol exposure disrupts the liver's inflammatory mechanism and releases proinflammatory mediators. Activation of the NLRP3 inflammasome is involved in liver fibrosis/cirrhosis, leading to hepatocyte destruction and metabolic dysregulation. Alcohol intake also affects liver epigenetics, promoting the development of alcoholic liver disease (ALD). Understanding the role of NLRP3 inflammasome and epigenetic modifications could lead to potential therapeutic targets for ALD.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Engineering, Biomedical
Mengzhen Wang, Qinrui Fu
Summary: Pyroptosis, a distinct mode of programmed cell death, differs significantly from apoptosis and cell necrosis. Mediated by the gasdermin protein, it leads to cellular outcomes such as swelling, membrane perforation, and release of cell contents. Recent research highlights the role of pyroptosis in disease etiology and progression, prompting scientists to explore ways to regulate pyroptosis pathways for disease management. However, there is a lack of research on the recent advancements in nanomaterials for modulating the pyroptosis pathway. This review article fills this gap by discussing the potential of nanomaterials in disease treatment through pyroptosis modulation and highlighting their mechanisms of action.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Cell Biology
Bao-Biao Zhuo, Lun-Qing Zhu, Chen Yao, Xi-Hua Wang, Shi-Xian Li, Rong Wang, Yuan Li, Zhuo-Yan Ling
Summary: We have shown that ADCK1, a mitochondrial protein, is upregulated in human osteosarcoma tissues and cells. ADCK1 plays a crucial role in cell viability, proliferation, migration, apoptosis, and mitochondrial functions. Inhibition of ADCK1 enhances doxorubicin-induced apoptosis and decreases cell growth. The mTOR pathway is important for ADCK1 expression. ADCK1 is a novel therapeutic target for osteosarcoma.
CELL DEATH & DISEASE
(2022)
