期刊
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
卷 44, 期 -, 页码 S43-S45出版社
ELSEVIER SCI LTD
DOI: 10.1016/S0020-1383(13)70010-X
关键词
Bone defects; Non-union; Bone shortening; Distraction osteogenesis; Bone grafts; Bone substitutes; Stem cells; Growth factors; Scaffolds; Gene therapy
资金
- Smith Nephew
Bone defects associated with non-unions occur as a result of the initial insult or as a consequence of bone excision following non-union development. Historically management of this clinical scenario consisted mainly of amputation, which provided a short recovery period but a significant loss of limb function. Today treatment has evolved and multiple options are available for reconstruction of the bone defect. Broadly these are: bone shortening with lengthening later or bone transport and 'docking' (distraction osteogenesis based techniques); the use of vascularised and non-vascularised bone grafts; bone substitutes; stem cells; growth factors; scaffolds and gene therapy. (C) 2013 Elsevier Ltd. All rights reserved.
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