Article
Chemistry, Multidisciplinary
Shutao Zhang, Xinhua Qu, Haozheng Tang, You Wang, Hongtao Yang, Weien Yuan, Bing Yue
Summary: The study shows that high-dose diclofenac inhibits the growth of MRSA without inducing drug-resistant mutations easily, while low-dose diclofenac can resensitize bacteria to beta-lactams and inhibit biofilm formation. Transcriptomic and proteomic analyses indicate that diclofenac reduces the expression of genes and proteins associated with antibiotic resistance and biofilm formation. Murine implant infection models suggest that diclofenac combined with beta-lactams can substantially alleviate MRSA infections in vivo, offering promising applications for preventing perioperative infections.
Article
Microbiology
Alexandra E. Chittams-Miles, Areej Malik, Erin B. Purcell, Claudia Muratori, Brian Conlon
Summary: Treatment with short electric pulses can enhance the effects of multiple antibiotics against methicillin-resistant Staphylococcus aureus (MRSA). This combination therapy reduces the necessary antibiotic dosage and improves the efficacy of treating S. aureus infections such as skin and soft-tissue infections (SSTIs). SSTIs are accessible to physical intervention, making electric pulse co-treatment a potential option for wound and abscess debridement.
MICROBIOLOGY SPECTRUM
(2023)
Article
Infectious Diseases
Moxi Yu, Yachen Hou, Meiling Cheng, Yongshen Liu, Caise Ling, Dongshen Zhai, Hui Zhao, Yaoyao Li, Yamiao Chen, Xiaoyan Xue, Xue Ma, Min Jia, Bin Wang, Pingan Wang, Mingkai Li
Summary: Infections caused by methicillin-resistant Staphylococcus aureus (MRSA) are difficult to treat due to antibiotic resistance, posing a significant threat to public health. A study examined the antibacterial activity of novel squaric amide derivatives against MRSA strains. The results showed that one derivative, squaric amide 2 (SA2), exhibited strong bactericidal activity, reduced infection size and bacterial count in an animal model.
Article
Mathematics, Applied
Bahar Acay, Mustafa Inc, Amir Khan, Abdullahi Yusuf
Summary: This study provides a detailed exposition of in-hospital community-acquired MRSA and hospital-acquired MRSA using Caputo fractional operator. Solutions of the infectious model are shown to exist and be unique, with stability analysis and iterative solutions provided. Sensitivity analysis is also carried out to identify key parameters for controlling infection spread, and solutions are obtained using Laplace-Adomian decomposition method with simulations using fractional-order alpha.
JOURNAL OF APPLIED MATHEMATICS AND COMPUTING
(2021)
Article
Biotechnology & Applied Microbiology
Santosh Paudel, Kamal Bagale, Swapnil Patel, Nicholas J. Kooyers, Ritwij Kulkarni
Summary: Human urine significantly alters the physiology and gene expression of MRSA, aiding the bacterium in adapting to the nutrient-limiting and immunologically hostile conditions within the urinary tract to facilitate UTI.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2021)
Article
Engineering, Biomedical
Shutao Zhang, Xinhua Qu, Juyang Jiao, Haozheng Tang, Minqi Wang, You Wang, Hongtao Yang, Weien Yuan, Bing Yue
Summary: Felodipine has antibacterial effects against MRSA, biofilm, and persisters. It can inhibit the expression of proteins associated with aminoglycoside resistance, eradicate formed biofilms and kill persisters. Felodipine also reduces MRSA virulence and modulates bacterial metabolism. It inhibits the growth of persisters by binding to a protease. In a mouse infection model, felodipine in combination with gentamicin alleviates bacterial burden and inflammation.
BIOACTIVE MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Siyao Gu, Bing Fan, Fang Wan, Tong Gao, Yuanyuan Qi, Jin Zhou, Yaou Zhang, Dayong Gu, Weidong Xie
Summary: Diabetic foot infection (DFI) is a common complication in diabetes patients, with foot infections being the leading cause of amputations. Methicillin-resistant Staphylococcus aureus (MRSA) has become a major challenge in DFI treatment due to its resistance to most antibiotics. This study found that canagliflozin exhibits antibacterial activity against MRSA by affecting bacterial metabolism, inhibiting biofilm formation, distorting the bacterial cell wall, and altering gene expression. These findings provide new insights for treating diabetic foot infections.
Article
Multidisciplinary Sciences
Tohid Piri-Gharaghie, Neda Jegargoshe-Shirin, Sara Saremi-Nouri, Seyed-Hossein Khademhosseini, Eskandar Hoseinnezhad-Lazarjani, Aezam Mousavi, Hamidreza Kabiri, Negin Rajaei, Anali Riahi, Ali Farhadi-Biregani, Sadegh Fatehi-Ghahfarokhi
Summary: This study aims to assess the antibacterial and anti-biofilm properties of Niosome-encapsulated Imipenem. The experiment discovered that Niosome-encapsulated Imipenem can effectively reduce the methicillin-resistant Staphylococcus epidermidis' resistance to antibiotics, enhance its anti-biofilm and antibiotic activity, and has the potential to be a new strategy for drug delivery.
SCIENTIFIC REPORTS
(2022)
Article
Microbiology
Joshua T. Smith, Elissa M. Eckhardt, Nicole B. Hansel, Tahmineh Rahmani Eliato, Isabella W. Martin, Cheryl P. Andam
Summary: Bloodstream infections caused by S. aureus, including methicillin-resistant strains (MRSA), have significant impacts on patient morbidity and mortality worldwide. This study provides important insights into the evolution and geographic spread of two distinct MRSA lineages that have been predominant in bloodstream infections over the past five decades. The success of these lineages can be attributed to their acquisition of diverse antimicrobial resistance genes and unique variants of the mobile genetic element SCCmec carrying the mecA gene. These findings have implications for global and local efforts in monitoring and controlling the spread of MRSA infections and multidrug resistance.
MICROBIOLOGY SPECTRUM
(2022)
Article
Microbiology
Jiun-Liang Chen, Tsung-Yu Huang, Wei-Bin Hsu, Chiang-Wen Lee, Yao-Chang Chiang, Pey-Jium Chang, Kuo-Ti Peng
Summary: This study investigated the genotypic and phenotypic characteristics of MRSA clones isolated from PJI patients in a hospital in Taiwan. The findings showed that ST239 MRSA isolates were highly resistant to multiple antibiotics, had a high biofilm formation ability, and infected patients typically exhibited fever and inflammation. Additionally, knee infections were mainly attributed to ST59 MRSA, and there was an increasing trend of infections caused by ST8 and other MRSA genotypes in PJI patients.
Article
Microbiology
Elodie Ramond, Anne Jamet, Xiongqi Ding, Daniel Euphrasie, Clemence Bouvier, Louison Lallemant, Xiangyan He, Laurence Arbibe, Mathieu Coureuil, Alain Charbit
Summary: The study established a Drosophila melanogaster larvae model for oral S. aureus infection, revealing that S. aureus infection stimulates host immunity and the catalase of S. aureus plays a key role in this complex environment. It is proposed that fly larvae can provide a general model for studying the colonization capabilities of human pathogens.
Article
Microbiology
Xiangri Kong, Bingmei Wang, Xiaoyu Chen, Li Wang, Xingye Wang, Juan Hou, Lin Wei, Liyan Sui, Chi Zhang, Jiyu Guan, Yanhe Luan, Wei Wang, Wu Song, Yicheng Zhao
Summary: Drug-resistant bacteria is a global public health concern. A natural compound called hinokiflavone was found to inhibit the activity of MRSA ClpP, reduce the virulence of S. aureus, and show potential as an adjuvant for treating MRSA infections.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Immunology
John Jairo Aguilera-Correa, Liisa Nohynek, Hanna-Leena Alakomi, Jaime Esteban, Kirsi-Marja Oksman-Caldentey, Riitta Puupponen-Pimiae, Teemu J. Kinnari, Ramon Perez-Tanoira
Summary: This study aimed to evaluate the effect of two arctic berry extracts on MRSA biofilm development and treatment. The results showed that all berry extracts except for the raspberry press cake hydrothermal extract prevented biofilm development of three MRSA strains.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Masakazu Kitahara, Shin Takayama, Tetsuya Akaishi, Akiko Kikuchi, Tadashi Ishii
Summary: This study demonstrated that administration of HET in acute stroke patients can effectively prevent MRSA colonization and reduce the incidence of infectious diseases, leading to improved rehabilitation outcomes within three months.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Infectious Diseases
Eric T. Sumrall, Marloes Hofstee, Daniel Arens, Christian Roehrig, Susanne Baertl, Dominic Gehweiler, Mathias Schmelcher, Martin J. Loessner, Stephan Zeiter, R. Geoff Richards, T. Fintan Moriarty
Summary: The study demonstrates that the addition of enzybiotics can enhance the treatment of severe MRSA ODRI by rapidly killing the bacteria and targeting biofilm formation.
Article
Critical Care Medicine
Andrija Jurina, Valentina Delimar, Zlatko Giljevic, Tajana Filipec Kanizaj, Andro Matkovic, Dinko Vidovic, Nikolina Jurjevic, Vinko Vidjak, Zeljko Duic, Mario Cuk, Mladen Japjec, Tomislav Dujmovic, Andrea Radeljak, Mirjana Marjana Kardum Paro, Marijana Vucic-Lovrencic, Mario Staresinic
Summary: This study investigated the prevalence of fragility spinal fractures among liver transplant candidates with cirrhosis. The results showed the detrimental impact of chronic liver disease and hepatic osteodystrophy on bone strength, and the correlation between DXA measurement and lumbar fragility fractures. These findings highlight the importance of adequate bone evaluation in liver transplant candidates.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)
Article
Critical Care Medicine
M. Scrivano, A. Vadal, G. Fedeli, R. Di Niccolo, D. Topa, S. Porcino, F. Pallotta, A. De Carli
Summary: This study compares the outcomes and complications of Ilioinguinal versus modified Stoppa approach in Open Reduction and Internal Fixation (ORIF) of anterior column acetabulum fractures. The results show that the modified Stoppa approach has a shorter operative time, less intra-operative blood loss, and fewer complications. The ilioinguinal approach achieves better anatomic reduction. However, there were no significant differences in terms of vascular lesions, clinical and functional outcomes between the two groups.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)
Article
Critical Care Medicine
Jacob Hartline, Christopher T. Cosgrove, Nathan N. O'Hara, Qasim M. Ghulam, Zachary D. Hannan, Robert V. O'Toole, Marcus F. Sciadini, Christopher G. Langhammer
Summary: In a young, healthy orthopedic trauma population with isolated extremity injury, traditional demographic factors and ballistic injury mechanism have a greater predictive value for long-term mortality after hospital discharge compared to popular markers of socioeconomic status.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)
Article
Critical Care Medicine
Youngmin Kwon, Jihye Lim, Chunui Lee
Summary: This study aims to investigate dental traumatic injuries related to standing electric scooters and compare them with injuries caused by other factors. The results indicate that crown-root fractures and avulsions are more common in electric scooter accidents. Additionally, relatively minor dental injuries, such as concussions and subluxations, are more likely to occur as combined injuries in electric scooter accidents. The study suggests the need for strengthened policies and enforcement of laws to prevent severe dental and craniofacial trauma associated with electric scooter use.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)
Article
Critical Care Medicine
Louise Kruse Jensen, Henrik Elvang Jensen, Hans Gottlieb
Summary: This study describes the histopathology of debrided bone tissue in chronic osteomyelitis (CO). The inflammatory response still exists after debridement, although it fades from the center. Sampling of debrided bone tissue must be performed initially during surgery to avoid underestimation of neutrophil infiltration.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)
Article
Critical Care Medicine
Alejandro Alejandrez, Motasem Refaat, Yeng Vue
Summary: This study aims to assess the rate of operative fixation of sacral fractures in pelvises with dysmorphic and nondysmorphic sacrums, as well as whether a difference exists in fracture morphology between groups. The study found no statistical difference in operative fixation rates between pelvises with dysmorphic and nondysmorphic sacrums, but a difference in fracture patterns was observed.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)
Article
Critical Care Medicine
Dong Wang, Shuo Diao, Xiaobin Zhou, Junlin Zhou, Yang Liu
Summary: This study discussed the role of fracture site tissue exosomes lncRNAs-mRNAs networks on post-injury adaptation (PIA) promoting bone mesenchymal stem cells (BMSCs) proliferation and migration. The results confirmed that PIA accelerated BMSCs proliferation and migration, and identified tissue exosomes as the key factor in this process. By analyzing the tissue exosomes lncRNAs-mRNAs networks, several hub genes, such as Akt1, Actb, and Uba52, were identified, and Kif11 was found to be a key gene in BMSCs regulated by tissue-derived exosomes of PIA treated rats.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)
Article
Critical Care Medicine
Lisa Reider, Jason R. Falvey, Safiyyah M. Okoye, Jennifer L. Wolff, Joseph F. Levy
Summary: Falls are a leading cause of injury and hospital readmissions in older adults, with over 3 million seeking hospital care for fall injuries annually in the United States. The annual acute treatment costs for these injuries amount to $20 billion, indicating the urgent need for evidence-based fall prevention interventions and investments in geriatric emergency departments.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)
Article
Critical Care Medicine
Mohamed Elbuzidi, Alyssa N. Wenzel, Andrew Harris, Majd Marrache, Julius K. Oni, Harpal S. Khanuja, Vishal Hegde
Summary: A retrospective propensity score matched cohort study was conducted using the American College of Surgeons National Surgical Quality Improvement Program (NSQIP) database to compare outcomes for patients with recently diagnosed COVID-19 infection and those without COVID-19 infection undergoing operative treatment of hip fractures. The results showed that COVID-19-positive patients had a higher risk of 30-day mortality, pneumonia, unplanned intubation, septic shock, longer length of hospital stay, and discharge to an acute care hospital. Active COVID-19 infection is an independent risk factor for complications and increased resource utilization in these patients.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)
Review
Critical Care Medicine
Jorge Mayor, Vera Birgel, Jan-Dierk Clausen, Goekmen Aktas, Stephan Sehmisch, Ann-Kathrin Einfeldt, Vasilis Giannoudis, Ahmed H. K. Abdelaal, Emmanouil Liodakis
Summary: This study provides a comprehensive overview of biomechanical research on the treatment of intertrochanteric fractures using cephalomedullary devices. Through a systematic literature search and synthesis analysis, the study highlights the need for standardization in biomechanical studies, and suggests strategies to enhance construct stability. The findings emphasize the importance of further research and meta-analyses to establish standardized protocols and enhance reliability.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)
Article
Critical Care Medicine
Patricia Rodarte, Jamieson O'Marr, Billy Haonga, Deogratias Patrick, Kian Niknam, Mayur Urva, Abigail Cortez, Willem-Jan Metsemakers, David Shearer, Saam Morshed
Summary: This study evaluates the diagnostic performance of telephone questionnaires in identifying patients with fracture-related infections (FRIs) after open tibia fracture fixation in Tanzania. The study shows that telephone questionnaires have adequate diagnostic performance, with drainage being the main indicator for FRIs.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)
Review
Critical Care Medicine
Zhiyi Liu, Guodong Hou, Wencong Zhang, Junyan Lin, Jinrong Yin, Huan Chen, Guowei Huang, Aiguo Li
Summary: Calcaneal tuberosity avulsion fracture, an extra-articular injury, is a rare fracture caused internally by intense contraction of the gastrocnemius-soleus complex, and externally by low-energy (possibly high-energy). The risk of injuries to the skin and Achilles tendon around the calcaneal tuberosity is closely related to the Lee classification and Carnero-Martin de Soto Classification of this type of fracture. Diagnosis is typically confirmed through X-ray, digital imaging, and CT, but MRI should also be used to assess the soft tissue. Recent advances in understanding this fracture have led to the development of different internal fixation devices and surgical procedures that provide stable fracture reduction and resistance to Achilles tendon forces. This article reviews the new insights into the anatomy, classification, risk factors, and treatment modalities of calcaneal tuberosity avulsion fracture in recent years.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)
Article
Critical Care Medicine
Win Wah, Janneke Berecki-Gisolf, Karen Walker-Bone
Summary: This study aimed to identify the incidence and factors associated with in-hospital complications of work-related musculoskeletal injuries. The results showed that age, gender, area-level disadvantage, hospital type, comorbidity, emergency admissions, anesthesia, and the type of injury were all associated with in-hospital complications. The most common complications were cardiovascular, gastrointestinal complications and adverse drug events.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)
Article
Critical Care Medicine
Gareth Rooke, Paul Sharplin, Richard Buckley
Summary: A 31-year-old female suffered a right fibula fracture with deltoid ligament injury after falling while climbing on wet rocks. She had ORIF surgery and recovered well, but has developed vague pain and hardware sensation at the lateral ankle 6 months later. Her past medical history includes breast reduction surgery and vaginal delivery, and she has a social history of alcohol consumption and past recreational drug use.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)
Review
Critical Care Medicine
Yuwei Wen, Danjiang Zhu, Qiang Wang, Baojian Song, Wei Feng
Summary: This study compared the clinical outcomes of compression screw and non-weight-bearing techniques in treating pediatric Jones fractures. The results showed that compared to non-weight-bearing techniques, compression screw fixation can shorten the radiographic union time, immobilization time, and facilitate earlier return to full weight bearing and daily life. We recommend the use of compression screw fixation for widely displaced fractures and school-age active adolescents.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)