Article
Critical Care Medicine
George D. Chloros, Vasileios P. Giannoudis, Nikolaos K. Kanakaris, Peter V. Giannoudis
Summary: The authors provide a technical trick to cope with the hardware complications that may occur during the use of the Reamer-Irrigator-Aspirator (RIA-2) system, specifically addressing the breakage of the reamer head and intramedullary retention of small metal debris.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2022)
Article
Chemistry, Multidisciplinary
Alexey Cherezov, Alexander Vasiliev, Hakim Ferroukhi
Summary: Interest in approximate computing has grown in various disciplines for energy and computation cost savings by sacrificing numerical simulation quality. Low-precision floating-point arithmetic, supported by future microprocessors and code compilers, has proved beneficial for weather modeling and neural network training. This study applies low-precision arithmetic to analyze uncertainty in nuclear reactor cores. Results show that a 15-bit floating-point precision can be used with acceptable degradation in accuracy, resulting in a 6x reduction in bit complexity and lower energy costs on low-precision hardware.
APPLIED SCIENCES-BASEL
(2023)
Article
Nuclear Science & Technology
Chaoqun Deng, Yanan He, Fengrui Xiang, Yingwei Wu, Jing Zhang, Wenxi Tian, Guanghui Su, Suizheng Qiu
Summary: This study investigates the thermomechanical behaviors of U3Si2-FeCrAl system as a potential accident tolerant fuel candidate. By simulating CABRI-REP tests and comparing with other systems, it is found that U3Si2-FeCrAl system can increase fuel temperature and delay gap closure during normal operation, but poses a threat to fuel central temperature under RIA conditions.
PROGRESS IN NUCLEAR ENERGY
(2022)
Article
Nuclear Science & Technology
J-M Labit, N. Marie, O. Clamens, E. Merle
Summary: CABRI is an experimental pulse reactor funded by the French IRSN, aiming to study the effects of RIA on nuclear fuels. The reactor involves complex physics and multiphysical effects, with reactivity insertion controlled by releasing a neutron absorber. Increased neutron flux leads to power increase and multiphysical effects inside the core.
NUCLEAR ENGINEERING AND DESIGN
(2021)
Article
Marine & Freshwater Biology
A. Gutierrez-Barral, E. Teira, M. Hernandez-Ruiz, E. Fernandez
Summary: The study revealed that increasing input of nitrogenous organic matter from allochthonous sources into coastal environments might promote the growth of potentially pathogenic bacteria belonging to the order Vibrionales, thus significantly impacting the composition of prokaryote communities.
ESTUARINE COASTAL AND SHELF SCIENCE
(2021)
Article
Endocrinology & Metabolism
Rasimcan Meral, Noemi Malandrino, Mary Walter, Adam H. Neidert, Ranganath Muniyappa, Elif Arioglu Oral, Rebecca J. Brown
Summary: The study found that three common leptin assays are not interchangeable and a reliable cut point to select responders to metreleptin was not identified.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Chemistry, Analytical
Nadia Arbouche, Estelle Godard, Laurie Gheddar, Jean-Sebastien Raul, Pascal Kintz
Summary: The case presented in this paper involves a nurse attempting to murder her daughter and commit suicide by injecting aspart insulin, which was successfully identified and distinguished from human insulin using high-resolution mass spectrometry. This highlights the importance of such techniques in forensic medicine.
JOURNAL OF ANALYTICAL TOXICOLOGY
(2022)
Article
Materials Science, Ceramics
Dong Zhao, Andre Broussard, Tiankai Yao, Kevin Yan, Heng Ban, Jie Lian
Summary: This paper presents an innovative approach using spark plasma sintering (SPS) combined with finite element modeling (FEM) to study the transient behavior of nuclear fuels. The temperature ramping rates of SPS can simulate the thermal profiles of loss-of-coolant-accident (LOCA) and reactivity-induced-accident (RIA) events. Experimental results show that micron-sized fresh UO2 pellets synthesized by SPS exhibit good thermal shock stability and anti-cracking performance under LOCA thermal testing, while cracking occurs under simulated RIA conditions due to the stress induced by large thermal gradients. The unique capability of SPS with controlled temperature ramping enables a cost-effective method for rapid screening and evaluation of nuclear fuels under power transients.
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
(2024)
Article
Chemistry, Analytical
Rani Gnanasekar, Vishwas Murhekar, V. B. Kadwad
Summary: In this study, a cost-effective FT4 RIA method was developed by immobilizing anti-T4 antibodies in polystyrene tubes using Protein A. The method showed high sensitivity and good correlation with established FT4 RIA kits.
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
(2022)
Article
Chemistry, Physical
Jiaming Li, Liangbao Jiang, Xiaoyu Li, Junjie Luo, Jiaxi Liu, Minbo Wang, Yue Yan
Summary: The impact of holding time on the structure, optical and electrical properties, and crystallization kinetics of amorphous indium tin oxide (ITO) thin films, as well as the mechanical properties of chemically strengthened glass substrates, was investigated using rapid infrared annealing (RIA) and conventional furnace annealing (CFA) technologies. The results showed that RIA produced ITO films with higher nucleation rate and smaller grain size compared to CFA. The sheet resistance of the ITO film remained stable (8.75 Ω/sq) when the RIA holding time exceeded 5 minutes. RIA technology exhibited less impact on the mechanical properties of chemically strengthened glass substrates compared to CFA technology, with only 12-15% of the compressive stress decline observed.
Review
Multidisciplinary Sciences
Juan Carlos Caicedo Mera, Melissa Andrea Cardenas Molano, Christian Camilo Garcia Lopez, Cristina Acevedo Triana, Jorge Martinez Cotrina
Summary: This article presents a review of research on oxytocin measurements in various fluids, with a main focus on saliva. It discusses the technical developments, laboratory techniques reliability, and physiological correlates of this hormone, contributing to the debates and perspectives on investigations involving this important biomarker in psychological and social processes.
Article
Environmental Sciences
P. Rodriguez-Velarte, J. M. F. Babarro, A. Cobelo-Garcia
Summary: There were no significant differences in the bioaccumulation of trace elements between the native Mytilus galloprovincialis and invasive Xenostrobus securis species in Vigo Ria, except for zinc and silver. Mytilus galloprovincialis showed a 4-fold enrichment in zinc compared to Xenostrobus securis, while Xenostrobus securis exhibited approximately 40-fold higher concentrations of silver. This high bioaccumulation of silver by Xenostrobus securis can be utilized for silver biomonitoring in the area.
MARINE POLLUTION BULLETIN
(2022)
Article
Obstetrics & Gynecology
Lesley M. McMahon, Wilson W. Stewart, Lyndsey Cuthill
Summary: Hydatidiform mole is a common complication of pregnancy, with accurate diagnosis being crucial for monitoring and managing patients. In the UK, in-house hCG radioimmunoassay is used for follow-up of HM patients, with ongoing research on evaluating alternative antibodies.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2021)
Article
Nuclear Science & Technology
J-M Labit, N. Marie, O. Clamens, E. Merle
Summary: This study investigates the heat exchange phenomena during fast transient processes, especially in the context of Reactivity-Initiated Accidents (RIA) in nuclear reactors. The research focuses on quantifying the heat exchanges between a heating wall and a coolant, with a particular emphasis on the single phase convection mechanisms in the CABRI reactor. The study proposes a method to model the heat transfer coefficient during transient events in the CABRI-RIA system, demonstrating the analytical model's potential for implementation in computational tools.
NUCLEAR ENGINEERING AND DESIGN
(2021)
Article
Engineering, Environmental
Lara Almeida, Fernando Rocha, Carla Candeias
Summary: This study characterizes the composition and properties of sediments used for pelotherapy in an open-air saline spa. The results show that the sediments in different areas of the spa have distinct mineral phases and concentrations of potential toxic elements, indicating a risk to the ecosystem and human health.
ENVIRONMENTAL GEOCHEMISTRY AND HEALTH
(2023)
Article
Orthopedics
Cyril Mauffrey, David J. Hak, Peter Giannoudis, Volker Alt, Christoph Nau, Ingo Marzi, Peter Augat, J. K. Oh, Johannes Frank, Andreas Mavrogenis, Xavier Flecher, Jean-Noel Argenson, Ashok Gavaskar, David Rojas, Yehia H. Bedeir
INTERNATIONAL ORTHOPAEDICS
(2019)
Article
Orthopedics
Nikolaos K. Kanakaris, Oghofori Obakponovwe, Matija Krkovic, Matt L. Costa, David Shaw, Khitish R. Mohanty, Robert M. West, Peter V. Giannoudis
INTERNATIONAL ORTHOPAEDICS
(2019)
Editorial Material
Critical Care Medicine
Richard Buckley, Peter Giannoudis
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2019)
Review
Critical Care Medicine
Vasiliki C. Panagiotopoulou, Peter Varga, R. Geoff Richards, Boyko Gueorguiev, Peter V. Giannoudis
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2019)
Editorial Material
Critical Care Medicine
Volker Alt, Peter V. Giannoudis
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2019)
Article
Medicine, General & Internal
Theodoros H. Tosounidis, Colin Holton, Vasileios P. Giannoudis, Nikolaos K. Kanakaris, Robert M. West, Peter V. Giannoudis
Summary: Study investigated correlation between elevated CRP and WBC levels in nonunion patients, finding elevated CRP levels increased infection risk. WBC count unreliable for predicting infection. All cases achieved solid union post-revision surgery.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Michalis Panteli, Marilena P. Giannoudi, Christopher J. Lodge, Robert M. West, Ippokratis Pountos, Peter V. Giannoudis
Summary: This study aimed to define the incidence of subtrochanteric femoral fractures and investigate associations with mortality and medical complications following intramedullary nail treatment. Risk factors for mortality included low albumin, dementia, pneumonia, and high Charlson comorbidity score. Factors such as ICU/HDU stay, asthma/COPD, and prolonged hospital stay were associated with higher incidence of hospital acquired pneumonia. Early identification of these factors could aid in prognostication and prevention of poor outcomes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Dionysios J. Papachristou, Stavros Georgopoulos, Peter Giannoudis, Elias Panagiotopoulos
Summary: Fracture-healing is a complex process that may fail, leading to delayed unions or non-unions. Research and clinical studies are focusing on unraveling the mechanisms regulating fracture-healing, aiming to develop more effective therapeutic strategies.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Michalis Panteli, James S. H. Vun, Robert M. West, Anthony Howard, Ippokratis Pountos, Peter V. Giannoudis
Summary: This study aimed to investigate the incidence, risk factors and pathogenic microorganisms causing infection in patients with subtrochanteric femoral fractures managed with an intramedullary nail. Deep infection was associated with non-union, open fracture, massive transfusion, post-operative transfusion and prolonged length of stay. Staphylococcus aureus and coliforms were the most common microorganisms identified in superficial and deep infections, respectively, with polymicrobial infection present in a significant proportion of cases.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Michalis Panteli, James S. H. Vun, Robert M. West, Anthony J. Howard, Ippokratis Pountos, Peter V. Giannoudis
Summary: This study developed and validated a predictive model for non-union following subtrochanteric fractures of the femur. By identifying risk factors and creating a risk score, high-risk patients can be identified early post-operatively. The scoring system demonstrated good discriminatory capability, calibration, and internal validity, providing valuable information for surgeons to intervene and modify surgery-related factors to reduce the risk of non-union.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Angelos Kaspiris, Argyris C. Hadjimichael, Elias S. Vasiliadis, Dionysios J. Papachristou, Peter V. Giannoudis, Elias C. Panagiotopoulos
Summary: This study investigated the clinical implantation of growth factors for intraoperative enhancement of osteogenesis in the treatment of long bone fractures and non-unions. The results showed that the application of BMP-2 and -7, PRP, and MSCs significantly increased the effectiveness of fracture treatment and postoperative functional scores.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
James Tebby, Vasileios P. Giannoudis, Sophia M. Wakefield, Fiona Lecky, Omar Bouamra, Peter V. Giannoudis
Summary: Managing patients with multiple injuries, especially those with comorbidities such as diabetes mellitus, remains challenging and increases mortality. This study investigates the impact of major trauma centres in the UK on the outcomes of polytrauma patients with diabetes. The findings show that while overall mortality has decreased, patients with diabetes still had higher mortality compared to other groups, highlighting diabetes as an independent risk factor for mortality in polytrauma patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biotechnology & Applied Microbiology
Jehan J. El-Jawhari, Payal Ganguly, Elena Jones, Peter Giannoudis
Summary: This review discusses the application of bone marrow-derived mesenchymal stromal cells in treating osteonecrosis, including donor-related factors, the impact of aging on donor-related variability, and factors influencing the quantity and function of these cells.
BIOENGINEERING-BASEL
(2021)
Correction
Medicine, General & Internal
G. R. Norris, J. X. Checketts, J. T. Scott, M. Vassar, B. L. Norris, P. Giannoudis
Review
Orthopedics
Paul Andrzejowski, Peter V. Giannoudis
JOURNAL OF ORTHOPAEDICS AND TRAUMATOLOGY
(2019)
Article
Critical Care Medicine
Andrija Jurina, Valentina Delimar, Zlatko Giljevic, Tajana Filipec Kanizaj, Andro Matkovic, Dinko Vidovic, Nikolina Jurjevic, Vinko Vidjak, Zeljko Duic, Mario Cuk, Mladen Japjec, Tomislav Dujmovic, Andrea Radeljak, Mirjana Marjana Kardum Paro, Marijana Vucic-Lovrencic, Mario Staresinic
Summary: This study investigated the prevalence of fragility spinal fractures among liver transplant candidates with cirrhosis. The results showed the detrimental impact of chronic liver disease and hepatic osteodystrophy on bone strength, and the correlation between DXA measurement and lumbar fragility fractures. These findings highlight the importance of adequate bone evaluation in liver transplant candidates.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)
Article
Critical Care Medicine
M. Scrivano, A. Vadal, G. Fedeli, R. Di Niccolo, D. Topa, S. Porcino, F. Pallotta, A. De Carli
Summary: This study compares the outcomes and complications of Ilioinguinal versus modified Stoppa approach in Open Reduction and Internal Fixation (ORIF) of anterior column acetabulum fractures. The results show that the modified Stoppa approach has a shorter operative time, less intra-operative blood loss, and fewer complications. The ilioinguinal approach achieves better anatomic reduction. However, there were no significant differences in terms of vascular lesions, clinical and functional outcomes between the two groups.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)
Article
Critical Care Medicine
Jacob Hartline, Christopher T. Cosgrove, Nathan N. O'Hara, Qasim M. Ghulam, Zachary D. Hannan, Robert V. O'Toole, Marcus F. Sciadini, Christopher G. Langhammer
Summary: In a young, healthy orthopedic trauma population with isolated extremity injury, traditional demographic factors and ballistic injury mechanism have a greater predictive value for long-term mortality after hospital discharge compared to popular markers of socioeconomic status.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)
Article
Critical Care Medicine
Youngmin Kwon, Jihye Lim, Chunui Lee
Summary: This study aims to investigate dental traumatic injuries related to standing electric scooters and compare them with injuries caused by other factors. The results indicate that crown-root fractures and avulsions are more common in electric scooter accidents. Additionally, relatively minor dental injuries, such as concussions and subluxations, are more likely to occur as combined injuries in electric scooter accidents. The study suggests the need for strengthened policies and enforcement of laws to prevent severe dental and craniofacial trauma associated with electric scooter use.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)
Article
Critical Care Medicine
Louise Kruse Jensen, Henrik Elvang Jensen, Hans Gottlieb
Summary: This study describes the histopathology of debrided bone tissue in chronic osteomyelitis (CO). The inflammatory response still exists after debridement, although it fades from the center. Sampling of debrided bone tissue must be performed initially during surgery to avoid underestimation of neutrophil infiltration.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)
Article
Critical Care Medicine
Alejandro Alejandrez, Motasem Refaat, Yeng Vue
Summary: This study aims to assess the rate of operative fixation of sacral fractures in pelvises with dysmorphic and nondysmorphic sacrums, as well as whether a difference exists in fracture morphology between groups. The study found no statistical difference in operative fixation rates between pelvises with dysmorphic and nondysmorphic sacrums, but a difference in fracture patterns was observed.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)
Article
Critical Care Medicine
Dong Wang, Shuo Diao, Xiaobin Zhou, Junlin Zhou, Yang Liu
Summary: This study discussed the role of fracture site tissue exosomes lncRNAs-mRNAs networks on post-injury adaptation (PIA) promoting bone mesenchymal stem cells (BMSCs) proliferation and migration. The results confirmed that PIA accelerated BMSCs proliferation and migration, and identified tissue exosomes as the key factor in this process. By analyzing the tissue exosomes lncRNAs-mRNAs networks, several hub genes, such as Akt1, Actb, and Uba52, were identified, and Kif11 was found to be a key gene in BMSCs regulated by tissue-derived exosomes of PIA treated rats.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)
Article
Critical Care Medicine
Lisa Reider, Jason R. Falvey, Safiyyah M. Okoye, Jennifer L. Wolff, Joseph F. Levy
Summary: Falls are a leading cause of injury and hospital readmissions in older adults, with over 3 million seeking hospital care for fall injuries annually in the United States. The annual acute treatment costs for these injuries amount to $20 billion, indicating the urgent need for evidence-based fall prevention interventions and investments in geriatric emergency departments.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)
Article
Critical Care Medicine
Mohamed Elbuzidi, Alyssa N. Wenzel, Andrew Harris, Majd Marrache, Julius K. Oni, Harpal S. Khanuja, Vishal Hegde
Summary: A retrospective propensity score matched cohort study was conducted using the American College of Surgeons National Surgical Quality Improvement Program (NSQIP) database to compare outcomes for patients with recently diagnosed COVID-19 infection and those without COVID-19 infection undergoing operative treatment of hip fractures. The results showed that COVID-19-positive patients had a higher risk of 30-day mortality, pneumonia, unplanned intubation, septic shock, longer length of hospital stay, and discharge to an acute care hospital. Active COVID-19 infection is an independent risk factor for complications and increased resource utilization in these patients.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)
Review
Critical Care Medicine
Jorge Mayor, Vera Birgel, Jan-Dierk Clausen, Goekmen Aktas, Stephan Sehmisch, Ann-Kathrin Einfeldt, Vasilis Giannoudis, Ahmed H. K. Abdelaal, Emmanouil Liodakis
Summary: This study provides a comprehensive overview of biomechanical research on the treatment of intertrochanteric fractures using cephalomedullary devices. Through a systematic literature search and synthesis analysis, the study highlights the need for standardization in biomechanical studies, and suggests strategies to enhance construct stability. The findings emphasize the importance of further research and meta-analyses to establish standardized protocols and enhance reliability.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)
Article
Critical Care Medicine
Patricia Rodarte, Jamieson O'Marr, Billy Haonga, Deogratias Patrick, Kian Niknam, Mayur Urva, Abigail Cortez, Willem-Jan Metsemakers, David Shearer, Saam Morshed
Summary: This study evaluates the diagnostic performance of telephone questionnaires in identifying patients with fracture-related infections (FRIs) after open tibia fracture fixation in Tanzania. The study shows that telephone questionnaires have adequate diagnostic performance, with drainage being the main indicator for FRIs.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)
Review
Critical Care Medicine
Zhiyi Liu, Guodong Hou, Wencong Zhang, Junyan Lin, Jinrong Yin, Huan Chen, Guowei Huang, Aiguo Li
Summary: Calcaneal tuberosity avulsion fracture, an extra-articular injury, is a rare fracture caused internally by intense contraction of the gastrocnemius-soleus complex, and externally by low-energy (possibly high-energy). The risk of injuries to the skin and Achilles tendon around the calcaneal tuberosity is closely related to the Lee classification and Carnero-Martin de Soto Classification of this type of fracture. Diagnosis is typically confirmed through X-ray, digital imaging, and CT, but MRI should also be used to assess the soft tissue. Recent advances in understanding this fracture have led to the development of different internal fixation devices and surgical procedures that provide stable fracture reduction and resistance to Achilles tendon forces. This article reviews the new insights into the anatomy, classification, risk factors, and treatment modalities of calcaneal tuberosity avulsion fracture in recent years.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)
Article
Critical Care Medicine
Win Wah, Janneke Berecki-Gisolf, Karen Walker-Bone
Summary: This study aimed to identify the incidence and factors associated with in-hospital complications of work-related musculoskeletal injuries. The results showed that age, gender, area-level disadvantage, hospital type, comorbidity, emergency admissions, anesthesia, and the type of injury were all associated with in-hospital complications. The most common complications were cardiovascular, gastrointestinal complications and adverse drug events.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)
Article
Critical Care Medicine
Gareth Rooke, Paul Sharplin, Richard Buckley
Summary: A 31-year-old female suffered a right fibula fracture with deltoid ligament injury after falling while climbing on wet rocks. She had ORIF surgery and recovered well, but has developed vague pain and hardware sensation at the lateral ankle 6 months later. Her past medical history includes breast reduction surgery and vaginal delivery, and she has a social history of alcohol consumption and past recreational drug use.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)
Review
Critical Care Medicine
Yuwei Wen, Danjiang Zhu, Qiang Wang, Baojian Song, Wei Feng
Summary: This study compared the clinical outcomes of compression screw and non-weight-bearing techniques in treating pediatric Jones fractures. The results showed that compared to non-weight-bearing techniques, compression screw fixation can shorten the radiographic union time, immobilization time, and facilitate earlier return to full weight bearing and daily life. We recommend the use of compression screw fixation for widely displaced fractures and school-age active adolescents.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)