Article
Environmental Sciences
Michal Pardo, Svenja Offer, Elena Hartner, Sebastiano Di Bucchianico, Christoph Bisig, Stefanie Bauer, Jana Pantzke, Elias J. Zimmermann, Xin Cao, Stephanie Binder, Evelyn Kuhn, Anja Huber, Seongho Jeong, Uwe Ka, Eric Schneider, Arunas Mesceriakovas, Jan Bendl, Ramona Brejcha, Angela Buchholz, Daniela Gat, Thorsten Hohaus, Narges Rastak, Erwin Karg, Gert Jakobi, Markus Kalberer, Tamara Kanashova, Yue Hu, Christoph Ogris, Annalisa Marsico, Fabian Theis, Tali Shalit, Thomas Gro, Christopher P. Rueger, Sebastian Oeder, Juergen Orasche, Andreas Paul, Till Ziehm, Zhi-Hui Zhang, Thomas Adam, Olli Sippula, Martin Sklorz, Juergen Schnelle-Kreis, Hendryk Czech, Astrid Kiendler-Scharr, Ralf Zimmermann, Yinon Rudich
Summary: This study investigates the toxicities of secondary organic aerosols (SOAs) derived from different precursor compounds. It shows that SOAs derived from a typical anthropogenic precursor have higher toxicological potency and activate different cellular mechanisms compared to those derived from a typical biogenic precursor.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Environmental Sciences
M. Kermenidou, Ll Balcells, C. Martinez-Boubeta, A. Chatziavramidis, I Konstantinidis, T. Samaras, D. Sarigiannis, K. Simeonidis
Summary: This research established a novel method of collecting quantitative data on combustion-emitted particulate matter through magnetic characterization and analysis, demonstrating varying levels of magnetically-responding particles in urban and suburban areas of Thessaloniki, Greece. The study found that Fe3O4 and similar ferrites, some of which attached to heavy metals, are the dominant magnetic contributors from anthropogenic high-temperature processes such as traffic emissions. Nasal cytologic samples collected from residents showed consistent magnetic behavior, confirming the critical role of nanosized magnetic particles in assessing air pollution threats.
ENVIRONMENTAL POLLUTION
(2021)
Article
Environmental Sciences
Monika Jankowska-Kieltyka, Adam Roman, Magdalena Mikrut, Marta Kowalska, Rudi van Eldik, Irena Nalepa
Summary: Exposure to airborne particulate matter is a potential health risk due to negative effects on cell viability and metabolic activity, primarily through increased ROS synthesis. PM impact is concentration-dependent and varies with exposure time, with different effects induced at different time points. Additionally, different types of PM can have varying degrees of impact based on their composition, with organic matter content and metal content playing a role.
Article
Immunology
Eun-Young Kim, Eom Ji Kim, Hoyeon Park, Yujin Lee, Do Kyung Kim, Youngjoo Sohn, Hyuk-Sang Jung
Summary: Research on the correlation between particulate matter (PM) and diseases is active, but the use of different PM samples by researchers makes it difficult to determine its components. In this study, the effects of PM with known constituents on BEAS-2B cells and asthmatic mice were investigated. The results showed that PM significantly increased cytokine levels, reactive oxygen species production, and DNA damage, while inhibiting certain cytokines. Additionally, PM affected the MAPK and autophagy pathways, leading to immune imbalance and lung function decline.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Xiaojia He, Zachery R. Jarrell, Matthew Ryan Smith, ViLinh Thi Ly, Yongliang Liang, Michael Orr, Young-Mi Go, Dean P. Jones
Summary: This study assessed the effects of two V2O5 nanomaterials on human airway epithelial cells using high-resolution metabolomics. The results showed dose-response effects of the nanomaterials on various metabolic pathways, as well as evidence of mitochondrial stress and increased lysosome fusion. These findings suggest that V2O5 nanomaterials may impact major metabolic pathways associated with lung diseases and highlight the potential of toxico-metabolomics in evaluating health risks.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2023)
Article
Environmental Sciences
Xiaozhe Yin, Meredith Franklin, Masoud Fallah-Shorshani, Martin Shafer, Rob McConnell, Scott Fruin
Summary: This study presents the largest scale research conducted in a single urban area, using monitoring of different particulate matter concentrations and developing regression and machine learning models to successfully predict 24 elemental components in eight Southern California communities. It was found that incorporating spatiotemporally resolved meteorology into the models improved the accuracy of predictions for particle distribution, especially near roadways for non-tailpipe emissions.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Chemistry, Multidisciplinary
Lorenzo Cursi, Silvia Vercellino, Mura M. McCafferty, Emily Sheridan, Vanya Petseva, Laurent Adumeau, Kenneth A. Dawson
Summary: Magnetic nanoparticles are valuable tools for studying complex intracellular bio-nano interactions. By synthesizing biocompatible multifunctional nanoparticles with fluorescent properties, intracellular tracking of nanoparticles can be achieved, providing a promising approach for studying bio-nano interactions.
Article
Chemistry, Multidisciplinary
Helene Barthel, Christian Darne, Laurent Gate, Athanase Visvikis, Carole Seidel
Summary: The study evaluated the impact of physical characteristics of multi-walled carbon nanotubes (MWCNTs) on cellular toxicity, revealing that MWCNTs could induce mitotic abnormalities and cellular morphological changes, converting epithelial cells to a fibroblast-like phenotype, with this transition being reversible.
Article
Environmental Sciences
Mengchan Zhu, Jian Wang, Cuicui Chen, Yuanlin Song, Jue Pan
Summary: This study identified differentially expressed genes and key pathways in response to urban PM exposure, shedding light on the complex molecular mechanisms underlying PM-induced lung toxicity and potentially providing new therapeutic targets for PM-related pulmonary diseases.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Chemistry, Physical
Cristina Chircov, Alexandra Catalina Birca, Alexandru Mihai Grumezescu, Bogdan Stefan Vasile, Ovidiu Oprea, Adrian Ionut Nicoara, Chih-Hui Yang, Keng-Shiang Huang, Ecaterina Andronescu
Summary: The study introduced a new method for the synthesis of magnetite nanoparticles using a microfluidic lab-on-chip device to achieve controlled properties. It investigated the influence of iron precursor solution concentration and flow on the final properties of the nanomaterials, ultimately achieving uniformity and stability in the synthesized nanoparticles.
Article
Chemistry, Multidisciplinary
Tereza Cervena, Andrea Rossnerova, Tana Zavodna, Jitka Sikorova, Kristyna Vrbova, Alena Milcova, Jan Topinka, Pavel Rossner
Summary: The evaluation of genotoxicity induced by nanomaterials in bronchial epithelial cells using different variants of the micronuclei assay showed that the DNA damage level is affected by the selected methodological approach. Transmission electron microscopy demonstrated the impact of cytochalasin-B on the transportation of NMs into cells, while dynamic light scattering measurement revealed the behavior of NMs in culture media. The genotoxic potential of various TiO2 and Ag particles differed, with the application of cytochalasin-B tending to increase the percentage of aberrant cells.
Article
Environmental Sciences
Chenzhi Yan, Xuan Wu, Xue Cao, Meng Li, Lei Zhou, Guangli Xiu, Jiayi Zeng
Summary: It is widely acknowledged that diesel exhaust particles (DEPs) are closely associated with organ system dysfunction. This study evaluated the potential toxicity of DEP using in vitro human BEAS-2B cell line and in vivo animal model Caenorhabditis elegans, showing that DEP exposure can impair cell and organism stability. The study also found that DEP exposure led to membrane integrity damage, decreased cell viability, and increased levels of reactive oxygen species, damaged DNA fragments, and apoptosis in cell lines.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Environmental Sciences
Lilan Wang, Yao Wang, Jianwen Chen, Xue-Min Yang, Xing-Tao Jiang, Peiqing Liu, Min Li
Summary: This study compared the effects of cigarette smoke condensate (CSC) to electronic cigarette smoke condensate (ECSC) on human lung epithelial cells (BEAS-2B) at equivalent nicotine levels. The results showed that compared to CSC, ECSC did not significantly impact cell effects and gene expression profile at equimolar nicotine concentrations.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Public, Environmental & Occupational Health
Qian Yuan, Haiqiao Zhang
Summary: This study aims to explore the hub genes and pathways involved in PM2.5 toxicity in human bronchial epithelial BEAS-2B cells. By analyzing the differential gene expression, functional enrichment, and protein-protein interactions, the study identifies key genes and pathways associated with long-term exposure to PM2.5. Additionally, the study reveals a decrease in the number of resting dendritic cells after exposure to PM2.5.
ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Thanpisit Lomphithak, Selin Helvacioglu, Ilaria Armenia, Sandeep Keshavan, Jesus G. Ovejero, Giovanni Baldi, Costanza Ravagli, Valeria Grazu, Bengt Fadeel
Summary: This study evaluated the cytotoxicity of iron oxide nanoparticles and their Co-functionalized counterparts, and found that cell death with features of ferroptosis occurred at higher concentrations, with the functionalized nanoparticles demonstrating stronger toxicity. Furthermore, it was shown that the cell death triggered by the nanoparticles was autophagy-dependent. Overall, high concentrations of polymer-coated iron oxide nanoparticles induce ferroptosis in susceptible human cancer cells.
Article
Engineering, Environmental
Huanhuan Jiang, Myoseon Jang
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2018)
Article
Chemistry, Multidisciplinary
Zechen Yu, Myoseon Jang
ACS EARTH AND SPACE CHEMISTRY
(2019)
Article
Chemistry, Multidisciplinary
Zechen Yu, Myoseon Jang, Soontae Kim, Changhan Bae, Bonyoung Koo, Ross Beardsley, Jinsoo Park, Lim Seok Chang, Hee Choon Lee, Yun-Kyu Lim, Jeong Hoon Cho
ACS EARTH AND SPACE CHEMISTRY
(2020)
Article
Environmental Sciences
Sanghee Han, Myoseon Jang
SCIENCE OF THE TOTAL ENVIRONMENT
(2020)
Article
Engineering, Environmental
Myoseon Jang, David E. Berthold, Zechen Yu, Cecilia Silva-Sanchez, H. Dail Laughinghouse, Nancy D. Denslow, Sanghee Han
ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS
(2020)
Article
Chemistry, Multidisciplinary
Zechen Yu, Myoseon Jang, Tianyu Zhang, Azad Madhu, Sanghee Han
Summary: The study simulated the formation of terpene secondary organic aerosol using a unified partitioning aerosol phase reaction model. By predicting oxygenated products and classifying them into groups based on volatility and reactivity, the model revealed three formation pathways including partitioning, oligomerization, and aqueous phase reactions. The model also included a peroxy radical autoxidation mechanism to form less volatile products.
ACS EARTH AND SPACE CHEMISTRY
(2021)
Article
Engineering, Environmental
Karen Sem, Myoseon Jang, Richard Pierce, Patricia Blum, Zechen Yu
Summary: Atmospheric processes can affect the longevity of harmful toxins in sea spray aerosols. Sunlight and O-3 can accelerate the degradation of brevetoxin (BTx) in aerosols, with oxidation being the main mechanism.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Chemistry, Physical
Zechen Yu, Myoseon Jang, Azad Madhu
Summary: This study developed a regression model to predict aerosol phase separation relative humidity for various organic and inorganic mixes, showing that organic compounds with lower oxygen to carbon ratios, higher molecular weights, and higher aerosol acidity have greater phase separation relative humidity. Conversely, a larger fraction of inorganic nitrate led to lower phase separation relative humidity. The resulting model was demonstrated for three different SOA systems, showing liquid-liquid phase separation at relative humidity below 80%.
JOURNAL OF PHYSICAL CHEMISTRY A
(2021)
Article
Chemistry, Multidisciplinary
Victoria Zorbas, Myoseon Jang, Baharan Emam, Jiwon Choi
Summary: The study used the HAAR model to predict the degradation of microcystin-LR (MC-LR) in cyanobacterial aerosol by atmospheric oxidants. The results showed that MC-LR underwent ozonolysis at night and photooxidation during the daytime. The model simulated the impact of humidity and aerosol compositions on MC-LR decay.
ACS EARTH AND SPACE CHEMISTRY
(2023)
Article
Environmental Sciences
Azad Madhu, Myoseon Jang, David Deacon
Summary: The formation of secondary organic aerosol (SOA) from diesel fuel is mainly derived from the atmospheric oxidation of aliphatic hydrocarbons. A model called Unified Partitioning Aerosol Phase Reaction (UNIPAR) was used to predict the formation of linear alkane SOA by simulating multiphase reactions of hydrocarbons. The results showed that the mass of alkane SOA is mainly contributed by alkanes with carbon numbers greater than or equal to C15 and is significantly influenced by gas-particle partitioning.
ATMOSPHERIC CHEMISTRY AND PHYSICS
(2023)
Article
Environmental Sciences
Sanghee Han, Myoseon Jang
Summary: This study used the UNIPAR model to predict the diurnal and nocturnal variation patterns of secondary organic aerosol (SOA) generated from biogenic hydrocarbons. It was found that daytime oxidation was mainly driven by OH radicals and O-3, while nighttime chemistry was dominated by O-3 and NO3 radicals. Environmental factors such as temperature, humidity, sunlight intensity, NOx levels, and seed conditions were found to have an impact on SOA formation.
ATMOSPHERIC CHEMISTRY AND PHYSICS
(2023)
Article
Environmental Sciences
Zechen Yu, Myoseon Jang, Soontae Kim, Kyuwon Son, Sanghee Han, Azad Madhu, Jinsoo Park
Summary: The UNIPAR model was incorporated with the CAMx model to predict the concentration of organic matter in urban atmospheres during the KORUS-AQ campaign. The simulation results showed that considering aqueous reactions can significantly improve the prediction of SOA formation under wet conditions. Aromatic SOA contributed significantly to the total OM during the low-level transport/haze period. The performance of CAMx-UNIPAR was better than that of the conventional CAMx model, although both models underestimated the observed OM.
ATMOSPHERIC CHEMISTRY AND PHYSICS
(2022)
Article
Environmental Sciences
Sanghee Han, Myoseon Jang
Summary: This study used the UNIPAR model to simulate the formation of secondary organic aerosol (SOA) from gasoline fuel and evaluated the model using experimental data. The results showed that gasoline SOA formation is mainly driven by aerosol-phase reactions and is sensitive to seed conditions, with a positive correlation with humidity and aerosol acidity. There is also a significant difference in SOA formation potential between arid and humid regions. Additionally, aqueous reactions and temperature have an impact on the formation of gasoline SOA.
ATMOSPHERIC CHEMISTRY AND PHYSICS
(2022)
Article
Environmental Sciences
Chufan Zhou, Myoseon Jang, Zechen Yu
ATMOSPHERIC CHEMISTRY AND PHYSICS
(2019)
Article
Environmental Sciences
Zechen Yu, Myoseon Jang
ATMOSPHERIC CHEMISTRY AND PHYSICS
(2018)