期刊
INHALATION TOXICOLOGY
卷 22, 期 -, 页码 15-20出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/08958378.2010.541337
关键词
Aerosol; inhalation studies; dosimetry; respiratory tract; mouse
类别
资金
- NIH [AI065359]
- Charles S. Stocking Family Fund
The availability of molecular and genetic tools has made the mouse the most common animal model for a variety of human diseases in toxicology studies. However, little is known about the factors that will influence the dose delivery to murine lungs during an inhalation study. Among these factors are the respiratory tract anatomy, lung physiology, and clearance characteristics. Therefore, the objective of this paper is to briefly review the current knowledge on the aforementioned factors in mice and their implications to the dose delivered to mouse models during inhalation studies. Representative scientific publications were chosen from searches using the NCBI PubMed and ISI Web of Knowledge databases. Relevant respiratory physiological differences have been widely reported for different mouse strains and sexes. The limited data on anatomical morphometry that is available for the murine respiratory tract indicates significant differences between mouse strains. These differences have implications to the dose delivered and the biological outcomes of inhalation studies.
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