期刊
INHALATION TOXICOLOGY
卷 21, 期 8-11, 页码 682-687出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/08958370802474728
关键词
polycyclic aromatic hydrocarbons; cooking-oil fumes; cooks; 1-hydroxypyrene; 8-hydroxy-2 '-deoxyguanosine; exhaust hood
类别
资金
- National Natural Science Foundation of China [30872149/C1504]
- Guangdong Natural Science Foundation [8451802003000336]
- Shenzhen Catering Service Trade Association (SCSA)
Previous investigations have indicated that cooks are exposed to polycyclic aromatic hydrocarbons (PAHs) from cooking-oil fumes. However, Emission of PAH and their carcinogenic potencies from cooking oil fumes sources have not been investigated among cooks. To investigate the urinary excretion of a marker for oxidative DNA damage, 8-hydroxydeoxyguanosine (8-OHdG), in different groups of cooks and different exposure groups, and to study the association between 8-OHdG and 1-hydroxypyrene(1-OHP), a biological marker for PAH exposure. Urine samples were collected from different groups of cooks (n = 86) and from unexposed controls (n = 36); all were male with similar age and smoking habits. The health status, occupational history, smoking, and alcohol consumption 24 h prior to sampling was estimated from questionnaires. The urine samples were frozen for later analyses of 8-OHdG and 1-OHP levels by high-performance liquid chromatography. Excretion in urine of 8-OHdG was similar for controls (mean 1.2 mu mol/mol creatinine, n = 36), and for those who had been in the kitchen with an exhaust-hood operating (mean 1.5 mu mol/mol creatinine, n = 45). Cooks exposed to cooking-oil fumes without exhaust-hood operation had significantly increased excretion of 8-OHdG (mean 2.3 mu mol/mol creatinine, n = 18), compared with controls. The urinary levels of In 1-OHP and In 8-OHdG were still significantly correlated in a multiple regression analysis. The results indicate that exposure to PAH or possibly other compounds in cooking-oil fumes may cause oxidative DNA damage.
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