Article
Gastroenterology & Hepatology
Markus F. Neurath, Michael Vieth
Summary: Mucosal healing is an important prognostic factor in the management of patients with inflammatory bowel disease. It can predict clinical remission and resection-free survival. There are two levels of mucosal healing: endoscopic healing and histological healing. Drug therapies and new techniques can have an impact on mucosal healing, but cannot provide a definitive cure.
Article
Cell Biology
Sandra Chanez-Paredes, Armando Montoya-Garcia, Karla F. Castro-Ochoa, Julio Garcia-Cordero, Leticia Cedillo-Barron, Mineko Shibayama, Porfirio Nava, Sven Flemming, Nicolas Schlegel, Alexis M. Gautreau, Hilda Vargas-Robles, Ricardo Mondragon-Flores, Michael Schnoor
Summary: The Arp2/3 inhibitory protein arpin plays a crucial role in maintaining the integrity of the intestinal epithelial barrier (IEB) and its expression is regulated by inflammatory factors. Lower levels of arpin can trigger dysfunction of IEB during inflammation. Treatment with the Arp2/3-specific inhibitor CK666 can alleviate inflammation-induced permeability barriers, suggesting a potential therapeutic strategy for IEB-related disorders.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, General & Internal
Timo Rath, Raja Atreya, Julia Bodenschatz, Wolfgang Uter, Carol I. Geppert, Francesco Vitali, Sebastian Zundler, Maximilian J. Waldner, Arndt Hartmann, Markus F. Neurath
Summary: In clinically remittent UC patients, endoscopic and/or histologic remission accurately predicts future major adverse outcomes (MAO) development, but ileal barrier healing is superior in predicting MAO-free survival. Ileal barrier healing represents a novel and superior surrogate parameter for stratification of UC patients according to their risk for development of complicated disease behavior.
FRONTIERS IN MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Lokman Pang, Jennifer Huynh, Mariah G. Alorro, Xia Li, Matthias Ernst, Ashwini L. Chand
Summary: Reduced STAT3 activity in mice leads to increased susceptibility to DSS-induced colitis, indicating that the IL-6/gp130/STAT3 signaling pathway orchestrates intestinal barrier function by modulating cytokine secretion and promoting epithelial integrity to maintain defense against bacteria. Therapeutically targeting this signaling axis may serve as a treatment strategy for IBD patients.
Article
Gastroenterology & Hepatology
Julien Kirchgesner, Rishi J. Desai, Maria C. Schneeweiss, Laurent Beaugerie, Sebastian Schneeweiss, Seoyoung C. Kim
Summary: Combination therapy with vedolizumab and thiopurines is associated with a lower risk of treatment failure compared to vedolizumab monotherapy in patients with CD, but the effect is less pronounced in UC.
Article
Medical Informatics
Marco Chierici, Nicolae Puica, Matteo Pozzi, Antonello Capistrano, Marcello Dorian Donzella, Antonio Colangelo, Venet Osmani, Giuseppe Jurman
Summary: The SI-CURA project aims to develop artificial intelligence solutions for discriminating different pathologies, including inflammatory bowel disease, based on endoscopic imaging. The deep learning prototype developed in this study achieves high performance in identifying disease patterns and shows potential as a decision support tool for endoscopy-based diagnosis.
BMC MEDICAL INFORMATICS AND DECISION MAKING
(2022)
Review
Immunology
Reza Yarani, Ali Shojaeian, Oana Palasca, Nadezhda T. Doncheva, Lars Juhl Jensen, Jan Gorodkin, Flemming Pociot
Summary: This review discusses the differential regulation of miRNAs in inflammatory bowel disease (IBD) and their potential diagnostic and therapeutic applications. Through literature curation and computational analysis, a consensus set of differentially expressed miRNAs in mucosal tissues was obtained. The role of these miRNAs and their potential targets in IBD are highlighted.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Tatsuki Noguchi, Soichiro Ishihara, Motoi Uchino, Hiroki Ikeuchi, Koji Okabayashi, Kitaro Futami, Shinji Tanaka, Hiroki Ohge, Hisashi Nagahara, Kazuhiro Watanabe, Michio Itabashi, Kinya Okamoto, Yoshiki Okita, Tsunekazu Mizushima, Yusuke Mizuuchi, Kazutaka Yamada, Yoshifumi Shimada, Yu Sato, Hideaki Kimura, Kenichi Takahashi, Koya Hida, Yusuke Kinugasa, Junji Okuda, Koji Daito, Fumikazu Koyama, Hideki Ueno, Takayuki Yamamoto, Tsunekazu Hanai, Atsuo Maemoto, Koji Oba, Yoichi Ajioka, Kenichi Sugihara
Summary: Patients with longstanding inflammatory bowel disease, such as ulcerative colitis and Crohn's disease, are at high risk of developing intestinal cancers. This study found significant differences between intestinal cancers associated with ulcerative colitis and Crohn's disease. Crohn's disease-associated cancers were diagnosed at more advanced stages, detected less frequently by surveillance, and had a poorer prognosis compared to those associated with ulcerative colitis.
JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Integrative & Complementary Medicine
Juan Li, Xiangge Tian, Jinming Liu, Yuying Mo, Xiaoyi Guo, Yang Qiu, Yuejian Liu, Xiaochi Ma, Yan Wang, Yongjian Xiong
Summary: The study found that Shaoyao Decoction alleviates colitis by activating GPX4, inhibiting cell death, and restoring the epithelial barrier function. Wogonoside, wogonin, palmatine, paeoniflorin, and liquiritin were identified as the key ingredients responsible for the anti-colitis effects of Shaoyao Decoction.
Article
Pharmacology & Pharmacy
Sitang Ge, Yating Yang, Lugen Zuo, Xue Song, Hexin Wen, Zhijun Geng, Yifan He, Zilong Xu, Huatao Wu, Mengdi Shen, Yuanyuan Ge, Xuejun Sun
Summary: This study investigated the effects of Sotetsuflavone (SF) on CD-like spontaneous colitis. The results showed that SF significantly improved colitis and protected intestinal barrier function in the CD model. SF also suppressed M1 macrophage-induced inflammatory responses via JNK and p38 signaling. SF may have therapeutic potential for CD treatment.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hongyu Xiao, Hailun Li, Yifan Wen, Dongxu Jiang, Shumin Zhu, Xueling He, Qingping Xiong, Jie Gao, Shaozhen Hou, Song Huang, Lian He, Jian Liang
Summary: TFP shows significant therapeutic effects on DSS-induced UC model by inhibiting inflammation and restoring intestinal barrier and mucus barrier function.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemical Research Methods
Florent Clerc, Karli R. Reiding, Noortje de Haan, Carolien A. M. Koeleman, Agnes L. Hipgrave Ederveen, Natalia Manetti, Viktoria Dotz, Vito Annese, Manfred Wuhrer
Summary: This study investigates the associations of immunoglobulin A1 and A2 glycosylation with inflammatory bowel diseases (IBD). Differences in IgA O- and N-glycosylation between patient groups were found to be associated with the diseases, and a statistical model was constructed to predict the disease group of the patients. These findings contribute to the development of noninvasive biomarkers for IBD and improvement in patient care.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Bingyu Wang, Zhiqiang Gong, Jingyu Zhan, Lei Yang, Quanyu Zhou, Xingxing Yuan
Summary: Xianglian pill (XLP) has been found to alleviate DSS-induced acute colitis in mice by inhibiting pro-inflammatory cytokines secretion, repairing intestinal epithelial barrier dysfunction, enhancing autophagy, and blocking the activation of the PI3K/Akt/mTOR pathway. Blocking autophagy attenuated the protective effects of XLP on colitis, suggesting that the underlying mechanism may involve Xianglian pill promoting autophagy by blocking the activation of the PI3K/Akt/mTOR signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Genetics & Heredity
Pan Xu, Montserrat Elizalde, Ad Masclee, Marieke Pierik, Daisy Jonkers
Summary: This study demonstrates that prednisolone has a beneficial effect on the epithelial barrier of CD patient-derived intestinal organoids and can restore barrier dysfunction induced by cytokines.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Article
Chemistry, Medicinal
Xiaojing Wang, Xuting Xie, Yanyang Li, Xueqian Xie, Shaowei Huang, Simin Pan, Yanling Zou, Zengfeng Pan, Qing Wang, Jinyan Chen, Lian Zhou, Xia Luo
Summary: The study discovered that quercetin has therapeutic effects on ulcerative colitis. Quercetin repairs the damaged intestinal barrier by activating AhR and enhancing the expression of tight junction proteins.
PHYTOTHERAPY RESEARCH
(2023)
Article
Hematology
Marie-Kristin Schwaegermann, Lukas Hobohm, Johanna Rausch, Michael Reuter, Thomas-Friedrich Griemert, Visvakanth Sivanathan, Tanja Falter, Martin F. Sprinzl, Karl J. Lackner, Peter R. Galle, Stavros Konstantinides, Matthias Theobald, Charis von Auer
Summary: Immune thrombotic thrombocytopenic purpura (iTTP) is a rare autoimmune disorder characterized by reduced activity of ADAMTS13 due to autoantibodies. This results in thrombotic microangiopathy, decreased platelet count, hemolysis, and tissue ischemia.
Article
Oncology
Benjamin Ruf, Cristiana Roggia, Christopher Schroeder, Sven Mattern, Falko Fend, Thomas Klag, Martin Goetz
Summary: Chromoendoscopy can facilitate the detection of gastric carcinoma foci in CDH1 mutation carriers. While chromoendoscopy identified all patients with gastric cancer, not all cancer foci present in these patients were detected. Therefore, the addition of chromoendoscopy to white light endoscopy could be used to enhance the diagnostic reliability of endoscopic surveillance for patients opting against prophylactic total gastrectomy.
JOURNAL OF GASTROINTESTINAL CANCER
(2023)
Letter
Gastroenterology & Hepatology
Christian Labenz, Frank Lammert, Peter R. Galle
JOURNAL OF HEPATOLOGY
(2023)
Article
Health Care Sciences & Services
Maurice Michel, Alisha Wahl, Malena Anders, Saleh A. Alqahtani, Wolfgang M. Kremer, Peter R. Galle, Christian Labenz, Daniel Grimm, Martin Sprinzl, Joern M. Schattenberg
Summary: Metabolic comorbidities, significant fibrosis, and a lower socioeconomic status may negatively affect the health-related quality of life in people living with human immunodeficiency virus (HIV).
QUALITY OF LIFE RESEARCH
(2023)
Article
Oncology
Chiun Hsu, Michel Ducreux, Andrew X. Zhu, Shukui Qin, Masafumi Ikeda, Tae-You Kim, Peter R. Galle, Richard S. Finn, Ethan Chen, Ning Ma, Youyou Hu, Lindong Li, Ann-Lii Cheng
Summary: The IMbrave150 trial showed that atezolizumab + bevacizumab is safe and effective in treating patients with hepatocellular carcinoma, including those with hepatitis B or hepatitis C infection.
Article
Gastroenterology & Hepatology
Sophia Heinrich, Thomas Austgen, Darko Castven, Moritz Hess, Christian Labenz, Martha Kirstein, Carolin Zimpel, Lena Stockhoff, Benjamin Maasoumy, Bernd Heinrich, Hans Heinrich Wedemeyer, Peter Robert Galle, Harald Binder, Marc Nguyen-Tat, Jens Uwe Marquardt
Summary: In this study, serum levels of M30 and M65 were found to be able to effectively distinguish responders from non-responders to terlipressin therapy in patients with hepatorenal syndrome (HRS), and predict dialysis- and liver transplantation (LTX)-free survival.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2023)
Article
Oncology
Masatoshi Kudo, Richard S. S. Finn, Peter R. R. Galle, Andrew X. X. Zhu, Michel Ducreux, Ann-Lii Cheng, Masafumi Ikeda, Kaoru Tsuchiya, Ken-ichi Aoki, Jing Jia, Riccardo Lencioni
Summary: The study demonstrates the efficacy and safety of atezolizumab + bevacizumab treatment in patients with baseline BCLC Stage B hepatocellular carcinoma, consistent with the overall study population.
Article
Gastroenterology & Hepatology
Marietta Iacucci, Tommaso Lorenzo Parigi, Rocio Del Amor, Pablo Meseguer, Giulio Mandelli, Anna Bozzola, Alina Bazarova, Pradeep Bhandari, Raf Bisschops, Silvio Danese, Gert De Hertogh, Jose G. Ferraz, Martin Goetz, Enrico Grisan, Xianyong Gui, Bu Hayee, Ralf Kiesslich, Mark Lazarey, Remo Panaccione, Adolfo Parra-Blanco, Luca Pastorelli, Timo Rath, Elin S. Royset, Gian Eugenio Tontini, Michael Vieth, Davide Zardo, Subrata Ghosh, Valery Naranjo, Vincenzo Villanacci
Summary: An artificial intelligence computer-aided diagnosis system was developed and validated to evaluate UC biopsies and predict prognosis. The system showed high accuracy and sensitivity in assessing biopsy results and predicting outcomes.
Article
Gastroenterology & Hepatology
Michael Bitzer, Sabrina Gross, Joerg Albert, Judit Boda-Heggemann, Thomas Brunner, Reiner Caspari, Enrico De Toni, Frank Dombrowski, Matthias Evert, Andreas Geier, Eleni Gkika, Martin Goetz, Thomas Helmberger, Ralf-Thorsten Hoffmann, Peter Huppert, Achim Kautz, David Krug, Christian La Fougere, Hauke Lang, Philipp Lenz, Tom Luedde, Andreas Mahnken, Silvio Nadalin, Hoa Huu Phuc Nguyen, Johann Ockenga, Karl Oldhafer, Philipp Paprottka, Philippe Pereira, Thorsten Persigehl, Ruben Plentz, Juergen Pohl, Heinrich Recken, Peter Reimer, Jutta Riemer, Ulrike Ritterbusch, Elke Roeb, Joern Ruessel, Barbara Schellhaas, Peter Schirmacher, Hans Juergen Schlitt, Irene Schmid, Andreas Schuler, Daniel Seehofer, Marianne Sinn, Andreas Stengel, Christoph Stoll, Andrea Tannapfel, Anne Taubert, Reina Tholen, Joerg Trojan, Ingo van Thiel, Arndt Vogel, Thomas Vogl, Frank Wacker, Oliver Waidmann, Heiner Wedemeyer, Henning Wege, Dane Wildner, Marcus-Alexander Woerns, Peter Galle, Nisar Malek
ZEITSCHRIFT FUR GASTROENTEROLOGIE
(2023)
Article
Gastroenterology & Hepatology
Michael Bitzer, Sabrina Gross, Joerg Albert, Judit Boda-Heggemann, Thomas Brunner, Reiner Caspari, Enrico De Toni, Frank Dombrowski, Matthias Evert, Andreas Geier, Eleni Gkika, Martin Goetz, Thomas Helmberger, Ralf-Thorsten Hoffmann, Peter Huppert, Achim Kautz, David Krug, Christian La Fougere, Hauke Lang, Philipp Lenz, Tom Luedde, Andreas Mahnken, Silvio Nadalin, Hoa Huu Phuc Nguyen, Johann Ockenga, Karl Oldhafer, Philipp Paprottka, Philippe Pereira, Thorsten Persigehl, Ruben Plentz, Juergen Pohl, Heinrich Recken, Peter Reimer, Jutta Riemer, Ulrike Ritterbusch, Elke Roeb, Joern Ruessel, Barbara Schellhaas, Peter Schirmacher, Hans Juergen Schlitt, Irene Schmid, Andreas Schuler, Daniel Seehofer, Marianne Sinn, Andreas Stengel, Christoph Stoll, Andrea Tannapfel, Anne Taubert, Reina Tholen, Joerg Trojan, Ingo van Thiel, Arndt Vogel, Thomas Vogl, Frank Wacker, Oliver Waidmann, Heiner Wedemeyer, Henning Wege, Dane Wildner, Marcus-Alexander Woerns, Peter Galle, Nisar Malek
ZEITSCHRIFT FUR GASTROENTEROLOGIE
(2023)
Article
Oncology
Masatoshi Kudo, Richard S. Finn, Ann-Lii Cheng, Andrew X. Zhu, Michel Ducreux, Peter R. Galle, Naoya Sakamoto, Naoya Kato, Michitaka Nakano, Jing Jia, Arndt Vogel
Summary: This exploratory analysis examined the prognostic impact of baseline albumin-bilirubin (ALBI) score in patients with unresectable hepatocellular carcinoma (HCC) treated with atezolizumab + bevacizumab or sorafenib. The study found that atezolizumab + bevacizumab improved overall survival and progression-free survival compared to sorafenib in patients with ALBI score of 1, but not in patients with ALBI score of 2. ALBI grade appeared to be prognostic for outcomes in both treatment groups.
Review
Gastroenterology & Hepatology
Simon J. Gairing, Eva M. Schleicher, Peter R. Galle, Christian Labenz
Summary: Hepatic encephalopathy is a significant complication of liver cirrhosis with detrimental effects on patients' quality of life. Identifying high-risk patients and implementing early prevention is crucial. Cognitive tests, composite scores, and blood-based biomarkers have shown promise in predicting the first-time occurrence of hepatic encephalopathy. However, the evidence for primary prophylaxis is limited.
HEPATOLOGY COMMUNICATIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Omar Hahad, Donya A. Gilan, Julian Chalabi, Sadeer Al-Kindi, Alexander K. Schuster, Felix Wicke, Matthias Buettner, Oliver Tuescher, Karl J. Lackner, Peter R. Galle, Stavros Konstantinides, Andreas Daiber, Philipp S. Wild, Thomas Muenzel
Summary: This study aims to investigate the association between social disadvantage and cardiovascular burden and mortality. The findings suggest that low socioeconomic status is associated with increased risk of cardiovascular disease and mortality, with education and occupation being stronger predictors compared to household net income.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tiemo Sven Gerber, Hagen Roland Witzel, Arndt Weinmann, Fabian Bartsch, Mario Schindeldecker, Peter R. Galle, Hauke Lang, Wilfried Roth, Dirk Andreas Ridder, Beate Katharina Straub
Summary: This study investigated the levels of 4-hydroxy-nonenal (4-HNE) in liver carcinomas and analyzed their correlation with clinical data and survival outcomes. The results showed that lower levels of 4-HNE were associated with unfavorable survival outcomes and aggressive tumor behavior in hepatocellular carcinoma (HCC). However, in intrahepatic cholangiocarcinoma (iCCA), 4-HNE levels were not correlated with prognostic parameters or survival outcomes.
Letter
Gastroenterology & Hepatology
Simon Johannes Gairing, Leonard Kaps, Eva Maria Schleicher, Peter Robert Galle, Christian Labenz
JOURNAL OF HEPATOLOGY
(2023)