Article
Gastroenterology & Hepatology
Mohammed Deputy, Kapil Sahnan, Guy Worley, Komal Patel, Violeta Balinskaite, Alex Bottle, Paul Aylin, Elaine M. Burns, Ailsa Hart, Omar Faiz
Summary: The Covid-19 pandemic has had a detrimental effect on inflammatory bowel disease (IBD) services, leading to delays in emergency care and access to investigations and surgeries. A study in England found significant decreases in hospital attendances for acute ulcerative colitis (UC) and acute Crohn's disease (CD), as well as a decrease in the volume of IBD procedures and investigations. The study also highlighted the importance of prioritizing care for patients with IBD to prevent clinical harm and a decrease in quality of life.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Medicine, Research & Experimental
Megan C. Buckley, Anand Kumar, Arun Swaminath
Summary: Although approved for certain uses at the state level in the USA, the exact role of cannabis in treating inflammatory bowel disease (IBD) remains uncertain. In addition to potential symptom management benefits, concerns such as dosing inconsistencies, dependence, and cannabinoid hyperemesis syndrome are associated with cannabis use.
ADVANCES IN THERAPY
(2021)
Review
Biochemistry & Molecular Biology
Vishal Khatri, Ramaswamy Kalyanasundaram
Summary: This review focuses on the association between IBD and gut inflammasome, as well as recent advances in research and therapeutic strategies for IBD, discussing inflammasomes and their components, outcomes from experimental animals and human studies, inflammasome inhibitors, and developments in inflammasome-targeted therapies for IBD.
Review
Biochemistry & Molecular Biology
HyunTaek Jung, Jae Seok Kim, Keum Hwa Lee, Kalthoum Tizaoui, Salvatore Terrazzino, Sarah Cargnin, Lee Smith, Ai Koyanagi, Louis Jacob, Han Li, Sung Hwi Hong, Dong Keon Yon, Seung Won Lee, Min Seo Kim, Paul Wasuwanich, Wikrom Karnsakul, Jae Il Shin, Andreas Kronbichler
Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract that mainly affects young people. Recent studies have shown that microRNAs (miRNAs) play an important role in the pathogenesis, diagnosis, and treatment of IBD.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Review
Medicine, General & Internal
Ugo Grossi, Gaetano Gallo, Gian Luca Di Tanna, Umberto Bracale, Mattia Ballo, Elisa Galasso, Andrea Kazemi Nava, Martino Zucchella, Francesco Cinetto, Marcello Rattazzi, Carla Felice, Giacomo Zanus
Summary: The safety and effectiveness of surgical treatment for hemorrhoidal disease in patients with inflammatory bowel disease (IBD) is currently poorly supported by evidence. However, cautious surgical management of non-responsive CD patients with inactive disease is still recommended, though further studies are needed to assess the potential benefits of non-excisional techniques in this population.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Michael J. Buie, Stephanie Coward, Abdel-Aziz Shaheen, Jayna Holroyd-Leduc, Lindsay Hracs, Christopher Ma, Remo Panaccione, Eric Benchimol, Charles N. Bernstein, Alain Bitton, Anthony R. Otley, Jennifer L. Jones, Sanjay K. Murthy, M. Ellen Kuenzig, Juan-Nicolas Pena-Sanchez, Laura E. Targownik, Harminder Singh, Antonio Avina-Zubieta, Gilaad G. Kaplan
Summary: Recent advances in IBD management have led to a decrease in hospitalization rates for IBD-related and non-IBD-related causes. The study observed a decline in all-cause hospitalization rates as well.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Uma Mahadevan, Millie D. Long, Sunanda Kane, Abhik Roy, Marla C. Dubinsky, Bruce E. Sands, Russell D. Cohen, Christina D. Chambers, William J. Sandborn
Summary: The study found that exposure to biologic, thiopurine, or combination therapy during pregnancy did not increase adverse maternal or fetal outcomes, and these treatments can be continued throughout pregnancy for women with IBD to maintain disease control.
Article
Surgery
Shannon N. Radomski, Miloslawa Stem, Michael Consul, Jay Rammohan Maturi, Haniee Chung, Susan Gearhart, Ada Graham, Vincent J. Obias
Summary: Research shows that the use of robotic surgical approaches in the management of inflammatory bowel disease (IBD) is increasing and is as safe as laparoscopic surgery. For patients with ulcerative colitis (UC), there is no difference in overall morbidity, serious morbidity, or conversion to open surgery between robotic and laparoscopic approaches. However, for patients with Crohn's disease (CD), the robotic approach has similar overall morbidity but higher rates of serious morbidity, shorter length of stay, and lower conversion rates to open surgery.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Medicine, General & Internal
Silvia Salvatori, Francesco Baldassarre, Michelangela Mossa, Giovanni Monteleone
Summary: Long COVID is common in patients with inflammatory bowel diseases (IBD), with fatigue being the most frequent symptom. It does not influence the frequency of IBD relapses, but is more prevalent in female patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Gastroenterology & Hepatology
Thomas M. Goodsall, Tran M. Nguyen, Claire E. Parker, Christopher Ma, Jane M. Andrews, Vipul Jairath, Robert Bryant
Summary: The study systematically identified ultrasound scoring indices for assessing inflammatory bowel disease activity, with common components including bowel wall thickness, colour Doppler imaging, and bowel wall stratification. The correlation between ultrasound indices and reference standards, as well as sensitivity, specificity, accuracy, and other properties, varied within certain ranges. However, reliability and responsiveness data were limited, and most studies were rated with unclear or high risk of bias.
JOURNAL OF CROHNS & COLITIS
(2021)
Review
Medicine, General & Internal
Katarzyna Akutko, Andrzej Stawarski
Summary: Inflammatory bowel diseases (IBD) are chronic inflammatory diseases of the digestive tract with periods of remission and relapses. The etiopathogenesis is not fully understood, leading to only symptomatic treatment. There is a constant need to search for new high safety profile therapies for IBD.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biotechnology & Applied Microbiology
Guihua Chen, Jun Shen
Summary: Inflammatory bowel disease (IBD) is a global disease with high morbidity and medical costs. Early diagnosis and intervention are crucial for controlling its progression.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Jurij Hanzel, Peter Bossuyt, Valerie Pittet, Mark Samaan, Monika Tripathi, Wladyslawa Czuber-Dochan, Johan Burisch, Salvatore Leone, Roberto Saldana, Filip Baert, Uri Kopylov, Susanna Jaghult, Michel Adamina, Naila Arebi, Krisztina Gecse
Summary: This study aimed to develop a core outcome set for real-world studies in adult patients with inflammatory bowel disease (IBD). Candidate outcomes and outcome measures were identified through a systematic review and a modified Delphi consensus process. The international panel agreed on the final core outcome set, which will facilitate the synthesis and generation of real-world evidence.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Gastroenterology & Hepatology
Rahul S. Dalal, Sonali Palchaudhuri, Christopher K. Snider, James D. Lewis, Shivan J. Mehta, Gary R. Lichtenstein
Summary: The study found a significant positive correlation between preadmission cannabis use and inpatient opioid exposure among patients with inflammatory bowel disease. Additionally, first patient-reported pain score and preadmission opioid use were also associated with inpatient opioid exposure.
INFLAMMATORY BOWEL DISEASES
(2021)
Editorial Material
Gastroenterology & Hepatology
Catherine Le Berre, Laurent Peyrin-Biroulet
Summary: The SPIRIT consensus group has agreed that the ultimate therapeutic goal in both CD and UC is to prevent disease impact on patients' lives, including health-related quality of life, disability, and fecal incontinence, as well as prevent complications in the short and long term, such as bowel damage, surgeries, disease extension, extraintestinal manifestations, and dysplasia or cancer. These recommendations will need to be validated in clinical studies before being implemented in disease-modification trials.
Article
Gastroenterology & Hepatology
William J. Sandborn, Geert R. D'Haens, Bruce E. Sands, Remo Panaccione, Siew C. Ng, Nervin Lawendy, Nicole Kulisek, Irene Modesto, Xiang Guo, Rajiv Mundayat, Chinyu Su, Ivana Vranic, Julian Panes
Summary: This study provides a summary of tofacitinib safety in the treatment of ulcerative colitis. The results showed a low incidence of adverse events, with stable rates in patients treated for at least 7.8 years. The incidence rates of important safety events were generally below 2.0, except for herpes zoster.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Gastroenterology & Hepatology
William J. Sandborn, Julian Panes, Silvio Danese, Zaineb Sharafali, Azra Hassanali, Rhian Jacob-Moffatt, Christopher Eden, Marco Daperno, John F. Valentine, David Laharie, Carolina Baia, Raja Atreya, Remo Panaccione, Grazyna Rydzewska, Humberto Aguilar, Severine Vermeire
Summary: This study compared the safety and efficacy of two doses of Etrolizumab with placebo in patients with Crohn's disease. The results showed that during the maintenance phase, Etrolizumab significantly improved clinical remission and endoscopic improvement in patients with moderately to severely active Crohn's disease compared to placebo. However, there was no significant difference in the effects of Etrolizumab and placebo on clinical remission and endoscopic improvement during the induction phase.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Edward V. Loftus, Jean-Frederic Colombel, Ken Takeuchi, Xiang Gao, Remo Panaccione, Silvio Danese, Marla Dubinsky, Stefan Schreiber, Dapo Ilo, Tricia Finney-Hayward, Wen Zhou, Charles Phillips, Yuri Sanchez Gonzalez, Lei Shu, Xuan Yao, Qing Zhou, Severine Vermeire
Summary: This study evaluated the efficacy of once-daily upadacitinib 45 mg in improving symptoms of ulcerative colitis. The analysis of pooled data from two phase 3 trials showed that upadacitinib provided rapid relief of UC symptoms from day 1, with significant improvements maintained until day 14. Patients treated with upadacitinib also achieved reductions in inflammatory markers and significant improvements in quality of life.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Jocelyn Jeong, Thomas D. Walters, Hien Q. Huynh, Sally Lawrence, David R. Mack, Colette Deslandres, Anthony Otley, Wael El-Matary, Mary Sherlock, Anne M. Griffiths, Eytan Wine, Kevan Jacobson, Peter Church, Matthew W. Carroll, Eric Benchimol, Herbert Brill, Jeff Critch, Kevin Bax, Prevost Jantchou, Mohsin Rashid, Gilaad G. Kaplan, Cynthia H. Seow, Kerri Novak, Jennifer C. deBruyn
Summary: This study examines the ancestral and phenotypic variation of Canadian children newly diagnosed with inflammatory bowel disease. It identifies differences between children of European and non-European descent in phenotypes of inflammatory bowel disease, disease location and behavior, family history, and immigrant status.
INFLAMMATORY BOWEL DISEASES
(2023)
Review
Medicine, Research & Experimental
Remo Panaccione, Wan-Ju Lee, Ryan Clark, Kristina Kligys, Rhiannon I. Campden, Stacy Grieve, Tim Raine
Summary: This study aimed to identify and characterize the dosing escalation patterns of advanced therapies in Crohn's disease (CD) and ulcerative colitis (UC). The study found that most studies aligned with regulatory recommendations, but there were also some studies indicating more diverse or aggressive dose escalation.
ADVANCES IN THERAPY
(2023)
Article
Gastroenterology & Hepatology
Patrick Hamilton, Katherine Buhler, John K. MacDonald, Gilaad G. Kaplan, Cynthia H. Seow, Cathy Lu, Kerri L. Novak, Christopher N. Andrews, Siddharth Singh, Vipul Jairath, Remo Panaccione, Christopher Ma
Summary: This study aimed to estimate the placebo response rates in patients with microscopic colitis (MC) and identify factors associated with placebo response. The analysis showed that approximately one-quarter of patients in MC trials responded to placebo, but with significant heterogeneity.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
Michael J. Buie, Stephanie Coward, Abdel-Aziz Shaheen, Jayna Holroyd-Leduc, Lindsay Hracs, Christopher Ma, Remo Panaccione, Eric Benchimol, Charles N. Bernstein, Alain Bitton, Anthony R. Otley, Jennifer L. Jones, Sanjay K. Murthy, M. Ellen Kuenzig, Juan-Nicolas Pena-Sanchez, Laura E. Targownik, Harminder Singh, Antonio Avina-Zubieta, Gilaad G. Kaplan
Summary: Recent advances in IBD management have led to a decrease in hospitalization rates for IBD-related and non-IBD-related causes. The study observed a decline in all-cause hospitalization rates as well.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Medicine, General & Internal
Edward V. Loftus Jr, Julian Panes, Ana P. Lacerda, Laurent Peyrin-Biroulet, Geert D'Haens, Remo Panaccione, Walter Reinisch, Edouard Louis, Minhu Chen, Hiroshi Nakase, Jakob Begun, Brigid S. Boland, Charles Phillips, Mohamed-Eslam F. Mohamed, Jianzhong Liu, Ziqian Geng, Tian Feng, Elena Dubcenco, Jean-Frederic Colombel
Summary: In two phase 3 trials, Upadacitinib, an oral JAK inhibitor, demonstrated superior efficacy compared to placebo in achieving clinical remission and endoscopic response in patients with moderate-to-severe Crohn's disease.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Nutrition & Dietetics
Jared L. L. Cooper, Ryan E. E. Rosentreter, Alexis Filyk, Zahra A. A. Premji, Hua Shen, Richard Ingram, Gilaad G. G. Kaplan, Christopher Ma, Kerri Novak, Remo Panaccione, Cynthia H. H. Seow, Florian Rieder, Maitreyi Raman, Cathy Lu
Summary: This systematic review evaluated the impact of dietary interventions on medical and surgical outcomes in patients with fibrostenotic Crohn's disease. The findings suggest that exclusive enteral nutrition and total parenteral nutrition may provide benefit for these patients.
FRONTIERS IN NUTRITION
(2023)
Review
Gastroenterology & Hepatology
Harris A. Ahmad, James E. East, Remo Panaccione, Simon Travis, James B. Canavan, Keith Usiskin, Michael F. Byrne
Summary: Inflammatory bowel disease, including Crohn's disease and ulcerative colitis, is a condition characterized by uncontrolled inflammation in the gastrointestinal tract. Artificial intelligence is increasingly being used to provide accurate evaluations of endoscopic appearance and histologic activity in patients with inflammatory bowel disease. These AI tools also have the potential to predict treatment response to biologic therapies and improve the standard of care, by personalizing treatment options and reducing costs.
INTESTINAL RESEARCH
(2023)
Review
Gastroenterology & Hepatology
Sudheer Kumar Vuyyuru, Virginia Solitano, Malcolm Hogan, John K. MacDonald, Alexa Zayadi, Claire E. Parker, Bruce E. Sands, Remo Panaccione, Neeraj Narula, Brian G. Feagan, Siddharth Singh, Vipul Jairath, Christopher Ma
Summary: This systematic review and meta-analysis evaluated the efficacy and safety of selective IL-23p19 and IL-12/23p40 inhibitors in patients with moderate-to-severe CD. The results demonstrated that targeting IL-23 is effective and safe for inducing and maintaining clinical and endoscopic remission.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Simon Travis, Alison Potts Bleakman, Marla C. Dubinsky, Stefan Schreiber, Remo Panaccione, Toshifumi Hibi, Theresa Hunter Gibble, Cem Kayhan, Christian Atkinson, Christophe Sapin, Eoin J. Flynn, David T. Rubin
Summary: Bowel urgency has a significant impact on the lives of patients from the United States and Europe, and there are disparities between patient and healthcare professional perceptions on the experience and impact of ulcerative colitis symptoms. The CONFIDE study aimed to evaluate these symptoms and communication gaps between patients and healthcare professionals in the US and Europe.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Sangmin Lee, Cynthia H. Seow, Kara Nerenberg, Stefania Bertazzon, Yvette Leung, Vivian Huang, Tara Whitten, Stephanie Coward, Remo Panaccione, Gilaad G. Kaplan, Amy Metcalfe
Summary: Attendance at a dedicated IBD-pregnancy clinic improves disease-specific pregnancy knowledge and does not affect perinatal outcomes in pregnant women with IBD.
INFLAMMATORY BOWEL DISEASES
(2023)
Meeting Abstract
Gastroenterology & Hepatology
R. Atreya, P. Irving, M. Fujiya, J. F. Colombel, S. Danese, L. Peyrin-Biroulet, T. Bessissow, R. Panaccione, G. D'Haens, S. van Haaren, E. Neimark, J. Zambrano, Y. Zhang, K. Kligys, M. Ferrante
JOURNAL OF CROHNS & COLITIS
(2023)