Article
Gastroenterology & Hepatology
Gayatri Pemmasani, Islam Elgendy, Mamas A. Mamas, Jonathan A. Leighton, Wilbert S. Aronow, William J. Tremaine
Summary: The study found that hospitalizations for ACS in patients with IBD have increased in recent years, but death rates have remained stable, with favorable risk profiles and mortality rates for IBD-ACS. Risk factors, management strategies, and mortality were similar between CD and UC, with complications more frequently associated with IBD strongly linked to mortality.
INFLAMMATORY BOWEL DISEASES
(2021)
Article
Obstetrics & Gynecology
K. Yu, A. S. Faye, T. Wen, J. R. Guglielminotti, Y. Huang, J. D. Wright, M. E. D'Alton, A. M. Friedman
Summary: The prevalence of inflammatory bowel disease is increasing among delivery hospitalizations, and disease severity is associated with adverse outcomes.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Review
Medicine, General & Internal
Ayman Jaaouani, Abdulrahman Ismaiel, Stefan-Lucian Popa, Dan L. Dumitrascu
Summary: This systematic review found a possible association between IBD and an increased risk of ACS, especially in younger patients. Factors such as hospitalizations, acute active flares, active disease periods, and complications in IBD patients are related to the risk of ACS. Further research is needed to investigate the role of corticosteroids and oral contraceptive pills in increasing ACS risk in IBD patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Health Care Sciences & Services
Wojciech Jan Skorupski, Marta Kaluzna-Oleksy, Maciej Lesiak, Aleksander Araszkiewicz, Wlodzimierz Skorupski, Stefan Grajek, Przemyslaw Mitkowski, Malgorzata Pyda, Marek Grygier
Summary: The study evaluates the outcomes of left main percutaneous coronary interventions in patients who are not suitable for coronary artery bypass graft surgery. The results show that these patients have higher complexity of disease and lower ejection fraction, but the procedure is successful with low complication rates. However, long-term all-cause mortality rate is slightly higher in these patients.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Medicine, General & Internal
Vikash Jaiswal, Nitya Batra, Mehak Dagar, Swatika Butey, Helen Huang, Jia Ee Chia, Sidra Naz, Evbayekha O. Endurance, Nishchita Raj, Srushti Patel, Dipansha Maroo, Song Peng Ang, Muhammed Hanif, Dattatreya Mukherjee, Zouina Sarfraz, Abhigan Babu Shrestha, David Song
Summary: A systematic review showed that patients with inflammatory bowel disease (IBD) have a higher risk of adverse cardiovascular outcomes, especially in women. The mortality rate, myocardial infarction rate, and cardiovascular event rate were found to be higher in IBD patients.
Article
Cardiac & Cardiovascular Systems
Thomas C. Gilliland, Yuxi Liu, Reza Mohebi, Hannah Miksenas, Sara Haidermota, Megan Wong, Xingdi Hu, Joaquim Rosado Cristino, Auris Browne, Jorge Plutzky, Sotirios Tsimikas, James L. Januzzi Jr, Pradeep Natarajan
Summary: This study investigated the relationships between Lp(a) and OxPLs with angiographic CAD and cardiovascular outcomes. The results showed that Lp(a) and OxPL-apoB were associated with multivessel CAD, and Lp(a), OxPL-apoB, and OxPL-apo(a) were associated with cardiovascular events.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Batric Popovic, Jeanne Varlot, Joseph Hennequin, Pierre Adrien Metzdorf, Nicolas Jay, Edoardo Camenzind, Aurelie Bannay
Summary: Patients with inflammatory bowel disease (IBD) who have suffered from myocardial infarction (MI) have a higher risk of recurrent MI compared to patients without IBD, but no significant difference was found in all-cause mortality, stroke, and hospitalization resulting from heart failure between the two groups.
Article
Cardiac & Cardiovascular Systems
Ville Kyto, Jussi Sipila, Aleksi Tornio, Paivi Rautava, Jarmo Gunn
Summary: In this population-based cohort study, gender was not an independent predictor of long-term major adverse cardiovascular events after CABG. However, men had higher long-term all-cause mortality while women had a higher risk of myocardial infarction.
ANNALS OF THORACIC SURGERY
(2021)
Review
Pharmacology & Pharmacy
Rocio Rivera Rodriguez, Jeremy James Johnson
Summary: Inflammatory Bowel Disease (IBD) is a chronic autoimmune disease characterized by intestinal inflammation. The incidence of IBD is rapidly increasing in newly developed countries, making it a global concern. Two major types of IBD, ulcerative colitis (UC) and Crohn's disease (CD), have different manifestations and locations of inflammation in the digestive tract. Current FDA-approved treatments for IBD are only effective for 50% of patients and come with serious side effects, highlighting the need for safer and more effective therapies. Plant-based diets, such as the Mediterranean diet rich in anti-inflammatory phytochemicals, have shown benefits in preventing and improving symptoms of IBD. Terpenes, a class of phytochemicals abundant in Mediterranean herbs and citrus fruits, have been studied for their potential to modulate inflammatory signaling in IBD. However, there is still conflicting and inconclusive evidence regarding their effectiveness. This review evaluates preclinical studies on terpenes and their impact on basic inflammatory signaling in IBD.
PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Cardiac & Cardiovascular Systems
Doosup Shin, Neng Dai, Seung Hun Lee, Ki Hong Choi, Adrien Lefieux, David Molony, Doyeon Hwang, Hyun Kuk Kim, Ki-Hyun Jeon, Hyun-Jong Lee, Ho-Jun Jang, Sang Lin Ha, Taek Kyu Park, Jeong Hoon Yang, Young Bin Song, Joo-Yong Hahn, Seung-Hyuk Choi, Joon-Hyung Doh, Eun-Seok Shin, Chang-Wook Nam, Bon-Kwon Koo, Hyeon-Cheol Gwon, Junbo Ge, Joo Myung Lee
Summary: This study aimed to evaluate the prognostic implications of physiological 2-dimensional disease patterns in relation to the distribution and local severity of coronary atherosclerosis. The study found that disease patterns significantly influenced post-PCI physiological results and determined the risk of target vessel failure.
JACC-CARDIOVASCULAR INTERVENTIONS
(2021)
Article
Cardiac & Cardiovascular Systems
Valentino Bianco, Arman Kilic, Thomas G. Gleason, Edgar Aranda-Michel, Andreas Habertheuer, Rishab Humar, Yisi Wang, Forozan Navid, Ibrahim Sultan
Summary: Propensity-matched outcomes showed no significant difference in postoperative mortality or readmission for reoperative coronary artery bypass grafting (CABG) up to 1 year, but higher 5-year mortality for reoperative patients was observed. Cox regression analysis did not identify reoperative CABG as a risk factor for long-term mortality.
ANNALS OF THORACIC SURGERY
(2021)
Review
Chemistry, Medicinal
Dandan Liu, Varma Saikam, Katie A. Skrada, Didier Merlin, Suri S. Iyer
Summary: Inflammatory bowel disease (IBD) is a chronic inflammation of the gastrointestinal tract, which can be diagnosed through endoscopy and biopsy. However, these methods are expensive and invasive, so alternative noninvasive biomarkers are being explored for disease management and prognosis.
MEDICINAL RESEARCH REVIEWS
(2022)
Article
Medicine, General & Internal
Sofia Sederholm Lawesson, Eva Swahn, Mats Pihlsgard, Therese Andersson, Oskar Angeras, Elin Bacsovics Brolin, Ellinor Bergdahl, Marie Blomberg, Christina Christersson, Isabel Goncalves, Omar Sigurvin Gunnarsson, Tomas Jernberg, Nina Johnston, Karin Leander, Caroline Lilliecreutz, Moa Pehrson, Annika Rosengren, Anette Sandstrom, Anna Sandstrom, Giovanna Sarno, Sara Sjalander, Teresia Svanvik, Erik Thunstrom, Anna Karin Wikstrom, Simon Timpka
Summary: According to a study in Sweden, there is a significant association between adverse pregnancy outcomes (such as preeclampsia, gestational hypertension, preterm delivery, etc.) and coronary artery disease. This association exists even among women with low cardiovascular disease risk. Further research is needed to understand the clinical importance of these associations.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Pediatrics
Alex Krauthammer, Ilana Weintraub, Ron Shaoul, Raffi Lev-Tzion, Efrat Broide, Michael Wilschanski, Aaron Lerner, Baruch Yerushalmi, Dror S. Shouval, Hussein Shamaly, Yael Haberman-Ziv, Batia Weiss
Summary: This study retrospectively evaluated the presentation and long-term outcomes of infants with early-onset inflammatory bowel disease (IO-IBD). The majority of patients had a severe disease presentation at diagnosis, but most achieved long-term remission. However, the surgery rate was high, mainly in the first few months after diagnosis.
FRONTIERS IN PEDIATRICS
(2023)
Review
Gastroenterology & Hepatology
Anna M. Buchner, Yecheskel Schneider, Gary R. Lichtenstein
Summary: Biological therapy targeting tumor necrosis factor-alpha has become crucial in treating patients with inflammatory bowel disease, but high costs limit accessibility. Biosimilars offer the potential to reduce expenditures and increase availability, providing more options for patients.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Carol Rouphael, Rocio Lopez, John McMichael, Carol A. Burke
Summary: The study compared baseline adenoma characteristics between patients undergoing colonoscopy in a historic versus contemporary cohort and found an increase in the proportion of patients with >= 3 nonadvanced adenomas in the contemporary cohort. However, follow-up colonoscopies showed that these patients did not have a significantly higher risk of metachronous advanced neoplasia compared to low-risk adenoma patients.
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
C. Roberto Simons-Linares, Suha Abushamma, Carlos Romero-Marrero, Amit Bhatt, Rocio Lopez, Sunguk Jang, John Vargo, Tyler Stevens, Robert O'Shea, William Carey, Prabhleen Chahal
Summary: This study showed that patients with cirrhosis hospitalized due to acute pancreatitis had similar mortality and morbidity rates compared to non-cirrhotic patients.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Letter
Gastroenterology & Hepatology
Amandeep Singh, Rajat Garg, Rocio Lopez, Naim Alkhouri
Summary: This study aims to develop a simple noninvasive fibrosis score to detect advanced fibrosis in patients with diabetes and compare its performance with other fibrosis scores.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Marc Monachese, Gautam Mankaney, Faris El-Khider, Carol Rouphael, Rocio Lopez, Carol A. Burke
Summary: Patients with small proximal and distal HPs are at increased risk of metachronous SSLs, underscoring the importance of considering these findings in surveillance recommendations and future studies with larger cohorts.
GASTROINTESTINAL ENDOSCOPY
(2021)
Article
Allergy
M. Macmurdo, R. Lopez, B. L. Udeh, J. Zein
Summary: This study aimed to determine the indirect impact of substance misuse on disease severity, healthcare utilization, and healthcare costs in patients with chronic obstructive lung disease. Using data from the National Readmissions Database, the study found that substance misuse was associated with an increase in hospital readmission rate and higher healthcare costs. Targeting substance misuse in this patient population has the potential for significant cost savings to the healthcare system.
Article
Substance Abuse
Maeve MacMurdo, Rocio Lopez, Belinda L. Udeh, Joe G. Zein
Summary: The study revealed that patients with alcohol use disorder (AUD) are more likely to experience respiratory failure and require mechanical ventilation in the emergency room when admitted with asthma or COPD. Patients with AUD also have increased hospitalization costs, longer stays, and a higher likelihood of readmission within 30 days.
Article
Emergency Medicine
Philip R. Wang, Rocio Lopez, Spencer S. Seballos, Matthew J. Campbell, Belinda L. Udeh, Michael P. Phelan
Summary: Analysis of NHAMCS data from 2010 to 2017 showed a positive trend in the medical management of migraine in US emergency departments, with a yearly decline in opioid prescriptions. During this period, ketorolac and metoclopramide were more frequently prescribed. Factors associated with increased opioid administration included female sex, older age, white race, higher pain scores, and Medicare or private insurance as primary payment source.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Multidisciplinary Sciences
Chihyun Park, Jean R. Clemenceau, Anna Seballos, Sara Crawford, Rocio Lopez, Tyler Coy, Gowtham Atluri, Tae Hyun Hwang
Summary: The study analyzed opioid-related mortality in Ohio from 2010 to 2016, finding higher death rates among white males aged 25-54 and a tendency for deaths to cluster in urban areas. Additionally, comorbidity analysis showed a relatively high co-occurrence of cardiovascular disease, anxiety, or drug abuse history with opioid-related deaths.
SCIENTIFIC REPORTS
(2021)
Article
Pathology
Ryan Demkowicz, Prashanthi N. Thota, Tanmayee Benjamin, Rocio Lopez, Haiyan Lu, Deepa T. Patil, Erinn Downs-Kelly, Jennifer A. Jeung, Keith K. Lai, James Lapinski, Erica C. Savage, John R. Goldblum, Ilyssa O. Gordon
Summary: This study confirms the importance of assessing specimen adequacy and evaluating the prevalence of SSIM. It is also the first to assess interobserver agreement for SSIM and dysplasia within SSIM. Overall agreement for SSIM by slide was 92% to 94%, and by patient was 82% to 94%, showing moderate to strong agreement.
ANNALS OF DIAGNOSTIC PATHOLOGY
(2021)
Article
Allergy
Peng Zhang, Rocio Lopez, Amy H. Attaway, Steve N. Georas, Sumita B. Khatri, Simon Abi-Saleh, Joe G. Zein
Summary: Asthmatic patients with diabetes mellitus (DM) had increased hospital length of stay, cost, and risk for readmission during asthma-related hospitalizations. They were also more likely to develop nonrespiratory complications during their hospital stay compared to patients without diabetes. However, the risk of mortality was similar between the two groups.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Article
Gastroenterology & Hepatology
Matheus Cavalcante Franco, Sunguk Jang, Bruno da Costa Martins, Tyler Stevens, Vipul Jairath, Rocio Lopez, John J. Vargo, Alan Barkun, Fauze Maluf-Filho
Summary: This study validates the accuracy of prognostic scores in predicting outcomes for cancer patients with upper gastrointestinal bleeding (UGIB), and develops a new score to predict the need for hemostatic therapy.
CLINICAL ENDOSCOPY
(2022)
Article
Pediatrics
Nawras Habash, Yamen Ezaizi, Ibrahim Kak, Praveen Kumar Conjeevaram Selvakumar, Rocio Lopez, Naim Alkhouri, Mohammad Nasser Kabbany
Summary: This study evaluated the performance of three fibrosis scores in assessing advanced fibrosis in children after liver transplantation. The FIB-4 score showed satisfactory accuracy in detecting advanced fibrosis, but there is still a need to develop a reliable pediatric fibrosis score.
PEDIATRIC TRANSPLANTATION
(2022)
Article
Surgery
Jesse D. Schold, Anne M. Huml, S. Ali Husain, Emilio D. Poggio, R. Blake Buchalter, Rocio Lopez, Bruce Kaplan, Sumit Mohan
Summary: In the United States, over 20% of procured kidneys for transplantation are not utilized. This study examined the factors associated with nonutilization and found that deceased donors from higher distressed communities were more likely to have their kidneys not utilized. The study also found regional variations in kidney nonutilization rates and minimal impact on recipient outcomes.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Anesthesiology
Josie Znidarsic, Kellie N. Kirksey, Stephen M. Dombrowski, Anne Tang, Rocio Lopez, Heather Blonsky, Irina Todorov, Dana Schneeberger, Jonathan Doyle, Linda Libertini, Starkey Jamie, Tracy Segall, Andrew Bang, Kathy Barringer, Bar Judi, Jane Pernotto Ehrman, Michael F. Roizen, Mladen Golubic
Summary: The study evaluated the effectiveness of a multidisciplinary, nonpharmacological approach using shared medical appointments to improve health-related quality of life and reduce opioid medication use in patients with chronic pain. Results showed that patients experienced reduced pain and improved physical, mental, and social health without increased use of opioid medications over an 8-week intervention.
Article
Gastroenterology & Hepatology
Marc Monachese, Peter J. Lee, Kevin Harris, Sunguk Jang, Amit Bhatt, Prabhleen Chahal, Rocio Lopez, Tyler Stevens
Summary: This study aimed to assess the ability of EUS and ePFT to predict disease progression in patients with suspected MCCP who had nondiagnostic baseline imaging. The results showed that abnormal ePFT and EUS Rosemont classification were significant predictors of disease progression.
ENDOSCOPIC ULTRASOUND
(2021)