Review
Immunology
Cornelia Heuberger, Johanna Pott, Kevin Joseph Maloy
Summary: Intestinal epithelial cells play a dual role in antigen presentation, potentially activating effector T cells while also suppressing immune responses through regulatory T cell activation. The expression of MHC class II on IECs is tightly regulated and its impact on immune responses can vary depending on the specific conditions and cellular context.
Article
Immunology
Hideaki Fujiwara, Keisuke Seike, Michael D. Brooks, Anna Mathew, Ilya Kovalenko, Anupama Pal, Ho-Joon Lee, Daniel Peltier, Stephanie Kim, Chen Liu, Katherine Oravecz-Wilson, Lu Li, Yaping Sun, Jaeman Byun, Yoshinobu Maeda, Max S. Wicha, Tom Saunders, Alnawaz Rehemtulla, Costas A. Lyssiotis, Subramanian Pennarthur, Pavan Reddy
Summary: The alteration of IEC-specific mitochondrial complex II component SDHA plays a critical role in regulating the severity of T cell-mediated intestinal diseases, including graft-versus-host disease, inflammatory bowel disease and immune checkpoint blockade-mediated colitis.
Article
Immunology
Hussein Hamade, Jasmine T. Stamps, Dalton T. Stamps, Shyam K. More, Lisa S. Thomas, Anna Y. Blackwood, Nawele L. Lahcene, Sofi L. Castanon, Brenda C. Salumbides, Yosuke Shimodaira, Helen S. Goodridge, Stephan R. Targan, Kathrin S. Michelsen
Summary: Intestinal dendritic cells play an important role in metabolic syndrome by preserving beneficial microbiota and maintaining intestinal epithelial barrier function.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Fisheries
Marta Maruszewska-Cheruiyot, Katarzyna Donskow-Lysoniewska, Katarzyna Krawczak, Maja Machcinska, Maria Doligalska
Summary: In an inflammatory environment, the mouse intestinal parasite adaptively affects dendritic cell function, exacerbating inflammatory colitis symptoms.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yaying You, Yongtao Xiao, Ying Lu, Jun Du, Hui Cai, Wei Cai, Weihui Yan
Summary: The pathogenesis of IBD is complicated and still unclear. This study found that through the activation of NOD2 and MDP, gut inflammation can be alleviated and intestinal barrier repair can be promoted by regulating autophagy in intestinal epithelial cells, reducing intestinal barrier damage.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Xuemeng Si, Zhuan Song, Ning Liu, Hai Jia, Haozhen Liu, Zhenlong Wu
Summary: This study found that alpha-ketoglutarate (alpha-KG) has preventive effects on Citrobacter rodentium-induced colitis by regulating endoplasmic reticulum stress and activating Wnt signaling to restore barrier function.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Yuting Zhong, Ye Tu, Qingshan Ma, Linlin Chen, Wenzhao Zhang, Xin Lu, Shuo Yang, Zhibin Wang, Lichao Zhang
Summary: This study found that curcumin has potential therapeutic effects in ulcerative colitis by inhibiting necroptosis of intestinal epithelial cells through blocking the phosphorylation of RIP3 and MLKL. In mouse models, curcumin also inhibited inflammatory responses caused by necroptosis signaling pathway and improved colitis pathology.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Cristina Bauset, Lluis Lis-Lopez, Sandra Coll, Laura Gisbert-Ferrandiz, Dulce C. Macias-Ceja, Marta Seco-Cervera, Francisco Navarro, Juan Esplugues, Sara Calatayud, Dolores Ortiz-Masia, Maria D. Barrachina, Jesus Cosin-Roger
Summary: This study found that the succinate receptor SUCNR1 plays a role in both basal and stimulated inflammatory pathways in intestinal epithelial cells. It is significantly involved in inflammasome activation in Ulcerative Colitis (UC).
Article
Cell & Tissue Engineering
Semir Beyaz, Charlie Chung, Haiwei Mou, Khristian E. Bauer-Rowe, Michael E. Xifaras, Ilgin Ergin, Lenka Dohnalova, Moshe Biton, Karthik Shekhar, Onur Eskiocak, Katherine Papciak, Kadir Ozler, Mohammad Almeqdadi, Brian Yueh, Miriam Fein, Damodaran Annamalai, Eider Valle-Encinas, Aysegul Erdemir, Karoline Dogum, Vyom Shah, Aybuke Alici-Garipcan, Hannah V. Meyer, Deniz M. Ozata, Eran Elinav, Alper Kucukural, Pawan Kumar, Jeremy P. McAleer, James G. Fox, Christoph A. Thaiss, Aviv Regev, Jatin Roper, Stuart H. Orkin, Omer H. Yilmaz
Summary: A high-fat diet reduces MHC class II gene expression in intestinal epithelial cells, affecting microbiome diversity. The expression of epithelial MHC class II is regulated by intestinal flora through PRR and IFNg signaling. MHC-II-ISCs have greater tumor-initiating capacity compared to MHC-II+ counterparts under the influence of a high-fat diet, showing the role of immune surveillance in suppressing tumorigenesis.
Article
Geriatrics & Gerontology
Rosemary A. Hoffman, Sulan Huang, Geetha Chalasani, Abbe N. Vallejo
Summary: The study found that the absolute numbers of intraepithelial cells (iIEC) and plasmacytoid dendritic cells (pDC) are significantly lower in aged mice compared to young mice, despite an increase in the expression of C-C ligand 25 (CCL25). In both young and aged mice, the proportion and absolute number of intraepithelial pDC decreased during acute endotoxemia induced by lipopolysaccharide (LPS), potentially contributing to inadequate responses to gastrointestinal pathogens in aging.
Article
Multidisciplinary Sciences
Luke Goudie, Nicole L. Mancini, Timothy E. Shutt, Graham P. Holloway, Chunlong Mu, Arthur Wang, Derek M. McKay, Jane Shearer
Summary: Intestinal homeostasis relies on optimal epithelial barrier function and permeability, which are regulated by intestinal epithelial cells (IEC) acting as gatekeepers. Mitochondrial-based processes provide the energy for these energy demanding processes. However, routine methods for examining IEC mitochondrial function are limited. This study presents standardized methods for quantifying mitochondrial energetics in an immortalized IEC line.
SCIENTIFIC REPORTS
(2022)
Review
Immunology
Dmitriy S. S. Kravtsov, Amy K. K. Erbe, Paul M. M. Sondel, Alexander L. L. Rakhmilevich
Summary: It is well established that CD8+ T cells are effector cells in the adaptive immune response against tumors, while CD4+ T cells can either help or suppress the generation of CD8+ cytotoxic T cells. However, recent evidence has shown that CD4+ T cells can also play a role in antitumor immunity by directly killing tumor cells, activating innate immune cells, or reducing tumor angiogenesis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Huazhi Zhang, Zhihui Cui, Du Cheng, Yanyun Du, Xiaoli Guo, Ru Gao, Jianwen Chen, Wanwei Sun, Ruirui He, Xiaojian Ma, Qianwen Peng, Bradley N. Martin, Wei Yan, Yueguang Rong, Chenhui Wang
Summary: The gene RNF186 has been identified in genome-wide association studies as a susceptibility gene for ulcerative colitis, and it plays a crucial role in autophagy activation in colonic epithelial cells and intestinal homeostasis by regulating the ubiquitination of EPHB2. The absence of RNF186 and EPHB2 leads to a more severe phenotype in a colitis model, while treatment with ephrin-B1-Fc recombinant protein shows promise as a potential therapy for inflammatory bowel diseases.
Article
Gastroenterology & Hepatology
Chiara Muzzi, Norika Watanabe, Eric Twomey, Garrit K. Meers, Holger M. Reichardt, Hanibal Bohnenberger, Sybille D. Reichardt
Summary: This study highlights the important role of intestinal epithelial cells as targets of glucocorticoid action in inflammatory bowel disease, and suggests that the effectiveness of controlling colitis directly impacts the progression of colorectal cancer.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yu Yu, Wenjing Yang, Anthony J. Bilotta, Xiaojing Zhao, Yingzi Cong, Yanqing Li
Summary: The study found that host-derived L-lactate can promote intestinal epithelial cell (IEC) migration by increasing mitochondrial ATP production in IEC, aiding in promoting intestinal wound healing. Additionally, administering mice with L-lactate can suppress colitis induced by dextran sulfate sodium.
Article
Gastroenterology & Hepatology
Stacey Meeker, Audrey Seamons, Lillian Maggio-Price, Jisun Paik
WORLD JOURNAL OF GASTROENTEROLOGY
(2016)
Meeting Abstract
Gastroenterology & Hepatology
Badal Roy, Ishfaq Ahmed, Audrey Seamons, Shrikant Anant, Lillian Maggio-Price, Seth Septer, Shahid Umar
Article
Pathology
Audrey Seamons, Piper M. Treuting, Stacey Meeker, Charlie Hsu, Jisun Paik, Thea Brabb, Sabine S. Escobar, Jonathan S. Alexander, Aaron C. Ericsson, Jason G. Smith, Lillian Maggio-Price
AMERICAN JOURNAL OF PATHOLOGY
(2018)
Article
Oncology
Stacey Meeker, Audrey Seamons, Jisun Paik, Piper M. Treuting, Thea Brabb, William M. Grady, Lillian Maggio-Price
Article
Gastroenterology & Hepatology
Jisun Paik, Stacey Meeker, Charlie C. Hsu, Audrey Seamons, Olesya Pershutkina, Jessica M. Snyder, Thea Brabb, Lillian Maggio-Price
Article
Veterinary Sciences
Charlie C. Hsu, Karuna Patil, Audrey Seamons, Thea L. Brabb, Piper M. Treuting, Jisun Paik, Stacey M. Meeker, Lillian Maggio-Price
COMPARATIVE MEDICINE
(2020)
Article
Veterinary Sciences
Stacey M. Meeker, Audrey Seamons, Piper M. Treuting, Jisun Paik, Thea Brabb, Charlie C. Hsu, William M. Grady, Lillian Maggio-Price
COMPARATIVE MEDICINE
(2020)
Article
Veterinary Sciences
Christina Pettan-Brewer, Riley J. Trost, Lillian Maggio-Price, Audrey Seamons, Susan C. Dowling
JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE
(2020)
Article
Nutrition & Dietetics
Audrey Seamons, Michael Haenisch, Stacey Meeker, Olesya Pershutkina, Thea Brabb, Piper M. Treuting, Jisun Paik
Article
Nutrition & Dietetics
Audrey Seamons, Olesya Staucean, Jessica M. Snyder, Thea Brabb, Charlie C. Hsu, Jisun Paik
Summary: Limited treatment options for inflammatory bowel disease (IBD) call for new, cheaper, and easier treatment options. ALDH1A inhibition shows potential as a new target for IBD treatment, as it can effectively reduce clinical symptoms and improve histopathologic colitis scores in a chronic mouse model of IBD. The inhibition also influences various immune cell phenotypes during colitis. Future studies should evaluate the efficacy of ALDH1A inhibition on active colitis and compare it to approved drugs.
Meeting Abstract
Oncology
Badal C. Roy, Ishfaq Ahmed, Audrey Seamons, Shrikant Anant, Lillian Maggio-Price, Seth Septer, Shahid Umar
Article
Veterinary Sciences
Charlie C. Hsu, Jisun Paik, Thea L. Brabb, Kevin D. O'Brien, Jinkyu Kim, Brittany G. Sullivan, Kelly L. Hudkins, Audrey Seamons, Jennifer C. Finley, Stacey M. Meeker, Lillian Maggio-Price
COMPARATIVE MEDICINE
(2015)
Article
Veterinary Sciences
Jisun Paik, Fiona Kwok, Audrey Seamons, Thea Brabb, Jinkyu Kim, Brittany Sullivan, Charlie Hsu, Kevin D. O'Brien, Lillian Maggio-Price
COMPARATIVE MEDICINE
(2015)
Article
Veterinary Sciences
Charlie C. Hsu, Jisun Paik, Piper M. Treuting, Audrey Seamons, Stacey M. Meeker, Thea L. Brabb, Lillian Maggio-Price
COMPARATIVE MEDICINE
(2014)