Article
Gastroenterology & Hepatology
Elisa Rosati, Gabriela Rios Martini, Mikhail Pogorelyy, Anastasia A. Minervina, Frauke Degenhardt, Mareike Wendorff, Soner Sari, Gabriele Mayr, Antonella Fazio, Christel Marie Dowds, Charlotte Hauser, Florian Tran, Witigo von Schoenfels, Julius Pochhammer, Maria A. Salnikova, Charlot Jaeckel, Johannes Boy Gigla, Sanaz Sedghpour Sabet, Matthias Hubenthal, Esther Schiminsky, Stefan Schreiber, Philip C. Rosenstiel, Alexander Scheffold, Paul G. Thomas, Wolfgang Lieb, Bernd Bokemeyer, Maria Witte, Konrad Aden, Alexander Hendricks, Clemens Schafmayer, Jan-Hendrick Egberts, Ilgar Z. Mamedov, Petra Bacher, Andre Franke
Summary: This study identified and characterized a subpopulation of unconventional Crohn-associated invariant T (CAIT) cells, enriched in the blood of Crohn's disease (CD) patients. These cells exhibit an innate-like phenotype with gene expression similar to unconventional T cells, but with distinct TCRs. Further investigation is needed to determine the implications and antigen reactivity of these CAIT cells for CD.
Article
Biochemistry & Molecular Biology
Rodrigo Papa-Gobbi, Cecilia I. Muglia, Andres Rocca, Renata Curciarello, Alicia M. Sambuelli, Martin Yantorno, Gustavo Correa, Luciano G. Morosi, Antonio Di Sabatino, Paolo Biancheri, Thomas T. MacDonald, Marta A. Toscano, Karina V. Marino, Gabriel A. Rabinovich, Guillermo H. Docena
Summary: The study found that transient regulation of O-glycan profile during inflammation modulates Gal-1 binding and LP T-cell survival in IBD patients.
Article
Gastroenterology & Hepatology
Julien Kirchgesner, Rishi J. Desai, Maria C. Schneeweiss, Laurent Beaugerie, Sebastian Schneeweiss, Seoyoung C. Kim
Summary: Combination therapy with vedolizumab and thiopurines is associated with a lower risk of treatment failure compared to vedolizumab monotherapy in patients with CD, but the effect is less pronounced in UC.
Article
Gastroenterology & Hepatology
Markus F. Neurath, Michael Vieth
Summary: Mucosal healing is an important prognostic factor in the management of patients with inflammatory bowel disease. It can predict clinical remission and resection-free survival. There are two levels of mucosal healing: endoscopic healing and histological healing. Drug therapies and new techniques can have an impact on mucosal healing, but cannot provide a definitive cure.
Review
Immunology
Reza Yarani, Ali Shojaeian, Oana Palasca, Nadezhda T. Doncheva, Lars Juhl Jensen, Jan Gorodkin, Flemming Pociot
Summary: This review discusses the differential regulation of miRNAs in inflammatory bowel disease (IBD) and their potential diagnostic and therapeutic applications. Through literature curation and computational analysis, a consensus set of differentially expressed miRNAs in mucosal tissues was obtained. The role of these miRNAs and their potential targets in IBD are highlighted.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Tatsuki Noguchi, Soichiro Ishihara, Motoi Uchino, Hiroki Ikeuchi, Koji Okabayashi, Kitaro Futami, Shinji Tanaka, Hiroki Ohge, Hisashi Nagahara, Kazuhiro Watanabe, Michio Itabashi, Kinya Okamoto, Yoshiki Okita, Tsunekazu Mizushima, Yusuke Mizuuchi, Kazutaka Yamada, Yoshifumi Shimada, Yu Sato, Hideaki Kimura, Kenichi Takahashi, Koya Hida, Yusuke Kinugasa, Junji Okuda, Koji Daito, Fumikazu Koyama, Hideki Ueno, Takayuki Yamamoto, Tsunekazu Hanai, Atsuo Maemoto, Koji Oba, Yoichi Ajioka, Kenichi Sugihara
Summary: Patients with longstanding inflammatory bowel disease, such as ulcerative colitis and Crohn's disease, are at high risk of developing intestinal cancers. This study found significant differences between intestinal cancers associated with ulcerative colitis and Crohn's disease. Crohn's disease-associated cancers were diagnosed at more advanced stages, detected less frequently by surveillance, and had a poorer prognosis compared to those associated with ulcerative colitis.
JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Genetics & Heredity
Dasa Jevsinek Skok, Nina Hauptman, Miha Jerala, Nina Zidar
Summary: Ulcerative colitis (UC) and Crohn's disease (CD) involve imbalance in cytokine levels, with INSL5, LEFTY1, and BMP8B identified as potential key genes that may play a role in both diseases and require further investigation for diagnostic potential.
Article
Gastroenterology & Hepatology
Marina Liso, Giulio Verna, Elisabetta Cavalcanti, Stefania De Santis, Raffaele Armentano, Angela Tafaro, Antonio Lippolis, Pietro Campiglia, Antonio Gasbarrini, Mauro Mastronardi, Theresa Torres Pizarro, Fabio Cominelli, Loris Riccardo Lopetuso, Marcello Chieppa
Summary: This study provides new insights and alternative approaches to treat ulcerative colitis (UC) patients. It suggests that anti-interleukin (IL)1 strategies, such as anakinra, may be a more effective therapeutic option for primary nonresponders to anti-tumor necrosis factor (TNF) therapy.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Biochemical Research Methods
Florent Clerc, Karli R. Reiding, Noortje de Haan, Carolien A. M. Koeleman, Agnes L. Hipgrave Ederveen, Natalia Manetti, Viktoria Dotz, Vito Annese, Manfred Wuhrer
Summary: This study investigates the associations of immunoglobulin A1 and A2 glycosylation with inflammatory bowel diseases (IBD). Differences in IgA O- and N-glycosylation between patient groups were found to be associated with the diseases, and a statistical model was constructed to predict the disease group of the patients. These findings contribute to the development of noninvasive biomarkers for IBD and improvement in patient care.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Kazuhiko Uchiyama, Tomohisa Takagi, Katsura Mizushima, Kohei Asaeda, Mariko Kajiwara, Saori Kashiwagi, Yuki Toyokawa, Yuma Hotta, Makoto Tanaka, Ken Inoue, Osamu Dohi, Tetsuya Okayama, Naohisa Yoshida, Kazuhiro Katada, Kazuhiro Kamada, Takeshi Ishikawa, Hiroaki Yasuda, Hideyuki Konishi, Mitsuo Kishimoto, Yuji Naito, Yoshito Itoh
Summary: This study aimed to investigate the relationship between mucosal cytokine expression and subsequent relapse in ulcerative colitis patients with a Mayo endoscopic subscore of 0. The results showed that several cytokines were significantly elevated in patients with subsequent relapse, with interleukin-8 expression being the most useful predictor.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Immunology
Jacinta B. Smith, Jason J. Herbert, Naomi R. Truong, Anthony L. Cunningham
Summary: Herpes simplex viruses (HSV) types 1 and 2 are common infections in humans, causing oral and genital herpes. There is currently no vaccine or immunotherapy available for these diseases, making it crucial to understand the immunopathogenesis of HSV infections to develop preventive and therapeutic interventions.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Amy L. Lightner, Sarah Vogler, John McMichael, Xue Jia, Miguel Regueiro, Taha Qazi, Scott R. Steele
Summary: While UC patients were more likely to have neoplasia detected during colonoscopy, the rates of progression from LGD and HGD to adenocarcinoma were equivalent in UC and CD, suggesting consistent endoscopic surveillance strategies for all IBD patients.
JOURNAL OF CROHNS & COLITIS
(2021)
Article
Cell Biology
Neda Dadgar, Jessica Altemus, Yan Li, Amy L. Lightner
Summary: This study evaluated the immunomodulatory potential of mesenchymal stem cells (MSCs) and their extracellular vesicles (EVs) derived from the mesentery of Crohn's disease patients. It was found that MSCs and EVs from the diseased mesentery lost their ability to attenuate colitis, while MSCs and EVs from subcutaneous tissues showed effective inhibition of T-cell activation and inflammation.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Medicine, Research & Experimental
Xu Feng, Ye Xiao, Jian He, Mi Yang, Qi Guo, Tian Su, Yan Huang, Jun Yi, Chang-Jun Li, Xiang-Hang Luo, Xiao-Wei Liu, Hai-Yan Zhou
Summary: A study found that the long noncoding RNA Gm31629 plays a crucial role in inflammatory bowel disease by promoting E2F pathways and cell proliferation, thus facilitating intestinal epithelial regeneration. Deficiency of Gm31629 may lead to worsened intestinal inflammation and delayed epithelial regeneration.
Review
Chemistry, Medicinal
Jose Israel Rodrigues Jr, Joice Kelly Gomes de Vasconcelos, Lylian Ellen Militao dos Santos Xavier, Amanda da Silva Gomes, Juliana Celia de Farias Santos, Samara Bomfim Gomes Campos, Amylly Sanuelly da Paz Martins, Marilia Oliveira Fonseca Goulart, Fabiana Andrea Moura
Summary: The objective of this study was to assess the effectiveness of treatment for inflammatory bowel diseases in modulating oxidative stress biomarkers and cytokine levels. A systematic review and meta-analysis were conducted, and it was found that antioxidant capacity and lipid peroxidation levels were not significantly modulated, while superoxide dismutase levels showed significant modulation. However, there is still limited research on oxidative stress biomarkers and cytokines in the context of alternative therapies for IBD treatment. The results highlight the potential of antioxidant supplementation in IBD management and emphasize the need for further investigations into its effects on oxidative stress biomarkers and cytokines.
Editorial Material
Gastroenterology & Hepatology
Giuliano Francesco Bonura, Paola Soriani, Paolo Biancheri, Tommaso Gabbani, Mauro Manno
Review
Cell Biology
Giovanni Santacroce, Marco Vincenzo Lenti, Antonio Di Sabatino
Summary: Intestinal fibrosis is a threatening complication of Crohn's disease. The mechanisms underlying its development are not fully understood, and targeted therapies are currently lacking. This review provides an overview of the main therapeutic targets and the most promising anti-fibrotic therapies for intestinal fibrosis.
Article
Environmental Sciences
Michele Di Stefano, Natascia Brondino, Vera Bonaso, Emanuela Miceli, Francesco Lapia, Giacomo Grandi, Elisabetta Pagani, Gino Roberto Corazza, Antonio Di Sabatino
Summary: Patients with self-reported lactose intolerance are often unaware of the clinical presentation of this condition and accurate information is needed. Detection of symptom onset after lactose intake is an inaccurate test for lactose intolerance. Analysis of psychological characteristics in patients undergoing hydrogen breath test is not useful for selecting the subgroup at risk for a nocebo response.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Review
Biochemistry & Molecular Biology
Michele Di Stefano, Emanuela Miceli, Caterina Mengoli, Gino Roberto Corazza, Antonio Di Sabatino
Summary: Celiac disease is a chronic autoimmune disorder affecting the small intestine, leading to villous atrophy, crypt hyperplasia, and an increase in intraepithelial lymphocytes. This condition often causes disturbances in bone mass and mineral metabolism, including changes in serum levels of vitamin D. A gluten-free diet can reverse these abnormalities, raising questions about the necessity of vitamin supplementation for all patients. Currently available data do not support widespread use of vitamin supplementation, and a thorough evaluation of bone and mineral metabolism is needed to determine which patients require this approach.
Letter
Gastroenterology & Hepatology
Paolo Biancheri, Paola Soriani, Tommaso Gabbani, Giuliano Francesco Bonura, Mauro Manno
DIGESTIVE AND LIVER DISEASE
(2023)
Review
Nutrition & Dietetics
Carlo Maria Rossi, Marco Vincenzo Lenti, Stefania Merli, Hellas Cena, Antonio Di Sabatino
Summary: Allergen-free diets are an effective therapy for eosinophilic esophagitis, but should be approached with caution to reduce side effects and improve adherence. Empirical diets with fewer eliminated food categories and a step-up approach are recommended to minimize endoscopies and improve clinical outcomes. Geographical sensitization patterns may be relevant in specific regions.
Article
Oncology
Marco Lucioni, Sara Fraticelli, Giovanni Santacroce, Arturo Bonometti, Nicola Aronico, Roberta Sciarra, Marco Vincenzo Lenti, Paola Ilaria Bianchi, Giuseppe Neri, Monica Feltri, Benedetto Neri, Giuseppina Ferrario, Roberta Riboni, Gino Roberto Corazza, Alessandro Vanoli, Luca Arcaini, Marco Paulli, Antonio Di Sabatino
Summary: This retrospective study aimed to describe the clinical-pathological characteristics of intestinal T-cell lymphomas (ITCL) and possibly identify their hallmarks. The study included 28 patients, with most cases associated with celiac disease. The presence of CD, peripheral lymphocytosis, advanced Lugano clinical stage, and the histological subtype ITCL-NOS were significantly associated with worse survival.
Article
Oncology
Chiara Barteselli, Stefano Mazza, Valentina Ravetta, Francesca Torello Viera, Letizia Veronese, Chiara Frigerio, Giulia Gori, Gaetano Bergamaschi, Carmelo Sgarlata, Antonio Facciorusso, Marcello Maestri, Antonio Di Sabatino, Andrea Anderloni
Summary: This study aimed to evaluate whether different ultrasound patterns were associated with tumor prognosis in hepatocellular carcinoma (HCC) patients. The findings demonstrated that different ultrasound patterns correlated with different survival outcomes and tumor behavior in patients with HCC.
Meeting Abstract
Medicine, General & Internal
G. Santacroce, M. V. Lenti, G. Fornasa, I. Spadoni, A. Pasini, G. R. Corazza, M. Rescigno, A. Di Sabatino
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Meeting Abstract
Medicine, General & Internal
C. Frenna, M. V. Lenti, E. Miceli, A. Pasini, G. Santacroce, A. Mauro, G. R. Corazza, A. Di Sabatino
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Meeting Abstract
Gastroenterology & Hepatology
N. Aronico, A. Bonometti, P. Bianchi, M. Lenti, G. Santacroce, S. Fraticelli, M. A. Latorre, G. Alunno, G. R. Corazza, M. Lucioni, M. Paulli, A. Di Sabatino
DIGESTIVE AND LIVER DISEASE
(2022)
Meeting Abstract
Gastroenterology & Hepatology
M. Lenti, D. G. Ribaldone, M. Vernero, Borrelli F. De Andreis, E. Savarino, F. Zingone, F. Sottotetti, M. Cappello, D. Brinch, N. Silvestris, C. M. Rossi, G. Santacroce, C. Klersy, F. De Grazia, A. Pagani, S. Muscarella, O. Brunetti, M. De Ruvo, A. Premoli, P. Pedrazzoli, G. R. Corazza, A. Di Sabatino
DIGESTIVE AND LIVER DISEASE
(2022)
Meeting Abstract
Gastroenterology & Hepatology
M. Lenti, E. Miceli, A. Pasini, G. Santacroce, A. Mauro, G. R. Corazza, A. Di Sabatino
DIGESTIVE AND LIVER DISEASE
(2022)
Meeting Abstract
Gastroenterology & Hepatology
M. Lenti, G. Fornasa, I Spadoni, A. Pasini, G. Santacroce, G. R. Corazza, M. Rescigno, A. Di Sabatino
DIGESTIVE AND LIVER DISEASE
(2022)
Meeting Abstract
Gastroenterology & Hepatology
M. Lenti, G. Broglio, C. Mengoli, S. Cococcia, Borrelli F. De Andreis, M. Delliponti, C. Klersy, G. R. Corazza, A. Di Sabatino
DIGESTIVE AND LIVER DISEASE
(2022)
