Article
Dentistry, Oral Surgery & Medicine
Rafaela D. Parolina de Carvalho, Jessica de Andrade Moreno, Sindy Magri Roque, Daniel Cheuk Hong Chan, Willy Bustillos Torrez, Rafael Nobrega Stipp, Bruno Bueno-Silva, Patricia Oliveira de Lima, Karina Cogo-Muller
Summary: Simvastatin showed strong antimicrobial activity against oral bacteria, especially against Porphyromonas gingivalis. It also exhibited synergistic interaction with amoxicillin against Streptococcus oralis and Streptococcus sanguinis. Simvastatin inhibited biofilm formation of P. gingivalis and reduced the metabolic activity and total counts of multispecies biofilm.
Article
Cardiac & Cardiovascular Systems
Ciaran N. Kohli-Lynch, James Lewsey, Kathleen A. Boyd, Dustin D. French, Neil Jordan, Andrew E. Moran, Naveed Sattar, David Preiss, Andrew H. Briggs
Summary: This study evaluates the cost-effectiveness of expanding preventive statin eligibility and novel approaches to prioritization from a Scottish health sector perspective. The findings suggest that generic pricing has made preventive statin therapy cost-effective for many adults. Additionally, an approach using absolute risk reduction (ARR)-guided therapy is more effective and cost-effective than the traditional method based on 10-year risk assessment.
Review
Clinical Neurology
Jong S. Kim
Summary: Hyperlipidemia is an important risk factor for ischemic stroke, and statins have been shown to benefit stroke patients. Guidelines now emphasize high-intensity statins and low LDL-C target strategies for stroke patients, but the benefits of lipid-lowering therapy vary among patients with different levels of cerebral arterial diseases.
Article
Health Care Sciences & Services
Tak Kyu Oh, In-Ae Song, Young-Tae Jeon
Summary: Statin therapy may have potential benefits for the prevention of COVID-19 in South Korea, but it does not affect the hospital mortality of patients diagnosed with COVID-19.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Bom Lee, Sung-Jin Hong, Seung-Woon Rha, Jung Ho Heo, Seung-Ho Hur, Hyun Hee Choi, Kyung-Jin Kim, Ju Han Kim, Hyun Kuk Kim, Ung Kim, Yu Jeong Choi, Yong-Joon Lee, Seung-Jun Lee, Chul-Min Ahn, Young-Guk Ko, Byeong-Keuk Kim, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang, Jung-Sun Kim
Summary: The combination therapy of moderate-intensity statin plus ezetimibe showed consistent effectiveness in reducing cardiovascular outcomes for patients with atherosclerotic cardiovascular disease (ASCVD), regardless of their baseline low-density lipoprotein cholesterol (LDL-C) levels.
Article
Health Care Sciences & Services
Armando Chaure-Pardos, Isabel Aguilar-Palacio, Ma Jose Rabanaque, Ma Jesus Lallana, Lina Maldonado, Sara Castel-Feced, Julian Librero, Jose Antonio Casasnovas, Sara Malo
Summary: This study analyzed the effectiveness of statin therapy for primary prevention of cardiovascular disease in low- and medium-risk patients. The results suggest that statin treatment for primary prevention in individuals with low and medium cardiovascular risk may be inefficient, but improves with better adherence and in patients with higher risk.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Sebastian-Edgar Baumeister, Birte Holtfreter, Stefan Lars Reckelkamm, Thomas Kocher, Zoheir Alayash, Benjamin Ehmke, Hansjorg Baurecht, Michael Nolde
Summary: Genetically proxied inhibition of NCP1L1 and PCSK9 was associated with lower odds of periodontitis, while genetically proxied HMGCR inhibition was not associated with periodontitis.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Article
Endocrinology & Metabolism
You-Bin Lee, Minji Koo, Eunjin Noh, Soon Young Hwang, Jung A. Kim, Eun Roh, So-Hyeon Hong, Kyung Mook Choi, Sei Hyun Baik, Geum Joon Cho, Hye Jin Yoo
Summary: This study explored the relationship between low-density lipoprotein cholesterol (LDL-C) levels and the risks of myocardial infarction (MI), stroke, and all-cause death among older adults. The findings indicate that lower LDL-C is associated with reduced risks of MI and stroke. However, the risk of all-cause death follows an inverted J-shaped pattern with LDL-C levels. Intensive statin therapy, which lowers LDL-C, is beneficial for older adults with cardiovascular risk factors like diabetes.
DIABETES & METABOLISM JOURNAL
(2022)
Article
Urology & Nephrology
Sunjae Bae, JiYoon B. Ahn, Corey Joseph, Ryan Whisler, Mark A. Schnitzler, Krista L. Lentine, Bernard S. Kadosh, Dorry L. Segev, Mara A. McAdams-DeMarco
Summary: Statins appear to be well tolerated in kidney transplant recipients, but their use may be associated with a slightly higher risk of post-transplant diabetes mellitus, cataract, and rhabdomyolysis.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Zhen Zhou, Joanne Ryan, Michael E. Ernst, Sophia Zoungas, Andrew M. Tonkin, Robyn L. Woods, John J. McNeil, Christopher M. Reid, Andrea J. Curtis, Rory Wolfe, Jo Wrigglesworth, Raj C. Shah, Elsdon Storey, Anne Murray, Suzanne G. Orchard, Mark R. Nelson
Summary: The study found that statin therapy in adults aged 65 and older was not associated with incident dementia, MCI, or declines in individual cognition domains. The impact of statin lipophilicity and baseline neurocognitive ability on these associations was also explored. Further confirmation from ongoing randomized trials is needed.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Neurosciences
Guangshuo Li, Shang Wang, Yunyun Xiong, Hongqiu Gu, Kaixuan Yang, Xin Yang, Chunjuan Wang, Chuanying Wang, Zixiao Li, Xingquan Zhao
Summary: This study aimed to compare in-hospital mortality and evacuation rates of intracranial hematoma in patients with primary intracerebral hemorrhage who were prior statin users and nonusers. The results showed that prior statin use was not associated with in-hospital mortality but reduced the proportion of patients undergoing evacuation of intracranial hematoma.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Immunology
Thomas Khoo, Hector Chinoy
Summary: The discovery of autoantibodies against the HMGCR enzyme has defined a subset of immune-mediated necrotizing myopathy strongly associated with statin medications. However, there are still many unanswered questions regarding the incidence, phenotype, treatment, and association with malignancies of anti-HMGCR IMNM. This review aims to summarize the current literature and discuss these remaining issues.
AUTOIMMUNITY REVIEWS
(2023)
Article
Cardiac & Cardiovascular Systems
Liping Zhu, Fangbo Liu, Qiang Hao, Tian Feng, Zeshuai Chen, Shengquan Luo, Rui Xiao, Mengxiang Sun, Ting Zhang, Xiaohang Fan, Xianqin Zeng, Jianguo He, Ping Yuan, Jinming Liu, Matthieu Ruiz, Jocelyn Dupuis, Qinghua Hu
Summary: Dietary levels of GGPP play a significant role in interfering with the effects of statin therapy in experimental pulmonary hypertension. Higher dietary GGPP content may reduce or abolish the therapeutic effects of statins, potentially through the activation of the RhoA-ROCK2 cascade and Rab10-mediated CaSR membrane trafficking.
Article
Hematology
Jeremy D. Furtado, Giacomo Ruotolo, Stephen J. Nicholls, Robert Dullea, Santos Carvajal-Gonzalez, Frank M. Sacks
Summary: This study suggests that increasing HDL by inhibiting CETP does not reduce the risk of cardiovascular disease but instead increases the levels of dysfunctional HDL subspecies associated with higher risk.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Medicine, General & Internal
Jong -Il Park, Seung-Jun Lee, Bum-Kee Hong, Yun-Hyeong Cho, Won-Yong Shin, Sang-Wook Lim, Woong-Chol Kang, Yongwhi Park, Sung-Yoon Lee, Yong-Joon Lee, Sung-Jin Hong, Chul-Min Ahn, Byeong-Keuk Kim, Young-Guk Ko, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang, Jung-Sun Kim
Summary: This study analyzed the effects of ezetimibe combination therapy with moderate-intensity statins in patients with atherosclerotic cardiovascular disease following percutaneous coronary intervention. The results showed that the combination therapy did not increase the risk of cardiovascular events and was effective in reducing low-density lipoprotein cholesterol levels.
Article
Pharmacology & Pharmacy
Richard A. Hansen, Yulia Khodneva, Stephen P. Glasser, Jingjing Qian, Nicole Redmond, Monika M. Safford
ANNALS OF PHARMACOTHERAPY
(2016)
Article
Pharmacology & Pharmacy
Enrique Seoane-Vazquez, Rosa Rodriguez-Monguio, Richard Hansen
CLINICAL DRUG INVESTIGATION
(2016)
Editorial Material
Gastroenterology & Hepatology
Seth D. Crockett, John A. Baron
Article
Peripheral Vascular Disease
Kalyani B. Sonawane Deshmukh, Jingjing Qian, Kimberly B. Garza, Bradley M. Wright, Peng Zeng, Cecilia M. Ganduglia Cazaban, Richard A. Hansen
JOURNAL OF CLINICAL HYPERTENSION
(2016)
Article
Peripheral Vascular Disease
Kalyani B. Sonawane, Jingjing Qian, Kimberly B. Garza, Bradley M. Wright, Peng Zeng, Cecilia M. Ganduglia-Cazaban, Richard A. Hansen
JOURNAL OF HYPERTENSION
(2016)
Editorial Material
Gastroenterology & Hepatology
Nazar Hafiz, Kevin G. Greene, Seth D. Crockett
Letter
Medicine, General & Internal
Seth D. Crockett
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2017)
Review
Public, Environmental & Occupational Health
Brendon M. O'Connell, Seth D. Crockett
CLINICAL EPIDEMIOLOGY
(2017)
Article
Gastroenterology & Hepatology
Ateev Mehrotra, Michele Morris, Rebecca A. Gourevitch, David S. Carrell, Daniel A. Leffler, Sherri Rose, Julia B. Greer, Seth D. Crockett, Andrew Baer, Robert E. Schoen
GASTROINTESTINAL ENDOSCOPY
(2018)
Article
Gastroenterology & Hepatology
Seth D. Crockett, Elizabeth L. Barry, Leila A. Mott, Dennis J. Ahnen, Douglas J. Robertson, Joseph C. Anderson, Kristen Wallace, Carol A. Burke, Robert S. Bresalier, Jane C. Figueiredo, Dale C. Snover, John A. Baron
Article
Gastroenterology & Hepatology
Sarah R. Lieber, Benjamin J. Heller, Christopher W. Howard, Robert S. Sandler, Seth Crockett, Alfred Sidney Barritt
Article
Gastroenterology & Hepatology
Seth D. Crockett, Mouen Khashab, Douglas K. Rex, Ian S. Grimm, Matthew T. Moyer, Amit Rastogi, Todd A. Mackenzie, Heiko Pohl
Summary: This study found that the risk of post-procedure bleeding is low for large serrated polyps removed via endoscopic mucosal resection (EMR), and there is no discernable benefit of prophylactic clipping of the resection base in this group. However, for large adenomatous polyps, clipping was associated with a lower risk of post-procedure bleeding and overall serious adverse events.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Oncology
Seth D. Crockett, Elizabeth L. Barry, Leila A. Mott, Dale C. Snover, Kristin Wallace, John A. Baron
Summary: This study found that risk factors for serrated polyps differed by race, alcohol and smoking status, and prior history of polyps. These findings allow for better risk stratification of patients undergoing colorectal cancer screening.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Letter
Gastroenterology & Hepatology
Seth D. Crockett, Uri Ladabaum
Article
Oncology
Soohyun Hwang, Allison J. Lazard, Meredith K. Reffner Collins, Alison T. Brenner, Hillary M. Heiling, Allison M. Deal, Seth D. Crockett, Daniel S. Reuland, Jennifer Elston Lafata
Summary: Text messages are an acceptable and effective way to engage diverse individuals in colorectal cancer screening decisions and support shared decision-making. Participants from historically marginalized categories, such as those with low income, low health literacy, and Black/African American background, showed high acceptability and willingness to use similar programs.