Article
Multidisciplinary Sciences
Tawnya M. Hansen, Zoann Nugent, Charles N. Bernstein, N. Jewel Samadder, Sanjay K. Murthy, Harminder Singh
Summary: The risk of death following CRC diagnosis is not affected by a diagnosis of IBD in recent years. There is a high proportion of post colonoscopy CRC among IBD-CRC patients, which has remained unchanged over the years and requires detailed root-cause analysis and interventions.
Review
Gastroenterology & Hepatology
Jordan E. Axelrad, Raymond K. Cross
Summary: Patients with chronic ulcerative and Crohn's colitis have a higher risk of developing colorectal neoplasia (CRN [dysplasia and cancer]) compared to the general population. Risk factors for CRN include the extent of colitis, cumulative inflammatory burden, family history of colorectal cancer, and primary sclerosing cholangitis. Best practices for preventing CRN involve controlling colonic inflammation, conducting high quality surveillance colonoscopy with or without enhanced imaging techniques, removing visible dysplasia if possible, and considering colectomy for patients with unresectable dysplasia, invisible multifocal low-grade dysplasia, or invisible high-grade dysplasia. The decision to stop dysplasia surveillance should be individualized and based on factors such as age, frailty, comorbid conditions, life expectancy, previous surveillance exam results, and risk factors for CRN.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Jose Maria Huguet, Luis Ferrer-Barcelo, Patricia Suarez, Eva Sanchez, Jose David Prieto, Victor Garcia, Javier Sempere
Summary: The detection of dysplasia in IBD patients is important and chromoendoscopy with targeted biopsy remains the preferred technique. However, other techniques such as virtual chromoendoscopy are being compared due to their similar results and fewer technical difficulties. New endoscopy techniques and improved devices have the potential to revolutionize the screening and follow-up of dysplasia in IBD patients. Further research is needed to define the optimal follow-up strategy.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Oncology
Mostafa Vaghari-Tabari, Niloufar Targhazeh, Soheila Moein, Durdi Qujeq, Forough Alemi, Maryam Majidina, Simin Younesi, Zatollah Asemi, Bahman Yousefi
Summary: Inflammatory Bowel Disease (IBD) is a chronic inflammatory disease with relapse and remission periods, and it increases the risk of colorectal cancer, especially in patients with Ulcerative colitis. The importance of miRNAs in the pathophysiology of IBD and colorectal cancer has been recognized, and they may be potential therapeutic targets.
CANCER CELL INTERNATIONAL
(2022)
Article
Gastroenterology & Hepatology
Jordan E. Axelrad, Adam Faye, James C. Slaughter, Noam Harpaz, Steven H. Itzkowitz, Shailja C. Shah
Summary: Colorectal strictures in patients with inflammatory bowel disease (IBD) are not independently associated with the risk of advanced colorectal neoplasia (ACRN) or colectomy, according to a retrospective cohort analysis. Further multicenter, prospective studies are needed to confirm these findings.
INFLAMMATORY BOWEL DISEASES
(2022)
Review
Biochemistry & Molecular Biology
Vishal Khatri, Ramaswamy Kalyanasundaram
Summary: This review focuses on the association between IBD and gut inflammasome, as well as recent advances in research and therapeutic strategies for IBD, discussing inflammasomes and their components, outcomes from experimental animals and human studies, inflammasome inhibitors, and developments in inflammasome-targeted therapies for IBD.
Review
Biochemistry & Molecular Biology
HyunTaek Jung, Jae Seok Kim, Keum Hwa Lee, Kalthoum Tizaoui, Salvatore Terrazzino, Sarah Cargnin, Lee Smith, Ai Koyanagi, Louis Jacob, Han Li, Sung Hwi Hong, Dong Keon Yon, Seung Won Lee, Min Seo Kim, Paul Wasuwanich, Wikrom Karnsakul, Jae Il Shin, Andreas Kronbichler
Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract that mainly affects young people. Recent studies have shown that microRNAs (miRNAs) play an important role in the pathogenesis, diagnosis, and treatment of IBD.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Surgery
Can Lu, Josefine Schardey, Tao Zhang, Alexander Crispin, Ulrich Wirth, Konrad W. Karcz, Alexandr Bazhin, Joachim Andrassy, Jens Werner, Florian Kuehn
Summary: This study conducted a systematic review and meta-analysis to compare the survival outcomes of IBD-associated and non-IBD-associated CRC. The results showed that IBD-CRC patients had a significantly worse overall survival than those without IBD. This may be attributed to more aggressive histological characteristics and a lower rate of R0 resections at the primary tumor site.
Article
Gastroenterology & Hepatology
Uma Mahadevan, Millie D. Long, Sunanda Kane, Abhik Roy, Marla C. Dubinsky, Bruce E. Sands, Russell D. Cohen, Christina D. Chambers, William J. Sandborn
Summary: The study found that exposure to biologic, thiopurine, or combination therapy during pregnancy did not increase adverse maternal or fetal outcomes, and these treatments can be continued throughout pregnancy for women with IBD to maintain disease control.
Article
Medicine, General & Internal
Silvia Salvatori, Francesco Baldassarre, Michelangela Mossa, Giovanni Monteleone
Summary: Long COVID is common in patients with inflammatory bowel diseases (IBD), with fatigue being the most frequent symptom. It does not influence the frequency of IBD relapses, but is more prevalent in female patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Gastroenterology & Hepatology
Thomas M. Goodsall, Tran M. Nguyen, Claire E. Parker, Christopher Ma, Jane M. Andrews, Vipul Jairath, Robert Bryant
Summary: The study systematically identified ultrasound scoring indices for assessing inflammatory bowel disease activity, with common components including bowel wall thickness, colour Doppler imaging, and bowel wall stratification. The correlation between ultrasound indices and reference standards, as well as sensitivity, specificity, accuracy, and other properties, varied within certain ranges. However, reliability and responsiveness data were limited, and most studies were rated with unclear or high risk of bias.
JOURNAL OF CROHNS & COLITIS
(2021)
Review
Medicine, General & Internal
Katarzyna Akutko, Andrzej Stawarski
Summary: Inflammatory bowel diseases (IBD) are chronic inflammatory diseases of the digestive tract with periods of remission and relapses. The etiopathogenesis is not fully understood, leading to only symptomatic treatment. There is a constant need to search for new high safety profile therapies for IBD.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Gastroenterology & Hepatology
Anouk M. Wijnands, Michiel E. de Jong, Maurice W. M. D. Lutgens, Frank Hoentjen, Sjoerd G. Elias, Bas Oldenburg
Summary: A systematic review and meta-analysis identified 13 risk factors and 5 protective factors for advanced colorectal neoplasia in IBD patients. These findings could contribute to an improved surveillance based on CRC risk stratification in IBD.
Article
Medicine, General & Internal
Naim Abu-Freha, Bracha Cohen, Michal Gordon, Sarah Weissmann, Emily H. Kestenbaum, Sergei Vosko, Muhammad Abu-Tailakh, Liza Ben-Shoshan, Daniel L. Cohen, Haim Shirin
Summary: This study investigated the prevalence and risk factors of CRC among a large cohort of IBD patients. The results showed that the rate of CRC was higher in CD and UC patients compared to the general population. Age, primary sclerosing cholangitis, diabetes mellitus, and glucocorticoids treatment were found to be predictors of CRC. Therefore, IBD patients, especially those with risk factors, should be closely monitored for CRC.
FRONTIERS IN MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Kristiina Rajamaki, Aurora Taira, Riku Katainen, Niko Valimaki, Anna Kuosmanen, Roosa-Maria Plaketti, Toni T. Seppala, Maarit Ahtiainen, Erkki-Ville Wirta, Emilia Vartiainen, Paivi Sulo, Janne Ravantti, Suvi Lehtipuro, Kirsi J. Granberg, Matti Nykter, Tomas Tanskanen, Ari Ristimaki, Selja Koskensalo, Laura Renkonen-Sinisalo, Anna Lepisto, Jan Bohm, Jussi Taipale, Jukka-Pekka Mecklin, Mervi Aavikko, Kimmo Palin, Lauri A. Aaltonen
Summary: By comprehensively characterizing IBD-associated tumorigenesis using multiple high-throughput approaches, distinct mechanisms of WNT pathway dysregulation were identified in IBD-CRC, which skew the tumors towards a mesenchymal subtype. Additionally, epigenetic modifications and noncoding mutations in specific genes were found in IBD-CRC, highlighting further differences compared to sCRC.
Article
Gastroenterology & Hepatology
William C. Chen, Richard R. P. Warner, Noam Harpaz, Hongfa Zhu, Sasan Roayaie, Michelle Kang Kim
Letter
Gastroenterology & Hepatology
Noam Harpaz, Samuel Ballentine, Jean-Frederic Colombel, Bruce E. Sands, Huabin Mabel Ko
Review
Gastroenterology & Hepatology
Ilyssa O. Gordon, Dominik Bettenworth, Arne Bokemeyer, Amitabh Srivastava, Christophe Rosty, Gert de Hertogh, Marie E. Robert, Mark A. Valasek, Ren Mao, Satya Kurada, Noam Harpaz, Paula Borralho, Reetesh K. Pai, Rish K. Pai, Robert Odze, Roger Feakins, Claire E. Parker, Tran Nguyen, Vipul Jairath, Mark E. Baker, David H. Bruining, J. G. Fletcher, Brian G. Feagan, Florian Rieder
Article
Cell Biology
Xiaoyan Liao, Vera Vavinskaya, Katherine Sun, Yansheng Hao, Xiaodong Li, Mark Valasek, Ruliang Xu, Alexandros D. Polydorides, Jane Houldsworth, Noam Harpaz
Meeting Abstract
Medicine, Research & Experimental
Zongxian Cao, Zhenjian Cai, Samuel Ballentine, Manju Ambelil, Alexandros Polydorides, Hongfa Zhu, Huaibin Mabel Ko, Qingqing Liu, Noam Harpaz
LABORATORY INVESTIGATION
(2019)
Meeting Abstract
Medicine, Research & Experimental
Samuel Ballentine, Noam Harpaz, Hongfa Zhu, Huaibin Mabel Ko, Qingqing Liu, Manju Ambelil, Zongxian Cao, Alexandros Polydorides
LABORATORY INVESTIGATION
(2019)
Meeting Abstract
Pathology
Samuel Ballentine, Noam Harpaz, Hongfa Zhu, Huaibin Mabel Ko, Qingqing Liu, Manju Ambelil, Zongxian Cao, Alexandros Polydorides
Meeting Abstract
Medicine, Research & Experimental
Natalie Patel, Till Clauditz, Mai Iwaya, Noam Harpaz, Gregory Lauwers, Robert Riddell, Dhanpat Jain
LABORATORY INVESTIGATION
(2019)
Meeting Abstract
Pathology
Natalie Patel, Till Clauditz, Mai Iwaya, Noam Harpaz, Gregory Lauwers, Robert Riddell, Dhanpat Jain
Meeting Abstract
Medicine, Research & Experimental
Xiaoyan Liao, Vera Vavinskaya, Katherine Sun, Yansheng Hao, Xiaodong Li, Mark Valasek, Jane Houldsworth, Noam Harpaz
LABORATORY INVESTIGATION
(2019)
Meeting Abstract
Medicine, Research & Experimental
Xiaoyan Liao, Yansheng Hao, Abul Ala Syed Rifat Mannan, Shafinaz Hussein, Noam Harpaz, Huaibin Mabel Ko
LABORATORY INVESTIGATION
(2019)
Meeting Abstract
Pathology
Xiaoyan Liao, Vera Vavinskaya, Katherine Sun, Yansheng Hao, Xiaodong Li, Mark Valasek, Jane Houldsworth, Noam Harpaz
Meeting Abstract
Pathology
Xiaoyan Liao, Yansheng Hao, Abul Ala Syed Rifat Mannan, Shafinaz Hussein, Noam Harpaz, Huaibin Mabel Ko
Meeting Abstract
Gastroenterology & Hepatology
Aryeh Stock, Huaibin M. Ko, Kanika Kamal, Clara Yzet, Yansheng Hao, Noam Harpaz, Russell B. McBride
Meeting Abstract
Gastroenterology & Hepatology
Samuel Ballentine, Huaibin M. Ko, Jean Frederic Colombel, Bruce E. Sands, Noam Harpaz