Article
Gastroenterology & Hepatology
Gaetano Bergamaschi, Fabiana Castiglione, Renata D'Inca, Marco Astegiano, Walter Fries, Monica Milla, Carolina Ciacci, Fernando Rizzello, Simone Saibeni, Rachele Ciccocioppo, Ambrogio Orlando, Fabrizio Bossa, Mariabeatrice Principi, Piero Vernia, Chiara Ricci, Maria L. Scribano, Giorgia Bodini, Dario Mazzucco, Gabrio Bassotti, Gabriele Riegler, Andrea Buda, Matteo Neri, Flavio Caprioli, Fabio Monica, Aldo Manca, Erica Villa, Gionata Fiorino, Michele Comberlato, Nicola Aronico, Cristina Della Corte, Roberta Caccaro, Paolo Gionchetti, Paolo Giuffrida, Paola Iovino, Marco Lenti, Caterina Mengoli, Lucienne Pellegrini, Alberto Pieraccini, Davide Ribaldone, Anna Testa, Cristina Ubezio, Anna Viola, Maurizio Vecchi, Catherine Klersy, Antonio Di Sabatino
Summary: The prevalence of anemia in Italian IBD patients is lower than previously reported, with the majority being caused by iron deficiency and leading to fatigue and decreased quality of life. However, a large proportion of patients with iron and/or vitamin deficiencies remain untreated.
INFLAMMATORY BOWEL DISEASES
(2023)
Review
Immunology
Yanrui Wu, Chuan Liu, Weiguo Dong
Summary: Growing evidence suggests that micronutrient status may affect the course of inflammatory bowel disease (IBD), but deficiencies are often overlooked during treatment. Studies have focused on vitamin D and iron supplementation, but research on other vitamins and minerals is still limited. This review provides an overview of the therapeutic effects of micronutrient supplementation in IBD, aiming to draw attention to monitoring and supplementation in IBD patients and provide perspectives for future research.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Tyler Atagozli, David E. Elliott, Mirac Nedim Ince
Summary: Helminths are multicellular invertebrates that live in the gut of vertebrate animals, including humans. They can cause pathology and require treatment, but can also have commensal or symbiotic relationships with their hosts. Epidemiological data suggests that helminth exposure may provide protection against immune disorders, such as allergies and autoimmune illnesses.
Article
Nutrition & Dietetics
Nabeel Moon, Bradley Figgins, Ellery Altshuler, Angela Pham, Amir Y. Kamel
Summary: Limited evidence is available on the prevalence, causes, and consequences of zinc and vitamin B-6 deficiencies in those with acutely exacerbated inflammatory bowel disease. Cases of two patients with IBD exacerbations demonstrated the need for increased screening for these deficiencies during disease exacerbation. Prophylactic oral zinc and pyridoxine supplementation may be considered for patients at risk for deficiencies during flares, with close monitoring for subsequent iron and copper deficiencies.
NUTRITION IN CLINICAL PRACTICE
(2022)
Article
Immunology
Huldani Huldani, Ria Margiana, Fawad Ahmad, Maria Jade Catalan Opulencia, Mohammad Javed Ansari, Dmitry Olegovich Bokov, Nargiza N. Abdullaeva, Homayoon Siahmansouri
Summary: Inflammatory bowel disease (IBD) is caused by various pathophysiologic pathways and immune-pathologic etiologies. Mesenchymal Stem Cells (MSCs) have been suggested as a potential treatment for IBD due to their immune regulatory functions. Clinical trials using MSCs from bone marrow, umbilical cord, and adipose tissue have shown promising results in terms of safety. However, further research is needed to obtain more reliable results and more support from laboratory evidence.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Chao Liu, Yuhong Jiang, Ganglei Liu, Zhushu Guo, Qianqian Jin, Dongju Long, Weihan Zhou, Ke Qian, Hua Zhao, Kuijie Liu
Summary: This study found that PPARGC1A was downregulated in DSS-induced colitis and DSS-stimulated colonic epithelial cells, and PDT treatment could upregulate PPARGC1A expression. Knockdown of PPARGC1A could attenuate the therapeutic effects of PDT on DSS-induced colitis and DSS-stimulated colonic epithelial cells.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Medicine, General & Internal
Aleksandra Kubas, Ewa Malecka-Wojciesko
Summary: Vaccination against COVID-19 is considered safe and effective for patients with IBD, although further research is needed to understand its safety in special populations. The willingness to receive the vaccine among IBD patients is conflicting, with concerns about effectiveness and safety being the most common reasons for hesitancy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Benjamin Langan Gordon, Jonathan S. Galati, Stevie Yang, Randy S. Longman, Dana Lukin, Ellen J. Scherl, Robert Battat
Summary: Vitamin C deficiency is common in patients with inflammatory bowel disease, especially in those with elevated inflammatory markers and penetrating disease.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Nutrition & Dietetics
Alicja Ewa Ratajczak, Aleksandra Szymczak-Tomczak, Anna Maria Rychter, Agnieszka Zawada, Agnieszka Dobrowolska, Iwona Krela-Kazmierczak
Summary: Folic acid, a water-soluble substance, plays a role in the synthesis of nucleic acids, amino acids, and proteins, as well as in the metabolism of homocysteine. The human body cannot synthesize folic acid and it must be obtained through diet. Folic acid deficiency may lead to anemia and other health issues.
Article
Biochemistry & Molecular Biology
Michaela K. Fiedler, Jonas Drechsel, Ronny Schmidt, Peter B. Luppa, Nina C. Bach, Stephan A. Sieber
Summary: Personalized assessment of vitamin levels in point-of-care (POC) devices is urgently needed. A diagnostic platform based on fluorescent probes was introduced, allowing easy and rapid readout of vitamin B6 levels in erythrocytes. The platform showed promising results in accurately reporting B6 levels in human erythrocyte samples.
ACS CHEMICAL BIOLOGY
(2023)
Review
Medicine, General & Internal
Aleksandra Szymczak-Tomczak, Alicja Ewa Ratajczak, Marta Kaczmarek-Rys, Szymon Hryhorowicz, Anna Maria Rychter, Agnieszka Zawada, Ryszard Slomski, Agnieszka Dobrowolska, Iwona Krela-Kazmierczak
Summary: Vitamin D plays various roles in patients with inflammatory bowel disease (IBD), including regulating bone mineral metabolism, modulating the immune system, and contributing to the pathogenesis of IBD. Vitamin D affects Th1 and Th2 lymphocytes, cytokine release, and the wnt/beta-catenin pathway. IBD is associated with dysbiosis of microbiota, abnormal inflammatory response, and vitamin D deficiency. Therefore, understanding the metabolic pathways, genetic determinants, and environmental factors of vitamin D is crucial for studying vitamin D supplementation in IBD patients, not only for osteoporosis prevention and therapy, but also for modulating the course and pharmacotherapy of IBD.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Pediatrics
Maya Ruban, Adam Slavick, Achiya Amir, Amir Ben-Tov, Hadar Moran-Lev, Yael Weintraub, Adi Anafy, Shlomi Cohen, Anat Yerushalmy-Feler
Summary: The rate of a positive family history of IBD in the pediatric IBD population is increasing, and patients with a positive family history are more likely to have a severe phenotype, receive more nutritional therapy, and less corticosteroids. Patients with a negative family history may require intensified biologic therapy.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Biochemistry & Molecular Biology
Kathleen Mikkelsen, Narges Dargahi, Sarah Fraser, Vasso Apostolopoulos
Summary: Vitamin B6 has anti-inflammatory properties and can reverse inflammatory effects. This study found that high-dose vitamin B6 has a global anti-inflammatory effect on monocyte/macrophage cells, downregulating the expression of various inflammatory mediators. These findings suggest that vitamin B6 could be a useful adjunct treatment for inflammatory-related diseases.
Article
Orthopedics
Samane Tavassoli, Iman Shahabinasab, Alireza Norouzi, Taghi Amiriani, Nafiseh Abdolahi, Somayeh Livani, Seyed Farzam Mirkamali, Honey Sadat Mirkarimi, Fazel Isapanah Amlashi, Sima Besharat
Summary: This study evaluated the musculoskeletal and radiologic manifestations in 96 IBD patients, finding that around half of the patients had related symptoms, but the majority had normal physical examination results. In terms of imaging, 34.4% of patients showed mild changes, mainly endplate sclerosis.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Gastroenterology & Hepatology
Heinz Zoller, Myles Wolf, Irina Blumenstein, Christian Primas, Stefan Lindgren, Lars L. Thomsen, Walter Reinisch, Tariq Iqbal
Summary: Despite comparable treatment efficacy for iron deficiency anaemia, FCM was associated with a higher incidence of hypophosphataemia compared to FDI. Further studies are needed to investigate the long-term clinical consequences of hypophosphataemia and the mechanisms underlying the differential effects of FCM and FDI on patient-reported fatigue.