Function of the intestinal epithelium and its dysregulation in inflammatory bowel disease

TGF-β1 gene-modified, immature dendritic cells delay the development of inflammatory bowel disease by inducing CD4+Foxp3+ regulatory T cells

(2010) Zhijian Cai et al.   Cellular & Molecular Immunology

E-Cadherin Marks a Subset of Inflammatory Dendritic Cells that Promote T Cell-Mediated Colitis

(2010) Karima R.R. Siddiqui et al.   IMMUNITY

A human gut microbial gene catalogue established by metagenomic sequencing

(2010) Junjie Qin et al.   NATURE

Genome-wide association identifies multiple ulcerative colitis susceptibility loci

(2010) Dermot P B McGovern et al.   NATURE GENETICS

Increased Susceptibility to Dextran Sulfate Sodium Induced Colitis in the T Cell Protein Tyrosine Phosphatase Heterozygous Mouse

(2010) Syed-Wajahat Hassan et al.   PLoS One

Generation of regulatory dendritic cells and CD4+Foxp3+ T cells by probiotics administration suppresses immune disorders

(2010) H.-K. Kwon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Defective Paneth Cell—Mediated Host Defense in Pediatric Ileal Crohn's Disease

(2009) Gøri Perminow et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Regulatory Lymphocytes and Intestinal Inflammation

(2009) Ana Izcue et al.   Annual Review of Immunology

Crohn's disease-associated adherent-invasiveE. coliare selectively favoured by impaired autophagy to replicate intracellularly

(2009) Pierre Lapaquette et al.   CELLULAR MICROBIOLOGY

Specific association of a CLEC16A/KIAA0350 polymorphism with NOD2/CARD15− Crohn's disease patients

(2009) Ana Márquez et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Patterns and Scales in Gastrointestinal Microbial Ecology

(2009) J. Gray Camp et al.   GASTROENTEROLOGY

Immunoglobulin A: FcαRI Interactions Induce Neutrophil Migration Through Release of Leukotriene B4

(2009) Lydia van der Steen et al.   GASTROENTEROLOGY

Biological Therapies for Inflammatory Bowel Diseases

(2009) Paul Rutgeerts et al.   GASTROENTEROLOGY

Protection of Epithelial Barrier Function by the Crohn's Disease Associated Gene Protein Tyrosine Phosphatase N2

(2009) Michael Scharl et al.   GASTROENTEROLOGY

An FcRn-Dependent Role for Anti-flagellin Immunoglobulin G in Pathogenesis of Colitis in Mice

(2009) Kanna Kobayashi et al.   GASTROENTEROLOGY

Nod2 regulates the host response towards microflora by modulating T cell function and epithelial permeability in mouse Peyer's patches

(2009) F. Barreau et al.   GUT

How intestinal epithelial cells tolerise dendritic cells and its relevance to inflammatory bowel disease

(2009) M Shale et al.   GUT

Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease

(2009) S. Brand   GUT

Polymorphisms in E-cadherin (CDH1) result in a mis-localised cytoplasmic protein that is associated with Crohn's disease

(2009) A. M. Muise et al.   GUT

The genetics of chronic inflammatory diseases

(2009) G. A. Heap et al.   HUMAN MOLECULAR GENETICS

Filaggrin loss-of-function variants are associated with atopic comorbidity in pediatric inflammatory bowel disease

(2009) J. Van Limbergen et al.   INFLAMMATORY BOWEL DISEASES

Intestinal barrier function: Molecular regulation and disease pathogenesis

(2009) Katherine R. Groschwitz et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Cd1d-dependent regulation of bacterial colonization in the intestine of mice

(2009) Edward E.S. Nieuwenhuis et al.   JOURNAL OF CLINICAL INVESTIGATION

Thymic development beyond β-selection requires phosphatidylinositol 3-kinase activation by CXCR4

(2009) Michelle L. Janas et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Defensins and inflammation: The role of defensins in inflammatory bowel disease

(2009) Malith Ramasundara et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Reciprocal Interactions between Commensal Bacteria and    Intraepithelial Lymphocytes during Mucosal Injury

(2009) A. S. Ismail et al.   JOURNAL OF IMMUNOLOGY

RANKL Is Necessary and Sufficient to Initiate Development of Antigen-Sampling M Cells in the Intestinal Epithelium

(2009) K. A. Knoop et al.   JOURNAL OF IMMUNOLOGY

Regulation of macrophage motility by Irgm1

(2009) Stanley C. Henry et al.   JOURNAL OF LEUKOCYTE BIOLOGY

IL-22 and IL-20 are key mediators of the epidermal alterations in psoriasis while IL-17 and IFN-γ are not

(2009) Kerstin Wolk et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Rapid Infliximab Infusions in Pediatric Inflammatory Bowel Disease

(2009) Alyson R Yeckes et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

A novel role for constitutively expressed epithelial-derived chemokines as antibacterial peptides in the intestinal mucosa

(2009) K Kotarsky et al.   Mucosal Immunology

A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population

(2009) Kouichi Asano et al.   NATURE GENETICS

Common variants at five new loci associated with early-onset inflammatory bowel disease

(2009) Marcin Imielinski et al.   NATURE GENETICS

Autoimmunity: increasing suspects in the CD4+ T cell lineup

(2009) Matthew T Palmer et al.   NATURE IMMUNOLOGY

A Crohn's disease–associated NOD2 mutation suppresses transcription of human IL10 by inhibiting activity of the nuclear ribonucleoprotein hnRNP-A1

(2009) Eiichiro Noguchi et al.   NATURE IMMUNOLOGY

Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1β production

(2009) Hendrik Poeck et al.   NATURE IMMUNOLOGY

Regulatory T cells exert checks and balances on self tolerance and autoimmunity

(2009) Kajsa Wing et al.   NATURE IMMUNOLOGY

Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry

(2009) Leonardo H Travassos et al.   NATURE IMMUNOLOGY

NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation

(2009) Rachel Cooney et al.   NATURE MEDICINE

Atorvastatin Reduces Plasma Levels of Chemokine (CXCL10) in Patients with Crohn's Disease

(2009) Olof Grip et al.   PLoS One

Nod2 is required for the regulation of commensal microbiota in the intestine

(2009) T. Petnicki-Ocwieja et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immune and non-immune functions of the (not so) neonatal Fc receptor, FcRn

(2009) Kristi Baker et al.   Seminars in Immunopathology

Selecting appropriate anti-TNF agents in inflammatory bowel disease

(2009) Laura Yun et al.   Expert Review of Gastroenterology & Hepatology

Genetic Analysis of Innate Immunity in Crohn's Disease and Ulcerative Colitis Identifies Two Susceptibility Loci Harboring CARD9 and IL18RAP

(2008) Alexandra Zhernakova et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A C-Type Lectin MGL1/CD301a Plays an Anti-Inflammatory Role in Murine Experimental Colitis

(2008) Kengo Saba et al.   AMERICAN JOURNAL OF PATHOLOGY

Stem Cells, Self-Renewal, and Differentiation in the Intestinal Epithelium

(2008) Laurens G. van der Flier et al.   Annual Review of Physiology

Novel MHC class I-related molecule MR1 affects MHC class I expression in 293T cells

(2008) Hatice Aldemir   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Higher constitutive IL15Rα expression and lower IL-15 response threshold in coeliac disease patients

(2008) D. Bernardo et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Regulatory T cells in inflammatory bowel disease

(2008) Elisa K Boden et al.   CURRENT OPINION IN GASTROENTEROLOGY

Structures and biological functions of IL-31 and IL-31 receptors

(2008) Qing Zhang et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Role of β7 Integrin and the Chemokine/Chemokine Receptor Pair CCL25/CCR9 in Modeled TNF-Dependent Crohn's Disease

(2008) Maria Apostolaki et al.   GASTROENTEROLOGY

A Randomized Trial of Ustekinumab, a Human Interleukin-12/23 Monoclonal Antibody, in Patients With Moderate-to-Severe Crohn's Disease

(2008) William J. Sandborn et al.   GASTROENTEROLOGY

Regulation of Gut Inflammation and Th17 Cell Response by Interleukin-21

(2008) Daniele Fina et al.   GASTROENTEROLOGY

Unique Role of Junctional Adhesion Molecule-A in Maintaining Mucosal Homeostasis in Inflammatory Bowel Disease

(2008) Stefania Vetrano et al.   GASTROENTEROLOGY

MAST3: a novel IBD risk factor that modulates TLR4 signaling

(2008) C Labbé et al.   GENES AND IMMUNITY

CD4+Foxp3+ regulatory T cell expansion induced by antigen-driven interaction with intestinal epithelial cells independent of local dendritic cells

(2008) A M Westendorf et al.   GUT

The Biology of Intestinal Immunoglobulin A Responses

(2008) Andrea Cerutti et al.   IMMUNITY

Multivesicular bodies in intestinal epithelial cells: responsible for MHC class II-restricted antigen processing and origin of exosomes

(2008) Jürgen Büning et al.   IMMUNOLOGY

Novel NOD2 haplotype strengthens the association between TLR4 Asp299gly and Crohnʼs disease in an Australian population

(2008) Georgia E. Hume et al.   INFLAMMATORY BOWEL DISEASES

Chemokines and chemokine receptors in mucosal homeostasis at the intestinal epithelial barrier in inflammatory bowel disease

(2008) Noah P. Zimmerman et al.   INFLAMMATORY BOWEL DISEASES

Comparative expression analysis and characterization of 20S proteasomes in human intestinal tissues

(2008) Alexander Visekruna et al.   INFLAMMATORY BOWEL DISEASES

Efficacy of Infliximab in Pediatric Crohnʼs Disease: A Randomized Multicenter Open-Label Trial Comparing Scheduled to On Demand Maintenance Therapy

(2008) Frank M. Ruemmele et al.   INFLAMMATORY BOWEL DISEASES

Intestinal barrier dysfunction in inflammatory bowel diseases

(2008) Michael A. McGuckin et al.   INFLAMMATORY BOWEL DISEASES

Filaggrin Expression in Oral, Nasal, and Esophageal Mucosa

(2008) Anna De Benedetto et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Molecular mechanism of intestinal permeability: interaction at tight junctions

(2008) Zakir Hossain et al.   Molecular BioSystems

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

(2008) Ken Cadwell et al.   NATURE

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

(2008) Jeffrey C Barrett et al.   NATURE GENETICS

Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5

(2008) Satoshi Uematsu et al.   NATURE IMMUNOLOGY

The immunity-related GTPase Irgm1 promotes the expansion of activated CD4+ T cell populations by preventing interferon-γ-induced cell death

(2008) Carl G Feng et al.   NATURE IMMUNOLOGY

Impaired Autophagy of an Intracellular Pathogen Induced by a Crohn's Disease Associated ATG16L1 Variant

(2008) Petric Kuballa et al.   PLoS One

Oral tolerance: intestinal homeostasis and antigen-specific regulatory T cells

(2008) Noriko M. Tsuji et al.   TRENDS IN IMMUNOLOGY

Functional differences between M cells and enterocytes in sampling luminal antigens

(2008) Jennelle M. Kyd et al.   VACCINE

Role of mucosal dendritic cells in inflammatory bowel disease

(2008) Jan Hendrik Niess   WORLD JOURNAL OF GASTROENTEROLOGY