Article
Microbiology
Gregoire Chevalier, Arnaud Laveissiere, Guillaume Desachy, Nicolas Barnich, Adeline Sivignon, Marc Maresca, Cendrine Nicoletti, Eric Di Pasquale, Margarita Martinez-Medina, Kenneth William Simpson, Vijay Yajnik, Harry Sokol, Temitayo Adegbamigbe, Tariq Ahmad, Ian Arnott, Yoram Bouhnik, Franck Carbonnel, Jean-Frederic Colombel, Glen Doherty, J. R. Fraser Cummings, Xavier Hebuterne, Hans Herfarth, David Kevans, Guillaume Pineton de Chambrun, Maria Nachury, Stephane Nancey, Xavier Roblin, Mark A. W. Tremelling, Jonathan Plassais, Francesco Strozzi, Alessandra Cervino, Rachel Morra, Christophe Bonny
Summary: The study identified a significant enrichment of FimH-expressing bacteria in the gut microbiome of CD patients, with FimH playing a crucial role in adhesion and inflammation induction. The specific FimH-blocker TAK-018 was shown to prevent bacterial adhesion and inflammation, potentially offering a promising treatment option for CD patients.
Article
Immunology
Liliana Lykowska-Szuber, Michal Walczak, Marzena Skrzypczak-Zielinska, Joanna Suszynska-Zajczyk, Kamila Stawczyk-Eder, Katarzyna Waszak, Piotr Eder, Anna Wozniak, Iwona Krela-Kazmierczak, Ryszard Slomski, Agnieszka Dobrowolska
Summary: Crohn's disease patients who do not respond to anti-TNF therapy may have alterations in the expression levels of specific genes, particularly TNFRSF1B, FCGR3A, and IL1B. This can be predicted by functional analysis in colon biopsies and cell culture models.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Karen Boland, Larbi Bedrani, Williams Turpin, Boyko Kabakchiev, Joanne Stempak, Krzysztof Borowski, Geoffrey Nguyen, A. Hillary Steinhart, Michelle Smith, Kenneth Croitoru, Mark S. Silverberg
Summary: Symptoms in patients with inflammatory bowel diseases (IBDs) may be related to the composition of the intestinal microbiome even after successful treatment, particularly in patients with persistent diarrhea where microbial diversity is lower.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Immunology
Marcela de Lima Moreira, Luana Oliveira Borges-Fernandes, Marcelo Antonio Pascoal-Xavier, Agata Lopes Ribeiro, Victoria Hellena Silva Pereira, Troi Pediongco, Marcio Sobreira da Silva Araujo, Andrea Teixeira-Carvalho, Andrea Lucchesi de Carvalho, Maria Vitoria Assumpcao Mourao, Flavia Alves Campos, Marineide Borges, Mariangela Carneiro, Zhenjun Chen, Eleanor Saunders, Malcolm McConville, Moriya Tsuji, James McCluskey, Olindo Assis Martins-Filho, Sidonia Barbara Guiomar Eckle, Jordana Grazziela Alves Coelho-dos-Reis, Vanessa Peruhype-Magalhaes
Summary: This study reveals the role of MAIT cells in protecting against visceral leishmaniasis, expanding our understanding of MAIT-cell immunity beyond bacterial and viral infections. The findings highlight the potential of MAIT-cell-based therapeutics and vaccines for the treatment and prevention of parasitic infections.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Nathan Calzadilla, Aisha Qazi, Anchal Sharma, Kai Mongan, Shane Comiskey, Jahnavi Manne, Alvin G. G. Youkhana, Sonam Khanna, Seema Saksena, Pradeep K. K. Dudeja, Waddah A. A. Alrefai, Ravinder K. K. Gill
Summary: This study found that chronic intestinal inflammation leads to changes in gut mucosal metabolism, with increased levels of various host- and microbe-derived metabolites such as angiotensin, purine, pyrimidine, endocannabinoid, and ceramide. Microbial-related tryptophan metabolites were significantly increased during chronic inflammation and strongly correlated with disease activity, providing new insights into the pathophysiology of inflammatory bowel diseases and potential targets for microbial-based therapeutics.
Article
Biochemistry & Molecular Biology
Chunyan Shao, Chenwen Zhu, Yun Zhu, Jiqing Hao, Yongxiang Li, Huaqing Hu, Li Si, Fei Zhong, Xuefu Wang, Hua Wang
Summary: Our study demonstrates the decreased frequency, altered phenotypes, and partially impaired function of MAIT cells in patients with gastric cancer, indicating a potential MAIT cell-based immunological surveillance of gastric cancer. This highlights the importance of further investigating the role of MAIT cells in malignant diseases to better understand their impact on disease progression and potential therapeutic implications.
CELL AND BIOSCIENCE
(2021)
Article
Gastroenterology & Hepatology
Jakub Hurych, Anna Mascellani Bergo, Tereza Lerchova, Lucie Hlinakova, Michal Kubat, Hana Malcova, Dita Cebecauerova, Jan Schwarz, Eva Karaskova, Tomas Hecht, Radim Vyhnanek, Lenka Toukalkova, Vojtech Dotlacil, Katerina Greinerova, Anabela Cizkova, Rudolf Horvath, Jiri Bronsky, Jaroslav Havlik, Ondrej Hradsky, Ondrej Cinek
Summary: Treatment with anti-TNF antibodies leads to changes in bacteriome and metabolome in children with CD, with specific alterations being associated with mucosal healing. However, similar changes were not observed in children with JIA, suggesting that the effects of anti-TNF on gut microbiota may be disease-specific.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Gastroenterology & Hepatology
Dotan Yogev, Bram Verstockt, Axel Dignass, Gili Focht, Ohad Atia, Iris Dotan, Severine Vermeire, Dan Turner
Summary: Evaluation of the modified version of the Mucosal Inflammation Noninvasive Index in adult Crohn's disease.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Cell Biology
Chaoxiang Zhong, Qiuju Yao, Jing Han, Jie Yang, Fei Jiang, Qiong Zhang, Haiyi Zhou, Yuchao Hu, Wei Wang, Yan Zhang, Ye Sun
Summary: This study investigated the correlation between SNPs in the MEG3/miR-181b signaling pathway and the severity of anal abscess in patients with Crohn's disease. The results showed that two SNPs, rs322931 (C>T) in miR-181b and rs7158663 (G>A) in MEG3, could aggravate the inflammatory response and affect the MEG3/miR-181b/TNF-alpha signaling pathway in Crohn's disease patients with anal abscess.
Review
Immunology
Heike Schmitt, Markus F. Neurath, Raja Atreya
Summary: Crohn's disease is a chronic inflammatory disorder of the gastrointestinal tract influenced by genetic susceptibility, environmental factors, and intestinal microbiome. Pro-inflammatory cytokines IL17 and IL23 play crucial roles in the pathogenesis of CD by causing excessive activation of the mucosal immune system. Treatments targeting these cytokines, such as selective IL23 inhibitors, have shown promising results in CD patients who failed previous anti-TNF therapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Cristian George Tieranu, Andrei Ovidiu Olteanu, Carmen Monica Preda, Nicolae Bacalbasa, Elena Milanesi, Maria Dobre, Ioana Tieranu, Teodora Ecaterina Manuc, Artsiom Klimko, Gabriel Becheanu, Elena Mirela Ionescu
Summary: This study identified four genes with significantly increased expression in the mucosa of patients with stricturing Crohn's disease compared to those with inflammatory Crohn's disease. These findings may help elucidate the mechanisms leading to disease-associated complications.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Jean-Paul Motta, Simone Palese, Carmine Giorgio, Kevin Chapman, Alexandre Denadai-Souza, Perrine Rousset, David Sagnat, Laura Guiraud, Anissa Edir, Carine Seguy, Laurent Alric, Delphine Bonnet, Barbara Bournet, Louis Buscail, Cyrielle Gilletta, Andre G. Buret, John L. Wallace, Morley D. Hollenberg, Eric Oswald, Elisabetta Barocelli, Sylvie Le Grand, Bruno Le Grand, Celine Deraison, Nathalie Vergnolle
Summary: Elevated thrombin activity in the colon of Crohn's disease patients may lead to tissue damage and inflammation. Experimental evidence suggests that colonic thrombin and protease-activated receptor-1 could be potential mechanisms involved in mucosal damage and loss of function.
JOURNAL OF CROHNS & COLITIS
(2021)
Article
Gastroenterology & Hepatology
Charles Caer, Frida Gorreja, Sophia K. Forsskahl, Siggeir F. Brynjolfsson, Louis Szeponik, Maria K. Magnusson, Lars G. Borjesson, Mattias Block, Elinor Bexe-Lindskog, Mary Jo Wick
Summary: The study showed that high expression of intestinal TREM-1 in IBD patients is associated with a high frequency of TREM-1(+) immature macrophages and TREM-1(+)CD11b(+) granulocytes, which contribute to the deleterious inflammatory microenvironment. Blocking the TREM-1 pathway, especially simultaneously with anti-TNF therapy, has potential as a new therapy for IBD.
JOURNAL OF CROHNS & COLITIS
(2021)
Article
Microbiology
Amira Metwaly, Jelena Jovic, Nadine Waldschmitt, Sevana Khaloian, Helena Heimes, Deborah Haecker, Mohamed Ahmed, Nassim Hammoudi, Lionel Le Bourhis, Aida Mayorgas, Kolja Siebert, Marijana Basic, Tobias Schwerd, Matthieu Allez, Julian Panes, Azucena Salas, Andre Bleich, Sebastian Zeissig, Pamela Schnupf, Fabio Cominelli, Dirk Haller
Summary: This study found that segmented filamentous bacteria (SFB) are associated with Crohn's disease (CD) and can induce ileo-colonic inflammation in mouse models. The severity of CD-like inflammation strongly correlates with the abundance of SFB. SFB colonization can be prevented by a purified diet, which also prevents disease development.
Article
Biochemical Research Methods
Leonie K. Amstein, Joerg Ackermann, Jennifer Hannig, Ivan Ikic, Simone Fulda, Ina Koch
Summary: This paper presents a mathematical model that describes the molecular switches in cell survival, apoptosis, and necroptosis in cellular signaling pathways. The model is verified and analyzed using Petri net techniques, and important checkpoints and pathways are identified in the TNFR1 signaling pathway.
PLOS COMPUTATIONAL BIOLOGY
(2022)