Article
Gastroenterology & Hepatology
Julien Kirchgesner, Rishi J. Desai, Maria C. Schneeweiss, Laurent Beaugerie, Sebastian Schneeweiss, Seoyoung C. Kim
Summary: Combination therapy with vedolizumab and thiopurines is associated with a lower risk of treatment failure compared to vedolizumab monotherapy in patients with CD, but the effect is less pronounced in UC.
Article
Medicine, General & Internal
Fen Xu, Juping Tang, Zhiping Zhu, Yan Chen, Wen Hu, Sha Lu, Yunxian Zhou, Ding Lin
Summary: This study investigated the medication adherence among patients with inflammatory bowel disease (IBD) in China and analyzed the influencing factors. The results showed poor medication adherence, especially among patients taking oral medication, those taking medications with a high frequency, and those with a low understanding of the disease. To improve medication adherence, medical staff should pay attention to individual patient factors, simplify medication regimens, and formulate effective coping strategies for drug management support.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Pediatrics
Maya Ruban, Adam Slavick, Achiya Amir, Amir Ben-Tov, Hadar Moran-Lev, Yael Weintraub, Adi Anafy, Shlomi Cohen, Anat Yerushalmy-Feler
Summary: The rate of a positive family history of IBD in the pediatric IBD population is increasing, and patients with a positive family history are more likely to have a severe phenotype, receive more nutritional therapy, and less corticosteroids. Patients with a negative family history may require intensified biologic therapy.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Gastroenterology & Hepatology
G. Leoncini, F. Donato, L. Reggiani-Bonetti, T. Salviato, M. Cadei, M. Daperno, M. B. Principi, A. Armuzzi, F. Caprioli, G. Canavese, V. Villanacci
Summary: The study revealed moderate interobserver agreement regarding the histopathological detection and classification of IBD-associated dysplasia. Further efforts are needed to integrate histopathological data with ancillary tests and molecular investigations.
TECHNIQUES IN COLOPROCTOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Nikolas Dovrolis, Anastasia Moschoviti, Smaragdi Fessatou, George Karamanolis, George Kolios, Maria Gazouli
Summary: This study examines the role of the microbiome in the onset of pediatric inflammatory bowel disease (IBD). Through analyzing the microbiota of nine IBD families, specific patterns of microbial taxa were identified among patients and their families. The results suggest a potential role of maternal factors in the establishment and modulation of the early life microbiome.
Review
Gastroenterology & Hepatology
Shubha Bhat, Florian Rieder
Summary: Current treatment options for inflammatory bowel diseases have limitations, leading to the need for the development of novel orally-administered medications. HIF-1α stabilizers, acting through inhibiting specific enzymes, have emerged as an innovative therapeutic strategy.
JOURNAL OF CROHNS & COLITIS
(2022)
Article
Pharmacology & Pharmacy
Snjezana Cuzic, Maja Antolic, Anja Ognjenovic, Darija Stupin-Polancec, Adriana Petrinic Grba, Boska Hrvacic, Miroslava Dominis Kramaric, Sanja Musladin, Lidija Pozgaj, Ivo Zlatar, Denis Polancec, Gorana Aralica, Marko Banic, Marija Urek, Brankica Mijandrusic Sincic, Aleksandar Cubranic, Ines Glojnaric, Martina Bosnar, Vesna Erakovic Haber
Summary: This study explored the expression of claudins in human disease and two different animal models of IBD. The diverse alterations in claudin expression by epithelial and inflammatory cells were recorded in IBD and both animal models. The results suggest that claudins are not exclusively expressed by epithelial cells, and changes in claudin mRNA levels should be interpreted in the context of overall tissue alterations.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sara Federici, Sharon Kredo-Russo, Rafael Valdes-Mas, Denise Kviatcovsky, Eyal Weinstock, Yulia Matiuhin, Yael Silberberg, Koji Atarashi, Munehiro Furuichi, Akihiko Oka, Bo Liu, Morine Fibelman, Iddo Nadav Weiner, Efrat Khabra, Nyssa Cullin, Noa Ben-Yishai, Dana Inbar, Hava Ben-David, Julian Nicenboim, Noga Kowalsman, Wolfgang Lieb, Edith Kario, Tal Cohen, Yael Friedman Geffen, Lior Zelcbuch, Ariel Cohen, Urania Rappo, Inbar Gahali-Sass, Myriam Golembo, Vered Lev, Mally Dori-Bachash, Hagit Shapiro, Claudia Moresi, Amanda Cuevas-Sierra, Gayatree Mohapatra, Lara Kern, Danping Zheng, Samuel Philip Nobs, Jotham Suez, Noa Stettner, Alon Harmelin, Naomi Zak, Sailaja Puttagunta, Merav Bassan, Kenya Honda, Harry Sokol, Corinna Bang, Andre Franke, Christoph Schramm, Nitsan Maharshak, Ryan Balfour Sartor, Rotem Sorek, Eran Elinav
Summary: A clade of Klebsiella pneumoniae strains has been found to be strongly associated with exacerbation and severity of inflammatory bowel diseases. By generating a lytic five-phage combination targeting these strains, effective suppression of the bacteria and attenuation of inflammation can be achieved.
Article
Gastroenterology & Hepatology
Erica J. Brenner, Millie D. Long, Michael D. Kappelman, Xian Zhang, Robert S. Sandler, Edward L. Barnes
Summary: This study developed a non-proprietary, IBD-specific medication adherence tool and investigated reasons for suboptimal medication adherence. The results showed that common reasons for suboptimal adherence include forgetting, feeling well, and cost.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Christopher Ma, Jurij Hanzel, Remo Panaccione, William J. Sandborn, Geert R. D'Haens, Vineet Ahuja, Raja Atreya, Charles N. Bernstein, Peter Bossuyt, Brian Bressler, Robert Bryant, Benjamin Cohen, Jean-Frederic Colombel, Silvio Danese, Axel Dignass, Marla C. Dubinsky, Phillip R. Fleshner, Richard B. Gearry, Stephen B. Hanauer, Ailsa Hart, Paulo Gustavo Kotze, Torsten Kucharzik, Peter L. Lakatos, Rupert W. Leong, Fernando Magro, Julian Panes, Laurent Peyrin-Biroulet, Zhihua Ran, Miguel Regueiro, Siddharth Singh, Antonino Spinelli, A. Hillary Steinhart, Simon P. Travis, C. Janneke van der Woude, Bruce Yacyshyn, Takayuki Yamamoto, Matthieu Allez, Willem A. Bemelman, Amy L. Lightner, Edouard Louis, David T. Rubin, Ellen J. Scherl, Corey A. Siegel, Mark S. Silverberg, Severine Vermeire, Claire E. Parker, Stefanie C. McFarlane, Leonardo Guizzetti, Michelle Smith, Niels Vande Casteele, Brian G. Feagan, Vipul Jairath
Summary: This study establishes a core outcome set for randomized controlled trials of CD and UC through a multidisciplinary collaboration involving patients and clinical experts. Candidate outcome domains and measures were generated from literature reviews and patient engagement. The study highlights the importance of harmonizing endpoints for drug development in inflammatory bowel disease.
Review
Immunology
Reza Yarani, Ali Shojaeian, Oana Palasca, Nadezhda T. Doncheva, Lars Juhl Jensen, Jan Gorodkin, Flemming Pociot
Summary: This review discusses the differential regulation of miRNAs in inflammatory bowel disease (IBD) and their potential diagnostic and therapeutic applications. Through literature curation and computational analysis, a consensus set of differentially expressed miRNAs in mucosal tissues was obtained. The role of these miRNAs and their potential targets in IBD are highlighted.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Tyler Atagozli, David E. Elliott, Mirac Nedim Ince
Summary: Helminths are multicellular invertebrates that live in the gut of vertebrate animals, including humans. They can cause pathology and require treatment, but can also have commensal or symbiotic relationships with their hosts. Epidemiological data suggests that helminth exposure may provide protection against immune disorders, such as allergies and autoimmune illnesses.
Article
Gastroenterology & Hepatology
Ken Lund, Floor Dijkstra Zegers, Jan Nielsen, Jacob Broder Brodersen, Torben Knudsen, Jens Kjeldsen, Michael Due Larsen, Bente Mertz Norgard
Summary: This study investigated the effect of inflammatory bowel disease (IBD) onset on the prescription pattern of non-IBD medication and the risk of becoming a new user. The results showed that the prescription of non-IBD medication significantly increased after IBD onset in patients of different age groups. Elderly patients had an increased risk of becoming new users of non-IBD medication.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Tatsuki Noguchi, Soichiro Ishihara, Motoi Uchino, Hiroki Ikeuchi, Koji Okabayashi, Kitaro Futami, Shinji Tanaka, Hiroki Ohge, Hisashi Nagahara, Kazuhiro Watanabe, Michio Itabashi, Kinya Okamoto, Yoshiki Okita, Tsunekazu Mizushima, Yusuke Mizuuchi, Kazutaka Yamada, Yoshifumi Shimada, Yu Sato, Hideaki Kimura, Kenichi Takahashi, Koya Hida, Yusuke Kinugasa, Junji Okuda, Koji Daito, Fumikazu Koyama, Hideki Ueno, Takayuki Yamamoto, Tsunekazu Hanai, Atsuo Maemoto, Koji Oba, Yoichi Ajioka, Kenichi Sugihara
Summary: Patients with longstanding inflammatory bowel disease, such as ulcerative colitis and Crohn's disease, are at high risk of developing intestinal cancers. This study found significant differences between intestinal cancers associated with ulcerative colitis and Crohn's disease. Crohn's disease-associated cancers were diagnosed at more advanced stages, detected less frequently by surveillance, and had a poorer prognosis compared to those associated with ulcerative colitis.
JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Pathology
Zhiyan Fu, Michel Kmeid, Soe Htet Arker, Georgi Lukose, Edward C. Lee, Gregory Y. Lauwers, Hwajeong Lee
Summary: This study aimed to identify histologic features of diverted colon segments in IBD patients and found that severe inflammatory activity, mucosal atrophy, and transmural inflammation were significantly greater in IBD patients compared to non-IBD cases. The inflammatory activity, presence of ulcer(s), IMLAs, TMLAs, and transmural inflammation in diverted colon segments of IBD patients may reflect the severity of underlying IBD.
Letter
Gastroenterology & Hepatology
Gilles Macaigne, Pierre Lahmek, Stephane Nahon, Alexandre Pariente
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2015)
Article
Gastroenterology & Hepatology
F. Carrat, P. Seksik, J. -F. Colombel, L. Peyrin-Biroulet, L. Beaugerie
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2017)
Article
Gastroenterology & Hepatology
Aurelien Amiot, Jean-Charles Grimaud, Laurent Peyrin-Biroulet, Jerome Filippi, Benjamin Pariente, Xavier Roblin, Anthony Buisson, Carmen Stefanescu, Caroline Trang-Poisson, Romain Altwegg, Philippe Marteau, Thibaud Vaysse, Anne Bourrier, Stephane Nancey, David Laharie, Matthieu Allez, Guillaume Savoye, Jacques Moreau, Charlotte Gagniere, Lucine Vuitton, Stephanie Viennot, Alexandre Aubourg, Anne-Laure Pelletier, Guillaume Bouguen, Vered Abitbol, Yoram Bouhnik
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2016)
Article
Gastroenterology & Hepatology
Stephane Nahon, Pierre Lahmek, Thierry Paupard, Bruno Lesgourgues, Stanislas Chaussade, Laurent Peyrin-Biroulet, Vered Abitbol
DIGESTIVE DISEASES AND SCIENCES
(2016)
Article
Gastroenterology & Hepatology
Caroline Prieux-Klotz, Stephane Nahon, Aurelien Amiot, Leila Sinayoko, Carole Galeano-Cassaz, Stanislas Chaussade, Romain Coriat, Pierre Lahmek, Vered Abitbol
DIGESTIVE DISEASES AND SCIENCES
(2017)
Article
Gastroenterology & Hepatology
Yael Abitbol, David Laharie, Jacques Cosnes, Matthieu Allez, Stephane Nancey, Aurelien Amiot, Alexandre Aubourg, Mathurin Fumery, Romain Altwegg, Pierre Michetti, Elise Chanteloup, Philippe Seksik, Clotilde Baudry, Mathurin Flamant, Guillaume Bouguen, Carmen Stefanescu, Anne Bourrier, Gilles Bommelaer, Nina Dib, Marc Andre Bigard, Stephanie Viennot, Xavier Hebuterne, Jean-Marc Gornet, Philippe Marteau, Yoram Bouhnik, Vered Abitbol, Stephane Nahon
JOURNAL OF CROHNS & COLITIS
(2016)
Article
Gastroenterology & Hepatology
Diane Lorenzo, Claire Gallois, Pierre Lahmek, Bruno Lesgourgues, Christine Champion, Claire Charpignon, Roger Faroux, Bruno Bour, Andre-Jean Remy, Chantal Naouri, Magali Picon, Eric Poncin, Gilles Macaigne, Jacques-Arnaud Seyrig, David Bernardini, Guy Bellaiche, Denis Grasset, Jean Henrion, Frederic Heluwaert, Rene Piperaud, Gilbert Bordes, Francois Bourhis, Jean-Pierre Arpurt, Alexandre Pariente, Stephane Nahon
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2017)
Article
Gastroenterology & Hepatology
D. Laharie, A. Bourreille, J. Branche, M. Allez, Y. Bouhnik, J. Filippi, F. Zerbib, G. Savoye, L. Vuitton, J. Moreau, A. Amiot, J. Cosnes, E. Ricart, O. Dewit, A. Lopez-Sanroman, M. Fumery, F. Carbonnel, G. Bommelaer, B. Coffin, X. Roblin, G. van Assche, M. Esteve, M. Farkkila, J. P. Gisbert, P. Marteau, S. Nahon, M. de Vos, J. Lambert, J. Y. Mary, E. Louis
Article
Gastroenterology & Hepatology
Gilles Macaigne, Pierre Lahmek, Christophe Locher, Jean Francois Boivin, Bruno Lesgourgues, Mathieu Yver, Laurent Costes, I. Abd Alsamad, Joel Cucherousset, Claire Charpignon, Helene Guyot, Benedicte Lambare, Jean-Michel Ghilain, Valerie Cales, Stephanie de Montigny-Lenhardt, Guy Bellaiche, Alexandre Pariente, Stephane Nahon
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
(2017)
Article
Gastroenterology & Hepatology
Gilles Macaigne, Pierre Lahmek, Christophe Locher, Bruno Lesgourgues, Laurent Costes, Max Pierre Nicolas, Anne Courillon-Mallet, Jean-Michel Ghilain, Guy Bellaiche, Stephanie de Montigny-Lehnardt, Georges Barjonet, Rene-Louis Vitte, Roger Faroux, Benedicte Lambare, Antoine Fleury, Alexandre Pariente, Stephane Nahon
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2014)
Article
Gastroenterology & Hepatology
Vered Abitbol, Pierre Lahmek, Anne Buisson, Alain Olympie, Cecile Poupardin, Stanislas Chaussade, Bruno Lesgourgues, Stephane Nahon
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2014)
Article
Gastroenterology & Hepatology
Stephane Nahon, Pierre Lahmek, Bruno Lesgourgues, Cecile Poupardin, Stanislas Chaussade, Laurent Peyrin-Biroulet, Vered Abitbol
JOURNAL OF CROHNS & COLITIS
(2014)
Article
Gastroenterology & Hepatology
Stephane Lecleire, Stephane Nahon, Abdullah Alatawi, Michel Antonietti, Ulriikka Chaput, Aude Di-Fiore, Raied Alhameedi, Philippe Marteau, Philippe Ducrotte, Xavier Dray
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2014)
Article
Medicine, General & Internal
E. Zamparini, P. Ahmed, M. Belhassan, C. Horaist, A. Bouguerba, S. Ayed, J. Barchasz, M. Boukari, D. Goldgran-Toledano, S. Yaacoubi, C. Bornstain, S. Nahon, F. Vincent
Article
Gastroenterology & Hepatology
A. Amiot, M. Serrero, L. Peyrin-Biroulet, J. Filippi, B. Pariente, X. Roblin, A. Buisson, C. Stefanescu, C. Trang-Poisson, R. Altwegg, P. Marteau, T. Vaysse, A. Bourrier, S. Nancey, D. Laharie, M. Allez, G. Savoye, J. Moreau, L. Vuitton, S. Viennot, A. Aubourg, A. -L. Pelletier, G. Bouguen, V. Abitbol, C. Gagniere, Y. Bouhnik
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2017)