Article
Green & Sustainable Science & Technology
Shi Feng, Prakash Lakshmanan, Yi Zhang, Tingting Zhang, Tao Liang, Weijin Zhang, Xinping Chen, Xiaozhong Wang
Summary: Food production is a significant contributor to anthropogenic greenhouse gas emissions. This study conducted a comprehensive meta-analysis of the carbon footprint of plant-based and animal-based food production in different continents. The results showed that Asia and Europe have higher carbon footprints for plant-based foods compared to other continents, while Africa has the lowest carbon footprint for plant-based foods. On the other hand, Africa and Asia have higher carbon footprints for animal-based foods compared to other continents, with North America and Oceania having the lowest. The study also revealed that Asia is the largest emitter of greenhouse gases from global food production. Overall, this research provides the most comprehensive assessment of the carbon footprint of food production at the continental and global scales, which can inform the development of strategies and policies to reduce greenhouse gas emissions.
JOURNAL OF CLEANER PRODUCTION
(2023)
Article
Gastroenterology & Hepatology
Sophie Vieujean, James O. Lindsay, Ferdinando D'Amico, Vineet Ahuja, Mark S. Silverberg, Ajit Sood, Jesus K. Yamamoto-Furusho, Masakazu Nagahori, Mamoru Watanabe, Ioannis E. Koutroubakis, Kalliopi Foteinogiannopoulou, Irit Avni Biron, Alissa Walsh, An Outtier, Rie Louise Moller Nordestgaard, Maria T. Abreu, Marla Dubinsky, Corey Siegel, Edouard Louis, Iris Dotan, Walter Reinisch, Silvio Danese, David T. Rubin, Laurent Peyrin-Biroulet
Summary: This study analyzes the reasons for non-enrollment of IBD patients in RCTs and finds that patients are lost at each step, with eligibility criteria, the risk of placebo assignment, and insufficient disease activity being the main barriers.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Environmental Sciences
Kathy McKay, Elizabeth O'Nions, Sarah Wayland, David Ferguson, Eilis Kennedy
Summary: This study analyzed tweets to explore the challenges faced by families of preterm babies and healthcare professionals involved, particularly the impact of the COVID-19 pandemic on families of preterm babies. It highlights the need for increased awareness and improved support for families of preterm babies.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Review
Biology
Virginia Brancato, Ilaria Brentari, Lucia Coscujuela Tarrero, Mattia Furlan, Francesco Nicassio, Michela A. Denti
Summary: Since the formalization of the Central Dogma of molecular biology, the relevance of RNA in modulating the flow of information from DNA to proteins has been clear. The discovery of non-coding transcripts and the impact of RNA therapies have further increased interest in RNA biology.
Review
Medicine, General & Internal
Natalia Arias-Casais, Jotheeswaran Amuthavalli Thiyagarajan, Monica Rodrigues Perracini, Eunok Park, Lieve van den Block, Yuka Sumi, Ritu Sadana, Anshu Banerjee, Zee-A Han
Summary: This study aimed to identify and categorize long-term care interventions for older adults based on the WHO's public health framework. The interventions were diverse, targeting various settings and areas to address chronic conditions, loss of capacity, and functional decline. However, the majority of interventions reported in the literature were from high-income settings, indicating a lack of research from low-resource settings.
Article
Biotechnology & Applied Microbiology
Bernd Bokemeyer, Tibor Hlavaty, Matthieu Allez, Pamela Selema, Shahrzad Moosavi, Mary Jane Cadatal, Heather Fowler, Markus Mueller, Katherine F. Liau, Javier P. Gisbert
Summary: This study investigated the use of CT-P13 in the treatment of patients with Crohn's disease and ulcerative colitis. The results showed that the safety information for CT-P13 was consistent with the known safety profile for IFX and did not alter the established benefit-risk profile of CT-P13.
EXPERT OPINION ON BIOLOGICAL THERAPY
(2023)
Article
International Relations
Janis van der Westhuizen
Summary: While much research focuses on how international achievement can strengthen domestic legitimacy, there is little analysis on how lack of domestic support can undermine status signaling. In rising democracies, state elites must balance the benefits of hosting mega-events in both practical and symbolic terms. Brazil struggled to rely on the expressive value of hosting the World Cup due to political fallout from the economic crisis, while South Africa saw the 2010 World Cup as a significant status and nation-building moment.
FOREIGN POLICY ANALYSIS
(2021)
Article
Gastroenterology & Hepatology
Jen-Hao Yeh, Tsung-Chin Wu, Po-Jen Hsiao, Daw-Shyong Perng, Jen-Chieh Chen, Gin-Ho Lo, Chia-Chang Hsu, Chih-Wen Lin
Summary: A retrospective study found that a 1-day low-residue diet (LRD) before colonoscopy can achieve comparable bowel preparation results to a 3-day LRD, regardless of the type of cleansing agent used or the use of supplemental laxatives.
ADVANCES IN DIGESTIVE MEDICINE
(2023)
Article
Health Policy & Services
Noor Khan, Joshua Rubin, Michelle Williams
Summary: The Mobilizing Computable Biomedical Knowledge (MCBK) community aims to ensure access and application of computable knowledge in health organizations. They work on developing national policies and standards for discoverable and accessible data, promoting the adoption of health knowledge, and supporting healthcare, research, public health, and education. This report summarizes the outcomes of the Fifth Annual MCBK meeting, a global gathering held virtually in July 2022 with over 200 participants from diverse domains.
LEARNING HEALTH SYSTEMS
(2023)
Article
Emergency Medicine
Mahdi Talebi, Morteza Talebi Doluee, Mohamadali Jafari, Hamid Zamani Moghaddam, Mahdi Foroughian, Mojtaba Moazzami, Hassan Gholami, Hamidreza Reihani
Summary: This study compared the emergency medicine residency curriculum of several countries with Iran, and found that while Iran's curriculum is comprehensive, there are limitations in terms of the duration of residency and the process of entering the field.
ARCHIVES OF ACADEMIC EMERGENCY MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Benjamin Click, Edward L. Barnes, Benjamin L. Cohen, Bruce E. Sands, John S. Hanson, Miguel Regueiro, David T. Rubin, Marla C. Dubinsky, Derek R. Gazis, Laura Dalfonso, Janet S. Hildebrand, Julie M. Crawford, Millie D. Long
Summary: Data on care patterns for inflammatory bowel disease (IBD) in real-world practice are limited. This study established a real-world cohort of IBD patients receiving care at academic and community sites, providing a valuable resource for research on treatment patterns and clinical outcomes. Patients with Crohn's disease (CD) had higher biologic utilization rates compared to ulcerative colitis (UC) patients, and CD patients receiving care at academic sites exhibited more complicated disease characteristics than those at community sites.
CROHNS & COLITIS 360
(2021)
Article
Gastroenterology & Hepatology
Benjamin Click, Edward L. Barnes, Benjamin L. Cohen, Bruce E. Sands, John S. Hanson, Miguel Regueiro, David T. Rubin, Marla C. Dubinsky, Derek R. Gazis, Laura Dalfonso, Janet S. Hildebrand, Julie M. Crawford, Millie D. Long
Summary: Data on care patterns for inflammatory bowel disease (IBD) from large-scale, diverse clinical cohorts in real-world practice are scarce. A real-world cohort of IBD patients at academic and community sites was developed for comparative study of therapies and disease natural history. CD patients had higher biologic utilization rates than UC patients, with those at academic sites showing more complicated disease characteristics.
CROHNS & COLITIS 360
(2021)
Article
Immunology
Jason P. Martens, Bastiaan T. Rutjens
Summary: Three studies found that the relative spirituality and religiosity of a region predict COVID-19 vaccination rates, with regions higher in spirituality and/or religiosity having lower vaccination rates. These results suggest that real-world behavior can be predicted by the relative spirituality and religiosity of a region.
Article
Hospitality, Leisure, Sport & Tourism
Ryan Yung, Catheryn Khoo-Lattimore, Girish Prayag, Ekaterina Surovaya
Summary: This study investigates the influence of VR on destination image and perceived destination choice risk for family tourism. The findings suggest that VR positively impacts both destination image and reduces perceived destination choice risk, with stronger cognitive and affective components of destination image attributed to immersive experiences. The study highlights the importance of tailored VR content for families in destination marketing strategies.
TOURISM RECREATION RESEARCH
(2021)
Article
Critical Care Medicine
Filip Haegdorens, Eirian Edwards, Ralph K. So, Christian P. Subbe
Summary: This cross-sectional study aimed to assess the readiness of international hospitals to implement consensus-based quality metrics for rapid response systems (RRS) and evaluate the feasibility of collecting these metrics. The study found variations in the adoption of quality metrics among hospitals, with certain metrics being collected less frequently. It highlights the importance of standardized quality metrics for effective RRS functioning and continuous improvement in patient care.
RESUSCITATION PLUS
(2023)
Article
Immunology
Gabriela Fonseca-Camarillo, Janette Furuzawa-Carballeda, Braulio Martinez-Benitez, Rafael Barreto-Zuniga, Jesus K. Yamamoto-Furusho
Summary: In patients with active UC, EMMPRIN, MMP23 and MMP10 were upregulated, indicating their involvement in the inflammatory process.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Erick M. Toro-Monjaraz, Gabriela Fonseca-Camarillo, Flora Zarate-Mondragon, Ericka Montijo-Barrios, Jose Cadena-Leon, David Avelar-Rodriguez, Jaime Ramirez-Mayans, Roberto Cervantes-Bustamante, Jesus K. Yamamoto-Furusho
Summary: In this study, it was observed that the immune response in CMPA appears to be mediated by a Th1, Th2, and Th17 cytokine profile, with the rectum being the main affected site.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Article
Immunology
Gabriela Fonseca-Camarillo, Janette Furuzawa-Carballeda, Angel A. Priego-Ranero, Braulio Martinez-Benitez, Rafael Barreto-Zuniga, Jesus K. Yamamoto-Furusho
Summary: This study is the first to characterize the gene and protein expression of the TOB/BTG family in rectal and ileum tissues of IBD patients. Results showed decreased expression of TOB1 and BTG1 genes in colonic mucosa of UC patients, while overexpression of TOB2 and BTG2 genes in patients with UC in remission. High TOB2 gene expression was associated with histological remission.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Monica R. Zavala-Solares, Gabriela Fonseca-Camarillo, Miguel Valdovinos, Julio Granados, Guido Grajales-Figueroa, Luis Zamora-Nava, Nancy Aguilar-Olivos, Luis R. Valdovinos-Garcia, Jesus K. Yamamoto-Furusho
Summary: This study found differential expression of inflammatory mediators in the esophageal mucosa of patients with different GERD endoscopic phenotypes. IL-1B and TNF-alpha could be useful for differentially diagnosing AAE and NAE in the non-erosive phenotype using endoscopic biopsies.
BMC GASTROENTEROLOGY
(2021)
Article
Immunology
Gabriela Fonseca-Camarillo, Janette Furuzawa-Carballeda, Natalia Razo-Lopez, Rafael Barreto-Zuniga, Braulio Martinez-Benitez, Jesus K. Yamamoto-Furusho
Summary: The study showed an increase in gene and protein expression of SPARC in patients with active UC, with significant correlation to histological activity. The results suggest that SPARC could be a marker of intestinal inflammation in UC.
Article
Gastroenterology & Hepatology
Bruce E. Sands, Laurent Peyrin-Biroulet, Jaroslaw Kierkus, Peter D. R. Higgins, Monika Fischer, Vipul Jairath, Fumihito Hirai, Geert D'Haens, Ruth M. Belin, Debra Miller, Elisa Gomez-Valderas, April N. Naegeli, Jay L. Tuttle, Paul F. Pollack, William J. Sandborn
Summary: Mirikizumab demonstrates efficacy and safety in patients with moderate-to-severe Crohn's disease. Significant endoscopic response is observed in the Mirikizumab groups compared to the placebo group at Week 12 and is sustained through Week 52. The frequency of adverse events is similar between Mirikizumab and placebo groups.
Article
Gastroenterology & Hepatology
William J. Sandborn, Laurent Peyrin-Biroulet, Daniel Quirk, Wenjin Wang, Chudy Nduaka, Arnab Mukherjee, Chinyu Su, Bruce E. Sands
Summary: In patients with ulcerative colitis who did not respond to initial treatment with tofacitinib, extended induction therapy (16 weeks) with 10 mg twice daily led to more than half of the patients (52.2%) achieving clinical response. Most delayed responders who continued to receive tofacitinib therapy were in remission at Month 36.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Gastroenterology & Hepatology
Bram Verstockt, Azucena Salas, Bruce E. Sands, Clara Abraham, Haim Leibovitzh, Markus Neurath, Niels Vande Casteele
Summary: IL-12 and IL-23 play a crucial role in intestinal homeostasis and inflammation, and are implicated in the pathogenesis of inflammatory bowel disease. Monoclonal antibodies targeting IL-12 and/or IL-23 have been developed for the treatment of Crohn's disease and ulcerative colitis. This Review summarizes the biological characteristics of IL-12 and IL-23, discusses their role in intestinal homeostasis and inflammation, and highlights the development of drugs targeting IL-12 and/or IL-23.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Immunology
Carlos A. Barrera-Ochoa, Gabriela Fonseca-Camarillo, Maria Elisa Vega-Memije, Janette Furuzawa-Carballeda, Karen Uriarte-Ruiz, Dheni Aide Fernandez-Camargo, Jesus K. Yamamoto-Furusho
Summary: This study is the first to report the expression of TOB/BTG family genes and proteins in skin tissues from patients with plaque psoriasis. The mRNA levels and protein expression of TOB/BTG family were significantly decreased in psoriatic skin tissue compared to non-inflammatory control skin tissue. The expression of TOB1/2, BTG1,2, and BTG4/CD16 double-positive cells was found to be higher in normal control skin tissues and much lower in patients with plaque psoriasis, especially in moderate-severe patients.
IMMUNOLOGIC RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Sophie Vieujean, James O. Lindsay, Ferdinando D'Amico, Vineet Ahuja, Mark S. Silverberg, Ajit Sood, Jesus K. Yamamoto-Furusho, Masakazu Nagahori, Mamoru Watanabe, Ioannis E. Koutroubakis, Kalliopi Foteinogiannopoulou, Irit Avni Biron, Alissa Walsh, An Outtier, Rie Louise Moller Nordestgaard, Maria T. Abreu, Marla Dubinsky, Corey Siegel, Edouard Louis, Iris Dotan, Walter Reinisch, Silvio Danese, David T. Rubin, Laurent Peyrin-Biroulet
Summary: This study analyzes the reasons for non-enrollment of IBD patients in RCTs and finds that patients are lost at each step, with eligibility criteria, the risk of placebo assignment, and insufficient disease activity being the main barriers.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Immunology
Gabriela Fonseca-Camarillo, Janette Furuzawa-Carballeda, Rafael Barreto-Zuniga, Braulio Martinez-Benitez, Jesus K. Yamamoto-Furusho
Summary: This study identified increased expression of IL-39 in patients with inflammatory bowel disease, suggesting its potential role in regulating inflammation.
IMMUNOLOGIC RESEARCH
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Amanda M. Johnson, Maria Barsky, Waseem Ahmed, Samantha Zullow, Jonathan S. Galati, Vipul Jairath, Neeraj Narula, Farhad Peerani, Benjamin H. Click, Elliot Coburn, Thucnhi T. Dang, Stephanie Gold, Manasi Agrawal, Rajat Garg, Manik Aggarwal, Danah Mohammad, Brendan P. Halloran, Gursimran Kochhar, Hannah Todorowski, Nabeeha Mohy-Ud-Din, James L. Izanec, Amanda M. Teeple, Christopher Gasink, Erik Muser, Zhijie Ding, Arun Swaminath, Komal Lakhani, Daniel Hogan, Samit Datta, Ryan C. Ungaro, Siddharth Singh, Brigid Boland, Matthew Bohm, Monika Fischer, Sagi Sashi, Anita Afzali, Thomas Ullman, Garrett Lawlor, Daniel C. Baumgart, Shannon Chang, David Hudesman, Dana J. Lukin, Ellen J. Scherl, Jean Frederic Colombel, Bruce E. Sands, Corey A. Siegel, Miguel D. Regueiro, William J. Sandborn, David H. Bruining, Sunanda V. Kane, Edward V. Loftus, Parambir Dulai
Meeting Abstract
Gastroenterology & Hepatology
Stephanie Gold, Manasi Agrawal, Vipul Jairath, Jonathan S. Galati, Elliot Coburn, Benjamin H. Click, Farhad Peerani, Neeraj Narula, Samantha Zullow, Waseem Ahmed, Maria Barsky, Amanda M. Johnson, Thucnhi T. Dang, Rajat Garg, Manik Aggarwal, Danah Mohammad, Brendan P. Halloran, Gursimran Kochhar, Hannah Todorowski, Nabeeha Mohy-Ud-Din, James L. Izanec, Amanda M. Teeple, Christopher Gasink, Erik Muser, Zhijie Ding, Arun Swaminath, Komal Lakhani, Daniel Hogan, Samit Datta, Siddharth Singh, Brigid Boland, Matthew Bohm, Monika Fischer, Sagi Sashi, David H. Bruining, Sunanda V. Kane, Edward V. Loftus, Anita Afzali, Thomas Ullman, Garrett Lawlor, Daniel C. Baumgart, Shannon Chang, David Hudesman, Dana J. Lukin, William J. Sandborn, Ellen J. Scherl, Corey A. Siegel, Miguel D. Regueiro, Jean Frederic Colombel, Bruce E. Sands, Parambir Dulai, Ryan C. Ungaro
Meeting Abstract
Gastroenterology & Hepatology
Bincy P. Abraham, Elyssa Ott, Christopher Busse, Conor J. Murphy, Lindsay Miller, Daniel C. Baumgart, Ellen J. Scherl, Christopher Gasink
Article
Gastroenterology & Hepatology
Bhairavi Balram, Harshad Joshi, Karen Wong, Karen I. Kroeker, Levinus A. Dieleman, Brendan P. Halloran, Daniel C. Baumgart, Farhad Peerani
Summary: This study found that continuing 5-ASA therapy in ulcerative colitis patients escalated to infliximab did not provide additional benefit in controlling inflammation, and was not associated with increased likelihood of achieving clinical and endoscopic remission.
DIGESTIVE DISEASES AND SCIENCES
(2021)
