Review
Biochemistry & Molecular Biology
Tyler Atagozli, David E. Elliott, Mirac Nedim Ince
Summary: Helminths are multicellular invertebrates that live in the gut of vertebrate animals, including humans. They can cause pathology and require treatment, but can also have commensal or symbiotic relationships with their hosts. Epidemiological data suggests that helminth exposure may provide protection against immune disorders, such as allergies and autoimmune illnesses.
Article
Genetics & Heredity
Marcos Calderon, Manuel J. More, Gustavo A. Gutierrez, Federico Abel Ponce de Leon
Summary: The project aimed to develop an alpaca single nucleotide polymorphism (SNP) microarray to improve the economic benefits and quality of life for small farm producers. The incorporation of molecular marker technology overcame current limitations for genetic improvement programs.
Article
Multidisciplinary Sciences
Yaxin Xu, Wentao Xue, Hongwei Gao, Jiabo Cui, Lingzhi Zhao, Chongge You
Summary: Studies have shown that TLRs gene polymorphisms may play a significant role in HBV and HCV infections, with certain SNPs affecting disease progression and prognosis. However, the exact mechanism of action still requires further exploration.
Article
Biochemistry & Molecular Biology
Saima Suleman, Gagan Chhabra, Rubab Raza, Arslan Hamid, Javed Anver Qureshi, Nihal Ahmad
Summary: This study assessed the association between nsSNPs of the CARD14 gene and psoriasis in a Pakistani population. The study found that two nsSNPs, rs2066965 and rs34367357, were associated with psoriasis, and that the heterozygous genotype of rs2066965 was more prevalent in patients with joint pain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Chuanyang Lu, Qiuni Chen, Hong Tao, Lei Xu, Jiaxin Li, Chunling Wang, Liang Yu
Summary: There is a causal relationship between inflammatory bowel disease (IBD) and diffuse large B-cell lymphoma (DLBCL), especially Crohn's disease.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Medicine, General & Internal
Aleksandra Kubas, Ewa Malecka-Wojciesko
Summary: Vaccination against COVID-19 is considered safe and effective for patients with IBD, although further research is needed to understand its safety in special populations. The willingness to receive the vaccine among IBD patients is conflicting, with concerns about effectiveness and safety being the most common reasons for hesitancy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Zixue Xuan, Yiwen Zhang, Jinying Jiang, Xiaowei Zheng, Xiaoping Hu, Xiuli Yang, Yanfei Shao, Guobing Zhang, Ping Huang
Summary: This study identified m(6)A-SNPs associated with breast cancer and explored their potential functions. The SNPs rs4829 and rs9610915 were found to potentially be associated with breast cancer due to having eQTL signals, altered gene expression, and proximity to m(6)A modification sites. Further research is needed to clarify how genetic variation affects epigenetic modification and its functions in breast cancer pathogenesis.
Article
Microbiology
Pranab Kumar Mahata, Regina Sharmila Dass, Archana Pan, Babylakshmi Muthusamy
Summary: This study extensively analyzed the morphological features of Aspergillus fungi isolated from fennel seeds, along with their classification, genetic characteristics, and SNP analysis. A total of 14 Aspergillus species were identified from 70 fennel samples, with A. niger and A. flavus being the most common species.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Laura Massarenti, Christina Aniol-Nielsen, Christian Enevold, Henrik Toft-Hansen, Claus Henrik Nielsen
Summary: Single nucleotide polymorphisms (SNPs) in insulin and insulin receptor genes may influence the interaction between the two molecules, and anti-insulin antibodies (IAs) may be associated with insulin treatment in patients with diabetes. This study found that two SNPs in the human insulin gene and two SNPs in the insulin receptor gene were associated with type 1 diabetes and glycaemic control.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Shewaye Fituma Natae, Mohammed Abdulridha Merzah, Janos Sandor, Roza Adany, Zsuzsanna Bereczky, Szilvia Fiatal
Summary: The study aimed to explore the combined VT risk predictability of five strongly associated SNPs and non-genetic risk factors in the Hungarian population. The results revealed that rs6025 and rs2036914 were significantly associated with VT risk, while rs8176719 showed significant association in some models. However, rs2066865 and rs1799963 were not significantly associated. The combination of genetic and non-genetic risk factors significantly increased the accuracy of VT risk prediction.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Health Care Sciences & Services
Tingting Zhao, Yiming Zhang, Joochul Lee, Angela R. Starkweather, Erin E. Young, Xiaomei Cong
Summary: This study found that certain genetic polymorphisms are associated with the risk and symptoms of irritable bowel syndrome, including abdominal pain, sleep disturbance, and fatigue. These findings contribute to the understanding of how genetic variations influence the development and changes of IBS symptoms over time.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Chao Liu, Yuhong Jiang, Ganglei Liu, Zhushu Guo, Qianqian Jin, Dongju Long, Weihan Zhou, Ke Qian, Hua Zhao, Kuijie Liu
Summary: This study found that PPARGC1A was downregulated in DSS-induced colitis and DSS-stimulated colonic epithelial cells, and PDT treatment could upregulate PPARGC1A expression. Knockdown of PPARGC1A could attenuate the therapeutic effects of PDT on DSS-induced colitis and DSS-stimulated colonic epithelial cells.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Immunology
Huldani Huldani, Ria Margiana, Fawad Ahmad, Maria Jade Catalan Opulencia, Mohammad Javed Ansari, Dmitry Olegovich Bokov, Nargiza N. Abdullaeva, Homayoon Siahmansouri
Summary: Inflammatory bowel disease (IBD) is caused by various pathophysiologic pathways and immune-pathologic etiologies. Mesenchymal Stem Cells (MSCs) have been suggested as a potential treatment for IBD due to their immune regulatory functions. Clinical trials using MSCs from bone marrow, umbilical cord, and adipose tissue have shown promising results in terms of safety. However, further research is needed to obtain more reliable results and more support from laboratory evidence.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lanxiao Cao, Luyan Gu, Jiali Pu, Dayao Lv, Jun Tian, Xinzhen Yin, Ting Gao, Zhe Song, Jinyu Lu, Gaohua Zhao, Baorong Zhang, Yaping Yan, Guohua Zhao
Summary: This study assessed variant burden in ET-associated genes in a large Chinese population cohort. The findings suggest that the rs10937625 variant in the STK32B gene may increase the risk of ET in the eastern Chinese population.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2023)
Article
Microbiology
Md-Mafizur Rahman, Sang-Jin Lim, Yung-Chul Park
Summary: A rapid and high-quality method based on single-nucleotide polymorphisms (SNPs) was developed to improve detection and reduce the burden of salmonellosis.
Article
Cardiac & Cardiovascular Systems
N. J. Earle, K. K. Poppe, A. P. Pilbrow, V. A. Cameron, R. W. Troughton, J. R. Skinner, D. R. Love, A. N. Shelling, G. A. Whalley, C. J. Ellis, A. M. Richards, R. N. Doughty
AMERICAN HEART JOURNAL
(2015)
Article
Medicine, General & Internal
Marcelo Sobral-Leite, Jelle Wesseling, Vincent T. H. B. M. Smit, Heli Nevanlinna, Martine H. van Miltenburg, Joyce Sanders, Ingrid Hofland, Fiona M. Blows, Penny Coulson, Gazinska Patrycja, Jan H. M. Schellens, Rainer Fagerholm, Paivi Heikkila, Kristiina Aittomaki, Carl Blomqvist, Elena Provenzano, Hamid Raza Ali, Jonine Figueroa, Mark Sherman, Jolanta Lissowska, Arto Mannermaa, Vesa Kataja, Veli-Matti Kosma, Jaana M. Hartikainen, Kelly-Anne Phillips, Fergus J. Couch, Janet E. Olson, Celine Vachon, Daniel Visscher, Hermann Brenner, Katja Butterbach, Volker Arndt, Bernd Holleczek, Maartje J. Hooning, Antoinette Hollestelle, John W. M. Martens, Carolien H. M. van Deurzen, Bob van de Water, Annegien Broeks, Jenny Chang-Claude, Georgia Chenevix-Trench, Douglas F. Easton, Paul D. P. Pharoah, Montserrat Garcia-Closas, Marjo de Graauw, Marjanka K. Schmidt
Review
Pharmacology & Pharmacy
Brenda Brenner S. Cerqueira, Annette Lasham, Andrew N. Shelling, Raida Al-Kassas
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2015)
Article
Oncology
Michelle K. Wilson, Peter Fong, Soizick Mesnage, Kathryn Chrystal, Andrew Shelling, Kathryn Payne, Helen Mackay, Lisa Wang, Stephane Laframboise, Marjan Rouzbahman, Wilfred Levin, Amit M. Oza
GYNECOLOGIC ONCOLOGY
(2015)
Article
Obstetrics & Gynecology
Lynsey M. Cree, Elizabeth R. Hammond, Andrew N. Shelling, Martin C. Berg, John C. Peek, Mark P. Green
HUMAN REPRODUCTION
(2015)
Article
Obstetrics & Gynecology
Elizabeth R. Hammond, Bert Stewart, John C. Peek, Andrew N. Shelling, Lynsey M. Cree
HUMAN REPRODUCTION
(2015)
Article
Cardiac & Cardiovascular Systems
Nikki Earle, Jodie Ingles, Richard D. Bagnall, Belinda Gray, Jackie Crawford, Warren Smith, Andrew N. Shelling, Donald R. Love, Chris Semsarian, Jonathan R. Skinner
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2015)
Article
Oncology
Annette Lasham, Sunali Y. Mehta, Sandra J. Fitzgerald, Adele G. Woolley, James I. Hearn, Daniel G. Hurley, Igor Ruza, Michael Algie, Andrew N. Shelling, Antony W. Braithwaite, Cristin G. Print
INTERNATIONAL JOURNAL OF CANCER
(2016)
Article
Biochemistry & Molecular Biology
Mohanraj Krishnan, John M. D. Thompson, Edwin A. Mitchell, Rinki Murphy, Lesley M. E. McCowan, Andrew N. Shelling
MOLECULAR BIOSYSTEMS
(2017)
Article
Pediatrics
Kathryn Dalrymple, John M. D. Thompson, Shahina Begum, Keith M. Godfrey, Lucilla Poston, Paul T. Seed, Lesley M. E. McCowan, Clare Wall, Andrew Shelling, Robyn North, Wayne S. Cutfield, Edwin A. Mitchell
Article
Pharmacology & Pharmacy
Yu Gao, Andrew N. Shelling, David Porter, Euphemia Leung, Zimei Wu
Summary: This study investigates the structural integrity and long-term stability of trastuzumab under different stress factors in formulation development. Results show that trastuzumab is resistant to mechanical and freeze-and-thaw stress, but unstable under acidic and alkaline environments. Low temperature and low concentration favor long-term stability. This study provides valuable stability information for developing trastuzumab-involved nano-formulation and clinical applications.
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
(2023)
Article
Psychology, Clinical
Y. Nina Gao, Brandon Coombes, Euijung Ryu, Vanessa Pazdernik, Gregory Jenkins, Richard Pendegraft, Joanna Biernacka, Mark Olfson
Summary: This study compares patients diagnosed with depression without anxiety, anxiety without depression, or both depression and anxiety, and identifies differences in the clinically observable phenome between these groups. The results show that patients diagnosed with depression only are more likely to have diagnoses of obesity, sleep apnea, and type II diabetes, while patients diagnosed with anxiety only are more likely to have diagnoses of palpitations, benign skin neoplasms, and cardiac dysrhythmias. Patients with comorbid depression and anxiety have higher rates of other mental health disorders, substance use disorders, sleep problems, and gastroesophageal reflux.
PSYCHOLOGICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Andrew N. Shelling, Noha Ahmed Nasef
Summary: Premature ovarian insufficiency (POI) is a condition characterized by dysfunction or early depletion of ovarian follicles, leading to early fertility loss in women. This review discusses the role of oxidative stress in ovarian aging and dysfunction associated with POI, focusing on mitochondrial dysfunction, apoptosis, inflammation, and genetic defects, autoimmunity, chemotherapy as hallmarks of POI that contribute to increased oxidative stress. Lifestyle factors, such as diet, low energy availability, and BMI, are also highlighted as potential risk factors for POI. Additionally, dietary interventions, including consumption of oily fish, mitochondria nutrient therapy, melatonin, dairy, and vitamins, are discussed as potential strategies for at-risk women, combined with personalized nutrition. Understanding the impact of lifestyle and oxidative stress on POI holds promise in reducing its burden.
Review
Chemistry, Multidisciplinary
Yu Gao, Mingtan Tang, Euphemia Leung, Darren Svirskis, Andrew Shelling, Zimei Wu
Review
Obstetrics & Gynecology
Chevy Chapman, Lynsey Cree, Andrew N. Shelling
INTERNATIONAL JOURNAL OF WOMENS HEALTH
(2015)