Article
Microbiology
Gregoire Chevalier, Arnaud Laveissiere, Guillaume Desachy, Nicolas Barnich, Adeline Sivignon, Marc Maresca, Cendrine Nicoletti, Eric Di Pasquale, Margarita Martinez-Medina, Kenneth William Simpson, Vijay Yajnik, Harry Sokol, Temitayo Adegbamigbe, Tariq Ahmad, Ian Arnott, Yoram Bouhnik, Franck Carbonnel, Jean-Frederic Colombel, Glen Doherty, J. R. Fraser Cummings, Xavier Hebuterne, Hans Herfarth, David Kevans, Guillaume Pineton de Chambrun, Maria Nachury, Stephane Nancey, Xavier Roblin, Mark A. W. Tremelling, Jonathan Plassais, Francesco Strozzi, Alessandra Cervino, Rachel Morra, Christophe Bonny
Summary: The study identified a significant enrichment of FimH-expressing bacteria in the gut microbiome of CD patients, with FimH playing a crucial role in adhesion and inflammation induction. The specific FimH-blocker TAK-018 was shown to prevent bacterial adhesion and inflammation, potentially offering a promising treatment option for CD patients.
News Item
Multidisciplinary Sciences
Smriti Mallapaty
Summary: Innate immunity may be the reason why children have better outcomes with the virus, but the Delta variant introduces new uncertainties.
Review
Biotechnology & Applied Microbiology
Kangsan Kim, Minjeong Kang, Byung-Kwan Cho
Summary: In recent years, there has been increasing interest in gut commensal engineering for therapeutic applications. Recent advancements in synthetic biology and systems biology have enabled effective utilization of gut commensals for therapy and diagnosis, including the rational design of synthetic microbial consortia and the construction of synthetic cells that can detect specific signals in the intestine and deliver therapeutic drugs in real-time.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Immunology
Andre F. Rendeiro, Charles Kyriakos Vorkas, Jan Krumsiek, Harjot K. Singh, Shashi N. Kapadia, Luca Vincenzo Cappelli, Maria Teresa Cacciapuoti, Giorgio Inghirami, Olivier Elemento, Mirella Salvatore
Summary: This study investigated the blood metabolomic data of COVID-19 patients using high-throughput targeted nuclear magnetic resonance (NMR) spectroscopy and high-dimensional flow cytometry. The findings showed significant changes in serum metabolome composition associated with disease severity and response to therapy. The study established a clinically annotated, biologically-interpretable space for precise disease monitoring and characterized the temporal dynamics of metabolomic change and treatment response. The results demonstrate that joint immuno-metabolic measurements can be used for patient stratification and early prediction of severe disease.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Jianbo Fu, Feng Zhu, Cheng-Jian Xu, Yang Li
Summary: Metabolic processes play a crucial role in immune regulation. Metabolomics provides a comprehensive approach to study the interactions between metabolism and immunity in physiology and disease. This review discusses recent technological developments in metabolomics and its integration with other omics approaches, providing guidance for researchers in the field of immune research.
Article
Cell Biology
Mathieu Claviere, Aude Lavedrine, Guenaelle Lamiral, Mariette Bonnet, Pauline Verlhac, Denitsa S. Petkova, Lucile Espert, Remi Duclaux-Loras, Julie Lucifora, Michel Rivoire, Gilles Boschetti, Stephane Nancey, Aurore Rozieres, Christophe Viret, Mathias Faure
Summary: This study investigates the effects of measles virus infection on cell susceptibility to bacterial infection. Researchers discovered that measles virus infection promotes the replication of Salmonella Typhimurium in infected cells and reduces the replication of Shigella flexneri. They also found that the expression levels of autophagy receptors SQSTM1/p62 and TAX1BP1/T6BP are decreased in measles virus-induced syncytia, preventing effective anti-Salmonella autophagy.
Article
Gastroenterology & Hepatology
F. Magro, J. Sabino, F. Rosini, M. Tripathi, P. Borralho, P. Baldin, S. Danese, A. Driessen, I. O. Gordon, M. Iacucci, N. Noor, M. Svrcek, L. Peyrin-Biroulet, R. Feakins
Summary: Inflammatory bowel disease (IBD) relies on mucosal healing as a significant therapeutic target and predictor of clinical course. In Crohn's disease (CD), there are limited studies on the importance of histological remission as a therapeutic target. Standardization of evaluating CD histological activity procedures is desirable. A consensus group by the European Crohn's and Colitis Organisation (ECCO) has developed position statements on CD histology to address these needs.
JOURNAL OF CROHNS & COLITIS
(2022)
Editorial Material
Multidisciplinary Sciences
Taylor A. Poor, Navdeep S. Chandel
Summary: Mitochondria, cellular organelles, possess their own DNA and RNA. A recent study discovered that the molecule fumarate can induce the release of these nucleic acids into the cytosol, leading to abnormal inflammation.
Article
Gastroenterology & Hepatology
Jeremy Adler, Sally J. Eder, Acham Gebremariam, Christopher J. Moran, Lee M. Bass, Jonathan Moses, Jeffery D. Lewis, Andrew A. M. Singer, Tina L. Morhardt, Joseph A. Picoraro, Vanessa Cardenas, George M. Zacur, Richard B. Colletti
Summary: The study evaluated a simplified method for retrospectively assessing colonoscopy reports, finding that it accurately and reliably correlates with assessments from colonoscopy videos.
INFLAMMATORY BOWEL DISEASES
(2022)
Review
Microbiology
Madeline R. Barron, Vincent B. Young
Summary: The relationship between the gut environment and bacterial colonization is of great significance. The complex interactions between multiple factors in the gut environment make it difficult to uncover the characteristics of the system using reductionist methods. The systems biology approach provides a more comprehensive perspective. This article explores the relationship between the gut environment and bacterial colonization from the perspective of systems biology, and provides guidance for future research.
Article
Multidisciplinary Sciences
Elsje G. Otten, Emma Werner, Ana Crespillo-Casado, Keith B. Boyle, Vimisha Dharamdasani, Claudio Pathe, Balaji Santhanam, Felix Randow
Summary: The study reveals that the ubiquitin coat on Salmonella invading the cytosol is formed through the ubiquitylation of the lipid A moiety of bacterial lipopolysaccharide by E3 ubiquitin ligase RNF213, which is a risk factor for moyamoya disease. RNF213 is essential for restricting bacterial proliferation and triggering the generation of the bacterial ubiquitin coat, leading to cell-autonomous immunity against intracellular bacteria.
Review
Immunology
Denis A. Mogilenko, Alexey Sergushichev, Maxim N. Artyomov
Summary: Immunometabolism has become a new interdisciplinary field of research in recent years, providing important insights into the regulation of immune responses. Traditional approaches and new technologies, such as spatially resolved metabolic imaging and computational algorithms, have helped us understand the complexity of immunometabolic regulation. This review discusses recent studies and technological developments that aim to capture the interplay between immune responses and metabolism.
ANNUAL REVIEW OF IMMUNOLOGY
(2023)
Review
Cell Biology
Raquel Linares, Ruben Frances, Ana Gutierrez, Oriol Juanola
Summary: This review explores the impact of bacterial antigen translocation, intestinal barrier permeability, host immune response, and genetic predisposition on the inflammatory response observed in CD patients. Evidence suggests that bacterial products translocating leads to uncontrolled inflammation in CD patients, with gut bacterial genomic fragments serving as a marker for increased risk of relapse.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Immunology
Noemie Alphonse, Ruth E. Dickenson, Abrar Alrehaili, Charlotte Odendall
Summary: Type III interferons (IFNs), or IFN lambdas, are cytokines that are produced in response to microbial ligands. They signal through the IFN lambda receptor complex (IFNLR) located on epithelial cells and select immune cells at barrier sites. While their multiple anti-viral activities have been extensively studied, their roles in immunity against bacteria are only recently emerging.
FRONTIERS IN IMMUNOLOGY
(2022)
Editorial Material
Immunology
Kevin M. Magnaye, Susan V. Lynch
Summary: The study found that Debaryomyces hansenii impairs intestinal healing in mice and is prevalent in the inflamed mucosa of CD patients, suggesting it may be an important factor in the pathophysiology of Crohn's disease.
Editorial Material
Biochemistry & Molecular Biology
Alan Huett
MOLECULAR SYSTEMS BIOLOGY
(2017)
Article
Multidisciplinary Sciences
Adam Collins, Alan Huett
Editorial Material
Cell Biology
Alan Huett, Ramnik Xavier
Article
Cell Biology
Alan Huett, Steven A. McCarroll, Mark J. Daly, Ramnik J. Xavier
Review
Cell Biology
Thaddeus S. Stappenbeck, John D. Rioux, Atsushi Mizoguchi, Tatsuya Saitoh, Alan Huett, Arlette Darfeuille-Michaud, Tom Wileman, Noboru Mizushima, Simon Carding, Shizuo Akira, Miles Parkes, Ramnik J. Xavier
Article
Microbiology
Alan Huett, Robert J. Heath, Jakob Begun, Slim O. Sassi, Leigh A. Baxt, Jatin M. Vyas, Marcia B. Goldberg, Ramnik J. Xavier
CELL HOST & MICROBE
(2012)
Article
Cell Biology
Pierre Lapaquette, Anne-Lise Glasser, Alan Huett, Ramnik J. Xavier, Arlette Darfeuille-Michaud
CELLULAR MICROBIOLOGY
(2010)
Article
Gastroenterology & Hepatology
Alan Huett, Gautam Goel, Ramnik J. Xavier
CURRENT OPINION IN GASTROENTEROLOGY
(2010)
Article
Gastroenterology & Hepatology
Shu-Chen Wei, Ian M. Rosenberg, Zhifang Cao, Alan S. Huett, Ramnik J. Xavier, Daniel K. Podolsky
INFLAMMATORY BOWEL DISEASES
(2012)
Article
Multidisciplinary Sciences
Aylwin C. Y. Ng, Jason M. Eisenberg, Robert J. W. Heath, Alan Huett, Cory M. Robinson, Gerard J. Nau, Ramnik J. Xavier
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2011)
Article
Biochemistry & Molecular Biology
Chiara Greco, Rosa Catania, Dario Leonardo Balacco, Vincenzo Taresco, Francesca Musumeci, Cameron Alexander, Alan Huett, Silvia Schenone
Article
Chemistry, Multidisciplinary
Rosa Catania, David Onion, Emanuele Russo, Mischa Zelzer, Giuseppe Mantovani, Alan Huett, Snow Stolnik
Summary: This study demonstrates the use of mechanoresponsive nano-sized liposomes for intracellular delivery of encapsulated cargo. The release of the cargo is triggered by external ultrasound stimulus and is facilitated by a spiropyran-based compound embedded in the liposomal lipid membrane.
Article
Pharmacology & Pharmacy
Rosa Catania, Francesca Mastrotto, Chris J. Moore, Cynthia Bosquillon, Franco H. Falcone, Alan Huett, Giuseppe Mantovani, Snow Stolnik
Summary: Targeted delivery of membrane-impermeable antibiotics can efficiently treat intracellular infections by enhancing cellular internalization, demonstrating the significance of targeted therapy in this context.
ADVANCED THERAPEUTICS
(2021)
Article
Physics, Applied
Fernando Perez-Cota, Rafael Fuentes-Dominguez, Salvatore La Cavera, William Hardiman, Mengting Yao, Kerry Setchfield, Emilia Moradi, Shakila Naznin, Amanda Wright, Kevin F. Webb, Alan Huett, Claire Friel, Virginie Sottile, Hany M. Elsheikha, Richard J. Smith, Matt Clark
JOURNAL OF APPLIED PHYSICS
(2020)