Review
Medicine, General & Internal
Katarzyna Akutko, Andrzej Stawarski
Summary: Inflammatory bowel diseases (IBD) are chronic inflammatory diseases of the digestive tract with periods of remission and relapses. The etiopathogenesis is not fully understood, leading to only symptomatic treatment. There is a constant need to search for new high safety profile therapies for IBD.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Food Science & Technology
Paulo Sergio Loubet Filho, Thais Otranto Dias, Vitoria Helena de Oliveira Teixeira Reis, Amanda Maria Tomazini Munhoz Moya, Elisvania Freitas dos Santos, Cinthia Bail Betim Cazarin
Summary: The incidence of inflammatory bowel diseases (IBD) has increased and its etiology remains unknown. Risk factors, including food intake, are associated with developing IBD. Functional foods (FF) can modulate the gut microbiota and improve the health quality of IBD patients.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Review
Biochemistry & Molecular Biology
Shaghayegh Baradaran Ghavami, Hamid Asadzadeh Aghdaei, Dario Sorrentino, Shabnam Shahrokh, Maryam Farmani, Fatemeh Ashrafian, Maria Pina Dore, Shahrbanoo Keshavarz Azizi Raftar, Seyed Mobin Khoramjoo, Mohammad Reza Zali
Summary: Inflammatory bowel diseases (IBDs) are immune-mediated, chronic relapsing diseases with a rising prevalence worldwide. Probiotic bacteria may impact immunomodulation by regulating dendritic cells to produce tolerogenic DCs, which could play a role in the treatment of IBD and associated conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Kairuo Wang, Qian Chen, Li Ding, Yefei Zhu, Xinyue Wang, Mengting Zhou, Meiqi Chang, Manman Pei, Yuanyuan Zhang, Yang Zhang, Yu Chen, Huanlong Qin
Summary: This study developed a mucoadhesive probiotic-mediated therapeutic strategy to achieve bioadhesion and prolong the residence time of oral medication in the intestinal tract. It effectively modulated intestinal inflammation and microbiota, enhancing the therapeutic effect.
Review
Nutrition & Dietetics
Natasha Haskey, Stephanie L. Gold, Jeremiah J. Faith, Maitreyi Raman
Summary: Evidence-based dietary guidance on fiber in inflammatory bowel disease (IBD) has been limited, but recent evidence suggests that dietary fiber can improve IBD symptoms and enhance health-related quality of life. However, there is limited knowledge about the optimal types and amounts of fiber for IBD patients. Individual microbiomes also play a role, necessitating a personalized nutritional approach. This review discusses dietary fiber mechanisms, novel fiber sources, and future directions in fiber research.
Review
Cell Biology
Jayshree Mishra, Madyson Stubbs, Longxiang Kuang, Nitza Vara, Priyam Kumar, Narendra Kumar
Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gastrointestinal tract. Probiotics and their engineering show great potential in treating chronic inflammatory conditions, including IBD. Personalized probiotic treatment is important due to the diversity of the gut microbiome in different populations.
MEDIATORS OF INFLAMMATION
(2022)
Review
Biochemistry & Molecular Biology
Zejing Zhao, Shumin Xu, Wangyang Zhang, Danjun Wu, Gensheng Yang
Summary: This review discusses the probiotic properties of Escherichia coli NISSLE 1917 (EcN) in the treatment of inflammatory bowel disease (IBD), particularly ulcerative colitis. The mechanisms of EcN in the remission of IBD are proposed, and recent advancements on functionalized EcN are compiled to provide novel therapeutic strategies for the prevention and treatment of IBD.
Article
Food Science & Technology
Chunxu Chen, Tianhui Li, Guijie Chen, Dan Chen, Yujia Peng, Bing Hu, Yi Sun, Xiaoxiong Zeng
Summary: Sialylated IgG is a glycoprotein in breast milk with anti-inflammatory properties. Previous research has shown that sialylated IgG can promote the growth of Bifidobacterium in the gut microbiota of healthy individuals. This study investigated the prebiotic effect of sialylated IgG on the gut microbiota of patients with inflammatory bowel disease (IBD) through in vitro fermentation.
Article
Food Science & Technology
Cuijiao Feng, Weiqin Zhang, Tao Zhang, Bohai Li, Qiuwen He, Lai-Yu Kwok, Heping Zhang
Summary: This study found that oral administration of pasteurized probiotic fermented milk can significantly alleviate IBD symptoms, reduce inflammation, and restore the stability of the gut microbiota.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Review
Gastroenterology & Hepatology
Indira Benjak Horvat, Ivana Gobin, Andrea Kresovic, Goran Hauser
Summary: The onset and manifestations of irritable bowel syndrome (IBS) are associated with various factors, and the use of probiotics in improving IBS symptoms remains controversial, requiring further research.
WORLD JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Microbiology
Limin Xu, Bingdong Liu, Liujing Huang, Ze Li, Yanbo Cheng, Ye Tian, Guihua Pan, Huijun Li, Yinlan Xu, Weidong Wu, Zongbin Cui, Liwei Xie
Summary: Inflammatory bowel disease (IBD) is a global public health problem. Probiotic consortia and metabolites have been found to ameliorate the symptoms of gut inflammation and regulate microbial dysbiosis. The effect of probiotic consortia is better than that of any single probiotic strain.
MICROBIOLOGY SPECTRUM
(2022)
Article
Multidisciplinary Sciences
Jun Liu, Yixin Wang, William John Heelan, Yu Chen, Zhaoting Li, Quanyin Hu
Summary: Inflammatory bowel diseases (IBDs) are associated with elevated levels of reactive oxygen species (ROS) and dysregulated gut microbiota. In this study, researchers developed ROS-scavenging nanoparticles (HPN) to effectively scavenge ROS. They targeted the colon tissue by conjugating HPN to modified probiotic Escherichia coli Nissle 1917 (EcN). To enhance the efficacy of bacteriotherapy, the EcN cells were encapsulated with a poly-norepinephrine (NE) layer for protection against environmental assaults and prolonged retention in the intestine. The HPN-NE-EcN treatment showed enhanced efficacy in colitis models and increased abundance and diversity of gut microbiota.
Review
Medicine, General & Internal
Juan Luo, Yong-Mei Xie, Mei Wu, Jin-Gui Zhao, Liang-Liang Hu
Summary: Enteral nutrition (EN) is an important diet-remission therapy for inflammatory bowel disease (IBD), especially in children. However, there are variations in the types and methods of EN worldwide, and the treatment is not yet standardized for pediatric IBD.
FRONTIERS IN MEDICINE
(2022)
Article
Microbiology
Zhen -Ping Zou, Yue Du, Ting -Ting Fang, Ying Zhou, Bang -Ce Ye
Summary: Engineered probiotic i-ROBOT has been developed to noninvasively monitor and record the occurrence and progression of inflammatory bowel disease (IBD) in real time, and release treatments based on disease-associated biomarkers. It provides a heritable genomic DNA sequence and a colorimetric signal by activating a base-editing system in response to the inflammatory marker thiosulfate. In experiments with mice, i-ROBOT effectively ameliorated colitis and showed potential for the treatment of gastrointestinal and metabolic disorders.
CELL HOST & MICROBE
(2023)
Review
Pharmacology & Pharmacy
Rocio Rivera Rodriguez, Jeremy James Johnson
Summary: Inflammatory Bowel Disease (IBD) is a chronic autoimmune disease characterized by intestinal inflammation. The incidence of IBD is rapidly increasing in newly developed countries, making it a global concern. Two major types of IBD, ulcerative colitis (UC) and Crohn's disease (CD), have different manifestations and locations of inflammation in the digestive tract. Current FDA-approved treatments for IBD are only effective for 50% of patients and come with serious side effects, highlighting the need for safer and more effective therapies. Plant-based diets, such as the Mediterranean diet rich in anti-inflammatory phytochemicals, have shown benefits in preventing and improving symptoms of IBD. Terpenes, a class of phytochemicals abundant in Mediterranean herbs and citrus fruits, have been studied for their potential to modulate inflammatory signaling in IBD. However, there is still conflicting and inconclusive evidence regarding their effectiveness. This review evaluates preclinical studies on terpenes and their impact on basic inflammatory signaling in IBD.
PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
Jose M. Remes-Troche, Hector Taboada-Liceaga, Samantha Gill, Mercedes Amieva-Balmori, Megan Rossi, Gildardo Hernandez-Ramirez, Jose F. Garcia-Mazcorro, Kevin Whelan
Summary: Nopal fiber supplementation at doses of 20 and 30 g/day was associated with short-term improvement in IBS symptoms, warranting a fully powered clinical trial of longer duration with symptomatic, physiological, and microbiological endpoints.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Critical Care Medicine
Danielle E. Bear, Liisa MacGowan, Maria Elstad, Zudin Puthucheary, Bronwen Connolly, Rebeka Wright, Nicholas Hart, Stephen Harridge, Kevin Whelan, Nicholas A. Barrett, Luigi Camporota
Summary: This study investigated the prevalence of low skeletal muscle index and density in adults with severe respiratory failure and their associations with clinical outcomes. The findings suggest that low skeletal muscle index was associated with a longer duration of venovenous extracorporeal membrane oxygenation, while higher skeletal muscle density was associated with improved ICU survival.
CRITICAL CARE MEDICINE
(2021)
Review
Gastroenterology & Hepatology
Aaron S. Bancil, Alicia M. Sandall, Megan Rossi, Benoit Chassaing, James O. Lindsay, Kevin Whelan
Summary: The global burden of inflammatory bowel disease [IBD] has increased over the 21st century, with factors such as a 'Western diet' and dietary emulsifiers potentially contributing to the rise in prevalence. These factors may trigger the pathogenesis of IBD through various mechanisms.
JOURNAL OF CROHNS & COLITIS
(2021)
Review
Gastroenterology & Hepatology
Samantha K. Gill, Megan Rossi, Balazs Bajka, Kevin Whelan
Summary: Dietary fiber has been shown to benefit gastrointestinal health through consumption of unrefined whole foods. Studies have demonstrated that dietary fiber can regulate gut and microbial effects, with important implications for gastrointestinal disorders.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2021)
Review
Gastroenterology & Hepatology
S. Mark Scott, Magnus Simren, Adam D. Farmer, Philip G. Dinning, Emma Carrington, Marc A. Benninga, Rebecca E. Burgell, Eirini Dimidi, Asma Fikree, Alexander C. Ford, Mark Fox, Caroline L. Hoad, Charles H. Knowles, Klaus Krogh, Karen Nugent, Jose Maria Remes-Troche, Kevin Whelan, Maura Corsetti
Summary: This article discusses the epidemiology, diagnosis, clinical associations, pathophysiology, and investigation of chronic constipation, focusing on contemporary hot topics and themes.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Nutrition & Dietetics
Kevin Whelan, Trevor Murrells, Myfanwy Morgan, Fraser Cummings, Catherine Stansfield, Anne Todd, Shaji Sebastian, Alan Lobo, Miranda C. E. Lomer, James O. Lindsay, Wladyslawa Czuber-Dochan
Summary: In patients with inflammatory bowel disease (IBD), impaired food-related quality of life (FR-QoL) is prevalent and associated with factors such as recurrent disease flares, reduced IBD-specific QoL, and greater IBD-related distress. Patients with poorer FR-QoL tend to have lower intakes of key nutrients important to IBD, including fiber, calcium, phosphorus, and magnesium, which are essential for gut health and bone mineralization.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Editorial Material
Nutrition & Dietetics
Christine M. Williams, Judy L. Buttriss, Kevin Whelan
JOURNAL OF HUMAN NUTRITION AND DIETETICS
(2021)
Review
Gastroenterology & Hepatology
Maura Corsetti, Steven Brown, Giuseppe Chiarioni, Eirini Dimidi, Thomas Dudding, Anton Emmanuel, Mark Fox, Alexander C. Ford, Pasquale Giordano, Ugo Grossi, Michelle Henderson, Charles H. Knowles, P. Ronan O'Connell, Eamonn M. M. Quigley, Magnus Simren, Robin Spiller, Kevin Whelan, William E. Whitehead, Andrew B. Williams, S. Mark Scott
Summary: This article summarizes contemporary perspectives and clinical challenges regarding treatment methods for patients with constipation, including behavioral, conservative, medical, and surgical treatments, and provides a management algorithm to guide clinical practice.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Nutrition & Dietetics
Kevin Whelan, Nicola Jones
Summary: This study investigated the availability, cost, ingredients, nutritional content, and on-pack claims of commercially-produced fermented foods in the UK. The research found that there were differences in the number of products, cost, and nutritional content among different categories of fermented foods. Commercially-produced fermented foods are diverse in their cost, nutritional content, ingredients, and use of on-pack claims.
JOURNAL OF HUMAN NUTRITION AND DIETETICS
(2022)
Article
Nutrition & Dietetics
Charlotte R. Hedin, Neil E. McCarthy, Petra Louis, Freda M. Farquharson, Sara McCartney, Andrew J. Stagg, James O. Lindsay, Kevin Whelan
Summary: This study found that supplementation with prebiotic oligofructose/inulin did not significantly impact calprotectin levels in patients with CD and their siblings, but had a more marked prebiotic effect in healthy siblings. Further research should focus on dietary intervention, including with prebiotics, in the primary prevention of CD.
CLINICAL NUTRITION
(2021)
Article
Gastroenterology & Hepatology
Heidi M. Staudacher, Megan Rossi, Thomas Kaminski, Eirini Dimidi, Frances S. E. Ralph, Bridgette Wilson, Lee D. Martin, Petra Louis, Miranda C. E. Lomer, Peter M. Irving, Kevin Whelan
Summary: The study found that a long-term personalized low FODMAP diet can improve symptoms in IBS patients, with no significant impact on Bifidobacteria, but lower concentrations of total SCFA, acetate, propionate, and butyrate.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Nutrition & Dietetics
Sara Mancell, Maeisha Islam, Anil Dhawan, Kevin Whelan
Summary: The study found that infants with cholestasis are at risk of fat-soluble vitamin deficiency, particularly in vitamin D and E. The implementation of vitamin supplementation is not standardized, with better performance in vitamin assessment, deficiency, and supplementation observed in infants with biliary atresia.
JOURNAL OF HUMAN NUTRITION AND DIETETICS
(2022)
Article
Nutrition & Dietetics
Selina R. Cox, Wladyslawa Czuber-Dochan, Catherine L. Wall, Hazel Clarke, Candice Drysdale, Miranda C. Lomer, James O. Lindsay, Kevin Whelan
Summary: This study aimed to investigate the effectiveness and acceptability of a web resource in enhancing food-related quality of life in newly diagnosed inflammatory bowel disease patients. The results showed that FR-QoL increased more in the web resource group, and IBD distress reduced, while the control group showed opposite results.
Article
Nutrition & Dietetics
Alice C. C. Creedon, Estella S. S. Hung, Eirini Dimidi, Terri Grassby, Sarah E. E. Berry, Kevin Whelan
Summary: Almonds contain unsaturated lipids, which are beneficial for human health. The unique properties of almonds affect their particle size distribution after chewing, making it difficult for the body to fully digest the almond lipids. Commercial grinding of almonds into flour changes the particle size distribution and slightly increases the predicted bioaccessibility of lipids.
Article
Nutrition & Dietetics
Eirini Dimidi, Katerina Belogianni, Kevin Whelan, Miranda C. E. Lomer
Summary: This study aimed to evaluate the effectiveness of a low FODMAP diet app. The results showed that using the app during FODMAP restriction can significantly reduce gut symptoms and help users detect dietary triggers for long-term self-management.