Article
Gastroenterology & Hepatology
Erica J. Brenner, Millie D. Long, Michael D. Kappelman, Xian Zhang, Robert S. Sandler, Edward L. Barnes
Summary: This study developed a non-proprietary, IBD-specific medication adherence tool and investigated reasons for suboptimal medication adherence. The results showed that common reasons for suboptimal adherence include forgetting, feeling well, and cost.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Julien Kirchgesner, Rishi J. Desai, Maria C. Schneeweiss, Laurent Beaugerie, Sebastian Schneeweiss, Seoyoung C. Kim
Summary: Combination therapy with vedolizumab and thiopurines is associated with a lower risk of treatment failure compared to vedolizumab monotherapy in patients with CD, but the effect is less pronounced in UC.
Review
Nutrition & Dietetics
Katarzyna Ferenc, Sara Jarmakiewicz-Czaja, Rafal Filip
Summary: Inflammatory bowel disease (IBD) is a chronic disease that involves periods of exacerbation and remission. Among various factors, a low-fiber diet may contribute to the development of IBD. Dietary fiber plays an essential role in influencing the composition of the intestinal microbiota, which is associated with intestinal dysbiosis and chronic inflammation in IBD. Different components of dietary fiber, such as beta-glucan, pectin, starch, inulin, fructooligosaccharides, and hemicellulose, can significantly impact IBD prevention by modifying the composition of the intestinal microbiota or enhancing intestinal barrier function. This review aims to provide insights into the effects of individual fiber components in the diet on the risk of IBD, including alterations in the intestinal microbiota.
Article
Surgery
J. A. Bunce, B. Doleman, J. N. Lund, G. M. Tierney
Summary: This study investigated the impact of surgeon subspeciality on outcomes after emergency laparotomy for inflammatory bowel disease (IBD). It found that colorectal surgeons had significantly better outcomes in terms of mortality and length of stay for the least urgent category of IBD emergency laparotomies. However, this association was not seen in more urgent cases.
WORLD JOURNAL OF SURGERY
(2023)
Article
Pediatrics
Maya Ruban, Adam Slavick, Achiya Amir, Amir Ben-Tov, Hadar Moran-Lev, Yael Weintraub, Adi Anafy, Shlomi Cohen, Anat Yerushalmy-Feler
Summary: The rate of a positive family history of IBD in the pediatric IBD population is increasing, and patients with a positive family history are more likely to have a severe phenotype, receive more nutritional therapy, and less corticosteroids. Patients with a negative family history may require intensified biologic therapy.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Biochemistry & Molecular Biology
Javier Conde, Marlene Schwarzfischer, Egle Katkeviciute, Janine Hafliger, Anna Niechcial, Nathalie Brillant, Roberto Manzini, Katharina Babler, Kirstin Atrott, Silvia Lang, Michael Scharl
Summary: This study investigated the interaction between the food additive TiO2 and the IBD risk gene Ptpn2 in the development of intestinal inflammation. Results showed that TiO2 exacerbated intestinal inflammation in Ptpn2 deficient mice by impacting the differentiation of intestinal macrophages. Furthermore, TiO2 was found to induce the secretion of IL-1 beta and suppress the expression of IL-10 in macrophages through different signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Gastroenterology & Hepatology
Shubha Bhat, Florian Rieder
Summary: Current treatment options for inflammatory bowel diseases have limitations, leading to the need for the development of novel orally-administered medications. HIF-1α stabilizers, acting through inhibiting specific enzymes, have emerged as an innovative therapeutic strategy.
JOURNAL OF CROHNS & COLITIS
(2022)
Article
Medicine, General & Internal
Fen Xu, Juping Tang, Zhiping Zhu, Yan Chen, Wen Hu, Sha Lu, Yunxian Zhou, Ding Lin
Summary: This study investigated the medication adherence among patients with inflammatory bowel disease (IBD) in China and analyzed the influencing factors. The results showed poor medication adherence, especially among patients taking oral medication, those taking medications with a high frequency, and those with a low understanding of the disease. To improve medication adherence, medical staff should pay attention to individual patient factors, simplify medication regimens, and formulate effective coping strategies for drug management support.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Snjezana Cuzic, Maja Antolic, Anja Ognjenovic, Darija Stupin-Polancec, Adriana Petrinic Grba, Boska Hrvacic, Miroslava Dominis Kramaric, Sanja Musladin, Lidija Pozgaj, Ivo Zlatar, Denis Polancec, Gorana Aralica, Marko Banic, Marija Urek, Brankica Mijandrusic Sincic, Aleksandar Cubranic, Ines Glojnaric, Martina Bosnar, Vesna Erakovic Haber
Summary: This study explored the expression of claudins in human disease and two different animal models of IBD. The diverse alterations in claudin expression by epithelial and inflammatory cells were recorded in IBD and both animal models. The results suggest that claudins are not exclusively expressed by epithelial cells, and changes in claudin mRNA levels should be interpreted in the context of overall tissue alterations.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
G. Leoncini, F. Donato, L. Reggiani-Bonetti, T. Salviato, M. Cadei, M. Daperno, M. B. Principi, A. Armuzzi, F. Caprioli, G. Canavese, V. Villanacci
Summary: The study revealed moderate interobserver agreement regarding the histopathological detection and classification of IBD-associated dysplasia. Further efforts are needed to integrate histopathological data with ancillary tests and molecular investigations.
TECHNIQUES IN COLOPROCTOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Qiong Huang, Yuqi Yang, Yan Zhu, Qiaohui Chen, Tianjiao Zhao, Zuoxiu Xiao, Mingyuan Wang, Xiangping Song, Yitian Jiang, Yunrong Yang, Jinping Zhang, Yang Xiao, Yayun Nan, Wei Wu, Kelong Ai
Summary: Oral antioxidant nanozymes show promise for treating inflammatory bowel disease (IBD). Metal-free melanin nanozymes (MeNPs) are proposed as a favorable therapy for IBD, offering excellent gastrointestinal stability, biocompatibility, and targeting abilities. MeNPs can alleviate the major pathological features of IBD and have potential for clinical use in treating inflammatory diseases.
Article
Biochemistry & Molecular Biology
Sara Federici, Sharon Kredo-Russo, Rafael Valdes-Mas, Denise Kviatcovsky, Eyal Weinstock, Yulia Matiuhin, Yael Silberberg, Koji Atarashi, Munehiro Furuichi, Akihiko Oka, Bo Liu, Morine Fibelman, Iddo Nadav Weiner, Efrat Khabra, Nyssa Cullin, Noa Ben-Yishai, Dana Inbar, Hava Ben-David, Julian Nicenboim, Noga Kowalsman, Wolfgang Lieb, Edith Kario, Tal Cohen, Yael Friedman Geffen, Lior Zelcbuch, Ariel Cohen, Urania Rappo, Inbar Gahali-Sass, Myriam Golembo, Vered Lev, Mally Dori-Bachash, Hagit Shapiro, Claudia Moresi, Amanda Cuevas-Sierra, Gayatree Mohapatra, Lara Kern, Danping Zheng, Samuel Philip Nobs, Jotham Suez, Noa Stettner, Alon Harmelin, Naomi Zak, Sailaja Puttagunta, Merav Bassan, Kenya Honda, Harry Sokol, Corinna Bang, Andre Franke, Christoph Schramm, Nitsan Maharshak, Ryan Balfour Sartor, Rotem Sorek, Eran Elinav
Summary: A clade of Klebsiella pneumoniae strains has been found to be strongly associated with exacerbation and severity of inflammatory bowel diseases. By generating a lytic five-phage combination targeting these strains, effective suppression of the bacteria and attenuation of inflammation can be achieved.
Review
Biochemistry & Molecular Biology
Tyler Atagozli, David E. Elliott, Mirac Nedim Ince
Summary: Helminths are multicellular invertebrates that live in the gut of vertebrate animals, including humans. They can cause pathology and require treatment, but can also have commensal or symbiotic relationships with their hosts. Epidemiological data suggests that helminth exposure may provide protection against immune disorders, such as allergies and autoimmune illnesses.
Article
Biochemistry & Molecular Biology
Nikolas Dovrolis, Anastasia Moschoviti, Smaragdi Fessatou, George Karamanolis, George Kolios, Maria Gazouli
Summary: This study examines the role of the microbiome in the onset of pediatric inflammatory bowel disease (IBD). Through analyzing the microbiota of nine IBD families, specific patterns of microbial taxa were identified among patients and their families. The results suggest a potential role of maternal factors in the establishment and modulation of the early life microbiome.
Review
Immunology
Reza Yarani, Ali Shojaeian, Oana Palasca, Nadezhda T. Doncheva, Lars Juhl Jensen, Jan Gorodkin, Flemming Pociot
Summary: This review discusses the differential regulation of miRNAs in inflammatory bowel disease (IBD) and their potential diagnostic and therapeutic applications. Through literature curation and computational analysis, a consensus set of differentially expressed miRNAs in mucosal tissues was obtained. The role of these miRNAs and their potential targets in IBD are highlighted.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Allergy
Qingqing Cai, Ling Ye, Robert Horne, Xiaofen Ye, Qing Xu, Meiling Jin, Xiaoyu Li, Qianzhou Lyu
Summary: This study found a significant relationship between illness perceptions, medication beliefs, and self-reported medication adherence in adult Chinese patients with asthma. Medication adherence was negatively correlated with illness identity, emotional response, and concerns about medication. Beliefs about medication necessity and emotional response to the illness were significantly associated with medication adherence, even after adjusting for illness perceptions, medication beliefs, and demographics.
Article
Health Care Sciences & Services
Alyssa M. Pandolfo, Robert Horne, Yogini Jani, Tom W. Reader, Natalie Bidad, David Brealey, Virve Enne, David M. Livermore, Vanya Gant, Stephen J. Brett
Summary: ICU clinicians' antibiotic decisions are influenced by their judgement of necessity for prescribing/not prescribing and their concerns about potential adverse consequences. Beliefs and perceptions strongly influence clinicians' views on antibiotic necessity, with clinicians often erring on the side of caution in uncertain situations.
BMJ QUALITY & SAFETY
(2022)
Article
Public, Environmental & Occupational Health
Kathryn King, Rob Horne, Vanessa Cooper, Elizabeth Glendinning, Susan Michie, Trudie Chalder
Summary: This article describes a theory-based intervention aimed at improving uptake and adherence to ART in HIV positive patients, using cognitive behavioral and motivational interviewing techniques. The intervention was developed following MRC guidance and informed by NICE guidelines, empirical evidence, and focus groups. Behavior change techniques were tailored to address perceptual and practical barriers identified in previous research, and the intervention materials underwent iterative development through feedback from focus groups.
TRANSLATIONAL BEHAVIORAL MEDICINE
(2022)
Review
Pediatrics
Christina J. Pearce, Amy H. Y. Chan, Tracy Jackson, Louise Fleming, Holly Foot, Andy Bush, Rob Horne
Summary: Adherence interventions in children with asthma vary in effectiveness. Effective intervention studies are more likely to be of high quality, tailored to individual perceptual and practical adherence barriers, and utilize multiple behavior change techniques.
PEDIATRIC PULMONOLOGY
(2022)
Review
Pharmacology & Pharmacy
Usman Talat, Kelly Ann Schmidtke, Saval Khanal, Amy Chan, Alice Turner, Robert Horne, Tim Chadborn, Natalie Gold, Anna Sallis, Ivo Vlaev
Summary: This systematic literature review examines 15 studies describing nudge interventions to optimize medication prescribing. The review finds that 80% of the interventions were effective, with prompts and defaults being the most commonly applied behavior change techniques. However, only a small number of interventions applied a sufficient array of techniques to influence all identified behavioral determinants.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Dora Arnold-Forster, Robert Horne, Will Nutland, Sonali Wayal, Michael Rayment, Caroline Rae, Monica Desai, Amanda Clarke, Ann Sullivan, Sheena McCormack, Mitzy Gafos
Summary: Using the perceptions and practicalities approach (PAPA) can help identify factors that influence PrEP adherence and tailor adherence support in PrEP programs.
Article
Health Care Sciences & Services
Andrew Farmer, Louise Jones, Nikki Newhouse, Cassandra Kenning, Nicola Williams, Yuan Chi, Y. Kiera Bartlett, Catrin Plumpton, Jenny McSharry, Rachel Cholerton, Emily Holmes, Stephanie Robinson, Julie Allen, Bernard Gudgin, Carmelo Velardo, Heather Rutter, Rob Horne, Lionel Tarassenko, Veronika Williams, Louise Locock, Rustam Rea, Ly-Mee Yu, Dyfrig Hughes, Peter Bower, David French
Summary: This study aims to test the effectiveness and cost-effectiveness of a mobile phone-based SMS text message intervention for reducing cardiovascular risk in patients with type 2 diabetes. The trial is currently in the follow-up phase and the results are expected to be published in 2024.
JMIR RESEARCH PROTOCOLS
(2022)
Article
Psychiatry
Nadia E. Crellin, Stefan Priebe, Nicola Morant, Glyn Lewis, Nick Freemantle, Sonia Johnson, Rob Horne, Vanessa Pinfold, Lyn Kent, Ruth Smith, Katherine Darton, Ruth E. Cooper, Maria Long, Jemima Thompson, Lisa Gruenwald, Robert Freudenthal, Jacki L. Stansfeld, Joanna Moncrieff
Summary: This study reveals that patients are commonly dissatisfied with the idea of taking antipsychotic medication on a long-term or life-long basis. The desire to reduce or stop medication is primarily motivated by adverse effects and health concerns. Patients value professional support in achieving reduction or discontinuation.
Article
Multidisciplinary Sciences
Walid Al-Qerem, Abdel Qader Al Bawab, Osama Abusara, Nimer Alkhatib, Robert Horne
Summary: The aim of this study was to validate the Arabic versions of the Beliefs about Medication Questionnaire-specific (BMQ-specific) and Medication Adherence Report Scale questionnaire (MARS-5). A total of 485 patients from secondary and tertiary care clinics in Jordan were recruited for a cross-sectional study. The results of exploratory and confirmatory factor analyses showed that the BMQ-specific had a two-factor model and the MARS-5 had a one-factor model. The internal consistency of the questionnaires was also confirmed. This study suggests that the Arabic versions of both BMQ-specific and MARS-5 are valid for the study population.
Review
Multidisciplinary Sciences
Amy Hai Yan Chan, Holly Foot, Christina Joanne Pearce, Rob Horne, Juliet Michelle Foster, Jeff Harrison
Summary: This systematic review and meta-analysis examines the effect of electronic adherence monitoring (EAM) on medication adherence and clinical outcomes across various chronic conditions and patient age groups. The results show that patients receiving EAM intervention had significantly better adherence compared to those who did not receive intervention. However, improved adherence did not consistently translate into clinical benefits. Patient acceptability towards EAM varied. Further research on the effects of EAM on clinical outcomes and patient acceptability is needed.
Article
Psychology, Multidisciplinary
Monika K. Heller, Sarah C. E. Chapman, Rob Horne
Summary: In clinical trials, patients often report more side-effects when receiving placebo, and medication beliefs and other psychological factors can predict the detection and attribution of side-effects.
ANNALS OF BEHAVIORAL MEDICINE
(2022)
Review
Endocrinology & Metabolism
Z. Paskins, O. Babatunde, A. Sturrock, L. S. Toh, R. Horne, I. Maidment
Summary: This article conducts a realist review to explore interventions that can improve the optimization of medication use in osteoporosis. The study finds that interventions that support patient-informed decision making and primary care clinician decision making are crucial in optimizing medication use. However, further research is needed to identify a sustainable, integrated, patient-centered, and cost- and clinically effective model of long-term care for osteoporosis patients.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Medicine, General & Internal
Molebogeng X. Rangaka, Yohhei Hamada, Trinh Duong, Henry Bern, Joanna Calvert, Marie Francis, Amy Louise Clarke, Alex Ghanouni, Charlotte Layton, Vanessa Hack, Ellen Owen-Powell, Julian Surey, Karen Sanders, Helen L. Booth, Angela Crook, Chris Griffiths, Robert Horne, Heinke Kunst, Marc Lipman, Mike Mandelbaum, Peter J. White, Dominik Zenner, Ibrahim Abubakar
Summary: This study aims to evaluate the effect of novel short-course rifapentine-based regimens for TB prevention and additional theory-based treatment support on treatment adherence. The study will recruit participants aged 16 to 65 who are eligible to start TB preventive therapy and will conduct a randomized controlled trial to assess the outcomes.
Article
Nursing
Anas Husam Khalifeh, Fadwa Naji Alhalaiqa, Shaher Hamad Hamaideh, Robert Horne, Ayman Mohammad Hamdan-Mansour
Summary: This study aimed to examine the effect of adherence therapy (AT) on medication adherence, health beliefs, self-efficacy, and depressive symptoms among patients diagnosed with major depressive disorder (MDD). The results showed that AT enhanced positive beliefs towards medication and illness, increased medication adherence self-efficacy, improved medication adherence, and decreased depressive symptoms.
INTERNATIONAL JOURNAL OF MENTAL HEALTH NURSING
(2023)
Article
Public, Environmental & Occupational Health
Sarah-Jane F. Stewart, Zoe Moon, Rob Horne
Summary: Nonadherence to medicines is a global problem with negative effects on both health and economic outcomes. This article explores the definition, measurement, impact, prevalence, and determinants of nonadherence. It also discusses the importance of a psychosocial perspective in developing interventions to improve adherence and provides recommendations for future research. Effective solutions for nonadherence are difficult to find due to a lack of strong theoretical basis. Tailoring adherence support to individuals' specific perceptions and practicalities can enhance its effectiveness.
PSYCHOLOGY & HEALTH
(2023)