Article
Multidisciplinary Sciences
Nicolas Rochereau, Xavier Roblin, Eva Michaud, Remi Gayet, Blandine Chanut, Fabienne Jospin, Blaise Corthesy, Stephane Paul
Summary: In this study, it was found that NOD2 mutation increases the transport of SIgA in the gut, potentially impacting gut inflammation by altering gut microfold cells.
NATURE COMMUNICATIONS
(2021)
Article
Immunology
Hideaki Fujiwara, Keisuke Seike, Michael D. Brooks, Anna Mathew, Ilya Kovalenko, Anupama Pal, Ho-Joon Lee, Daniel Peltier, Stephanie Kim, Chen Liu, Katherine Oravecz-Wilson, Lu Li, Yaping Sun, Jaeman Byun, Yoshinobu Maeda, Max S. Wicha, Tom Saunders, Alnawaz Rehemtulla, Costas A. Lyssiotis, Subramanian Pennarthur, Pavan Reddy
Summary: The alteration of IEC-specific mitochondrial complex II component SDHA plays a critical role in regulating the severity of T cell-mediated intestinal diseases, including graft-versus-host disease, inflammatory bowel disease and immune checkpoint blockade-mediated colitis.
Article
Biochemistry & Molecular Biology
Simona Pergolizzi, Alessio Alesci, Antonio Centofanti, Marialuisa Aragona, Socrate Pallio, Ludovico Magaudda, Giuseppina Cutroneo, Eugenia Rita Lauriano
Summary: Crohn's disease is a chronic intestinal inflammation that is associated with inflammatory bowel disease. Intestinal 5-HT signaling is linked to patients with inflammatory bowel disease. Our study reveals the correlation between different types of intestinal cells in maintaining the inflammatory state in Crohn's disease.
Article
Immunology
Hussein Hamade, Jasmine T. Stamps, Dalton T. Stamps, Shyam K. More, Lisa S. Thomas, Anna Y. Blackwood, Nawele L. Lahcene, Sofi L. Castanon, Brenda C. Salumbides, Yosuke Shimodaira, Helen S. Goodridge, Stephan R. Targan, Kathrin S. Michelsen
Summary: Intestinal dendritic cells play an important role in metabolic syndrome by preserving beneficial microbiota and maintaining intestinal epithelial barrier function.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Paul Bigot, Simon Chesseron, Ahlame Saidi, Damien Sizaret, Christelle Parent, Agnes Petit-Courty, Yves Courty, Fabien Lecaille, Gilles Lalmanach
Summary: Chronic obstructive pulmonary disease (COPD) is an irreversible disease mainly caused by smoking. The protein occludin, involved in the cohesion of epithelial tight junctions, is found to be decreased in lung biopsies of smokers and correlates with smoking history, COPD grades, and cathepsin S (CatS) activity. Cigarette smoke-elicited CatS induces an alteration of epithelial integrity via the proteolytic injury of occludin, highlighting the emerging role of CatS in smoking-related lung diseases and the relevance of targeting CatS in the treatment of emphysema and COPD.
Review
Cell Biology
Raquel Linares, Ruben Frances, Ana Gutierrez, Oriol Juanola
Summary: This review explores the impact of bacterial antigen translocation, intestinal barrier permeability, host immune response, and genetic predisposition on the inflammatory response observed in CD patients. Evidence suggests that bacterial products translocating leads to uncontrolled inflammation in CD patients, with gut bacterial genomic fragments serving as a marker for increased risk of relapse.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Nicole L. Mancini, Sruthi Rajeev, Timothy S. Jayme, Arthur Wang, Asa Keita, Matthew L. Workentine, Samira Hamed, Johan D. Soderholm, Fernando Lopes, Timothy E. Shutt, Jane Shearer, Derek M. McKay
Summary: LF82 E coli infection caused significant disruption of epithelial mitochondrial function and structure, leading to mitochondrial fragmentation and dysfunction. Inhibitors targeting mitochondrial fission partially reduced the observed effects, suggesting potential strategies to maintain cellular homeostasis and mitigate infection-induced epithelial barrier dysfunction.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Chansu Lee, Sung-Noh Hong, Eun-Ran Kim, Dong-Kyung Chang, Young-Ho Kim
Summary: Patients with Crohn’s disease exhibit reduced epithelial proliferation and wound healing ability in intestinal organoids, potentially due to decreased cell proliferation. The study findings suggest impaired epithelial regeneration ability in patients with CD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Nga Le, Claire Mazahery, Kien Nguyen, Alan D. Levine
Summary: The study reveals that communication between T cells and the intestinal epithelium can impact epithelial barrier function by regulating the assembly of tight junction complex. Activated T cells have different effects on ion flux and cell morphology, ultimately leading to cell death or disruption.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Immunology
Jose L. Sanchez-Trincado, Hector F. Pelaez-Prestel, Esther M. Lafuente, Pedro A. Reche
Summary: The oral epithelial cells (OECs) have the ability to suppress immune responses by reducing the expression and release of specific molecules in dendritic cells (DCs) and impairing T cell activation. This suppression is mediated through the regulation of IFN gamma and TNF alpha production and is independent of specific interactions between CD40/CD40L, CD58/CD2, and PD-L1/PD-1.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Analytical
Kanae Sakai, Shigenori Miura, Jun Sawayama, Shoji Takeuchi
Summary: A new glass microfluidic chip was developed to directly observe the cross section of epithelial cell layers and easily assess permeability without laborious manual sampling. This chip provides a powerful tool for analysis of epithelial cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Immunology
Nassim Hammoudi, Sarah Hamoudi, Julie Bonnereau, Hugo Bottois, Kevin Perez, Madeleine Bezault, Deborah Hassid, Victor Chardiny, Celine Grand, Brice Gergaud, Joelle Bonnet, Leila Chedouba, My-Linh Tran Minh, Jean-Marc Gornet, Clotilde Baudry, Helene Corte, Leon Maggiori, Antoine Toubert, Jacqueline McBride, Camille Brochier, Margaret Neighbors, Lionel Le Bourhis, Matthieu Allez
Summary: This study developed an ex vivo model to assess lympho-epithelial interactions in Crohn's Disease (CD) patients. The results showed that mucosal T cells from CD patients have a direct deleterious effect on the epithelial cells, while this effect is not observed in controls. This effect can be inhibited by limiting lympho-epithelial interactions.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Mohammad Ikbal Choudhury, Yizeng Li, Panagiotis Mistriotis, Ana Carina N. Vasconcelos, Eryn E. Dixon, Jing Yang, Morgan Benson, Debonil Maity, Rebecca Walker, Leigha Martin, Fatima Koroma, Feng Qian, Konstantinos Konstantopoulos, Owen M. Woodward, Sean X. Sun
Summary: This study demonstrates that renal epithelial cells can generate pressure gradients and drive fluid transport using a microfluidic platform. The fluid flux is from apical to basal for normal cells, and reversed in polycystic kidney disease cells. These findings highlight the importance of mechanical forces and hydraulic pressure in kidney function and morphological changes.
NATURE COMMUNICATIONS
(2022)
Article
Virology
Jonas L. Delva, Cliff Van Waesberghe, Wim Van den Broeck, Jochen A. Lamote, Nick Vereecke, Sebastiaan Theuns, Liesbeth Couck, Herman W. Favoreel
Summary: The PRV vaccine strain Bartha plays a critical role in eradicating the disease in many countries, but its interaction with host cells and the immune system remains poorly understood. Bartha-infected epithelial cells produce increased amounts of infectious virus, leading to pDC hyperactivation. This phenotype is caused by the deletion of genes encoding US2 and gE/gI.
JOURNAL OF VIROLOGY
(2022)
Article
Biology
Matous Voboril, Jiri Brezina, Tomas Brabec, Jan Dobes, Ondrej Ballek, Martina Dobesova, Jasper Manning, Richard S. Blumberg, Dominik Filipp
Summary: mTECs and DCs in the thymus work together to present self-antigens derived from medullary thymic epithelial cells, which is essential for central tolerance. Research has shown that different subsets of thymic DCs selectively target distinct subsets of mTECs, with XCR1(+) activated DC subset being the most potent in cooperative antigen transfer.