Review
Nutrition & Dietetics
Lewis Steell, Stuart R. Gray, Richard K. Russell, Jonathan MacDonald, John Paul Seenan, Sze Choong Wong, Daniel R. Gaya
Summary: Musculoskeletal deficits are commonly reported in patients with inflammatory bowel disease (IBD), particularly Crohn's disease. The adverse effects on bone and muscle are multifactorial, including inflammation, nutritional deficits, and therapies, leading to increased risk of osteoporosis and sarcopenia. Ib children with IBD, these factors may impact optimal bone and muscle accrual.
Article
Nutrition & Dietetics
Sarah M. M. Ajabnoor, Atheer Attar, Noof BinJahlan, Nawal Almutairi, Shimaa Bashmail, Almoutaz Hashim, Alastair Forbes, Hani Jawa
Summary: This study investigated the practices and perceptions of gastroenterologists in Saudi Arabia regarding the use of enteral nutrition (EN) in patients with inflammatory bowel disease (IBD). The results showed that EN was mostly used for the prevention and correction of undernutrition, preoperative optimization, and induction of remission in patients with active and long-standing Crohn's disease (CD). The study also identified barriers to using EN, such as low patient acceptance and poor adherence.
Article
Pediatrics
Dilsat Gundogdu, Nafiye Urganci, Merve Usta
Summary: The aim of the study was to assess the prevalence of sleep disturbance in pediatric IBD patients and evaluate the relationship between clinical features of IBD, disease activity, inflammatory markers and quality of sleep. The results showed that the PSQI score was significantly higher in the patient group than the control group, and there was a strong correlation between disease activity and sleep quality. The Pediatric Crohn's Disease Activity Index and Pediatric Ulcerative Colitis Activity Index were strong predictors of sleep disorders in pediatric patients with IBD.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Review
Biochemistry & Molecular Biology
Kristina A. Dvornikova, Olga N. Platonova, Elena Y. Bystrova
Summary: Inflammatory bowel disease (IBD) is a serious global public health concern, with various factors involved in its pathogenesis. Histamine and its receptors may play a significant role in the gut due to the high immunomodulatory activity of histamine and the immune-mediated nature of IBD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pediatrics
Asha Jois, George Alex
Summary: Inflammatory bowel disease is a common cause of chronic diarrhea in children and has been increasing worldwide. It includes different subtypes, such as Crohn's disease and ulcerative colitis. Diagnosis requires various investigations including imaging and endoscopy. Treatment depends on the severity and subtype, involving immunosuppressive therapies. Poorly controlled disease can lead to psychosocial impacts, growth impairment, and long-term risks. A multidisciplinary team is recommended for managing the disease. This review focuses on the latest clinical practices for diagnosis and management of inflammatory bowel disease in children.
INDIAN JOURNAL OF PEDIATRICS
(2023)
Article
Gastroenterology & Hepatology
Michal Kori, Yonatan Zamir, Sami Or Yermiyahu, Inessa Ainbinder, Svetlana Daichman, Gavriel David Pinto, Yiska Loewenberg Weisband, Shira Greenfeld, Revital Kariv, Natan Lederman, Eran Matz, Raanan Shamir, Iris Dotan, Dan Turner
Summary: This study found that the prevalence of coeliac disease (CeD) and coeliac autoimmunity (CeA) is higher in patients with inflammatory bowel diseases (IBD), especially in paediatric-onset IBD and Crohn's disease (CD). The diagnosis of CeD usually precedes the diagnosis of IBD, and patients with both IBD and CeD receive more intensified treatment for IBD.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Gastroenterology & Hepatology
Jocelyn Jeong, Thomas D. Walters, Hien Q. Huynh, Sally Lawrence, David R. Mack, Colette Deslandres, Anthony Otley, Wael El-Matary, Mary Sherlock, Anne M. Griffiths, Eytan Wine, Kevan Jacobson, Peter Church, Matthew W. Carroll, Eric Benchimol, Herbert Brill, Jeff Critch, Kevin Bax, Prevost Jantchou, Mohsin Rashid, Gilaad G. Kaplan, Cynthia H. Seow, Kerri Novak, Jennifer C. deBruyn
Summary: This study examines the ancestral and phenotypic variation of Canadian children newly diagnosed with inflammatory bowel disease. It identifies differences between children of European and non-European descent in phenotypes of inflammatory bowel disease, disease location and behavior, family history, and immigrant status.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Nutrition & Dietetics
Julie Rempel, Kanika Grover, Wael El-Matary
Summary: Children and adolescents with inflammatory bowel disease (IBD) are at risk of developing anemia and various micronutrient deficiencies at diagnosis and one year follow-up. Factors such as age and albumin levels may play a role in predicting anemia in these patients.
Article
Multidisciplinary Sciences
Yuanhao Yang, Hannah Musco, Steve Simpson-Yap, Zhihong Zhu, Ying Wang, Xin Lin, Jiawei Zhang, Bruce Taylor, Jacob Gratten, Yuan Zhou
Summary: The study found a strong genetic correlation between MS and UC, while the genetic relationship between MS and CD was weaker. Using Mendelian randomization, there was suggestive evidence for a causal effect of MS on UC and IBD, but not a clear causal effect of IBD or UC on MS. The study also observed consistent patterns of tissue-specific heritability enrichment for MS and IBDs, as well as cell-type-specific enrichment in specific cell types.
NATURE COMMUNICATIONS
(2021)
Review
Immunology
Susanna Esposito, Giulia Antoniol, Marialuisa Labate, Lucrezia Passadore, Patrizia Alvisi, Valeria Dacco, Chiara Ghizzi, Carla Colombo, Nicola Principi
Summary: The incidence of inflammatory bowel diseases (IBDs) is rising globally, leading to a higher risk of infections in children with dysfunctional immune systems. Vaccines are essential for preventing these infections, and should be administered according to specific immunization guidelines for IBD patients. Compliance with vaccination recommendations is generally low, highlighting the need for multidisciplinary educational programs to improve vaccination coverage and protect children with IBD from vaccine-preventable diseases.
Article
Microbiology
Julia Eckenberger, James C. Butler, Charles N. Bernstein, Fergus Shanahan, Marcus J. Claesson
Summary: The interaction between non-antibiotic drugs and the gut microbiome, as well as the effects of treatment on the composition of the gut microbiota in inflammatory bowel disease (IBD) patients, were investigated. The study found that treatments accounted for a relatively small proportion of the geographic contribution to microbiome variance between Irish and Canadian participants, but additive effects from multiple medications contributed significantly to microbiome differences between UC and CD.
Article
Gastroenterology & Hepatology
Matthew D. Coates, Djibril M. Ba, Guodong Liu, Shannon Dalessio, Douglas L. Leslie, Xuemei Huang
Summary: This study did not find a statistically significant association between inflammatory bowel disease (IBD) and Parkinson's disease (PD). Previous associations between these disorders may have been confounded by environmental and socioeconomic factors.
INFLAMMATORY BOWEL DISEASES
(2022)
Review
Biochemistry & Molecular Biology
Chang-Kee Hyun
Summary: There is considerable comorbidity between metabolic disorders such as obesity, type 2 diabetes, and non-alcoholic fatty liver disease, and inflammatory bowel diseases like Crohn's disease and ulcerative colitis. Dysfunction in the intestinal barrier and pro-inflammatory responses in the intestinal immune system are key factors linking the pathogenesis of these diseases. Disrupted gut microbial composition and alterations in gut microbiota-derived metabolites are also closely related to the development of both metabolic disorders and IBD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Yang Meng, Zongbiao Tan, Chuan Liu, Weiguo Dong, Changzheng Chen
Summary: Iridocyclitis (IC) is more likely to occur in patients with ulcerative colitis (UC) and Crohn's disease (CD). The bidirectional Mendelian randomization (MR) analysis showed a positive association between UC/CD and IC, with a stronger association found between CD and IC. However, there was no evidence of IC leading to an increased risk of UC or CD. Ophthalmic examinations are important for patients with inflammatory bowel disease (IBD), particularly those with CD.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Guiping Kong, Zhifeng Liu, Yan Lu, Mei Li, Hongmei Guo
Summary: This systematic review and meta-analysis found no correlation between H. pylori infection and the occurrence of IBD in children.
