期刊
INFLAMMATION RESEARCH
卷 59, 期 7, 页码 503-510出版社
SPRINGER BASEL AG
DOI: 10.1007/s00011-009-0154-z
关键词
Insulin-like growth factor-I; Inflammation; Interleukin-6; C-reactive protein; YKL-40
资金
- NovoNordisk Scandinavia
- Herlev Hospital
- Danish Medical Association Research Foundation
- Prosektor dr. med. Axel Emil Soeborg Ohlsen and wife Else Soeborg Ohlsens foundation
The objective of the present study was to test the hypothesis that circulating levels of insulin-like growth factor-I (IGF-I) are inversely associated with inflammatory processes in an elderly background population. We conducted a population-based study comprising 629 individuals, aged 50-89 years. Associations between plasma IGF-I versus interleukin 6 (IL-6) and the acute phase proteins high sensitive C-reactive protein (hsCRP) and YKL-40 were evaluated by linear regression analyses. Subsequently, the population was dichotomised at a CRP level of 3.0 mg/L and the associations were re-evaluated in the two subgroups. Adjusted for confounding variables, plasma IGF-I was inversely related to IL-6, hsCRP and YKL-40 (all P < 0.001). The strongest association was found for YKL-40 with a 34% reduction in YKL-40 per twofold increase in IGF-I. A significant inverse association between IGF-I and all markers of inflammation persisted in individuals with hsCRP below 3.0 mg/L whereas only YKL-40 was significantly associated with IGF-I in individuals with hsCRP above 3.0 mg/L. The data support the hypothesis of an inverse association between GH/IGF-I signalling and inflammation, and suggest that the relationship between the IGF-I and inflammation might be more predominant in healthy individuals with a low inflammatory activity.
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