Article
Biochemistry & Molecular Biology
Yunkai Zhang, Ying Gao, Yuyu Jiang, Yingying Ding, Huiying Chen, Yan Xiang, Zhenzhen Zhan, Xingguang Liu
Summary: Macrophages play a critical role in immune homeostasis and host defense, but their uncontrolled activation can lead to tissue injury and autoimmunity. This study investigates the molecular mechanisms of macrophage activation and identifies lysine-specific demethylase 5B (KDM5B) as a key player in the activation of NF-kappa B signaling cascade and pro-inflammatory cytokine production. KDM5B deficiency or inhibition protects against immunologic injury in animal models, suggesting it as a potential therapeutic target for autoimmune and inflammatory disorders.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Immunology
Zilin Xiao, Shuoming Luo, Yuemin Zhou, Haipeng Pang, Wenfeng Yin, Jiabi Qin, Zhiguo Xie, Zhiguang Zhou
Summary: This study examined the association between three SNPs in the IFIH1 gene and autoimmune diseases. The rs1990760 SNP was not significantly associated with type 1 diabetes in the Chinese population. However, the meta-analysis showed significant associations between rs1990760 and rs3747517 and autoimmune diseases susceptibility, especially in the Caucasian population.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Genetics & Heredity
Zubo Wu, Suyuan Wu, Tao Liang
Summary: The association between two NLRP3 gene polymorphisms and susceptibility to autoimmune diseases is controversial, with rs35829419 showing no significant association but potentially protective effect in rheumatoid arthritis, and rs10754558 significantly reducing the risk of AIDs, especially in Latin American individuals.
FRONTIERS IN GENETICS
(2021)
Article
Rheumatology
Eunji Ha, Sang-Cheol Bae, Kwangwoo Kim
Summary: A large trans-ancestral meta-analysis identified 11 new susceptibility loci for RA, explaining a significant portion of the heritability in East Asians and Europeans, and confirmed 71 known non-HLA susceptibility loci. The study also highlighted the importance of CD4(+) T-cell activation and potential non-immune organs in RA pathogenesis, providing insights into genetic etiology and variant-driven RA pathogenesis.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Review
Genetics & Heredity
Joana Couceiro, Irina Matos, Jose Joao Mendes, Pedro V. Baptista, Alexandra R. Fernandes, Alexandre Quintas
Summary: Preterm birth is a major clinical and public health challenge worldwide, with a prevalence of 11%. The etiology of this condition remains unclear, with most cases being spontaneous. Risk factors for preterm birth include inflammatory diseases and genetic background, and there is evidence suggesting a common genetic background with autoimmune diseases.
Review
Immunology
Ainsley Ryan Yan Bin Lee, Shi Yin Wong, Sen Hee Tay
Summary: This study conducted a systematic review and meta-analysis on the efficacy of COVID-19 booster vaccines. The results showed that booster doses are effective in inducing seroconversion in non-responders and are not associated with major adverse events.
Review
Multidisciplinary Sciences
Xiao-Qing Liu, Pei-Lin Zhou, Xin-Yu Yin, Ai-Xue Wang, Da-Hu Wang, Yun Yang, Qiang Liu
Summary: This study conducted a meta-analysis to investigate the association between circulating inflammatory factors and psoriasis, aiming to elucidate the mechanisms underlying psoriasis and improve clinical diagnosis and treatment.
Review
Rheumatology
Shintaro Akiyama, Shadi Hamdeh, Dejan Micic, Atsushi Sakuraba
Summary: Patients with autoimmune diseases have a higher risk of COVID-19, primarily due to glucocorticoid use. Monotherapy with b/tsDMARDs is associated with a lower risk of hospitalisation and death.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Immunology
Lingxiang Yu, Ming Shao, Tingting Zhou, Huimin Xie, Feier Wang, Jiangping Kong, Shenqian Xu, Zongwen Shuai, Faming Pan
Summary: Based on the results of meta-analysis, the CTLA-4 (+49 A/G) gene rs231775 G allele increases the risk of autoimmune diseases in Caucasian populations, particularly in relation to both RA in Caucasian and Mongolian populations. Larger sample sizes and more elaborately designed studies are needed to further clarify the relationship between the CTLA-4 (+49 A/G) gene rs231775 G allele and autoimmune diseases, especially AS and SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Immunology
Liuting Zeng, Ying Deng, Kailin Yang, Junpeng Chen, Qi He, Hua Chen
Summary: Based on the analysis of 14 randomized controlled trials, fecal microbiota transplantation has shown some safety and efficacy in the treatment of autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Gastroenterology & Hepatology
Soma Fukuda, Shintaro Akiyama, Ahmad Tarakji, Shadi Hamdeh, Hideo Suzuki, Kiichiro Tsuchiya
Summary: This article evaluates the prevalence and clinical characteristics of AIP-IBD patients through a systematic review and meta-analysis. The results showed that 10.5% of AIP patients also had IBD, while 0.6% of IBD patients also had AIP. Additionally, AIP-IBD patients had a higher risk of recurrence and colectomy.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Rheumatology
Nazariy Koval, Mariana Alves, Rui Placido, Ana G. Almeida, Joao Eurico Fonseca, Joaquim J. Ferreira, Fausto J. Pinto, Daniel Caldeira
Summary: The use of DOACs, particularly rivaroxaban, among patients with APS is associated with a 69% increased risk of thromboembolic events compared to VKA, while the risks of major bleeding, all bleeding events, and mortality are not significantly different. The certainty of these results is very low.
Review
Immunology
Valeria Morales-Ruiz, Victor Hugo Juarez-Vaquera, Marcos Rosetti-Sciutto, Fausto Sanchez-Munoz, Laura Adalid-Peralta
Summary: This study compared the efficacy of intravenous immunoglobulin (IVIg) administration with corticosteroids, plasmapheresis, and placebo in treating autoimmune neurological diseases. The meta-analysis showed that IVIg treatment was beneficial for patient improvement compared to placebo, had similar effects to plasmapheresis, and had no significant difference in efficacy compared to corticosteroid treatment.
AUTOIMMUNITY REVIEWS
(2022)
Review
Medicine, Research & Experimental
Naoual El Menyiy, Aicha El Allam, Sara Aboulaghras, Imane Jaouadi, Saad Bakrim, Nasreddine El Omari, Mohammad Ali Shariati, Alevtin Miftakhutdinov, Polrat Wilairatana, Mohammad S. Mubarak, Abdelhakim Bouyahya
Summary: Autoimmune diseases are caused by the overactivity of the immune system towards self-constituents. Natural compounds derived from medicinal plants have shown potential in modulating the inflammatory responses of these diseases, presenting a promising approach for treatment and prevention.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Endocrinology & Metabolism
Dania Akeil Abed Alkader, Naweedullah Asadi, Uzma Solangi, Ransherjit Singh, Sayed Farhad Rasuli, Muhammad Jawad Farooq, F. N. U. Raheela, Radeyah Waseem, Syed Mujahid Gilani, Kiran Abbas, Moiz Ahmed, Desmond Boakye Tanoh, Hussain Haider Shah, Ayusha Dulal, Muhammad Sheheryar Hussain, Abdul Subhan Talpur
Summary: There is a significant difference in the diversity and composition of the gut microbiota in patients with autoimmune thyroid diseases (AITDs).
FRONTIERS IN ENDOCRINOLOGY
(2023)
