Article
Cell Biology
Yasir Mohamud, Hui Tang, Yuan Chao Xue, Huitao Liu, Chen Seng Ng, Amirhossein Bahreyni, Honglin Luo
Summary: Coxsackievirus B3 targets TFEB for proteolytic processing to disrupt host lysosomal function and enhance viral infection.
Article
Multidisciplinary Sciences
Beatriz Alvarez-Rodriguez, Javier Buceta, Ron Geller
Summary: Despite limited understanding, a comprehensive analysis reveals significant variation in the neutralization sites targeted by polyclonal antibody responses to non-enveloped viruses in individual humans. This knowledge helps predict viral escape and identify key structural and evolutionary parameters. A minimum of two mutations is required for significant escape from multiple sera.
NATURE COMMUNICATIONS
(2023)
Article
Virology
Chengrui Niu, Wei Xu, Sidong Xiong
Summary: The appendix plays a role in regulating the composition of the intestinal microbiota and has an impact on cardiac infection and inflammation.
Article
Chemistry, Multidisciplinary
Jingzhe Wang, Tonggong Liu, Siyao Gu, Hui-hui Yang, Weidong Xie, Cheng Gao, Dayong Gu
Summary: This study introduces a novel cardiomyocyte sponge to trap and neutralize the virus causing viral myocarditis. The sponge effectively inhibits virus infection by maintaining cellular morphology. The most significant implication of this study is the development of a universal antivirus infection strategy for treating known and unknown virus outbreaks.
Article
Microbiology
Yuxuan Fu, Sidong Xiong
Summary: This study found that exosomes can serve as vehicles for CVB3 virus, delivering the virus into cells and infecting receptor-negative cells. Exosomes carrying CVB3 virus have higher infection efficiency compared to free virus, and can overcome restrictions to viral tropism by accessing different routes.
Article
Virology
Siwen Bao, Hao Wang, Wang Li, Likai Ji, Xiaochun Wang, Quan Shen, Shixing Yang, Chenglin Zhou, Wen Zhang
Summary: Coxsackievirus B3 infection induces dynamic changes in the gut virome, with significant variations in the abundance of Caudovirales and Microviridae as potential biomarkers for the infection process. This study provides insights into the gut virome alterations following Enterovirus infection, offering implications for clinical treatment and prevention strategies.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Review
Virology
Anja Geisler, Ahmet Hazini, Lisanne Heimann, Jens Kurreck, Henry Fechner
Summary: CVB3 as an oncolytic virus shows broad anti-tumor activity and enhances treatment efficacy by inducing an immune response against tumors. The toxicity in healthy tissues varies and can be reduced through genetic engineering. However, further efforts are needed to develop CVB3 as a therapeutic agent for cancer treatment in clinical practice.
Article
Plant Sciences
Bowen Sun, Lin Lin, Tian Yao, Jingchun Yao, Guimin Zhang, Yunlun Li, Chao Li
Summary: This study found that Jingfang Granules (JFG) significantly alleviated pathological damage in the cardiac tissues of coxsackievirus B3-induced viral myocarditis mice and attenuated the expression of inflammatory genes. JFG may exert its therapeutic effects by enhancing autophagy to suppress cell apoptosis, thereby reducing cell damage.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Microbiology
Tingjun Liu, Yuhan Li, Shengjie Chen, Lulu Wang, Xiaolan Liu, Qingru Yang, Yan Wang, Xiaorong Qiao, Jing Tong, Xintao Deng, Shihe Shao, Hua Wang, Hongxing Shen
Summary: This study identified a significantly decreased expression of circDDX17 after Coxsackievirus B3 (CVB3) infection. Further experiments demonstrated that circDDX17 enhanced CVB3 replication by downregulating the expression of miR-1248, which in turn regulated CVB3 replication through interacting with the gene coding for NOTCH Receptor 2 (NOTCH2).
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Paolo Carai, Giulia Ruozi, Alexandra Paye, Yannick Debing, Francesca Bortolotti, Julie Lecomte, Lorena Zentilin, Elizabeth A. Jones, Mauro Giacca, Stephane Heymans
Summary: Viral myocarditis is a significant cause of heart failure in both children and adults, and the molecular determinants and cardioprotective molecules involved in cardiac inflammation and cardiomyocyte necrosis are not well characterized. In this study, researchers used an in vivo method called functional selection to identify novel immunomodulatory molecules in a mouse model of Coxsackievirus B3-induced myocarditis. They found that IL9 and four other cytokines were cardioprotective factors in this model.
SCIENTIFIC REPORTS
(2022)
Article
Virology
Martin Voss, Vera Braun, Clara Bredow, Peter-Michael Kloetzel, Antje Beling
Summary: Infection with coxsackievirus B3 results in impaired protein homeostasis and accumulation of ubiquitinylated proteins, attributed to viral proteins 2B and 3A. During the exponential replication phase, oxidative damage of membrane proteins is reduced due to the recruitment of glutathione. The proteasome is shown to play a role in processing viral precursor proteins during infection.
Article
Oncology
Amirhossein Bahreyni, Huitao Liu, Yasir Mohamud, Yuan Chao Xue, Jingchun Zhang, Honglin Luo
Summary: The study found that miR-CVB3-1.1 can safely infect and lyse breast cancer cells, significantly inhibiting tumor growth and metastasis. Mice treated with miR-CVB3-1.1 showed reduced toxicity and prolonged survival.
Article
Biochemistry & Molecular Biology
Xiaomin Yu, Yejia Zhang, Ke Pei, Junjun Tan, Huizhen Tian, Tian Xu, Fadi Liu, Nanqin Peng, Yilin Huang, Xinying Huang, Xinlei Huang, Jianfeng Wu, Qiong Liu, Lingbing Zeng, Wei Hua, Xiaotian Huang
Summary: L. plantarum FLPL05 has been found to inhibit CVB3 infection and improve CVB3-induced pancreatitis by regulating the BCL2/BAX/CASP3 signaling pathway. Moreover, its exopolysaccharide (EPS) also showed antiviral activity against CVB3.
Article
Virology
Yu-Jheng Lin, Li-Chiu Wang, Huey-Pin Tsai, Chia-Yu Chi, Chih-Peng Chang, Shun-Hua Chen, Shih-Min Wang
Summary: Curcumin exhibits antiviral and anti-inflammatory effects in CVB3 infection, improving survival rate and clinical scores in mice and reducing viral titer and liver damage.
Article
Virology
Sandra Pinkert, Meike Kespohl, Nicolas Kelm, Ziya Kaya, Arnd Heuser, Karin Klingel, Antje Beling
Summary: The study demonstrates that the use of tramadol in the CVB3 myocarditis mouse model does not have disruptive effects on viral pathogenicity or immune response in the heart. This supports the consideration of the demonstrated protocol as a general analgesic strategy for CVB3 infection.
