Article
Biochemistry & Molecular Biology
Juan Cai, Lin Huang, Hongri Tang, Hongling Xu, Lingjun Wang, Minghui Zheng, Hongsong Yu, Hui Liu
Summary: The MIF produced by Thelazia callipaeda can induce M2-like macrophage polarization through TLR4-mediated activation of the PI3K-Akt pathway, potentially aiding in disrupting the host immune system.
Article
Cell Biology
Zhi-Song Ji, Hua Jiang, Yue Xie, Qi-Peng Wei, Xiao-Fang Yin, Jin-Hai Ye, Xiao-Zhen Quan, Yan-Li Lan, Meng Zhao, Xiao-Long Tian, Ya-Jun Zhang, Xue-Zhou Yang
Summary: The chemerin signaling pathway involving CMKLR1/Akt/CEBP alpha axis plays a crucial role in regulating macrophage polarization and mediating the pathogenic effects of chemerin on preeclampsia. Targeting chemerin signaling may offer potential benefits for the prevention and treatment of preeclampsia.
CELL BIOLOGY AND TOXICOLOGY
(2022)
Article
Multidisciplinary Sciences
Da Meng, Xin Deng, Yi Wu, Jingyi Wu, Yaqiong Zhang, JiaYu Zhang, Yi Zhao, Yanyun Che
Summary: Corilagin, a polyphenolic tannic acid compound, has been found to have significant anti-inflammatory activity in atherosclerotic mice. It decreases plaque area and lipid accumulation, improves the expression of anti-inflammatory factors, and inhibits the production of proinflammatory factors. Moreover, Corilagin suppresses the activation of TLR4-NF & kappa;B/MAPK signaling pathway.
Article
Gastroenterology & Hepatology
Zhihao Xu, Feiyang Xi, Xinxin Deng, Yuqi Ni, Changqin Pu, Dan Wang, Weiming Lou, Xufang Zeng, Ning Su, Chen Chen, Ziqiang Zeng, Libin Deng, Meixiu Jiang
Summary: This study aimed to evaluate the role of osteopontin (OPN) in nonalcoholic fatty liver disease (NAFLD) and clarify the mechanisms involved. OPN was significantly upregulated in NAFLD patients and its expression was related to disease stage and progression. OPN promoted macrophage M1 polarization by activating the JAK1/STAT1-induced HMGB1 secretion in hepatocytes.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2023)
Article
Medicine, Research & Experimental
Amany A. Alzokaky, Ahmed A. Al-Karmalawy, Mohamed A. Saleh, Walied Abdo, Amira E. Farage, Amany Belal, Mohammed A. S. Abourehab, Samar A. Antar
Summary: The study aims to investigate the preventive role of Metformin in DOX-induced cardiotoxicity. The results showed that Metformin reduced cardiac toxicity caused by DOX, possibly by inhibiting the HMGB1/NF-Kappa B inflammatory pathway and preserving heart function.
Article
Immunology
Shushu Qian, Xuan Han, Xiaocao Sha, Fang Tian, Hong Huang, Pengjun Jiang, Guoshun Huang, Bangyun Ma, Hong Zhang, Yiye Zhu, Xuemei Sun
Summary: This study investigated the inhibitory effect of the aqueous extract of Cimicifuga dahurica (CRAE) on multiple myeloma (MM) and its molecular biological mechanism. The results showed that CRAE can suppress tumor growth by reprogramming macrophage polarization in the tumor microenvironment and promoting the conversion of M2 macrophages to M1 phenotype. This conversion is dependent on the TLR4-MyD88-TAK1-NF-Kappa B signaling pathway. This study reveals the mechanism of CRAE as a potential novel option for cancer immunotherapy.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Jing Chen, Yuxuan Fu, Sidong Xiong
Summary: Psoriasis is a common immune-mediated chronic inflammatory skin disease. This study found that HMGB1 plays a role in the hyperproliferation of keratinocytes and the polarization of macrophages, suggesting it may be a potential target for the treatment of psoriasis.
MOLECULAR IMMUNOLOGY
(2023)
Article
Agriculture, Multidisciplinary
Yue Shang, Min Jiang, Nan Chen, Xue-Li Jiang, Zi-Ying Zhan, Zhi-Hong Zhang, Rong-Mei Zuo, Hui Wang, Xiao-Qi Lan, Jie Ren, Yan-Ling Wu, Zhen-Yu Cui, Ji-Xing Nan, Li-Hua Lian
Summary: This study investigated the inhibitory effects of Digitoflavone (DG) on inflammation and lipid accumulation in alcoholic liver disease (ALD). The results showed that DG reduced lipid and inflammatory levels in ALD mice by inhibiting the HMGB1-TLR4 axis.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Cell Biology
Mauricio Castro-Sepulveda, Mauro Tunon-Suarez, Giovanni Rosales-Soto, Ronald Vargas-Foitzick, Louise Deldicque, Hermann Zbinden-Foncea
Summary: TLR4 pathway is involved in the regulation of mitochondrial morphology in human skeletal muscle, and this regulation may be associated with insulin resistance in patients with type 2 diabetes mellitus.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Chemistry, Medicinal
Liuhua Pei, Yifei Le, Hang Chen, Jiafan Feng, Zhijun Liu, Ji Zhu, Cui Wang, Lin Chen, Xiaobing Dou, Dezhao Lu
Summary: The study revealed that cynaroside can promote phenotypic transition of hepatic macrophages from M1 to M2, alleviating sepsis-induced liver inflammation. Results suggest that cynaroside has a novel role in modulating immunometabolic pathways through affecting pyruvate kinase M2-mediated glycolysis, which could be valuable in sepsis treatment.
Article
Chemistry, Multidisciplinary
Shuodan Huang, Yan Gao, Huiying Li, Ruoran Wang, Xiaomei Zhang, Xiaoyu Wang, Di Huang, Linxuan Zhang, Helder A. Santos, Zhenyu Yin, Bing Xia
Summary: Trace Mn2+ bound to bovine serum albumin (BSA) to form Mn@BSA nanocomplexes can potentiate pro-inflammatory responses through TLR4-mediated signaling cascades. Furthermore, assembly of the resultant Mn@BSA nanocomplexes into larger nanowires enables robust and long-duration interactions with membrane-bound TLR4s via phagocytosis, boosting the immunostimulation of macrophages.
ADVANCED MATERIALS
(2023)
Article
Multidisciplinary Sciences
Matthew Stephens, Shan Liao, Pierre-Yves von der Weid
Summary: The location of TLR4 and the type of bacterial-derived LPS play a key role in the activation of macrophages. Different bacterial species signal to macrophages through different pathways, allowing the cells to distinguish between bacteria and initiate specialized immune responses using TLR4.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, Research & Experimental
Changhe Hou, Ming Lu, Zixiong Lei, Shuangwu Dai, Wei Chen, Shaohua Du, Qinglin Jin, Zhongxin Zhou, Haomiao Li
Summary: This study found that high mobility group box 1 (HMGB1) is overexpressed in osteosarcoma tissues and is positively correlated with AJCC III and IV stages, lymph node metastasis, and distant metastasis. HMGB1 regulates macrophage polarization through the receptor RAGE. Polarized M2 macrophages induce osteosarcoma migration and invasion, activating HMGB1 expression in osteosarcoma cells to form a positive feedback regulation.
LABORATORY INVESTIGATION
(2023)
Article
Immunology
Shuai Teng, Zhaowei Zhu, Chenkai Wu, Yuhu He, Shenghua Zhou
Summary: This study discovers that Inflachromene (ICM) can inhibit the phenotypic conversion of vascular smooth muscle cells (VSMCs) and reduce excessive neointimal hyperplasia. ICM regulates the Toll-like receptor 4 (TLR4)-nuclear factor-κB (NF-κB) pathway by inhibiting the expression of high mobility group box proteins (HMGBs) 1 and 2, thereby attenuating neointimal hyperplasia.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Engineering, Environmental
Xuting Liu, Bin Lu, Juanli Fu, Xiaokang Zhu, Erqun Song, Yang Song
Summary: The study revealed that amorphous SiO2 NPs induce pro-inflammatory responses in HUVECs by regulating signal pathways, leading to increased levels of ROS, LDH, inflammatory factors, and cell adhesion molecules. The translocation and release of HMGB1, regulated by ROS and NLRP3 inflammasome, was shown to play a key role in activating the NF-kappa B signaling pathway and inducing the inflammatory response in HUVECs. This provides new insights into the cytotoxicity induced by SiO2 NPs and offers safety guidance for further nanomaterial applications.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Materials Science, Biomaterials
Lilong Du, Qiang Yang, Jiamin Zhang, Meifeng Zhu, Xinlong Ma, Yang Zhang, Lianyong Wang, Baoshan Xu
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2019)
Article
Engineering, Biomedical
Pingli Wu, Lina Wang, Wen Li, Yu Zhang, Yifan Wu, Dengke Zhi, Hongjun Wang, Lianyong Wang, Deling Kong, Meifeng Zhu
Article
Chemistry, Multidisciplinary
Lan Li, Yili Wang, Rui Guo, Sheng Li, Jingyu Ni, Shan Gao, Xiumei Gao, Jingyuan Mao, Yan Zhu, Pingli Wu, Hongjun Wang, Deling Kong, Han Zhang, Meifeng Zhu, Guanwei Fan
JOURNAL OF CONTROLLED RELEASE
(2020)
Article
Materials Science, Biomaterials
Yanhong Zhao, Xiaoming Ding, Yunsheng Dong, Xun Sun, Lianyong Wang, Xinlong Ma, Meifeng Zhu, Baoshan Xu, Qiang Yang
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2020)
Article
Chemistry, Multidisciplinary
Hongyu Yan, Xingyan Mi, Adam C. Midgley, Xinchen Du, Ziqi Huang, Tingting Wei, Ruihua Liu, Tengzhi Ma, Dengke Zhi, Dashuai Zhu, Ting Wang, Guowei Feng, Ying Zhao, Weiye Zhang, Ju He, Meifeng Zhu, Deling Kong, Kai Wang
Review
Cell Biology
Linna Zhao, Liji Yang, Yuying Guo, Jie Xiao, Junping Zhang, Shixin Xu
Summary: Stroke is a lethal neurological disease that poses a grave economic burden on society, yet there remains an absence of precise effective treatment strategies. The gut microbiota plays a significant role in stroke prevention and treatment, with interventions through symbiotic microorganisms showing promise in improving stroke prognosis.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Engineering, Biomedical
Wen Li, Yanli Bai, Jiasong Cao, Shan Gao, Pan Xu, Guowei Feng, Lichen Wang, Hongjun Wang, Deling Kong, Meng Fan, Jun Zhang, Meifeng Zhu
Summary: This study demonstrates the fabrication of highly inter-connected ioECM scaffolds, which improve the therapeutic effect of stem cell therapy in a limb ischemic model by enhancing stem cell survival, viability, and paracrine activities. The research provides reference value for the design and fabrication of ECM-based biomaterials for cell transplantation.
ACTA BIOMATERIALIA
(2021)
Article
Engineering, Biomedical
Xianhao Dong, Siyang Liu, Yueyue Yang, Shan Gao, Wenlei Li, Jiasong Cao, Ye Wan, Ziqi Huang, Guanwei Fan, Quan Chen, Hongjun Wang, Meifeng Zhu, Deling Kong
Summary: Research on nerve conduits composed of oriented microfiber-bundle cores and randomly organized nanofiber sheaths has shed light on the regulatory role of microfiber orientation in promoting peripheral nerve regeneration, elucidating a cascade of biological responses and ultimately enhancing nerve regeneration outcomes.
Article
Materials Science, Biomaterials
Zhuyan Jiang, Kaihui Zhang, Lilong Du, Zhaojun Cheng, Tongxing Zhang, Ji Ding, Wen Li, Baoshan Xu, Meifeng Zhu
Summary: Chitosan scaffolds with adjustable microchannels were successfully fabricated using a combination of 3D printing and freeze-drying methods, allowing precise control of microchannel arrangement, diameter, and density. The scaffolds promoted cell growth and distribution in vitro, and tissue ingrowth and vascular formation in vivo. This study opens up new possibilities for the development of chitosan scaffolds in tissue engineering and regenerative medicine.
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Article
Multidisciplinary Sciences
Xinchen Du, Le Wu, Hongyu Yan, Zhuyan Jiang, Shilin Li, Wen Li, Yanli Bai, Hongjun Wang, Zhaojun Cheng, Deling Kong, Lianyong Wang, Meifeng Zhu
Summary: Researchers have developed an alkylated chitosan sponge with highly interconnective microchannels, demonstrating its advantages in anti-infective, pro-coagulant, hemostatic, and wound healing capacities, making it suitable for treating noncompressible hemorrhages.
NATURE COMMUNICATIONS
(2021)
Article
Polymer Science
Xingyu Yuan, Wen Li, Bin Yao, Zhao Li, Deling Kong, Sha Huang, Meifeng Zhu
Summary: Synthetic vascular grafts made from the polymer PLCL show great promise for directing tissue regeneration. A tri-layered structure composed of a smooth inner layer, circumferentially aligned fibrous middle layer, and randomly distributed fibrous outer layer was successfully prepared using ink printing, wet spinning, and electrospinning techniques. These grafts exhibited kink resistance and mechanical properties equivalent to clinical standard conduits, and showed visible guiding effects on specific vascular cells.
Article
Multidisciplinary Sciences
Dengke Zhi, Quhan Cheng, Adam C. Midgley, Qiuying Zhang, Tingting Wei, Yi Li, Ting Wang, Tengzhi Ma, Muhammad Rafique, Shuang Xia, Yuejuan Cao, Yangchun Li, Jing Li, Yongzhe Che, Meifeng Zhu, Kai Wang, Deling Kong
Summary: Inspired by the architectural design of steel fiber reinforcement, poly(epsilon-caprolacton) (PCL) fiber skeletons were used to improve the mechanical strength and tissue regeneration of biotubes. The heat-treated medium-fiber-angle PB (hMPB) demonstrated superior performance in mechanical testing and animal models, showing potential as an alternative to autologous vessels in clinical applications.
Article
Cell & Tissue Engineering
Yuying Guo, Dongsheng Hu, Lu Lian, Linna Zhao, Mingli Li, Huijing Bao, Shixin Xu
Summary: This review briefly presents current brain drug delivery strategies and the application of nanocarriers, specifically EVs. EVs, as naturally derived nanoscale vesicles, have been extensively studied in drug delivery due to their superior properties. The cellular origin of EVs affects their properties, and stem cell-derived EVs have shown promise as drug carriers. However, there are still challenges in the clinical application of EVs as drug carriers.
STEM CELL REVIEWS AND REPORTS
(2023)
Article
Nanoscience & Nanotechnology
Wen Li, Pingli Wu, Yu Zhang, Adam C. Midgley, Xingyu Yuan, Yifan Wu, Lina Wang, Zhihong Wang, Meifeng Zhu, Deling Kong
ACS APPLIED BIO MATERIALS
(2019)
