Article
Agriculture, Dairy & Animal Science
Jinbang Xiao, Shanshan Li, Ruixue Zhang, Zongjie Wang, Xinyan Zhang, Aihua Wang, Yaping Jin, Pengfei Lin
Summary: Endometritis is a common reproductive disease in domestic animals caused by Gram-negative bacterial infection, where the ISGylation modification system can regulate the inflammatory response by modulating the TLR4/NF-kappa B signaling pathway. Experimental evidence shows that ISG15 can inhibit LPS-induced inflammatory response through ISGylation.
Article
Biochemistry & Molecular Biology
Nuoer Chen, Bin Ma, Shuai Guo, Baoyi Yin, Jinxin Zhang, Ganzhen Deng
Summary: MiR-196b is up-regulated in bovine endometritis and inhibits inflammatory factors by targeting NRAS, thereby alleviating LPS-induced inflammatory injury.
MOLECULAR IMMUNOLOGY
(2022)
Review
Immunology
Daniel Arthur Corpuz Fisher, Jared Scott Fowles, Amy Zhou, Stephen Tracy Oh
Summary: Myeloid neoplasms such as AML, MPNs, and MDS involve clonal dominance and remodeling of bone marrow niche leading to malignant hematopoiesis. Inflammatory signaling hyperactivation and cytokine overproduction play critical roles, with cytokines like TNF potentially contributing to malignant clonal dominance. Targeting cytokine-mediated signaling may be a promising therapeutic strategy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Ayodele Olaolu Oladejo, Yajuan Li, Bereket Habte Imam, Xiaoyu Ma, Wenxiang Shen, Xiaohu Wu, Wei Jiang, Jie Yang, Yanan Lv, Xuezhi Ding, Shengyi Wang, Zuoting Yan
Summary: The study investigates the regulatory role of miR-24-3p and TRAF6 in the innate immune response of endometritis. Overexpression of miR-24-3p can suppress the secretion of inflammatory cytokines and deactivation of the NF-kappa B/MAPK pathway, thereby attenuating endometrial inflammation and expression of pro-inflammatory mediators.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Immunology
Xinxin Qian, Yan Wang, Xingmei Li, Yuewen Li, Liping Li
Summary: This study found that TNIP2 alleviated endometritis by inhibiting the NF-kappa B pathway, suggesting a potential therapeutic target for endometritis.
IMMUNITY INFLAMMATION AND DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Shusuke Yasuda, Mano Horinaka, Yosuke Iizumi, Wakana Goi, Mamiko Sukeno, Toshiyuki Sakai
Summary: Cellular senescence is a state of irreversible cell growth arrest that triggers the production of pro-inflammatory cytokines, known as SASP. Oridonin has been identified as a potential inhibitor of SASP, potentially through modulation of the NF-kappa B and p38 pathways.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Cell Biology
Yun-yun Shao, Yao Guo, Xiao-juan Feng, Jun-jin Liu, Zhuang-peng Chang, Gui-feng Deng, Ding Xu, Jian-ping Gao, Rui-gang Hou
Summary: Oridonin showed therapeutic effects in experimental PI-IBS by repairing intestinal barrier function, potentially through the regulatory role of PXR/NF-κB signaling pathway. Oridonin may serve as a PXR ligand for the development of drugs in the therapy for PI-IBS.
Article
Neurosciences
Philippa Malko, Xiaoling Jia, Ian Wood, Lin-Hua Jiang
Summary: Microglial cell function and inflammation are regulated by the activation of Piezo1 channel. This study found that the activation of Piezo1 channel can inhibit the pro-inflammatory activation and production of pro-inflammatory cytokines in microglial cells by initiating intracellular Ca2+ signaling to inhibit the NF-kappa B inflammatory signaling pathway.
Review
Biochemistry & Molecular Biology
Lukasz Zdrojkowski, Tomasz Jasinski, Graca Ferreira-Dias, Bartosz Pawlinski, Malgorzata Domino
Summary: This review discusses the impact and role of the NF-kappa B pathway on the development and progression of various endometrial diseases. NF-kappa B modulates immune responses in endometritis, endometrosis, endometriosis, and endometrial carcinoma, leading to changes in cell migration, proliferation, and inflammation intensity. The dysregulation of the immune system involving NF-kappa B-induced chemokine and cytokine production contributes to the pathogenesis of these diseases. Additionally, the influence of estrogen and progesterone cannot be overlooked in the regulation of endometrial diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Ling Lin, Shuyi Chen, Hua Wang, Bin Gao, Bhaskar Kallakury, Krithika Bhuvaneshwar, Katherine Cahn, Yuriy Gusev, Xue Wang, Yunan Wu, John L. Marshall, Xiuling Zhi, Aiwu Ruth He
Summary: This study found that the loss of SPTBN1 in HCC cells leads to an increase in pro-inflammatory cytokines, further affecting the activation of the NF-kappa B pathway, promoting the formation and development of liver cancer. The loss of SPTBN1 can affect the inflammatory response and tumor development of HCC cells by regulating the SOCS1/p65 pathway.
Article
Plant Sciences
Parvathi Annamalai, Elden Berla Thangam
Summary: The methanolic extract from Vitex trifolia L. leaves demonstrated significant anti-inflammatory effects in a rat model of inflammation, reducing edema and leukocyte infiltration. It also lowered the levels of pro-inflammatory cytokines and increased the concentration of anti-inflammatory cytokines. Additionally, the extract inhibited the nuclear translocation of NF-Kappa B, indicating its potential role in down-regulating the inflammatory signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Tomasz Jasinski, Lukasz Zdrojkowski, Ewa Kautz, Edyta Juszczuk-Kubiak, Graca Ferreira-Dias, Malgorzata Domino
Summary: Endometritis is a significant factor that reduces mares' fertility. The NF-kappa B pathway may not play a role in regulating inflammatory responses in equine endometritis.
REPRODUCTION IN DOMESTIC ANIMALS
(2022)
Article
Biochemistry & Molecular Biology
Ji-Won Park, Jinseon Choi, Juhyun Lee, Jin-Mi Park, Seong-Man Kim, Jae-Hong Min, Da-Yun Seo, Soo-Hyeon Goo, Ju-Hee Kim, Ok-Kyoung Kwon, Kihoon Lee, Kyung-Seop Ahn, Sei-Ryang Oh, Jae-Won Lee
Summary: In this study, the ameliorative effects of Methyl p-coumarate (MH) on airway inflammation in an experimental model of allergic asthma were evaluated. The results showed that MH exerted anti-inflammatory activity by suppressing the secretion of inflammatory cytokines, inhibiting cell adhesion, and reducing lung inflammation in mice. The findings suggest that MH has the potential to be used as an adjuvant in asthma therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Talha Umar, Xiaofei Ma, Baoyi Yin, Saqib Umer, Arshad Zahoor, Muhammad Akhtar, Zaima Umar, Aftab Shaukat, Ganzhen Deng
Summary: Research has shown that miR-424-5p inhibits the inflammatory response in endometritis by suppressing IRAK2 expression, indicating its potential as a unique medical treatment for endometritis and other inflammation-related diseases.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Miao Zhang, Chengkun Yin, Yan Chen, Juan Wang, Jing Jiang
Summary: This study reveals the importance of TREM1 and USF2 in endometritis. TREM1 regulates inflammation by binding to TLR2/4 and modulating the NF-kappa B signaling pathway. USF2 promotes the development of endometritis by upregulating TREM1 expression.
