期刊
INFLAMMATION
卷 38, 期 2, 页码 858-870出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10753-014-9995-x
关键词
flavonoids; COX; human whole blood assay; cytokines; chemokine
资金
- Fundacao para a Ciencia e a Tecnologia (FCT, Portugal)
- European Union
- QREN
- FEDER
- COMPETE
- Organic Chemistry Research Unit (QOPNA) [PEst-C/QUI/UI0062/2013]
- University of Aveiro
- Organic Chemistry Research Unit
- Fundacao para a Ciencia e a Tecnologia (FCT) [SFRH/BD/72966/2010, SFRH/BPD/76909/2011]
- FSE
- MCTES
- Fundação para a Ciência e a Tecnologia [SFRH/BD/72966/2010] Funding Source: FCT
Cyclooxygenase 2 (COX-2) and the production of cytokines/chemokines are important targets for the modulation of the inflammatory response. Although a large variety of inhibitors of these pathways have been commercialized, some of those inhibitors present severe side effects, governing the search for new molecules, as alternative anti-inflammatory agents. This study was undertaken to study an hitherto not evaluated group of flavonoids, concerning its capacity to inhibit COX-1 and COX-2 enzymes, as well as to inhibit the production of the cytokines and a chemokine, in a complex matrix involved in the systemic inflammatory process, the blood, aiming the establishment of a structure-activity relationship. The results obtained reveal promising flavonoids for the modulation of the inflammatory process, namely the ones presenting a catechol group in B ring, as some flavonoids were able to simultaneously inhibit the production of inflammatory prostaglandin E-2 and pro-inflammatory cytokines.
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