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Medicine, Research & Experimental
Nihal Inandiklioglu, Zuleyha Doganyigit, Asli Okan, Emin Kaymak, Sibel Silici
Summary: In this study, the protective effect of apilarnil on kidney damage in a sepsis model induced by LPS was investigated. The results showed that the 0.8 g/kg dose of apilarnil significantly reduced the expression levels of inflammatory markers and improved renal histological scores. This suggests that apilarnil may have potential renoprotective effects through modulation of the local immune response in LPS-induced sepsis.
Article
Pharmacology & Pharmacy
Yadong Li, Li Zhang, Ping Zhang, Zhiying Hao
Summary: The study demonstrated that dehydrocorydaline (Deh) alleviates sepsis-induced cardiomyocyte injury by inhibiting the TRAF6/NF-kappa B pathway, showing anti-inflammatory and anti-oxidative stress properties.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Ying-Ya Cao, Zhen Wang, Zhong-Han Wang, Xiao-Gan Jiang, Wei-Hua Lu
Summary: The study found that the miR-155 inhibitor alleviates sepsis-induced inflammation and intestinal barrier dysfunction by inactivating NF-kappa B signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Xiaomei Chen, Ze Liu, Lingkun Huang, Zhenhua Li, Xingui Dai
Summary: The study found that interferon regulatory factor three (IRF3) and subsequent activation of the Hippo pathway play a crucial role in the inflammatory damage and repair of lipopolysaccharide (LPS)-induced acute kidney injury (AKI). Activation of IRF3 led to excessive production of type I interferon (IFN) and triggered the Hippo pathway, resulting in impaired proliferation and repair in renal tubular epithelial cells and worsening of AKI. In conclusion, IRF3 promotes the development of sepsis-associated AKI (SAKI) by modulating the Hippo pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Yuying Li, Huiping Qiu, Shuihong Yao, Qunfeng Li, Yuemin Ding, Yanhui Cao, Xuming Chen, Xiaoping Zhu
Summary: The study shows that Gen can promote the recovery of SCI rats, reduce inflammation, and enhance motor function and axon regeneration by inhibiting the IKKs/NF-κB signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Yuchao Wang, Yue Zheng, Bingcai Qi, Yanwu Liu, Xuan Cheng, Jianyu Feng, Wenqing Gao, Tong Li
Summary: ALA alleviates MI by inhibiting inflammation, oxidation, apoptosis, and autophagy through the HMGB1/NF-κB pathway, and induces M2b polarization, potentially serving as a potential strategy for MI treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jeung-Hyun Koo, Hwang Chan Yu, Seonhwa Nam, Dong-Chan Kim, Jun Ho Lee
Summary: This study investigated the potential of the selective CK2a inhibitor, TBBt, in sepsis-induced AKI. The results demonstrated that TBBt could reduce renal damage, alleviate inflammation, and inhibit apoptosis through the inactivation of MAPK and NF-?B signaling pathways. Therefore, inhibiting CK2a might be a promising therapeutic strategy for sepsis-induced AKI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Jinxiang Wang, Guowu Xu, Heng Jin, Yanfen Chai, Xinyue Yang, Ziquan Liu, Shike Hou, Haojun Fan
Summary: The study found that ulinastatin can alleviate acute kidney injury induced by rhabdomyolysis by suppressing the TLR4/NF-κB signaling pathway. This provides a new mechanism for understanding the protective effect of ulinastatin on rhabdomyolysis-induced acute kidney injury.
Article
Cell Biology
Jinxiang Wang, Guowu Xu, Heng Jin, Yanfen Chai, Xinyue Yang, Ziquan Liu, Shike Hou, Haojun Fan
Summary: Ulinastatin (UTI), a broad-spectrum serine protease inhibitor with strong anti-inflammatory and cytoprotective actions, has been found to alleviate rhabdomyolysis-induced acute kidney injury (RM-AKI) by suppressing inflammatory response and apoptosis through inhibiting TLR4/NF-kappa B signaling pathway. This study provides a new mechanism for the protective effect of UTI on RM-AKI.
Article
Food Science & Technology
Lingli Sun, Shuai Wen, Qiuhua Li, Xingfei Lai, Ruohong Chen, Zhenbiao Zhang, Dongli Li, Shili Sun
Summary: L-theanine can prevent alcohol-induced liver inflammation by regulating the expression of phosphorylated NF-kappa B, TNF-alpha, and IKK alpha, showing potential therapeutic effects in alleviating alcohol-induced liver damage.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Pharmacology & Pharmacy
Zhe Wang, Zhida Chen, Xinyi Wang, Yepeng Hu, Jing Kong, Jiabin Lai, Tiekun Li, Bibi Hu, Yikai Zhang, Xianan Zheng, Xiaoxian Liu, Shengyao Wang, Shu Ye, Qiao Zhou, Chao Zheng
Summary: The study found that Sappanone A (SA) has a protective effect on diabetic kidney disease (DKD) by reducing kidney damage and inflammation. SA exerts its effects by inhibiting the nuclear factor kappa B (NF-kappa B) pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Zhijuan Xie, Lanji Wei, Jianying Chen, Zhong Chen
Summary: This study investigated the antioxidant effect and potential mechanism of calcium dobesilate (CaD) in lipopolysaccharide-induced acute kidney injury (AKI) in mice. The results showed that CaD alleviated renal dysfunction and kidney injury, reduced oxidative stress and inflammation, and inhibited apoptosis through targeting NF-kappa B signaling pathway.
Article
Immunology
Huizhen Chen, Feixue Liu, Dapeng Dai, Yuanyuan Ming, Yao Xu, Zhengqian Huang, Le Zhang, Yong Sun
Summary: This study demonstrates that liensinine can ameliorate acute lung injury (ALI) by modulating the Src/TRAF6/TAK1 axis and blocking the activation of the NF-kappa B pathway, thereby reducing the release of inflammatory factors and improving lung tissue injury. These findings highlight the potential therapeutic efficacy of liensinine for the treatment of ALI.
INFLAMMOPHARMACOLOGY
(2023)
Article
Immunology
Weihuang Qiu, Sheng An, Tingjie Wang, Jiaxin Li, Binmei Yu, Zhenhua Zeng, Zhongqing Chen, Bo Lin, Xianzhong Lin, Youguang Gao
Summary: This study finds that ferroptosis exacerbates sepsis-induced acute kidney injury. Melatonin can suppress ferroptosis and alleviate kidney injury by upregulating the Nrf2/HO-1 pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Xinfeng Qian, Linjun Yang
Summary: ROCK2 is upregulated in LPS-induced HK-2 cells and knockdown of ROCK2 reverses cell damage caused by LPS by inhibiting the activation of the NF-κB/NLRP3 signaling pathway, thereby alleviating apoptosis and inflammation.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)