Article
Pharmacology & Pharmacy
Xiaolu Yu, Junnan Zhou, Fuli Zhao, Xuan Liu, Yuhang Mao, Li Diao, Chuanjun Wen, Mei Liu
Summary: Tomatidine (Td) shows inhibitory effects on inflammatory responses in arthritis and therapeutic effects on synovial inflammation and joint destruction in rats. Td can significantly suppress the production of pro-inflammatory cytokines and may act by reducing the activation of MAPKs and NF-κB.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Applied
Jinyang Cai, Xin Li, Xing Wang, Chengfei Jiang, Dan Shen, Xianwei Cui, Kaipeng Xie, Chenbo Ji, Yan Cao
Summary: In this study, a novel peptide named BCCY-1 corresponding to human beta-casein sequence was identified in human milk, showing immunomodulatory activity by enhancing monocyte migration. BCCY-1 exerts its effects by activating NF-κB and MAPK signaling pathways.
Article
Biotechnology & Applied Microbiology
Jingya Yang, Jing Li, Lanzhu Yang, Ruohui Guo
Summary: This research found that Alkannin attenuated LPS-induced inflammation by inhibiting NF-kappa B and MAPK signaling. This finding may provide a new theoretical basis for exploring new strategies against rheumatoid arthritis.
Article
Oncology
Xuezhong Gao, Xiaodiao Kang, Hongwei Lu, Enxing Xue, Rong Chen, Jun Pan, Jianfeng Ma
Summary: The study found that piceatannol (PIC) has significant therapeutic effects on rheumatoid arthritis (RA), inhibiting inflammatory responses, promoting apoptosis, and regulating the NF-kappa B and MAPK signaling pathways in RA-fibroblast-like synoviocytes (FLSs).
MOLECULAR MEDICINE REPORTS
(2022)
Article
Cell Biology
Qoyama Noel Baito, Halmat M. Jaafar, Talar Ahmad Merza Mohammad
Summary: In this study, piperine was found to induce apoptosis and reduce proliferation of rheumatoid arthritis fibroblast-like synoviocytes (RA-FLSs) through inhibition of the NF-kappa B pathway. It also decreased the expression of genes related to RA-FLS proliferation, apoptosis inhibition, and inflammation, while increasing the expression of apoptosis-related genes. Moreover, piperine reduced the secretion of cytokines and chemokines by FLSs as a result of NF-kappa B inhibition.
CELLULAR IMMUNOLOGY
(2023)
Article
Cell Biology
Yuanxi Yang, Xin Ran, Hefei Wang, Yingsheng Chen, Shuang Hou, Zhanqing Yang, Shoupeng Fu, Juxiong Liu, Guiqiu Hu, Wenjin Guo
Summary: Evodiamine was found to significantly alleviate pathological injury and pro-inflammatory cytokine production in breast tissue, as well as inhibit the activation of inflammation-related pathways.
Article
Veterinary Sciences
Jingjing Cao, Yanhui Ni, Huaxing Zhang, Xiaoran Ning, Xiaoyong Qi
Summary: RA is an autoimmune disease that can cause joint inflammation and destruction. KLF7 expression was found to be upregulated in synovial tissues of rats with arthritis, and its loss suppressed cell proliferation, pro-inflammatory factors, and MMP expression in FLSs through inhibition of NF-kappa B and JNK pathways. miR-9a-5p negatively regulated KLF7 expression, suggesting a potential role for KLF7 as a therapeutic target for RA.
EXPERIMENTAL ANIMALS
(2021)
Article
Integrative & Complementary Medicine
Wang Xiao-He, Dai Ce, Wang Jun, Liu Rui, Li Lei, Yin Zong-Sheng
Summary: Neohesperidin (Neo) has shown potential as a therapeutic drug for rheumatoid arthritis by inhibiting abnormal activation of RA fibroblast-like synoviocytes, reducing inflammation and oxidative stress, inducing apoptosis, and blocking migration of the cells. The compound may offer promise in managing RA progression.
CHINESE JOURNAL OF NATURAL MEDICINES
(2021)
Article
Biochemistry & Molecular Biology
Shuang Zhang, Masayuki Harada, Takeshi Kimura, Noboru Ashida
Summary: Cancer-associated fibroblasts (CAFs) are important components of the tumor microenvironment and play critical roles in tumorigenesis. In this study, the researchers investigated the role of IKK beta, a key kinase for NF-kappa B activation, in activated CAFs. The results showed that IKK beta has a tumor-suppressing function in activated CAFs, and its deletion leads to enhanced tumor growth and upregulation of tumor-promoting factors.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Jin-Kyu Kang, Hyun-Kyu Kang, Chang-Gu Hyun
Summary: Spiramycin has anti-inflammatory effects by inhibiting the production of pro-inflammatory mediators and cytokines in macrophages, suggesting its potential as a candidate for topical anti-inflammatory agents.
Article
Biochemistry & Molecular Biology
Dae-Kyum Kim, Jin-Won Huh, Hyeonseung Yu, Yeji Lee, Yongxin Jin, Un-Hwan Ha
Summary: This study investigated the impact of DnaJ on IL-1 beta expression in macrophages and found that DnaJ modulates macrophages to secrete IL-1 beta by activating NF-kappa B and MAPK signaling pathways. ERK was identified as a positive mediator for IL-1 beta expression, while p38 acted as a negative mediator. Furthermore, the reciprocal actions of MAPKs were found to regulate the activation of inflammasome-related molecules. The study also explored the involvement of CD91/CD40 in ERK signaling-mediated IL-1 beta production from DnaJ-treated macrophages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Tenglin Xu, Yating Zheng, Benjin Liu, Mingxing Kou, Qian Jiang, Jiasen Liu, Hongtao Kang, Mingfa Yang, Dongchun Guo, Liandong Qu
Summary: Pasteurella multocida primarily causes hemorrhagic septicemia and pneumonia in poultry and livestock. Pmorf0222, encoding the PM0222 protein, is identified as a virulence factor that affects the pathogenesis of P. multocida infection. The study demonstrates that PM0222 induces the secretion of proinflammatory cytokines through TLR1/2-NF-kappa B/MAPK signaling and inflammasome activation. Further experiments reveal that Pmorf0222 also influences the synthesis of the capsule, adhesion, serum sensitivity, and biofilm formation.
INFECTION AND IMMUNITY
(2023)
Article
Cell Biology
Yoshinori Aoki, Hongmei Dai, Fumika Furuta, Tomohisa Akamatsu, Takuya Oshima, Naoto Takahashi, Yu-ichi Goto, Akira Oka, Masayuki Itoh
Summary: Microglial cells have an important role in the brain's immune system. LOX-1 expression was confirmed in microglial cells in the neonatal hypoxic-ischemic encephalopathy model brain. LOX-1 activates cytokines and chemokines through intracellular pathways. This study investigated the role and molecular mechanism of LOX-1 gene transcription in microglial cells under hypoxic and ischemic conditions.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Immunology
Mehrnoosh Adib, Mahdi Taghadosi, Mohammad Naghi Tahmasebi, Arash Sharafat Vaziri, Ahmadreza Jamshidi, Mahdi Mahmoudi, Elham Farhadi
Summary: This study investigates the effects of PRIMA-1(MET) on apoptosis induction and inhibition of pro-inflammatory cytokines in fibroblast-like synoviocytes (FLSs) in rheumatoid arthritis (RA). The results show that PRIMA-1(MET) induces apoptosis in RA-FLSs, upregulates Noxa expression, and downregulates IL-6, IL-1β, p53, and phospho-IKBa expression. Furthermore, PRIMA-1(MET) treatment suppresses pro-inflammatory cytokine production and inhibits NF-kappa B activity. Therefore, PRIMA-1(MET) could be considered as a new therapeutic strategy for rheumatoid arthritis.
INFLAMMOPHARMACOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Yeli Zhou, Jing Li, Chenglong Wang, Zheer Pan
Summary: The study discovered that fumitremorgin C alleviates inflammation and extracellular matrix degradation induced by AGE through the activation of the SIRT1/NF-kappa B/MAPK pathway, thus preventing the progression of osteoarthritis.