期刊
INFLAMMATION
卷 34, 期 5, 页码 352-361出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10753-010-9241-0
关键词
anti-inflammatory; cyclooxygenase-2; matrix metalloproteinase-9; nitric oxide; n-propyl gallate; reactive oxygen species
资金
- National Research Foundation of Korea (NRF)
- Ministry of Education, Science and Technology [2009-0072536]
- National Research Foundation of Korea [2009-0072536] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
The present study aimed to assess anti-inflammatory activity and underlying mechanism of n-propyl gallate, the n-propyl ester of gallic acid. n-Propyl gallate was shown to contain anti-inflammatory activity using two experimental animal models, acetic acid-induced permeability model in mice, and air pouch model in rats. It suppressed production of nitric oxide and induction of inducible nitric oxide synthase and cyclooxygenase-2 in the lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells. It was able to diminish reactive oxygen species level elevated in the LPS-stimulated RAW264.7 macrophage cells. It also suppressed gelatinolytic activity of matrix metalloproteinase-9 enhanced in the LPS-stimulated RAW264.7 macrophage cells. It inhibited inhibitory kappa B-alpha degradation and enhanced NF-kappa B promoter activity in the stimulated macrophage cells. It was able to suppress phosphorylation of c-Jun NH(2)-terminal kinase 1/2 (JNK1/2) and activation of c-Jun promoter activity in the stimulated macrophage cells. In brief, n-propyl gallate possesses anti-inflammatory activity via down-regulation of NF-kappa B and JNK pathways.
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